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Danny N Dhanasekaran

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
AddressBRC 1417C
975 NE 10th St
Oklahoma City OK 73104
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    Collapse Research 
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    P20GM103639     (DHANASEKARAN, DANNY N.)Sep 5, 2012 - Jun 30, 2024
    Mentoring Translational Cancer Research in Oklahoma
    Role: Principal Investigator

    R01CA123233     (DHANASEKARAN, DANNY N.)Dec 15, 2007 - Nov 30, 2014
    Regulation of JNK-signaling molecules by the gep oncogenes
    Role: Principal Investigator

    R01CA116984     (DHANASEKARAN, DANNY N.)Jun 27, 2007 - Apr 30, 2014
    G Proteins and Their Receptors in Tumor Cell Metastasis
    Role: Principal Investigator

    R21CA125752     (DHANASEKARAN, DANNY N.)Jun 26, 2007 - Mar 31, 2010
    G-Protein Signaling in Pancreatic Cancer
    Role: Principal Investigator

    R01GM049897     (DHANASEKARAN, DANNY N.)Mar 1, 1996 - Jun 30, 2006
    Functional analysis of G alpha 12/G alpha 13 G-proteins
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Roy RV, Means N, Rao G, Asfa S, Madka V, Dey A, Zhang Y, Choudhury M, Fung KM, Dhanasekaran DN, Friedman JE, Crawford HC, Rao CV, Bhattacharya R, Mukherjee P. Pancreatic Ubap2 deletion regulates glucose tolerance, inflammation, and protection from cerulein-induced pancreatitis. Cancer Lett. 2023 Oct 19; 578:216455. PMID: 37865160.
      Citations:    Fields:    Translation:Animals
    2. Yan F, Ha JH, Yan Y, Ton SB, Wang C, Mutembei B, Alhajeri ZA, McNiel AF, Keddissi AJ, Zhang Q, Jayaraman M, Dhanasekaran DN, Tang Q. Optical Coherence Tomography of Tumor Spheroids Identifies Candidates for Drug Repurposing in Ovarian Cancer. IEEE Trans Biomed Eng. 2023 06; 70(6):1891-1901. PMID: 37015385; PMCID: PMC10482500.
      Citations:    Fields:    Translation:Humans
    3. Nadhan R, Kashyap S, Ha JH, Jayaraman M, Song YS, Isidoro C, Dhanasekaran DN. Targeting Oncometabolites in Peritoneal Cancers: Preclinical Insights and Therapeutic Strategies. Metabolites. 2023 Apr 30; 13(5). PMID: 37233659; PMCID: PMC10222714.
      Citations: 2     
    4. Vidoni C, Ferraresi A, Vallino L, Salwa A, Ha JH, Seca C, Garavaglia B, Dhanasekaran DN, Isidoro C. Glycolysis Inhibition of Autophagy Drives Malignancy in Ovarian Cancer: Exacerbation by IL-6 and Attenuation by Resveratrol. Int J Mol Sci. 2023 Jan 15; 24(2). PMID: 36675246.
      Citations: 1     Fields:    
    5. Nadhan R, Isidoro C, Song YS, Dhanasekaran DN. Signaling by LncRNAs: Structure, Cellular Homeostasis, and Disease Pathology. Cells. 2022 08 13; 11(16). PMID: 36010595; PMCID: PMC9406440.
      Citations: 7     Fields:    Translation:Cells
    6. Wang W, Jo H, Park S, Kim H, Kim SI, Han Y, Lee J, Seol A, Kim J, Lee M, Lee C, Dhanasekaran DN, Ahn T, Song YS. Integrated analysis of ascites and plasma extracellular vesicles identifies a miRNA-based diagnostic signature in ovarian cancer. Cancer Lett. 2022 08 28; 542:215735. PMID: 35569696.
      Citations: 12     Fields:    Translation:HumansCells
    7. Esposito A, Ferraresi A, Salwa A, Vidoni C, Dhanasekaran DN, Isidoro C. Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I. Cancers (Basel). 2022 Apr 25; 14(9). PMID: 35565270; PMCID: PMC9101105.
