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David C Kem

TitleProf,Regents
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
AddressHHODC 2900
1000 N Lincoln Blvd
Oklahoma City OK 73104
Phone405/271-5896
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    F06TW001419     (KEM, DAVID C)Aug 4, 1989
    NIH
    INOSITOL - CALCIUM MEDIATED ANP RELEASE
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Li H, Guo Y, Zhang G, Deng J, Fischer H, Craig LB, Yu X, Kem DC. Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model. Exp Physiol. 2021 Apr; 106(4):902-912. PMID: 33576068.
      Citations: 1     Fields:    
    2. Deng J, Guo Y, Zhang G, Zhang L, Kem D, Yu X, Jiang H, Li H. M2 muscarinic autoantibodies and thyroid hormone promote susceptibility to atrial fibrillation and sinus tachycardia in an autoimmune rabbit model. Exp Physiol. 2021 Apr; 106(4):882-890. PMID: 33550676.
      Citations:    Fields:    
    3. Li H, Zhang G, Guo Y, Deng J, Fischer H, Craig LB, Kem DC, Yu X. Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model. Physiol Rep. 2021 01; 8(24):e14672. PMID: 33356018.
      Citations:    Fields:    
    4. Kem DC, Li H, Yu X, Weedin E, Reynolds AC, Forsythe E, Beel M, Fischer H, Hines B, Guo Y, Deng J, Liles JT, Nuss Z, Elkosseifi M, Aston CE, Burks HR, Craig LB. The Role of GnRH Receptor Autoantibodies in Polycystic Ovary Syndrome. J Endocr Soc. 2020 Aug 01; 4(8):bvaa078. PMID: 32803090.
      Citations:    
    5. Deng J, Wang M, Guo Y, Fischer H, Yu X, Kem D, Li H. Activation of a7nAChR via vagus nerve prevents obesity-induced insulin resistance via suppressing endoplasmic reticulum stress-induced inflammation in Kupffer cells. Med Hypotheses. 2020 Mar 14; 140:109671. PMID: 32182560.
      Citations: 1     Fields:    
    6. Shimasaki C, Frye RE, Trifiletti R, Cooperstock M, Kaplan G, Melamed I, Greenberg R, Katz A, Fier E, Kem D, Traver D, Dempsey T, Latimer ME, Cross A, Dunn JP, Bentley R, Alvarez K, Reim S, Appleman J. Evaluation of the Cunningham Panel™ in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms. J Neuroimmunol. 2020 02 15; 339:577138. PMID: 31884258.
      Citations: 4     Fields:    Translation:Humans
    7. Li H, Zhang G, Zhou L, Nuss Z, Beel M, Hines B, Murphy T, Liles J, Zhang L, Kem DC, Yu X. Adrenergic Autoantibody-Induced Postural Tachycardia Syndrome in Rabbits. J Am Heart Assoc. 2019 10; 8(19):e013006. PMID: 31547749.
      Citations: 5     Fields:    Translation:AnimalsPHPublic Health
    8. Badiudeen T, Forsythe EA, Bennett G, Li H, Yu X, Beel M, Nuss Z, Blick KE, Okamoto LE, Arnold AC, Paranjape SY, Black BK, Maxey C, Kem DC, Raj SR. A functional cell-based bioassay for assessing adrenergic autoantibody activity in postural tachycardia syndrome. J Transl Autoimmun. 2019 Dec; 2:100006. PMID: 32743496.
      Citations:    
    9. Yu X, Li H, Murphy TA, Nuss Z, Liles J, Liles C, Aston CE, Raj SR, Fedorowski A, Kem DC. Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome. J Am Heart Assoc. 2018 04 04; 7(8). PMID: 29618472.
      Citations: 20     Fields:    Translation:Humans
    10. Fedorowski A, Li H, Yu X, Koelsch KA, Harris VM, Liles C, Murphy TA, Quadri SMS, Scofield RH, Sutton R, Melander O, Kem DC. Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace. 2017 Jul 01; 19(7):1211-1219. PMID: 27702852.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    11. Myers JM, Cooper LT, Kem DC, Stavrakis S, Kosanke SD, Shevach EM, Fairweather D, Stoner JA, Cox CJ, Cunningham MW. Cardiac myosin-Th17 responses promote heart failure in human myocarditis. JCI Insight. 2016 Jun 16; 1(9). PMID: 27366791.
