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Daniel J Carr

TitleProf,George L Cross Rsrch
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentOphthalmology
AddressDMEI 415
608 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    T32EY023202     (CALLEGAN, MICHELLE C)May 1, 2014 - Mar 31, 2026
    NIH
    Vision Science Training Program
    Role: Principal Investigator
    R01EY021238     (CARR, DANIEL J)Dec 1, 2010 - Nov 30, 2021
    NIH
    Corneal Lymphatics & Adaptive Immunity
    Role: Principal Investigator
    R21EY018834     (CARR, DANIEL J)Jan 1, 2009 - Dec 31, 2010
    NIH
    Ocular Lymphangiogenesis
    Role: Principal Investigator
    R01AI067309     (CARR, DANIEL J)Jul 1, 2007 - Jun 30, 2011
    NIH
    The Role of CXCL9 in Genital HSV-2 Infection
    Role: Principal Investigator
    R21EY015566     (CARR, DANIEL J)Apr 1, 2004 - Mar 31, 2007
    NIH
    Anti-Viral Gene Delivery in the Nervous System
    Role: Principal Investigator
    R01AI053108     (CARR, DANIEL J)Apr 1, 2003 - Dec 31, 2023
    NIH
    The Neuroimmunology of Viral Infection
    Role: Principal Investigator
    R01EY012409     (CARR, DANIEL J)Dec 1, 1998 - Nov 30, 2002
    NIH
    NEUROIMMUNOLOGY OF AED IN OCULAR HSV-1 INFECTION
    Role: Principal Investigator
    R01NS035470     (CARR, DANIEL J)Jul 1, 1996 - Oct 31, 1999
    NIH
    NEUROIMMUNOLOGY OF HSV-1 REACTIVATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Carr DJJ, Filiberti A, Gmyrek GB. Complement Suppresses the Initial Type 1 Interferon Response to Ocular Herpes Simplex Virus Type 1 Infection in Mice. Pathogens. 2024 Jan 13; 13(1). PMID: 38251381; PMCID: PMC10820508.
      Citations:    
    2. Filiberti A, Gmyrek GB, Berube AN, Carr DJJ. Osteopontin contributes to virus resistance associated with type I IFN expression, activation of downstream ifn-inducible effector genes, and CCR2+CD115+CD206+ macrophage infiltration following ocular HSV-1 infection of mice. Front Immunol. 2022; 13:1028341. PMID: 36685562; PMCID: PMC9846535.
      Citations: 2     Fields:    Translation:AnimalsCells
    3. Gmyrek GB, Berube AN, Sjoelund VH, Carr DJJ. HSV-1 0?NLS vaccine elicits a robust B lymphocyte response and preserves vision without HSV-1 glycoprotein M or thymidine kinase recognition. Sci Rep. 2022 09 23; 12(1):15920. PMID: 36151255; PMCID: PMC9508094.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Berube A, Gmyrek GB, Royer DJ, Carr DJJ. Tripartite-Motif 21 (TRIM21) Deficiency Results in a Modest Loss of Herpes Simplex Virus (HSV)-1 Surveillance in the Trigeminal Ganglia Following Cornea Infection. Viruses. 2022 03 12; 14(3). PMID: 35336995.
      Citations: 3     Fields:    Translation:AnimalsCells
    5. Gmyrek GB, Predki P, Gershburg E, Carr DJJ. Noncognate Signals Drive Enhanced Effector CD8+ T Cell Responses through an IFNAR1-Dependent Pathway after Infection with the Prototypic Vaccine, 0?NLS, against Herpes Simplex Virus 1. J Virol. 2022 03 23; 96(6):e0172421. PMID: 35045268.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Carr DJJ, Berube A, Gershburg E. The Durability of Vaccine Efficacy against Ocular HSV-1 Infection Using ICP0 Mutants 0?NLS and 0?RING Is Lost over Time. Pathogens. 2021 Nov 12; 10(11). PMID: 34832625.