      Citations: 12     
    8. Gunderson CC, Radhakrishnan R, Gomathinayagam R, Husain S, Aravindan S, Moore KM, Dhanasekaran DN, Jayaraman M. Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis. Biomark Insights. 2022; 17:11772719221088404. PMID: 35370397.
      Citations: 1     
    9. Vidoni C, Ferraresi A, Esposito A, Maheshwari C, Dhanasekaran DN, Mollace V, Isidoro C. Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy. J Cancer Prev. 2021 Dec 30; 26(4):224-236. PMID: 35047448; PMCID: PMC8749320.
      Citations: 17     
    10. Ha JH, Jayaraman M, Nadhan R, Kashyap S, Mukherjee P, Isidoro C, Song YS, Dhanasekaran DN. Unraveling Autocrine Signaling Pathways through Metabolic Fingerprinting in Serous Ovarian Cancer Cells. Biomedicines. 2021 Dec 16; 9(12). PMID: 34944743.
      Citations: 6     
    11. Ferraresi A, Esposito A, Girone C, Vallino L, Salwa A, Ghezzi I, Thongchot S, Vidoni C, Dhanasekaran DN, Isidoro C. Resveratrol Contrasts LPA-Induced Ovarian Cancer Cell Migration and Platinum Resistance by Rescuing Hedgehog-Mediated Autophagy. Cells. 2021 11 17; 10(11). PMID: 34831435; PMCID: PMC8625920.
      Citations: 17     Fields:    Translation:HumansCells
    12. Ha JH, Jayaraman M, Yan M, Dhanasekaran P, Isidoro C, Song YS, Dhanasekaran DN. GNAi2/gip2-Regulated Transcriptome and Its Therapeutic Significance in Ovarian Cancer. Biomolecules. 2021 08 14; 11(8). PMID: 34439877.
      Citations: 3     Fields:    Translation:HumansCells
    13. Ha JH, Jayaraman M, Yan M, Dhanasekaran P, Isidoro C, Song YS, Dhanasekaran DN. Identification of GNA12-driven gene signatures and key signaling networks in ovarian cancer. Oncol Lett. 2021 Oct; 22(4):719. PMID: 34429759.
      Citations: 2     
    14. Lee J, Han Y, Wang W, Jo H, Kim H, Kim S, Yang KM, Kim SJ, Dhanasekaran DN, Song YS. Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy. Biomolecules. 2021 07 27; 11(8). PMID: 34439774; PMCID: PMC8393583.
      Citations: 9     Fields:    Translation:HumansAnimals
    15. Kim S, Han Y, Kim SI, Lee J, Jo H, Wang W, Cho U, Park WY, Rando TA, Dhanasekaran DN, Song YS. Computational modeling of malignant ascites reveals CCL5-SDC4 interaction in the immune microenvironment of ovarian cancer. Mol Carcinog. 2021 05; 60(5):297-312. PMID: 33721368; PMCID: PMC8080545.
      Citations: 8     Fields:    Translation:HumansCells
    16. Salwa A, Ferraresi A, Chinthakindi M, Vallino L, Vidoni C, Dhanasekaran DN, Isidoro C. BECN1 and BRCA1 Deficiency Sensitizes Ovarian Cancer to Platinum Therapy and Confers Better Prognosis. Biomedicines. 2021 Feb 18; 9(2). PMID: 33670664; PMCID: PMC7922320.
      Citations: 10     
    17. Ferraresi A, Girone C, Esposito A, Vidoni C, Vallino L, Secomandi E, Dhanasekaran DN, Isidoro C. How Autophagy Shapes the Tumor Microenvironment in Ovarian Cancer. Front Oncol. 2020; 10:599915. PMID: 33364196; PMCID: PMC7753622.