      Citations: 35     Fields:    
    12. Li H, Murphy T, Zhang L, Huang B, Veitla V, Scherlag BJ, Kem DC, Yu X. ß1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits. Endocrinology. 2016 Jan; 157(1):16-22. PMID: 26517045.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Li H, Zhang L, Huang B, Veitla V, Scherlag BJ, Cunningham MW, Aston CE, Kem DC, Yu X. A peptidomimetic inhibitor suppresses the inducibility of ß1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J Interv Card Electrophysiol. 2015 Dec; 44(3):205-12. PMID: 26446828.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Liles C, Li H, Veitla V, Liles JT, Murphy TA, Cunningham MW, Yu X, Kem DC. AT2R autoantibodies block angiotensin II and AT1R autoantibody-induced vasoconstriction. Hypertension. 2015 Oct; 66(4):830-5. PMID: 26259590.
      Citations: 6     Fields:    Translation:HumansAnimals
    15. Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW, Yu X. Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension. 2015 Apr; 65(4):793-9. PMID: 25691619.
      Citations: 8     Fields:    Translation:Animals
    16. Galloway A, Li H, Vanderlinde-Wood M, Khan M, Benbrook A, Liles C, Zillner C, Rao V, Cunningham MW, Yu X, Kem DC. Activating autoantibodies to the ß1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism. Endocrine. 2015 Jun; 49(2):457-63. PMID: 25500789.
      Citations: 7     Fields:    Translation:Humans
    17. Li H, Yu X, Cicala MV, Mantero F, Benbrook A, Veitla V, Cunningham MW, Kem DC. Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in primary aldosteronism. J Am Soc Hypertens. 2015 Jan; 9(1):15-20. PMID: 25537460.
      Citations: 11     Fields:    Translation:Humans
    18. Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R, Yu X. Atrial tachyarrhythmias induced by the combined effects of ß1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J Cardiovasc Transl Res. 2014 Aug; 7(6):581-9. PMID: 24903978.
      Citations: 4     Fields:    Translation:Animals
    19. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The Propensity for Inducing Atrial Fibrillation: A Comparative Study on Old versus Young Rabbits. J Aging Res. 2014; 2014:684918. PMID: 24719763.
      Citations:    
    20. Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc. 2014 Feb 26; 3(1):e000755. PMID: 24572257.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    21. Kem DC, Li H, Velarde-Miranda C, Liles C, Vanderlinde-Wood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism. J Clin Endocrinol Metab. 2014 May; 99(5):1790-7. PMID: 24552217.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    22. Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced ß1-adrenergic autoantibody expression in the rabbit. . 2014 Feb; 306(3):H422-8. PMID: 24271491.
      Citations:    
    23. Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem. 2013 Oct 18; 288(42):30734-30741. PMID: 24043632.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to ß2-adrenergic receptor in the rabbit. Heart Rhythm. 2013 Mar; 10(3):436-41. PMID: 23178688.
      Citations: 9     Fields:    Translation:Animals
    25. Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X. Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension. 2012 Feb; 59(2):402-8. PMID: 22215709.
      Citations: 16     Fields:    Translation:HumansAnimals
    26. Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H, Khan M, Hamlett S, Cunningham MW, Kem DC. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. J Am Soc Hypertens. 2012 Jan-Feb; 6(1):40-7. PMID: 22130180.
      Citations: 13     Fields:    Translation:Humans
    27. Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, Kem D, Zou MH. Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 2011 Jun; 60(6):1770-8. PMID: 21562078.
      Citations: 166     Fields:    Translation:AnimalsCells
    28. Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Lazzara R, Yu X. Opposing cardiac effects of autoantibody activation of ß-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol. 2011 May 05; 148(3):331-6. PMID: 20053466.
      Citations: 12     Fields:    Translation:HumansAnimals
    29. Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, Kem DC. Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves' hyperthyroidism. J Am Coll Cardiol. 2009 Sep 29; 54(14):1309-16. PMID: 19778674.
      Citations: 35     Fields:    Translation:HumansAnimals
    30. Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res. 2010 Jan 15; 85(2):312-20. PMID: 19744947.