      Citations: 4     
    7. Gurley JM, Gmyrek GB, Hargis EA, Bishop GA, Carr DJJ, Elliott MH. The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation. Cells. 2021 08 12; 10(8). PMID: 34440839.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Filiberti A, Gmyrek GB, Berube AN, Royer DJ, Carr DJJ. An intact complement system dampens cornea inflammation during acute primary HSV-1 infection. Sci Rep. 2021 05 13; 11(1):10247. PMID: 33986436.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Carr DJJ, Berube AN, Filiberti A, Gmyrek GB. Lack of neonatal Fc receptor does not diminish the efficacy of the HSV-1 0?NLS vaccine against ocular HSV-1 challenge. Vaccine. 2021 04 28; 39(18):2526-2536. PMID: 33814229.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Joyce JD, Patel AK, Murphy B, Carr DJJ, Gershburg E, Bertke AS. Assessment of Two Novel Live-Attenuated Vaccine Candidates for Herpes Simplex Virus 2 (HSV-2) in Guinea Pigs. Vaccines (Basel). 2021 Mar 13; 9(3). PMID: 33805768.
      Citations: 9     
    11. Gmyrek GB, Filiberti A, Montgomery M, Chitrakar A, Royer DJ, Carr DJJ. Herpes Simplex Virus 1 (HSV-1) 0?NLS Live-Attenuated Vaccine Protects against Ocular HSV-1 Infection in the Absence of Neutralizing Antibody in HSV-1 gB T Cell Receptor-Specific Transgenic Mice. J Virol. 2020 11 23; 94(24). PMID: 32999018.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    12. Carr DJJ, Gmyrek GB, Filiberti A, Berube AN, Browne WP, Gudgel BM, Sjoelund VH. Distinguishing Features of High- and Low-Dose Vaccine against Ocular HSV-1 Infection Correlates with Recognition of Specific HSV-1-Encoded Proteins. Immunohorizons. 2020 10 09; 4(10):608-626. PMID: 33037098.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Gurley JM, Gmyrek GB, McClellan ME, Hargis EA, Hauck SM, Dozmorov MG, Wren JD, Carr DJJ, Elliott MH. Neuroretinal-Derived Caveolin-1 Promotes Endotoxin-Induced Inflammation in the Murine Retina. Invest Ophthalmol Vis Sci. 2020 10 01; 61(12):19. PMID: 33079993.
      Citations: 8     Fields:    Translation:AnimalsCells
    14. Filiberti A, Gmyrek GB, Montgomery ML, Sallack R, Carr DJJ. Loss of Osteopontin Expression Reduces HSV-1-Induced Corneal Opacity. Invest Ophthalmol Vis Sci. 2020 08 03; 61(10):24. PMID: 32785676.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Rao CV, Asch AS, Carr DJJ, Yamada HY. "Amyloid-beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease. Aging Cell. 2020 03; 19(3):e13109. PMID: 31981470.
      Citations: 26     Fields:    Translation:HumansAnimals
    16. Montgomery ML, Callegan MC, Fuller KK, Carr DJJ. Ocular Glands Become Infected Secondarily to Infectious Keratitis and Play a Role in Corneal Resistance to Infection. J Virol. 2019 08 15; 93(16). PMID: 31167909.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Royer DJ, Hendrix JF, Larabee CM, Reagan AM, Sjoelund VH, Robertson DM, Carr DJJ. Vaccine-induced antibodies target sequestered viral antigens to prevent ocular HSV-1 pathogenesis, preserve vision, and preempt productive neuronal infection. Mucosal Immunol. 2019 05; 12(3):827-839. PMID: 30670763.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Royer DJ, Elliott MH, Le YZ, Carr DJJ. Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522. PMID: 29625473.
      Citations: 13     Fields:    Translation:AnimalsCells
    19. Royer DJ, Carr DJJ. Reply to "Highly Efficacious Novel Vaccine, Humoral Immunity, and Ocular Herpes Simplex Virus 1: Reality or Myth?" J Virol. 2017 12 01; 91(23). PMID: 29138328.