      Citations: 26     
    18. Wang W, Im J, Kim S, Jang S, Han Y, Yang KM, Kim SJ, Dhanasekaran DN, Song YS. ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer. Antioxidants (Basel). 2020 Nov 16; 9(11). PMID: 33207824; PMCID: PMC7698236.
      Citations: 10     
    19. Gomathinayagam R, Ha JH, Jayaraman M, Song YS, Isidoro C, Dhanasekaran DN. Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets. J Cancer Prev. 2020 Sep 30; 25(3):136-151. PMID: 33033708.
      Citations: 14     
    20. Xiong X, Rao G, Roy RV, Zhang Y, Means N, Dey A, Tsaliki M, Saha S, Bhattacharyya S, Dhar Dwivedi SK, Rao CV, McCormick DJ, Dhanasekaran D, Ding K, Gillies E, Zhang M, Yang D, Bhattacharya R, Mukherjee P. Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer. FASEB J. 2020 09; 34(9):12024-12039. PMID: 32692445.
      Citations: 5     Fields:    Translation:HumansCells
    21. Kim SI, Kang N, Leem S, Yang J, Jo H, Lee M, Kim HS, Dhanasekaran DN, Kim YK, Park T, Song YS. Metagenomic Analysis of Serum Microbe-Derived Extracellular Vesicles and Diagnostic Models to Differentiate Ovarian Cancer and Benign Ovarian Tumor. Cancers (Basel). 2020 May 21; 12(5). PMID: 32455705; PMCID: PMC7281409.
      Citations: 13     
    22. Ha JH, Jayaraman M, Radhakrishnan R, Gomathinayagam R, Yan M, Song YS, Isidoro C, Dhanasekaran DN. Differential effects of thymoquinone on lysophosphatidic acid-induced oncogenic pathways in ovarian cancer cells. J Tradit Complement Med. 2020 May; 10(3):207-216. PMID: 32670815.
      Citations: 6     
    23. Vallino L, Ferraresi A, Vidoni C, Secomandi E, Esposito A, Dhanasekaran DN, Isidoro C. Modulation of non-coding RNAs by resveratrol in ovarian cancer cells: In silico analysis and literature review of the anti-cancer pathways involved. J Tradit Complement Med. 2020 May; 10(3):217-229. PMID: 32670816; PMCID: PMC7340874.
      Citations: 14     
    24. Han Y, Kim B, Cho U, Park IS, Kim SI, Dhanasekaran DN, Tsang BK, Song YS. Mitochondrial fission causes cisplatin resistance under hypoxic conditions via ROS in ovarian cancer cells. Oncogene. 2019 11; 38(45):7089-7105. PMID: 31409904.
      Citations: 71     Fields:    Translation:HumansCells
    25. Vidoni C, Ferraresi A, Secomandi E, Vallino L, Dhanasekaran DN, Isidoro C. Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds. Semin Cancer Biol. 2020 11; 66:34-44. PMID: 31054926.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    26. Han Y, Jo H, Cho JH, Dhanasekaran DN, Song YS. Resveratrol as a Tumor-Suppressive Nutraceutical Modulating Tumor Microenvironment and Malignant Behaviors of Cancer. Int J Mol Sci. 2019 Feb 20; 20(4). PMID: 30791624; PMCID: PMC6412705.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    27. Kim S, Lee M, Dhanasekaran DN, Song YS. Activation of LXR?/? by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer. BMC Cancer. 2018 Dec 10; 18(1):1232. PMID: 30526541; PMCID: PMC6288854.
      Citations: 23     Fields:    Translation:HumansCells
    28. Radhakrishnan R, Ha JH, Jayaraman M, Liu J, Moxley KM, Isidoro C, Sood AK, Song YS, Dhanasekaran DN. Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts. Cancer Lett. 2019 02 01; 442:464-474. PMID: 30503552.
      Citations: 48     Fields:    Translation:HumansCells
    29. Srivastava A, Moxley K, Ruskin R, Dhanasekaran DN, Zhao YD, Ramesh R. A Non-invasive Liquid Biopsy Screening of Urine-Derived Exosomes for miRNAs as Biomarkers in Endometrial Cancer Patients. AAPS J. 2018 07 09; 20(5):82. PMID: 29987691.