      Citations: 33     Fields:    Translation:HumansAnimals
    31. Heflin LA, Street CB, Papavassiliou DV, Kem DC, Wu DH, O'Rear EA. Transient stenotic-like occlusions as a possible mechanism for renovascular hypertension due to aneurysm. J Am Soc Hypertens. 2009 May-Jun; 3(3):192-200. PMID: 20409959.
      Citations:    Fields:    
    32. Yu X, Patterson E, Stavrakis S, Huang S, De Aos I, Hamlett S, Cunningham MW, Lazarra R, Kem DC. Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors. J Am Soc Hypertens. 2009 Mar-Apr; 3(2):133-40. PMID: 20409953.
      Citations: 4     Fields:    
    33. Yu X, Patterson E, Kem DC. Targeting proteasomes for cardioprotection. Curr Opin Pharmacol. 2009 Apr; 9(2):167-72. PMID: 19097937.
      Citations: 10     Fields:    Translation:HumansAnimals
    34. Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, Cunningham MW. Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity. 2008 Sep; 41(6):442-53. PMID: 18781470.
      Citations: 23     Fields:    Translation:HumansCells
    35. Huang S, Patterson E, Yu X, Garrett MW, De Aos I, Kem DC. Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction. . 2008 Mar; 294(3):H1298-303. PMID: 18192226.
      Citations:    
    36. Kem DC, Yu X, Patterson E, Huang S, Stavrakis S, Szabo B, Olansky L, McCauley J, Cunningham MW. Autoimmune hypertensive syndrome. Hypertension. 2007 Nov; 50(5):829-34. PMID: 17923587.
      Citations: 6     Fields:    Translation:HumansAnimals
    37. Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X. Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report. Endocr Pract. 2007 Mar-Apr; 13(2):153-8. PMID: 17490929.
      Citations:    Fields:    Translation:Humans
    38. Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol. 2007 Feb 19; 6:6. PMID: 17309798.
      Citations: 24     Fields:    Translation:AnimalsCells
    39. Patterson E, Yu X, Huang S, Garrett M, Kem DC. Suppression of autonomic-mediated triggered firing in pulmonary vein preparations, 24 hours postcoronary artery ligation in dogs. J Cardiovasc Electrophysiol. 2006 Jul; 17(7):763-70. PMID: 16836675.
      Citations: 5     Fields:    Translation:Animals
    40. Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. . 2005 Nov; 289(5):H1960-7. PMID: 15994860.
      Citations:    
    41. Kem DC, Lyons DF, Wenzl J, Halverstadt D, Yu X. Renin-dependent hypertension caused by nonfocal stenotic aberrant renal arteries: proof of a new syndrome. Hypertension. 2005 Aug; 46(2):380-5. PMID: 15967872.
      Citations: 6     Fields:    Translation:Humans
    42. Yu X, Patterson E, Huang S, Garrett MW, Kem DC. Tumor necrosis factor alpha, rapid ventricular tachyarrhythmias, and infarct size in canine models of myocardial infarction. J Cardiovasc Pharmacol. 2005 Feb; 45(2):153-9. PMID: 15654264.
      Citations: 10     Fields:    Translation:Animals
    43. Castro OL, Yu X, Kem DC. Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension. 2002 Apr; 39(4):935-8. PMID: 11967253.
      Citations: 6     Fields:    Translation:Humans
    44. Yu X, Zhang M, Kyker K, Patterson E, Benovic JL, Kem DC. Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac beta-adrenergic receptors. Circulation. 2000 Nov 14; 102(20):2535-40. PMID: 11076829.
      Citations: 5     Fields:    Translation:AnimalsCells
    45. Nagykaldi Z, Kem D, Lazzara R, Szabo B. Conditioning of beta(1)-adrenoceptor effect via beta(2)-subtype on L-type Ca(2+) current in canine ventricular myocytes. . 2000 Sep; 279(3):H1329-37. PMID: 10993800.
      Citations:    
    46. Nagykáldi Z, Kem D, Lazzara R, Szabó B. [The coupling of canine ventricular myocyte beta2-adrenoceptors to L-type calcium current]. Acta Pharm Hung. 1999 Nov; 69(5):247-57. PMID: 10652792.