      Citations:    Fields:    Translation:HumansCells
    20. Carr DJJ. Herpes Simplex Virus 1, Macrophages, and the Cornea. J Virol. 2017 11 01; 91(21). PMID: 29030534.
      Citations:    Fields:    Translation:HumansCells
    21. Chucair-Elliott AJ, Gurung HR, Carr MM, Carr DJJ. Colony Stimulating Factor-1 Receptor Expressing Cells Infiltrating the Cornea Control Corneal Nerve Degeneration in Response to HSV-1 Infection. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4670-4682. PMID: 28903153.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Royer DJ, Carr MM, Gurung HR, Halford WP, Carr DJJ. The Neonatal Fc Receptor and Complement Fixation Facilitate Prophylactic Vaccine-Mediated Humoral Protection against Viral Infection in the Ocular Mucosa. J Immunol. 2017 09 01; 199(5):1898-1911. PMID: 28760885.
      Citations: 13     Fields:    Translation:AnimalsCells
    23. Menendez CM, Carr DJJ. Herpes simplex virus-1 infects the olfactory bulb shortly following ocular infection and exhibits a long-term inflammatory profile in the form of effector and HSV-1-specific T cells. J Neuroinflammation. 2017 06 23; 14(1):124. PMID: 28645309.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Gurung HR, Carr MM, Bryant K, Chucair-Elliott AJ, Carr DJ. Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. Mucosal Immunol. 2018 01; 11(1):172-185. PMID: 28378806.
      Citations: 26     Fields:    Translation:AnimalsCells
    25. Royer DJ, Carr MM, Chucair-Elliott AJ, Halford WP, Carr DJJ. Impact of Type I Interferon on the Safety and Immunogenicity of an Experimental Live-Attenuated Herpes Simplex Virus 1 Vaccine in Mice. J Virol. 2017 04 01; 91(7). PMID: 28122977.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    26. Menendez CM, Carr DJJ. Defining nervous system susceptibility during acute and latent herpes simplex virus-1 infection. J Neuroimmunol. 2017 07 15; 308:43-49. PMID: 28302316.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    27. Chucair-Elliott AJ, Carr MM, Carr DJJ. Long-term consequences of topical dexamethasone treatment during acute corneal HSV-1 infection on the immune system. J Leukoc Biol. 2017 05; 101(5):1253-1261. PMID: 28115476.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. Zander RA, Guthmiller JJ, Graham AC, Pope RL, Burke BE, Carr DJ, Butler NS. Type I Interferons Induce T Regulatory 1 Responses and Restrict Humoral Immunity during Experimental Malaria. PLoS Pathog. 2016 Oct; 12(10):e1005945. PMID: 27732671.
      Citations: 46     Fields:    Translation:AnimalsCells
    29. Gurung HR, Carr MM, Carr DJ. Cornea lymphatics drive the CD8+ T-cell response to herpes simplex virus-1. Immunol Cell Biol. 2017 01; 95(1):87-98. PMID: 27577867.
      Citations: 8     Fields:    Translation:AnimalsCells
    30. Royer DJ, Conrady CD, Carr DJ. Herpesvirus-Associated Lymphadenitis Distorts Fibroblastic Reticular Cell Microarchitecture and Attenuates CD8 T Cell Responses to Neurotropic Infection in Mice Lacking the STING-IFNa/ß Defense Pathways. J Immunol. 2016 09 15; 197(6):2338-52. PMID: 27511736.
      Citations: 10     Fields:    Translation:AnimalsCells
    31. Chucair-Elliott AJ, Jinkins J, Carr MM, Carr DJ. IL-6 Contributes to Corneal Nerve Degeneration after Herpes Simplex Virus Type I Infection. Am J Pathol. 2016 10; 186(10):2665-78. PMID: 27497323.
      Citations: 23     Fields:    Translation:AnimalsCells
    32. Menendez CM, Jinkins JK, Carr DJ. Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency. J Immunol. 2016 08 15; 197(4):1262-75. PMID: 27357149.