      Citations: 52     Fields:    Translation:HumansCells
    30. Han Y, Cho U, Kim S, Park IS, Cho JH, Dhanasekaran DN, Song YS. Tumour microenvironment on mitochondrial dynamics and chemoresistance in cancer. Free Radic Res. 2018 Dec; 52(11-12):1271-1287. PMID: 29607684.
      Citations: 13     Fields:    Translation:HumansCells
    31. Chakraborty PK, Murphy B, Mustafi SB, Dey A, Xiong X, Rao G, Naz S, Zhang M, Yang D, Dhanasekaran DN, Bhattacharya R, Mukherjee P. Cystathionine ß-synthase regulates mitochondrial morphogenesis in ovarian cancer. FASEB J. 2018 08; 32(8):4145-4157. PMID: 29494264.
      Citations: 21     Fields:    Translation:HumansCells
    32. Ha JH, Radhakrishnan R, Jayaraman M, Yan M, Ward JD, Fung KM, Moxley K, Sood AK, Isidoro C, Mukherjee P, Song YS, Dhanasekaran DN. LPA Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response. Cancer Res. 2018 04 15; 78(8):1923-1934. PMID: 29386184.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    33. Xia D, Lai DV, Wu W, Webb ZD, Yang Q, Zhao L, Yu Z, Thorpe JE, Disch BC, Ihnat MA, Jayaraman M, Dhanasekaran DN, Stratton KL, Cookson MS, Fung KM, Lin HK. Transition from androgenic to neurosteroidal action of 5a-androstane-3a, 17ß-diol through the type A ?-aminobutyric acid receptor in prostate cancer progression. J Steroid Biochem Mol Biol. 2018 04; 178:89-98. PMID: 29155210.
      Citations: 7     Fields:    Translation:HumansCells
    34. Ferraresi A, Titone R, Follo C, Castiglioni A, Chiorino G, Dhanasekaran DN, Isidoro C. The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells. Mol Carcinog. 2017 Dec; 56(12):2681-2691. PMID: 28856729.
      Citations: 17     Fields:    Translation:HumansCells
    35. Dhanasekaran DN, Reddy EP. JNK-signaling: A multiplexing hub in programmed cell death. Genes Cancer. 2017 Sep; 8(9-10):682-694. PMID: 29234486; PMCID: PMC5724802.
      Citations: 149     
    36. Kim B, Jung JW, Jung J, Han Y, Suh DH, Kim HS, Dhanasekaran DN, Song YS. PGC1a induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells. Oncotarget. 2017 Sep 01; 8(36):60299-60311. PMID: 28947972; PMCID: PMC5601140.
      Citations: 33     Fields:    
    37. Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017 05 22; 8:14634. PMID: 28530221.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    38. Jayaraman M, Radhakrishnan R, Mathews CA, Yan M, Husain S, Moxley KM, Song YS, Dhanasekaran DN. Identification of novel diagnostic and prognostic miRNA signatures in endometrial cancer. Genes Cancer. 2017 May; 8(5-6):566-576. PMID: 28740575.
      Citations: 27     
    39. Kim S, Gwak H, Kim HS, Kim B, Dhanasekaran DN, Song YS. Malignant ascites enhances migratory and invasive properties of ovarian cancer cells with membrane bound IL-6R in vitro. Oncotarget. 2016 Dec 13; 7(50):83148-83159. PMID: 27825119; PMCID: PMC5347759.