      Citations: 1     Fields:    Translation:Animals
    47. Nagykaldi Z, Kem D, Lazzara R, Szabo B. Canine ventricular myocyte beta2-adrenoceptors are not functionally coupled to L-type calcium current. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1240-51. PMID: 10517658.
      Citations: 6     Fields:    Translation:Animals
    48. Dogan S, Turnbaugh D, Zhang M, Cofie DQ, Fugate RD, Kem DC. Thromboxane A2 receptor mediation of calcium and calcium transients in rat cardiomyocytes. Life Sci. 1997; 60(12):943-52. PMID: 9061051.
      Citations: 5     Fields:    Translation:Animals
    49. Zhang M, Turnbaugh D, Cofie D, Dogan S, Koshida H, Fugate R, Kem DC. Protein kinase C modulation of cardiomyocyte angiotensin II and vasopressin receptor desensitization. Hypertension. 1996 Feb; 27(2):269-75. PMID: 8567051.
      Citations: 6     Fields:    Translation:AnimalsCells
    50. Van der Bent V, Church DJ, Vallotton MB, Meda P, Kem DC, Capponi AM, Lang U. [Ca2+]i and protein kinase C in vasopressin-induced prostacyclin and ANP release in rat cardiomyocytes. Am J Physiol. 1994 Feb; 266(2 Pt 2):H597-605. PMID: 8141361.
      Citations: 3     Fields:    Translation:AnimalsCells
    51. Kem DC, Johnson EI, Capponi AM, Chardonnens D, Lang U, Blondel B, Koshida H, Vallotton MB. Effect of angiotensin II on cytosolic free calcium in neonatal rat cardiomyocytes. Am J Physiol. 1991 Jul; 261(1 Pt 1):C77-85. PMID: 1830456.
      Citations: 11     Fields:    Translation:AnimalsCells
    52. Kem DC, Brown RD. Renin--from beginning to end. N Engl J Med. 1990 Oct 18; 323(16):1136-7. PMID: 2215582.
      Citations: 2     Fields:    Translation:Humans
    53. Fujimura A, Kem DC, Kyker KD, Parker KM. The mechanism of polyethylene glycol-induced natriuresis in rats: role of atrial natriuretic hormone. Life Sci. 1990; 47(4):327-33. PMID: 2388533.
      Citations:    Fields:    Translation:Animals
    54. Fujimura A, Kyker KD, Kem DC. Infusion of atrial natriuretic hormone in DOCA/salt and spontaneously hypertensive rats. Acta Endocrinol (Copenh). 1989 Oct; 121(4):567-72. PMID: 2529729.
      Citations:    Fields:    Translation:Animals
    55. Fujimura A, Lowry RW, Kem DC. Calcium infusion increases plasma atrial natriuretic factor in spontaneously hypertensive rats. Hypertension. 1989 Jul; 14(1):98-103. PMID: 2525528.
      Citations: 2     Fields:    Translation:Animals
    56. Schiebinger RJ, Pratt JH, Kem DC. The adrenal capsule alters the response of zona glomerulosa cells to atrial natriuretic peptide. Endocrinology. 1988 Jul; 123(1):492-7. PMID: 2968238.
      Citations:    Fields:    Translation:AnimalsCells
    57. Craven TG, Kem DC, Schiebinger RJ. Atrial natriuretic peptides: the role of phenylalanine on biological activity. Endocrinology. 1988 Mar; 122(3):826-30. PMID: 2963740.
      Citations:    Fields:    Translation:Animals
    58. Schiebinger RJ, Kem DC, Brown RD. Effect of atrial natriuretic peptide on ACTH, dibutyryl cAMP, angiotensin II and potassium-stimulated aldosterone secretion by rat adrenal glomerulosa cells. Life Sci. 1988; 42(8):919-26. PMID: 2830448.
      Citations: 2     Fields:    Translation:AnimalsCells
    59. Devenport L, Manes G, Thomas T, Mena S, Kem D, Knehans A. Aldosterone and the mobilization of energy. Appetite. 1987 Apr; 8(2):81-90. PMID: 3592652.