      Citations: 33     Fields:    Translation:AnimalsCells
    33. Royer DJ, Gurung HR, Jinkins JK, Geltz JJ, Wu JL, Halford WP, Carr DJJ. A Highly Efficacious Herpes Simplex Virus 1 Vaccine Blocks Viral Pathogenesis and Prevents Corneal Immunopathology via Humoral Immunity. J Virol. 2016 06 01; 90(11):5514-5529. PMID: 27030264.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    34. Drevets P, Chucair-Elliott A, Shrestha P, Jinkins J, Karamichos D, Carr DJ. The use of human cornea organotypic cultures to study herpes simplex virus type 1 (HSV-1)-induced inflammation. Graefes Arch Clin Exp Ophthalmol. 2015 Oct; 253(10):1721-8. PMID: 26047535.
      Citations: 9     Fields:    Translation:HumansCells
    35. Royer DJ, Zheng M, Conrady CD, Carr DJ. Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils. Invest Ophthalmol Vis Sci. 2015 Jun; 56(6):3763-75. PMID: 26066745.
      Citations: 39     Fields:    Translation:AnimalsCells
    36. Chucair-Elliott AJ, Zheng M, Carr DJ. Degeneration and regeneration of corneal nerves in response to HSV-1 infection. Invest Ophthalmol Vis Sci. 2015 Jan 13; 56(2):1097-107. PMID: 25587055.
      Citations: 60     Fields:    Translation:AnimalsCells
    37. Bryant-Hudson KM, Gurung HR, Zheng M, Carr DJ. Tumor necrosis factor alpha and interleukin-6 facilitate corneal lymphangiogenesis in response to herpes simplex virus 1 infection. J Virol. 2014 Dec; 88(24):14451-7. PMID: 25297992.
      Citations: 28     Fields:    Translation:AnimalsCells
    38. Li X, Gu X, Boyce TM, Zheng M, Reagan AM, Qi H, Mandal N, Cohen AW, Callegan MC, Carr DJ, Elliott MH. Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation. Invest Ophthalmol Vis Sci. 2014 Aug 26; 55(10):6224-34. PMID: 25159208.
      Citations: 19     Fields:    Translation:AnimalsCells
    39. Kroll CM, Zheng M, Carr DJ. Enhanced resistance of CXCR3 deficient mice to ocular HSV-1 infection is due to control of replication in the brain ependyma. J Neuroimmunol. 2014 Nov 15; 276(1-2):219-23. PMID: 25139013.
      Citations: 7     Fields:    Translation:AnimalsCells
    40. Chucair-Elliott AJ, Conrady C, Zheng M, Kroll CM, Lane TE, Carr DJ. Microglia-induced IL-6 protects against neuronal loss following HSV-1 infection of neural progenitor cells. Glia. 2014 Sep; 62(9):1418-34. PMID: 24807365.
      Citations: 59     Fields:    Translation:AnimalsCells
    41. Chan AY, Mann SN, Chen H, Stone DU, Carr DJ, Mandal NA. Sphingolipids in ocular inflammation. Adv Exp Med Biol. 2014; 801:623-9. PMID: 24664751.
      Citations: 2     Fields:    Translation:Humans
    42. Bryant-Hudson KM, Chucair-Elliott AJ, Conrady CD, Cohen A, Zheng M, Carr DJJ. HSV-1 targets lymphatic vessels in the eye and draining lymph node of mice leading to edema in the absence of a functional type I interferon response. Am J Pathol. 2013 Oct; 183(4):1233-1242. PMID: 23911821.