      Citations: 23     Fields:    Translation:HumansCells
    40. Ha JH, Yan M, Gomathinayagam R, Jayaraman M, Husain S, Liu J, Mukherjee P, Reddy EP, Song YS, Dhanasekaran DN. Aberrant expression of JNK-associated leucine-zipper protein, JLP, promotes accelerated growth of ovarian cancer. Oncotarget. 2016 Nov 08; 7(45):72845-72859. PMID: 27655714.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    41. Kim B, Kim HS, Kim S, Haegeman G, Tsang BK, Dhanasekaran DN, Song YS. Adipose Stromal Cells from Visceral and Subcutaneous Fat Facilitate Migration of Ovarian Cancer Cells via IL-6/JAK2/STAT3 Pathway. Cancer Res Treat. 2017 Apr; 49(2):338-349. PMID: 27456942; PMCID: PMC5398386.
      Citations: 25     Fields:    Translation:HumansCells
    42. Ha JH, Ward JD, Radhakrishnan R, Jayaraman M, Song YS, Dhanasekaran DN. Lysophosphatidic acid stimulates epithelial to mesenchymal transition marker Slug/Snail2 in ovarian cancer cells via Gai2, Src, and HIF1a signaling nexus. Oncotarget. 2016 Jun 21; 7(25):37664-37679. PMID: 27166196.
      Citations: 34     Fields:    Translation:HumansCells
    43. Nguyen CB, Kotturi H, Waris G, Mohammed A, Chandrakesan P, May R, Sureban S, Weygant N, Qu D, Rao CV, Dhanasekaran DN, Bronze MS, Houchen CW, Ali N. (Z)-3,5,4'-Trimethoxystilbene Limits Hepatitis C and Cancer Pathophysiology by Blocking Microtubule Dynamics and Cell-Cycle Progression. Cancer Res. 2016 08 15; 76(16):4887-96. PMID: 27287718.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    44. Srivastava A, Babu A, Filant J, Moxley KM, Ruskin R, Dhanasekaran D, Sood AK, McMeekin S, Ramesh R. Exploitation of Exosomes as Nanocarriers for Gene-, Chemo-, and Immune-Therapy of Cancer. J Biomed Nanotechnol. 2016 Jun; 12(6):1159-73. PMID: 27319211.
      Citations: 42     Fields:    Translation:HumansCells
    45. Gwak H, Kim Y, An H, Dhanasekaran DN, Song YS. Metformin induces degradation of cyclin D1 via AMPK/GSK3? axis in ovarian cancer. Mol Carcinog. 2017 02; 56(2):349-358. PMID: 27128966.
      Citations: 29     Fields:    Translation:HumansCells
    46. Gwak H, Kim S, Dhanasekaran DN, Song YS. Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Lett. 2016 Feb 28; 371(2):347-53. PMID: 26704305.
      Citations: 40     Fields:    Translation:HumansCells
    47. Seo JA, Kim B, Dhanasekaran DN, Tsang BK, Song YS. Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Lett. 2016 Feb 01; 371(1):30-7. PMID: 26607901.
      Citations: 40     Fields:    Translation:HumansCells
    48. Chakraborty PK, Xiong X, Mustafi SB, Saha S, Dhanasekaran D, Mandal NA, McMeekin S, Bhattacharya R, Mukherjee P. Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015 Nov 10; 6(35):37367-84. PMID: 26452259.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    49. Ali N, Chandrakesan P, Nguyen CB, Husain S, Gillaspy AF, Huycke M, Berry WL, May R, Qu D, Weygant N, Sureban SM, Bronze MS, Dhanasekaran DN, Houchen CW. Inflammatory and oncogenic roles of a tumor stem cell marker doublecortin-like kinase (DCLK1) in virus-induced chronic liver diseases. Oncotarget. 2015 Aug 21; 6(24):20327-44. PMID: 25948779.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    50. Yan M, Ha JH, Dhanasekaran DN. Ga13 Stimulates the Tyrosine Phosphorylation of Ric-8A. J Mol Signal. 2015 Jul 27; 10:3. PMID: 27096001.
      Citations: 4     
    51. Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN. Determinant role for the gep oncogenes, Ga12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015 Jul; 6(7-8):356-364. PMID: 26413218.
