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Simon Stepan Terzyan

TitleScientist,Staff
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentBiochemistry/Molecular Biology
AddressBRC 472
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-8313
Fax0
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yarla NS, Pathuri G, Gali H, Terzyan S, Panneerselvam J, Chandrakesan P, Scotti MT, Houchen C, Madka V, Rao CV. Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. J Inflamm Res. 2020; 13:1261-1278. PMID: 33408499.
      Citations:    
    2. Terzyan SS, Nguyen LT, Burgett AWG, Heroux A, Smith CA, You Y, Hanigan MH. Crystal structures of glutathione- and inhibitor-bound human GGT1: Critical interactions within the cysteinylglycine binding site. J Biol Chem. 2020 Nov 13. PMID: 33187988.
      Citations:    Fields:    
    3. Subbiah V, Shen T, Terzyan SS, Liu X, Hu X, Patel KP, Hu M, Cabanillas M, Behrang A, Meric-Bernstam F, Vo PTT, Mooers BHM, Wu J. Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol. 2021 02; 32(2):261-268. PMID: 33161056.
      Citations: 2     Fields:    Translation:Humans
    4. Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem. 2019 07 05; 294(27):10428-10437. PMID: 31118272.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Terzyan SS, Cook PF, Heroux A, Hanigan MH. Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 06; 26(6):1196-1205. PMID: 28378915.
      Citations: 3     Fields:    Translation:HumansCells
    6. Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 02 10; 292(6):2510-2518. PMID: 28011641.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    7. Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86. PMID: 26013825.
      Citations: 8     Fields:    Translation:HumansCells
    8. Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Inhibition of human ?-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J. 2013 Mar 15; 450(3):547-57. PMID: 23301618.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    9. Ghosh AK, Venkateswara Rao K, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective ß-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J Med Chem. 2012 Nov 08; 55(21):9195-207. PMID: 22954357.
      Citations: 10     Fields:    Translation:HumansCells
    10. Kurien BT, D'Souza A, Terzyan S, Scofield RH. Putative sequences on Ro60 three-dimensional structure accessible for 4-hydroxy-2-nonenal (HNE) modification compared to in vitro HNE modification of Ro60 sequences. Mol Immunol. 2012 Apr; 50(4):185-92. PMID: 22336572.
      Citations:    Fields:    Translation:AnimalsCells
    11. Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Appl Microbiol Biotechnol. 2012 May; 94(4):1041-9. PMID: 22270239.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Parthasarathy S, Altuve A, Terzyan S, Zhang X, Kuczera K, Rivera M, Benson DR. Accommodating a nonconservative internal mutation by water-mediated hydrogen bonding between ß-sheet strands: a comparison of human and rat type B (mitochondrial) cytochrome b5. Biochemistry. 2011 Jun 21; 50(24):5544-54. PMID: 21574570.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochem Biophys Res Commun. 2011 Apr 08; 407(2):400-5. PMID: 21396916.
      Citations: 6     Fields:    
    14. Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD. The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes. Infect Immun. 2009 Nov; 77(11):4714-23. PMID: 19720758.
      Citations: 14     Fields:    Translation:AnimalsCells
    15. Lee KN, Jackson KW, Terzyan S, Christiansen VJ, McKee PA. Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry. 2009 Jun 16; 48(23):5149-58. PMID: 19402713.
      Citations: 11     Fields:    Translation:HumansCells
    16. Chvyrkova I, Zhang XC, Terzyan S. Lethal factor of anthrax toxin binds monomeric form of protective antigen. Biochem Biophys Res Commun. 2007 Aug 31; 360(3):690-5. PMID: 17617379.
      Citations: 3     Fields:    Translation:Cells
    17. Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J. 2007 Jul 25; 26(14):3484-93. PMID: 17581628.
      Citations: 64     Fields:    Translation:HumansCells
    18. Wang L, Cowley AB, Terzyan S, Zhang X, Benson DR. Comparison of cytochromes b5 from insects and vertebrates. Proteins. 2007 May 01; 67(2):293-304. PMID: 17299762.
      Citations: 7     Fields:    Translation:AnimalsCells
    19. Wang L, Sun N, Terzyan S, Zhang X, Benson DR. A histidine/tryptophan pi-stacking interaction stabilizes the heme-independent folding core of microsomal apocytochrome b5 relative to that of mitochondrial apocytochrome b5. Biochemistry. 2006 Nov 21; 45(46):13750-9. PMID: 17105194.
      Citations: 13     Fields:    Translation:AnimalsCells
    20. Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB. Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem J. 2006 May 01; 395(3):473-81. PMID: 16422668.
      Citations: 14     Fields:    Translation:HumansCells
    21. Bourne PC, Terzyan SS, Cloud G, Landolfi NF, Vásquez M, Edmundson AB. Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms. Acta Crystallogr D Biol Crystallogr. 2004 Oct; 60(Pt 10):1761-9. PMID: 15388922.
      Citations:    Fields:    Translation:HumansAnimalsCells
    22. Zhu G, Zhai P, Liu J, Terzyan S, Li G, Zhang XC. Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol. 2004 Oct; 11(10):975-83. PMID: 15378032.
      Citations: 50     Fields:    Translation:Cells
    23. Terzyan S, Wakeham N, Zhai P, Rodgers K, Zhang XC. Characterization of Lys-698-to-Met substitution in human plasminogen catalytic domain. Proteins. 2004 Aug 01; 56(2):277-84. PMID: 15211511.