      Citations: 15     Fields:    Translation:AnimalsCells
    43. Bryant-Hudson K, Conrady CD, Carr DJ. Type I interferon and lymphangiogenesis in the HSV-1 infected cornea - are they beneficial to the host? Prog Retin Eye Res. 2013 Sep; 36:281-91. PMID: 23876483.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    44. Fung KY, Mangan NE, Cumming H, Horvat JC, Mayall JR, Stifter SA, De Weerd N, Roisman LC, Rossjohn J, Robertson SA, Schjenken JE, Parker B, Gargett CE, Nguyen HP, Carr DJ, Hansbro PM, Hertzog PJ. Interferon-e protects the female reproductive tract from viral and bacterial infection. Science. 2013 Mar 01; 339(6123):1088-92. PMID: 23449591.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    45. Conrady CD, Zheng M, van Rooijen N, Drevets DA, Royer D, Alleman A, Carr DJ. Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013 Mar 15; 190(6):2807-17. PMID: 23382563.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    46. Bryant-Hudson KM, Carr DJ. CXCL1-deficient mice are highly sensitive to pseudomonas aeruginosa but not herpes simplex virus type 1 corneal infection. Invest Ophthalmol Vis Sci. 2012 Oct 01; 53(11):6785-92. PMID: 22952118.
      Citations: 14     Fields:    Translation:AnimalsCells
    47. Conrady CD, Zheng M, Stone DU, Carr DJ. CD8+ T cells suppress viral replication in the cornea but contribute to VEGF-C-induced lymphatic vessel genesis. J Immunol. 2012 Jul 01; 189(1):425-32. PMID: 22649204.
      Citations: 37     Fields:    Translation:AnimalsCells
    48. Zheng M, Conrady CD, Ward JM, Bryant-Hudson KM, Carr DJ. Comparison of the host immune response to herpes simplex virus 1 (HSV-1) and HSV-2 at two different mucosal sites. J Virol. 2012 Jul; 86(13):7454-8. PMID: 22532684.
      Citations: 8     Fields:    Translation:AnimalsCells
    49. Bryant-Hudson KM, Carr DJ. PD-L1-expressing dendritic cells contribute to viral resistance during acute HSV-1 infection. Clin Dev Immunol. 2012; 2012:924619. PMID: 22474484.
      Citations: 14     Fields:    Translation:AnimalsCells
    50. Wuest T, Zheng M, Efstathiou S, Halford WP, Carr DJ. The herpes simplex virus-1 transactivator infected cell protein-4 drives VEGF-A dependent neovascularization. PLoS Pathog. 2011 Oct; 7(10):e1002278. PMID: 21998580.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    51. Wuest TR, Thapa M, Zheng M, Carr DJ. CXCL10 expressing hematopoietic-derived cells are requisite in defense against HSV-1 infection in the nervous system of CXCL10 deficient mice. J Neuroimmunol. 2011 May; 234(1-2):103-8. PMID: 21470697.
      Citations: 10     Fields:    Translation:AnimalsCells
    52. Conrady CD, Jones H, Zheng M, Carr DJ. A Functional Type I Interferon Pathway Drives Resistance to Cornea Herpes Simplex Virus Type 1 Infection by Recruitment of Leukocytes. J Biomed Res. 2011 Mar; 25(2):111-119. PMID: 21709805.
      Citations: 31     
    53. Conrady CD, Halford WP, Carr DJ. Loss of the type I interferon pathway increases vulnerability of mice to genital herpes simplex virus 2 infection. J Virol. 2011 Feb; 85(4):1625-33. PMID: 21147921.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    54. Wuest TR, Carr DJ. VEGF-A expression by HSV-1-infected cells drives corneal lymphangiogenesis. J Exp Med. 2010 Jan 18; 207(1):101-15. PMID: 20026662.
      Citations: 110     Fields:    Translation:AnimalsCells
    55. Conrady CD, Drevets DA, Carr DJ. Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J Neuroimmunol. 2010 Mar 30; 220(1-2):1-9. PMID: 19819030.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    56. Thapa M, Carr DJ. CXCR3 deficiency increases susceptibility to genital herpes simplex virus type 2 infection: Uncoupling of CD8+ T-cell effector function but not migration. J Virol. 2009 Sep; 83(18):9486-501. PMID: 19587047.
      Citations: 36     Fields:    Translation:AnimalsCells
    57. Conrady CD, Thapa M, Wuest T, Carr DJ. Loss of mandibular lymph node integrity is associated with an increase in sensitivity to HSV-1 infection in CD118-deficient mice. J Immunol. 2009 Mar 15; 182(6):3678-87. PMID: 19265146.