      Citations: 8     
    52. Song YS, Kim HS, Aoki D, Dhanasekaran DN, Tsang BK. Ovarian cancer. Biomed Res Int. 2014; 2014:764323. PMID: 25587539; PMCID: PMC4283453.
      Citations: 8     Fields:    Translation:Humans
    53. Ward JD, Ha JH, Jayaraman M, Dhanasekaran DN. LPA-mediated migration of ovarian cancer cells involves translocalization of Gai2 to invadopodia and association with Src and ß-pix. Cancer Lett. 2015 Jan 28; 356(2 Pt B):382-91. PMID: 25451317.
      Citations: 26     Fields:    Translation:HumansCells
    54. Yang YM, Lee WH, Lee CG, An J, Kim ES, Kim SH, Lee SK, Lee CH, Dhanasekaran DN, Moon A, Hwang S, Lee SJ, Park JW, Kim KM, Kim SG. Ga12 gep oncogene deregulation of p53-responsive microRNAs promotes epithelial-mesenchymal transition of hepatocellular carcinoma. Oncogene. 2015 May 28; 34(22):2910-21. PMID: 25065598.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    55. Gomathinayagam R, Muralidharan J, Ha JH, Varadarajalu L, Dhanasekaran DN. Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration. Genes Cancer. 2014 Mar; 5(3-4):84-99. PMID: 25053987.
      Citations: 13     
    56. Dhanasekaran D. G protein signaling in tumor cell growth and metastasis. Mol Cytogenet. 2014; 7(Suppl 1 Proceedings of the International Conference on Human):I56. PMID: 24940381; PMCID: PMC4043405.
    57. Ha JH, Ward JD, Varadarajalu L, Kim SG, Dhanasekaran DN. The gep proto-oncogene Ga12 mediates LPA-stimulated activation of CREB in ovarian cancer cells. Cell Signal. 2014 Jan; 26(1):122-32. PMID: 24055910.
      Citations: 9     Fields:    Translation:HumansCells
    58. Dhanasekaran DN. JNK Signaling Network and Cancer. Genes Cancer. 2013 Sep; 4(9-10):332-3. PMID: 24349630; PMCID: PMC3863342.
      Citations: 2     
    59. Dhanasekaran DN. Monographs editor. Genes Cancer. 2013 Sep; 4(9-10):331. PMID: 24349629; PMCID: PMC3863343.
    60. Gardner JA, Ha JH, Jayaraman M, Dhanasekaran DN. The gep proto-oncogene Ga13 mediates lysophosphatidic acid-mediated migration of pancreatic cancer cells. Pancreas. 2013 Jul; 42(5):819-28. PMID: 23508014.
      Citations: 18     Fields:    Translation:HumansCells
    61. Ward JD, Dhanasekaran DN. LPA Stimulates the Phosphorylation of p130Cas via Gai2 in Ovarian Cancer Cells. Genes Cancer. 2012 Sep; 3(9-10):578-91. PMID: 23486563; PMCID: PMC3591094.
      Citations: 19     
    62. Singhal A, Jayaraman M, Dhanasekaran DN, Kohli V. Molecular and serum markers in hepatocellular carcinoma: predictive tools for prognosis and recurrence. Crit Rev Oncol Hematol. 2012 May; 82(2):116-40. PMID: 21680198.
      Citations: 26     Fields:    Translation:HumansCells
    63. Goldsmith ZG, Ha JH, Jayaraman M, Dhanasekaran DN. Lysophosphatidic Acid Stimulates the Proliferation of Ovarian Cancer Cells via the gep Proto-Oncogene Ga(12). Genes Cancer. 2011 May; 2(5):563-75. PMID: 21901169.
      Citations: 28     
    64. Kashef K, Radhakrishnan R, Lee CM, Reddy EP, Dhanasekaran DN. Neoplastic transformation induced by the gep oncogenes involves the scaffold protein JNK-interacting leucine zipper protein. Neoplasia. 2011 Apr; 13(4):358-64. PMID: 21472140; PMCID: PMC3071084.