      Citations:    Fields:    Translation:Animals
    60. Fiorica V, Kem DC. Plasma norepinephrine, blood pressure and heart rate response to graded change in body position. Aviat Space Environ Med. 1985 Dec; 56(12):1166-71. PMID: 4084169.
      Citations: 3     Fields:    Translation:Humans
    61. Trachewsky D, Kem DC. Antihypertensive effect of riboflavin analogues in spontaneously hypertensive rats. J Lab Clin Med. 1985 Aug; 106(2):223-8. PMID: 4020249.
      Citations: 1     Fields:    Translation:Animals
    62. Kem DC, Feldman M, Starkweather G, Li CH. Effect of human beta-endorphin on plasma aldosterone concentrations in normal human subjects. J Clin Endocrinol Metab. 1985 Mar; 60(3):440-3. PMID: 3156141.
      Citations:    Fields:    Translation:Humans
    63. Kem DC, Tang K, Hanson CS, Brown RD, Painton R, Weinberger MH, Hollifield JW. The prediction of anatomical morphology of primary aldosteronism using serum 18-hydroxycorticosterone levels. J Clin Endocrinol Metab. 1985 Jan; 60(1):67-73. PMID: 3964794.
      Citations: 6     Fields:    Translation:Humans
    64. Brown RD, Kem DC, Hogan MJ, Hegstad RL. Evaluation of a test using saralasin to differentiate primary aldosteronism due to an aldosterone-producing adenoma from idiopathic hyperaldosteronism. Metabolism. 1984 Aug; 33(8):734-8. PMID: 6748946.
      Citations:    Fields:    Translation:Humans
    65. Lyons DF, Eisen BR, Clark MR, Pysher TJ, Welsh JD, Kem DC. Concurrent Cushing's and Zollinger-Ellison syndromes in a patient with islet cell carcinoma. Case report and review of the literature. Am J Med. 1984 Apr; 76(4):729-33. PMID: 6324590.
      Citations: 2     Fields:    Translation:Humans
    66. Lyons DF, Kem DC, Brown RD, Hanson CS, Carollo ML. Single dose captopril as a diagnostic test for primary aldosteronism. J Clin Endocrinol Metab. 1983 Nov; 57(5):892-6. PMID: 6352726.
      Citations: 7     Fields:    Translation:Humans
    67. Lyons DF, Streck WF, Kem DC, Brown RD, Galloway DC, Williams GR, Chrysant SG, Danisa K, Carollo M. Captopril stimulation of differential renins in renovascular hypertension. Hypertension. 1983 Jul-Aug; 5(4):615-22. PMID: 6345367.
      Citations: 1     Fields:    Translation:Humans
    68. Gilchrist M, Kem DC, Washburn D. The effect of acidosis and alkalosis on in vitro aldosterone production. Metabolism. 1983 Jul; 32(7):697-700. PMID: 6306387.
      Citations:    Fields:    Translation:Animals
    69. Chrysant SG, Brown RD, Kem DC, Brown JL. Antihypertensive and metabolic effects of a new converting enzyme inhibitor, enalapril. Clin Pharmacol Ther. 1983 Jun; 33(6):741-6. PMID: 6303673.
      Citations: 10     Fields:    Translation:HumansCTClinical Trials
    70. Billman GE, Keyl MJ, Dickey DT, Kem DC, Keil LC, Stone HL. Hormonal and renal response to plasma volume expansion in the primate Macaca mulatta. Am J Physiol. 1983 Feb; 244(2):H201-5. PMID: 6186149.
      Citations: 2     Fields:    Translation:Animals
    71. Brown RD, Billman GE, Kem DC, Stone HL, Jiang NS, Kao P, Hegstad RL. The effect of metoclopramide and dopamine on plasma aldosterone concentration in normal man and rhesus monkeys (Macaca mulatta): a new model to study dopamine control of aldosterone secretion. J Clin Endocrinol Metab. 1982 Nov; 55(5):828-32. PMID: 7119085.
      Citations: 1     Fields:    Translation:HumansAnimals
    72. Fiorica V, Galloway DC, Males JL, Painton RP, Kem DC. Epinephrine fraction of adrenal vein blood in pheochromocytoma. Am J Med Sci. 1982 Nov-Dec; 284(3):9-15. PMID: 7148891.