      Citations: 23     Fields:    Translation:AnimalsCells
    58. Wuest TR, Carr DJ. Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol. 2008 Dec 01; 181(11):7985-93. PMID: 19017990.
      Citations: 70     Fields:    Translation:AnimalsCells
    59. Carr DJ, Austin BA, Halford WP, Stuart PM. Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways. J Neuroimmunol. 2009 Jan 03; 206(1-2):39-43. PMID: 19042034.
      Citations: 8     Fields:    Translation:AnimalsCells
    60. Muse M, Kane JA, Carr DJ, Farber JM, Lane TE. Insertion of the CXC chemokine ligand 9 (CXCL9) into the mouse hepatitis virus genome results in protection from viral-induced encephalitis and hepatitis. Virology. 2008 Dec 20; 382(2):132-44. PMID: 18973912.
      Citations: 10     Fields:    Translation:AnimalsCells
    61. Thapa M, Carr DJ. Herpes simplex virus type 2-induced mortality following genital infection is blocked by anti-tumor necrosis factor alpha antibody in CXCL10-deficient mice. J Virol. 2008 Oct; 82(20):10295-301. PMID: 18684827.
      Citations: 11     Fields:    Translation:AnimalsCells
    62. Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ, Borghesi LA, Farrar MA, Kincade PW. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood. 2008 Nov 01; 112(9):3753-61. PMID: 18552210.
      Citations: 69     Fields:    Translation:AnimalsCells
    63. Templeton A, Nguyen G, Ash JD, Straub RH, Carr DJ. Chemical sympathectomy increases susceptibility to ocular herpes simplex virus type 1 infection. J Neuroimmunol. 2008 Jun 15; 197(1):37-46. PMID: 18495255.
      Citations: 7     Fields:    Translation:AnimalsCells
    64. Wuest TR, Carr DJ. The role of chemokines during herpes simplex virus-1 infection. Front Biosci. 2008 May 01; 13:4862-72. PMID: 18508551.
      Citations: 33     Fields:    Translation:HumansCells
    65. Carr DJ, Wuest T, Ash J. An increase in herpes simplex virus type 1 in the anterior segment of the eye is linked to a deficiency in NK cell infiltration in mice deficient in CXCR3. J Interferon Cytokine Res. 2008 Apr; 28(4):245-51. PMID: 18439102.
      Citations: 24     Fields:    Translation:AnimalsCells
    66. Thapa M, Welner RS, Pelayo R, Carr DJ. CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system. J Immunol. 2008 Jan 15; 180(2):1098-106. PMID: 18178850.
      Citations: 70     Fields:    Translation:AnimalsCells
    67. Austin BA, Halford WP, Williams BR, Carr DJ. Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. J Immunol. 2007 Apr 15; 178(8):5166-72. PMID: 17404299.
      Citations: 10     Fields:    Translation:AnimalsCells
    68. Wuest T, Farber J, Luster A, Carr DJ. CD4+ T cell migration into the cornea is reduced in CXCL9 deficient but not CXCL10 deficient mice following herpes simplex virus type 1 infection. Cell Immunol. 2006 Oct; 243(2):83-9. PMID: 17296171.
      Citations: 35     Fields:    Translation:AnimalsCells
    69. Thapa M, Kuziel WA, Carr DJ. Susceptibility of CCR5-deficient mice to genital herpes simplex virus type 2 is linked to NK cell mobilization. J Virol. 2007 Apr; 81(8):3704-13. PMID: 17267483.
      Citations: 64     Fields:    Translation:AnimalsCells
    70. Wuest T, Austin BA, Uematsu S, Thapa M, Akira S, Carr DJ. Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10. J Neuroimmunol. 2006 Oct; 179(1-2):46-52. PMID: 16884784.
      Citations: 39     Fields:    Translation:AnimalsCells
    71. Carr DJ, Wuest T, Tomanek L, Silverman RH, Williams BR. The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology. 2006 Aug; 118(4):520-6. PMID: 16895559.