      Citations: 11     Fields:    Translation:AnimalsCells
    65. Jalagadugula G, Mao G, Kaur G, Dhanasekaran DN, Rao AK. Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):921-7. PMID: 21252065; PMCID: PMC3066073.
      Citations: 11     Fields:    Translation:HumansCells
    66. Radhakrishnan R, Ha JH, Dhanasekaran DN. Mitogenic Signaling by the gep Oncogene Involves the Upregulation of S-Phase Kinase-Associated Protein 2. Genes Cancer. 2010 Oct; 1(10):1033-43. PMID: 21533006; PMCID: PMC3083023.
      Citations: 7     
    67. Jalagadugula G, Mao G, Kaur G, Goldfinger LE, Dhanasekaran DN, Rao AK. Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency. Blood. 2010 Dec 23; 116(26):6037-45. PMID: 20876458; PMCID: PMC3031389.
      Citations: 34     Fields:    Translation:HumansCells
    68. Yang YM, Lee S, Nam CW, Ha JH, Jayaraman M, Dhanasekaran DN, Lee CH, Kwak MK, Kim SG. G(alpha)12/13 inhibition enhances the anticancer effect of bortezomib through PSMB5 downregulation. Carcinogenesis. 2010 Jul; 31(7):1230-7. PMID: 20478922.
      Citations: 11     Fields:    Translation:HumansCells
    69. Reddy HK, Gra?a X, Dhanasekaran DN, Litvin J, Reddy EP. Requirement of Cdk4 for v-Ha-ras-Induced Breast Tumorigenesis and Activation of the v-ras-Induced Senescence Program by the R24C Mutation. Genes Cancer. 2010 Jan; 1(1):69-80. PMID: 20634902; PMCID: PMC2904236.
      Citations: 13     
    70. Xu H, Dhanasekaran DN, Lee CM, Reddy EP. Regulation of neurite outgrowth by interactions between the scaffolding protein, JNK-associated leucine zipper protein, and neuronal growth-associated protein superior cervical ganglia clone 10. J Biol Chem. 2010 Feb 05; 285(6):3548-3553. PMID: 19959466; PMCID: PMC2823494.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    71. Dhanasekaran DN, Radhika V, Proikas-Cezanne T, Jayaraman M, Ha J. Heterologous expression of olfactory receptors for targeted chemosensing. Ann N Y Acad Sci. 2009 Jul; 1170:157-60. PMID: 19686128.
      Citations:    Fields:    Translation:Animals
    72. Suzuki H, Kimura K, Shirai H, Eguchi K, Higuchi S, Hinoki A, Ishimaru K, Brailoiu E, Dhanasekaran DN, Stemmle LN, Fields TA, Frank GD, Autieri MV, Eguchi S. Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):217-24. PMID: 19095998; PMCID: PMC2704976.
      Citations: 20     Fields:    Translation:AnimalsCells
    73. Jalagadugula G, Dhanasekaran DN, Rao AK. Phorbol 12-myristate 13-acetate (PMA) responsive sequence in Galphaq promoter during megakaryocytic differentiation. Regulation by EGR-1 and MAP kinase pathway. Thromb Haemost. 2008 Nov; 100(5):821-8. PMID: 18989526; PMCID: PMC2688737.
      Citations: 2     Fields:    Translation:HumansCells
    74. Dhanasekaran DN, Reddy EP. JNK signaling in apoptosis. Oncogene. 2008 Oct 20; 27(48):6245-51. PMID: 18931691; PMCID: PMC3063296.
      Citations: 654     Fields:    Translation:HumansCells
    75. Dhanasekaran DN, Johnson GL. MAPKs: function, regulation, role in cancer and therapeutic targeting. Oncogene. 2007 May 14; 26(22):3097-9. PMID: 17496908.
      Citations: 48     Fields:    Translation:HumansAnimals
    76. Dhanasekaran DN, Kashef K, Lee CM, Xu H, Reddy EP. Scaffold proteins of MAP-kinase modules. Oncogene. 2007 May 14; 26(22):3185-202. PMID: 17496915.