      Citations: 1     Fields:    Translation:Humans
    73. Washburn DD, Kem DC, Orth DN, Nicholson WE, Chrétien M, Mount CD. Effect of beta-lipotropin on aldosterone production in the isolated rat adrenal cell preparation. J Clin Endocrinol Metab. 1982 Mar; 54(3):613-8. PMID: 7056844.
      Citations: 4     Fields:    Translation:AnimalsCells
    74. Perez GO, Kem DC, Oster JR, Vaamonde CA. Effect of acute metabolic acidosis on the renin-aldosterone system. Mechanism of increases in plasma aldosterone in dogs infused with lactic acid. J Lab Clin Med. 1980 Aug; 96(2):371-8. PMID: 6249877.
      Citations: 2     Fields:    Translation:Animals
    75. Chrysant SG, Luu TM, Danisa K, Kem DC, Manion CV. Systemic and renal hemodynamic effects of trimazosin: a new vasodilator. J Cardiovasc Pharmacol. 1980; 2(2):205-14. PMID: 6171687.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    76. Wambach G, Higgins JR, Kem DC, Kaufmann W. Interaction of synthetic progestagens with renal mineralocorticoid receptors. Acta Endocrinol (Copenh). 1979 Nov; 92(3):560-7. PMID: 574701.
      Citations: 2     Fields:    Translation:AnimalsCells
    77. Rovner DR, Conn JW, Cohen EL, Berlinger FG, Kem DC, Gordon DL. 17 alpha-Hydroxylase deficiency. A combination of hydroxylation defect and reversible blockade in aldosterone biosynthesis. Acta Endocrinol (Copenh). 1979 Mar; 90(3):490-504. PMID: 218415.
      Citations: 2     Fields:    Translation:Humans
    78. Weinberger MH, Grim CE, Hollifield JW, Kem DC, Ganguly A, Kramer NJ, Yune HY, Wellman H, Donohue JP. Primary aldosteronism: diagnosis, localization, and treatment. Ann Intern Med. 1979 Mar; 90(3):386-95. PMID: 218482.
      Citations: 42     Fields:    Translation:Humans
    79. Kem DC, Frohlich ED, de Carvalho JG, Dunn FG, Chrysant SG, Danisa K, Wambach G. Hemodynamic correlates of saralasin: responsiveness in hypertension. Kidney Int Suppl. 1979 Mar; (9):S68-74. PMID: 289866.
      Citations:    Fields:    Translation:HumansCells
    80. Chrysant SG, Danisa K, Kem DC, Dillard BL, Smith WJ, Frohlich ED. Racial differences in pressure, volume and renin interrelationships in essential hypertension. Hypertension. 1979 Mar-Apr; 1(2):136-41. PMID: 399939.
      Citations: 21     Fields:    Translation:Humans
    81. Chrysant SG, Walsh GM, Kem DC, Frohlich ED. Hemodynamic and metabolic evidence of salt sensitivity in spontaneously hypertensive rats. Kidney Int. 1979 Jan; 15(1):33-7. PMID: 491394.
      Citations: 4     Fields:    Translation:Animals
    82. Kem DC, Weinberger MH, Higgins JR, Kramer NJ, Gomez-Sanchez C, Holland OB. Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. J Clin Endocrinol Metab. 1978 Apr; 46(4):552-60. PMID: 225341.
      Citations: 17     Fields:    Translation:Humans
    83. de Carvalho JG, Dunn FG, Kem DC, Chrysant SG, Froholich ED. Hemodynamic correlates of saralasin-induced arterial pressure changes. Circulation. 1978 Feb; 57(2):373-8. PMID: 618629.
      Citations: 1     Fields:    Translation:Humans
    84. Holland OB, Gomez-Sanchez CE, Kem DC, Weinberger MH, Kramer NJ, Higgins JR. Evidence against prolactin stimulation of aldosterone in normal human subjects and patients with primary aldosteronism, including a patient with primary aldosteronism and a prolactin-producing pituitary microadenoma. J Clin Endocrinol Metab. 1977 Nov; 45(5):1064-76. PMID: 925132.