      Citations: 6     Fields:    Translation:AnimalsCells
    72. Austin BA, James CM, Härle P, Carr DJ. Direct application of plasmid DNA containing type I interferon transgenes to vaginal mucosa inhibits HSV-2 mediated mortality. Biol Proced Online. 2006; 8:55-62. PMID: 16900260.
      Citations: 6     
    73. Halford WP, Weisend C, Grace J, Soboleski M, Carr DJ, Balliet JW, Imai Y, Margolis TP, Gebhardt BM. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J. 2006 Jun 09; 3:44. PMID: 16764725.
      Citations: 64     Fields:    Translation:AnimalsCells
    74. Austin BA, Halford W, Silverman RH, Williams BR, Carr DJ. OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures. J Interferon Cytokine Res. 2006 Apr; 26(4):220-5. PMID: 16704298.
      Citations: 7     Fields:    Translation:AnimalsCells
    75. Carr DJJ, Ash J, Lane TE, Kuziel WA. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol. 2006 Mar; 87(Pt 3):489-499. PMID: 16476970.
      Citations: 27     Fields:    Translation:AnimalsCells
    76. Carr DJ, Tomanek L. Herpes simplex virus and the chemokines that mediate the inflammation. Curr Top Microbiol Immunol. 2006; 303:47-65. PMID: 16570856.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    77. Carr DJ, Campbell IL. Herpes simplex virus type 1 induction of chemokine production is unrelated to viral load in the cornea but not in the nervous system. Viral Immunol. 2006; 19(4):741-6. PMID: 17201669.
      Citations: 10     Fields:    Translation:AnimalsCells
    78. Austin BA, James C, Silverman RH, Carr DJ. Critical role for the oligoadenylate synthetase/RNase L pathway in response to IFN-beta during acute ocular herpes simplex virus type 1 infection. J Immunol. 2005 Jul 15; 175(2):1100-6. PMID: 16002711.
      Citations: 36     Fields:    Translation:AnimalsCells
    79. Carr DJ, Tomanek L, Silverman RH, Campbell IL, Williams BR. RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2. J Virol. 2005 Jul; 79(14):9341-5. PMID: 15994831.
      Citations: 11     Fields:    Translation:Animals
    80. Wickham S, Lu B, Ash J, Carr DJ. Chemokine receptor deficiency is associated with increased chemokine expression in the peripheral and central nervous systems and increased resistance to herpetic encephalitis. J Neuroimmunol. 2005 May; 162(1-2):51-9. PMID: 15833359.
      Citations: 31     Fields:    Translation:AnimalsCells
    81. Härle P, Möbius D, Carr DJ, Schölmerich J, Straub RH. An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen-induced arthritis. Arthritis Rheum. 2005 Apr; 52(4):1305-13. PMID: 15818682.
      Citations: 47     Fields:    Translation:Animals
    82. Al-Khatib K, Williams BR, Silverman RH, Halford W, Carr DJ. Dichotomy between survival and lytic gene expression in RNase L- and PKR-deficient mice transduced with an adenoviral vector expressing murine IFN-beta following ocular HSV-1 infection. Exp Eye Res. 2005 Feb; 80(2):167-73. PMID: 15670795.
      Citations: 3     Fields:    Translation:AnimalsCells
    83. John-Philip B, Carr DJ. Transfection of Mülller cells with type I interferon transgenes: resistance to HSV-1 infection. Methods Mol Med. 2005; 116:221-32. PMID: 16000865.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    84. Al-Khatib K, Williams BR, Silverman RH, Halford W, Carr DJ. Distinctive roles for 2',5'-oligoadenylate synthetases and double-stranded RNA-dependent protein kinase R in the in vivo antiviral effect of an adenoviral vector expressing murine IFN-beta. J Immunol. 2004 May 01; 172(9):5638-47. PMID: 15100308.
      Citations: 10     Fields:    Translation:AnimalsCells
    85. Wickham S, Ash J, Lane TE, Carr DJ. Consequences of CXCL10 and IL-6 induction by the murine IFN-alpha1 transgene in ocular herpes simplex virus type 1 infection. Immunol Res. 2004; 30(2):191-200. PMID: 15477660.