      Citations: 132     Fields:    Translation:HumansAnimals
    77. Goldsmith ZG, Dhanasekaran DN. G protein regulation of MAPK networks. Oncogene. 2007 May 14; 26(22):3122-42. PMID: 17496911.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    78. Radhika V, Proikas-Cezanne T, Jayaraman M, Onesime D, Ha JH, Dhanasekaran DN. Chemical sensing of DNT by engineered olfactory yeast strain. Nat Chem Biol. 2007 Jun; 3(6):325-30. PMID: 17486045.
      Citations: 30     Fields:    Translation:Animals
    79. Sun L, Mao G, Kunapuli SP, Dhanasekaran DN, Rao AK. Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization. Platelets. 2007 May; 18(3):217-23. PMID: 17497434.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    80. Dhanasekaran DN. An open access journal of molecular signaling: a critical need at a critical time. J Mol Signal. 2006 Nov 10; 1:1. PMID: 17224077; PMCID: PMC1761142.
    81. Jalagadugula G, Dhanasekaran DN, Kim S, Kunapuli SP, Rao AK. Early growth response transcription factor EGR-1 regulates Galphaq gene in megakaryocytic cells. J Thromb Haemost. 2006 Dec; 4(12):2678-86. PMID: 16995904.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    82. Dhanasekaran DN. Transducing the signals: a G protein takes a new identity. Sci STKE. 2006 Aug 08; 2006(347):pe31. PMID: 16896192.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    83. Kashef K, Xu H, Reddy EP, Dhanasekaran DN. Endodermal differentiation of murine embryonic carcinoma cells by retinoic acid requires JLP, a JNK-scaffolding protein. J Cell Biochem. 2006 Jul 01; 98(4):715-22. PMID: 16619266.
      Citations: 11     Fields:    Translation:AnimalsCells
    84. Reece EA, Wu YK, Zhao Z, Dhanasekaran D. Dietary vitamin and lipid therapy rescues aberrant signaling and apoptosis and prevents hyperglycemia-induced diabetic embryopathy in rats. Am J Obstet Gynecol. 2006 Feb; 194(2):580-5. PMID: 16458664.
      Citations: 33     Fields:    Translation:AnimalsCells
    85. Kumar RN, Ha JH, Radhakrishnan R, Dhanasekaran DN. Transactivation of platelet-derived growth factor receptor alpha by the GTPase-deficient activated mutant of Galpha12. Mol Cell Biol. 2006 Jan; 26(1):50-62. PMID: 16354679; PMCID: PMC1317640.
      Citations: 13     Fields:    Translation:AnimalsCells
    86. Kashef K, Lee CM, Ha JH, Reddy EP, Dhanasekaran DN. JNK-interacting leucine zipper protein is a novel scaffolding protein in the Galpha13 signaling pathway. Biochemistry. 2005 Nov 01; 44(43):14090-6. PMID: 16245925.
      Citations: 17     Fields:    Translation:AnimalsCells
    87. Jayaraman M, Radhika V, Bamne MN, Ramos R, Briggs R, Dhanasekaran DN. Engineered Saccharomyces cerevisiae strain BioS-OS1/2, for the detection of oxidative stress. Biotechnol Prog. 2005 Sep-Oct; 21(5):1373-9. PMID: 16209540.
      Citations: 1     Fields:    Translation:Animals
    88. Reece EA, Ma XD, Zhao Z, Wu YK, Dhanasekaran D. Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways. Am J Obstet Gynecol. 2005 Mar; 192(3):967-72. PMID: 15746699.
      Citations: 22     Fields:    Translation:Animals
    89. Luthin GR, Wang P, Zhou H, Dhanasekaran D, Ruggieri MR. Role of m1 receptor-G protein coupling in cell proliferation in the prostate. Life Sci. 1997; 60(13-14):963-8. PMID: 9121362; PMCID: PMC3277865.
      Citations: 12     Fields:    Translation:HumansCells
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