      Citations: 1     Fields:    Translation:HumansCells
    24. Terzyan S, Ramsland PA, Voss EW, Herron JN, Edmundson AB. Three-dimensional structures of idiotypically related Fabs with intermediate and high affinity for fluorescein. J Mol Biol. 2004 Jun 18; 339(5):1141-51. PMID: 15178254.
      Citations: 4     Fields:    Translation:Cells
    25. Terzyan S, Zhu G, Li G, Zhang XC. Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr D Biol Crystallogr. 2004 Jan; 60(Pt 1):54-60. PMID: 14684892.
      Citations: 7     Fields:    Translation:HumansCells
    26. Zhu G, Zhai P, He X, Terzyan S, Zhang R, Joachimiak A, Tang J, Zhang XC. Crystal structure of the human GGA1 GAT domain. Biochemistry. 2003 Jun 03; 42(21):6392-9. PMID: 12767220.
      Citations: 6     Fields:    Translation:HumansCells
    27. Terzyan SS, Bourne CR, Ramsland PA, Bourne PC, Edmundson AB. Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95. J Mol Recognit. 2003 Mar-Apr; 16(2):83-90. PMID: 12720277.
      Citations: 3     Fields:    Translation:HumansCells
    28. Zhu G, He X, Zhai P, Terzyan S, Tang J, Zhang XC. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. FEBS Lett. 2003 Feb 27; 537(1-3):171-6. PMID: 12606052.
      Citations: 9     Fields:    Translation:Cells
    29. Zhu G, Liu J, Terzyan S, Zhai P, Li G, Zhang XC. High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. J Biol Chem. 2003 Jan 24; 278(4):2452-60. PMID: 12433916.
      Citations: 16     Fields:    Translation:HumansCells
    30. Cowley AB, Altuve A, Kuchment O, Terzyan S, Zhang X, Rivera M, Benson DR. Toward engineering the stability and hemin-binding properties of microsomal cytochromes b5 into rat outer mitochondrial membrane cytochrome b5: examining the influence of residues 25 and 71. Biochemistry. 2002 Oct 01; 41(39):11566-81. PMID: 12269800.
      Citations: 9     Fields:    Translation:AnimalsCells
    31. Wakeham N, Terzyan S, Zhai P, Loy JA, Tang J, Zhang XC. Effects of deletion of streptokinase residues 48-59 on plasminogen activation. Protein Eng. 2002 Sep; 15(9):753-61. PMID: 12456874.
      Citations: 14     Fields:    Translation:HumansCells
    32. Oganesyan V, Oganesyan N, Terzyan S, Qu D, Dauter Z, Esmon NL, Esmon CT. The crystal structure of the endothelial protein C receptor and a bound phospholipid. J Biol Chem. 2002 Jul 12; 277(28):24851-4. PMID: 12034704.
      Citations: 64     Fields:    Translation:AnimalsCells
    33. Bourne PC, Ramsland PA, Shan L, Fan ZC, DeWitt CR, Shultz BB, Terzyan SS, Moomaw CR, Slaughter CA, Guddat LW, Edmundson AB. Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties. Acta Crystallogr D Biol Crystallogr. 2002 May; 58(Pt 5):815-23. PMID: 11976493.
      Citations: 13     Fields:    Translation:HumansCells
    34. Altuve A, Silchenko S, Lee KH, Kuczera K, Terzyan S, Zhang X, Benson DR, Rivera M. Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5. Biochemistry. 2001 Aug 14; 40(32):9469-83. PMID: 11583146.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    35. Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M. Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution. Acta Crystallogr D Biol Crystallogr. 2001 Apr; 57(Pt 4):498-505. PMID: 11264578.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    36. Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M. Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. J Mol Biol. 2000 Oct 13; 303(1):49-60. PMID: 11021969.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    37. Hong L, Koelsch G, Lin X, Wu S, Terzyan S, Ghosh AK, Zhang XC, Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science. 2000 Oct 06; 290(5489):150-3. PMID: 11021803.
      Citations: 127     Fields:    Translation:HumansCells
    38. Terzyan S, Wang CS, Downs D, Hunter B, Zhang XC. Crystal structure of the catalytic domain of human bile salt activated lipase. Protein Sci. 2000 Sep; 9(9):1783-90. PMID: 11045623.
      Citations: 10     Fields:    Translation:HumansCells
    39. Wang X, Terzyan S, Tang J, Loy JA, Lin X, Zhang XC. Human plasminogen catalytic domain undergoes an unusual conformational change upon activation. J Mol Biol. 2000 Jan 28; 295(4):903-14. PMID: 10656799.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    40. Terzyan SS, Peracaula R, de Llorens R, Tsushima Y, Yamada H, Seno M, Gomis-Rüth FX, Coll M. The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. J Mol Biol. 1999 Jan 08; 285(1):205-14. PMID: 9878400.
      Citations: 13     Fields:    Translation:HumansCells
    41. Sherman MB, Orlova EV, Terzyan SS, Kleine R, Kiselev NA. On the negative straining of the protein crystal structure. Ultramicroscopy. 1981; 7(2):131-8. PMID: 6175064.
      Citations: 2     Fields:    Translation:Cells
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