      Citations: 6     Fields:    Translation:AnimalsCells
    86. Härle P, Carr DJ. Large-scale generation of plasmids that express type I interferon. Methods Mol Biol. 2004; 249:1-6. PMID: 14573886.
      Citations:    Fields:    Translation:HumansAnimalsCells
    87. Carr DJ, Chodosh J, Ash J, Lane TE. Effect of anti-CXCL10 monoclonal antibody on herpes simplex virus type 1 keratitis and retinal infection. J Virol. 2003 Sep; 77(18):10037-46. PMID: 12941914.
      Citations: 45     Fields:    Translation:AnimalsCells
    88. Al-khatib K, Williams BR, Silverman RH, Halford W, Carr DJ. The murine double-stranded RNA-dependent protein kinase PKR and the murine 2',5'-oligoadenylate synthetase-dependent RNase L are required for IFN-beta-mediated resistance against herpes simplex virus type 1 in primary trigeminal ganglion culture. Virology. 2003 Aug 15; 313(1):126-35. PMID: 12951027.
      Citations: 30     Fields:    Translation:AnimalsCells
    89. Carr DJ, Al-khatib K, James CM, Silverman R. Interferon-beta suppresses herpes simplex virus type 1 replication in trigeminal ganglion cells through an RNase L-dependent pathway. J Neuroimmunol. 2003 Aug; 141(1-2):40-6. PMID: 12965252.
      Citations: 15     Fields:    Translation:AnimalsCells
    90. Al-Khatib K, Campbell IL, Carr DJ. Resistance to ocular herpes simplex virus type 1 infection in IL-12 transgenic mice. J Neuroimmunol. 2002 Nov; 132(1-2):41-8. PMID: 12417432.
      Citations: 3     Fields:    Translation:AnimalsCells
    91. Härle P, Cull V, Guo L, Papin J, Lawson C, Carr DJ. Transient transfection of mouse fibroblasts with type I interferon transgenes provides various degrees of protection against herpes simplex virus infection. Antiviral Res. 2002 Oct; 56(1):39-49. PMID: 12323398.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    92. Carr DJ, Noisakran S. The antiviral efficacy of the murine alpha-1 interferon transgene against ocular herpes simplex virus type 1 requires the presence of CD4(+), alpha/beta T-cell receptor-positive T lymphocytes with the capacity to produce gamma interferon. J Virol. 2002 Sep; 76(18):9398-406. PMID: 12186922.
      Citations: 10     Fields:    Translation:AnimalsCells
    93. Al-Khatib K, Williams BR, Silverman RH, Halford WP, Carr DJ. Absence of PKR attenuates the anti-HSV-1 activity of an adenoviral vector expressing murine IFN-beta. J Interferon Cytokine Res. 2002 Aug; 22(8):861-71. PMID: 12396725.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Härle P, Cull V, Agbaga MP, Silverman R, Williams BR, James C, Carr DJ. Differential effect of murine alpha/beta interferon transgenes on antagonization of herpes simplex virus type 1 replication. J Virol. 2002 Jul; 76(13):6558-67. PMID: 12050368.
      Citations: 27     Fields:    Translation:AnimalsCells
    95. Carr DJ, Ash J, Al-Khatib K, Campbell IL. Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following herpes simplex virus type 1 infection. DNA Cell Biol. 2002 May-Jun; 21(5-6):467-73. PMID: 12167250.
      Citations: 1     Fields:    Translation:AnimalsCells
    96. Härle P, Sainz B, Carr DJ, Halford WP. The immediate-early protein, ICP0, is essential for the resistance of herpes simplex virus to interferon-alpha/beta. Virology. 2002 Feb 15; 293(2):295-304. PMID: 11886249.
      Citations: 77     Fields:    Translation:AnimalsCells
    97. Carr DJ, Härle P, Gebhardt BM. The immune response to ocular herpes simplex virus type 1 infection. Exp Biol Med (Maywood). 2001 May; 226(5):353-66. PMID: 11393165.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
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