      Citations: 2     Fields:    Translation:Humans
    85. Higgins JR, Wambach G, Kem DC, Gomez-Sanchez C, Holland OB, Kaplan NM. Interaction of 16beta-hydroxydehydroepiandrosterone with renal mineralocorticoid receptors. J Lab Clin Med. 1977 Feb; 89(2):250-6. PMID: 137938.
      Citations:    Fields:    Translation:AnimalsCells
    86. Kem DC, Weinberger MH, Gomez-Sanchez C, Higgins JR, Kramer NJ. The role of ACTH in the episodic release of aldosterone in patients with idiopathic adrenal hyperplasia, hypertension, and hyperaldosteronism. J Lab Clin Med. 1976 Aug; 88(2):261-70. PMID: 182890.
      Citations: 4     Fields:    Translation:Humans
    87. Gomez-Sanchez C, Holland OB, Higgins JR, Kem DC, Kaplan NM. Circadian rhythms of serum renin activity and serum corticosterone, prolactin, and aldosterone concentrations in the male rat on normal and low-sodium diets. Endocrinology. 1976 Aug; 99(2):567-72. PMID: 954653.
      Citations: 10     Fields:    Translation:Animals
    88. Kaplan NM, Kem DC, Holland OB, Kramer NJ, Higgins J, Gomez-Sanchez C. The intravenous furosemide test: a simple way to evaluate renin responsiveness. Ann Intern Med. 1976 Jun; 84(6):639-45. PMID: 937875.
      Citations: 17     Fields:    Translation:Humans
    89. Weinberger MH, Kem DC, Gomez-Sanchez C, Kramer NJ, Martin BT, Nugent CA. The effect of dexamethasone on the control of plasma aldosterone concentration in normal recumbent man. J Lab Clin Med. 1975 Jun; 85(6):957-67. PMID: 166119.
      Citations: 4     Fields:    Translation:Humans
    90. Gomez-Sanchez C, Murry BA, Kem DC, Kaplan NM. A direct radioimmunoassay of corticosterone in rat serum. Endocrinology. 1975 Mar; 96(3):796-8. PMID: 1116485.
      Citations: 7     Fields:    Translation:AnimalsCells
    91. Kem DC, Gomez-Sanchez C, Kramer NJ, Holland OB, Higgins JR. Plasma aldosterone and renin activity response to ACTH infusion in dexamethasone-suppressed normal and sodium-depleted man. J Clin Endocrinol Metab. 1975 Jan; 40(1):116-24. PMID: 163263.
      Citations: 5     Fields:    Translation:Humans
    92. Kem DC, Weinberger MH, Gomez-Sanchez C, Kramer NJ, Lerman R, Furuyama S, Nugent CA. Circadian rhythm of plasma aldosterone concentration in patients with primary aldosteronism. J Clin Invest. 1973 Sep; 52(9):2272-7. PMID: 4353776.
      Citations: 14     Fields:    Translation:Humans
    93. Gomez-Sanchez C, Kem DC, Kaplan NM. A radioimmunoassay for plasma aldosterone by immunologic purification. J Clin Endocrinol Metab. 1973 Apr; 36(4):795-8. PMID: 4686388.
      Citations: 6     Fields:    Translation:Humans
    94. Kem DC, Weinberger MH, Mayes DM, Nugent CA. Saline suppression of plasma aldosterone in hypertension. Arch Intern Med. 1971 Sep; 128(3):380-6. PMID: 5093210.
      Citations: 15     Fields:    Translation:Humans
    95. Cohen EL, Grim CE, Conn JW, Blough WM, Guyer RB, Kem DC, Lucas CP. Accurate and rapid measurement of plasma renin activity by radioimmunoassay. Results in normal and hypertensive people. J Lab Clin Med. 1971 Jun; 77(6):1025-38. PMID: 4327019.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    96. Kem DC, Mayes D, Weinberger M, Nugent CA. Saline suppression of plasma aldosterone and plasma renin activity in hypertension. Ariz Med. 1971 Apr; 28(4):264-6. PMID: 5572938.
      Citations:    Fields:    Translation:Humans
    97. Mayes D, Furuyama S, Kem DC, Nugent CA. A radioimmunoassay for plasma aldosterone. J Clin Endocrinol Metab. 1970 May; 30(5):682-5. PMID: 5444558.
      Citations: 38     Fields:    Translation:HumansAnimals
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