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Deepa S Sathyaseelan

TitleProf,Asst
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
AddressBRC 1303
975 NE 10th St
Oklahoma City OK 73104
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    Collapse Research 
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    2R01AG059718-06     (SATHYASEELAN, DEEPA)Jul 15, 2024 - Jun 30, 2029
    NIH/NIA
    The role of hepatocyte necroptosis and inflammation in liver-brain crosstalk in aging
    Role: Principal Investigator
    R03CA262044     (SATHYASEELAN, DEEPA)Mar 1, 2022 - Feb 29, 2024
    NIH
    Role of necroptosis in inflammation and NAFLD to HCC progression
    Role: Principal Investigator
    R03CA262044     (SATHYASEELAN, DEEPA)Mar 1, 2022 - Feb 29, 2024
    NIH/NCI
    Role of necroptosis in inflammation and NAFLD to HCC progression
    Role: Principal Investigator
    R01AG059718     (SATHYASEELAN, DEEPA)May 1, 2019 - Jun 30, 2029
    NIH
    The Role of Necroptosis in Aging
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ohene-Marfo P, Nguyen HVM, Mohammed S, Thadathil N, Tran A, Nicklas EH, Wang D, Selvarani R, Farriester JW, Varshney R, Kinter M, Richardson A, Rudolph MC, Deepa SS. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model. Int J Mol Sci. 2024 Feb 28; 25(5). PMID: 38474061; PMCID: PMC10931720.
      Citations:    Fields:    Translation:HumansAnimals
    2. Deepa SS, Thadathil N, Corral J, Mohammed S, Pham S, Rose H, Kinter MT, Richardson A, D?az-Garc?a CM. MLKL overexpression leads to Ca2+ and metabolic dyshomeostasis in a neuronal cell model. Cell Calcium. 2024 May; 119:102854. PMID: 38430790; PMCID: PMC10990772.
      Citations:    Fields:    Translation:AnimalsCells
    3. Ohene-Marfo P, Nguyen HVM, Mohammed S, Thadathil N, Tran A, Nicklas EH, Wang D, Selvarani R, Farriester J, Varshney R, Kinter M, Richardson A, Rudolph M, Deepa SS. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model. bioRxiv. 2024 Jan 11. PMID: 38260537; PMCID: PMC10802562.
      Citations:    
    4. Kotey SK, Tan X, Fleming O, Kasiraju RR, Dagnell AL, Van Pelt KN, Rogers J, Hartson SD, Thadathil N, Selvarani R, Ranjit R, Logan S, Deepa SS, Richardson A, Cheng Y. Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages. Geroscience. 2024 Apr; 46(2):2739-2754. PMID: 38159133.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Selvarani R, Van Michelle Nguyen H, Thadathil N, Wolf RF, Freeman WM, Wiley CD, Deepa SS, Richardson A. Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases. Geroscience. 2023 Oct 04. PMID: 37792157.
      Citations: 1     Fields:    Translation:Animals
    6. Mohammed S, Thadathil N, Ohene-Marfo P, Tran AL, Van Der Veldt M, Georgescu C, Oh S, Nicklas EH, Wang D, Haritha NH, Luo W, Janknecht R, Miller BF, Wren JD, Freeman WM, Deepa SS. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis. Mol Cancer Res. 2023 May 19. PMID: 37204757.
      Citations: 6     Fields:    Translation:Animals
    7. Bhaskaran S, Kumar G, Thadathil N, Piekarz KM, Mohammed S, Lopez SD, Qaisar R, Walton D, Brown JL, Murphy A, Smith N, Saunders D, Beckstead MJ, Plafker S, Lewis TL, Towner R, Deepa SS, Richardson A, Axtell RC, Van Remmen H. Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis. Redox Biol. 2023 02; 59:102550. PMID: 36470129; PMCID: PMC9720104.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Thadathil N, Selvarani R, Mohammed S, Nicklas EH, Tran AL, Kamal M, Luo W, Brown JL, Lawrence MM, Borowik AK, Miller BF, Van Remmen H, Richardson A, Deepa SS. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma. Aging Cell. 2022 Aug; 21(8):e13676. PMID: 35869934.
      Citations: 17     Fields:    Translation:Animals
    9. Swetha M, Keerthana CK, Rayginia TP, Nath LR, Haritha NH, Shabna A, Kalimuthu K, Thangarasu AK, Aiswarya SU, Jannet S, Pillai S, Harikumar KB, Sundaram S, Anto NP, Wu DH, Lankalapalli RS, Towner R, Isakov N, Deepa SS, Anto RJ. Augmented Efficacy of Uttroside B over Sorafenib in a Murine Model of Human Hepatocellular Carcinoma. Pharmaceuticals (Basel). 2022 May 22; 15(5). PMID: 35631464.
      Citations: 3     
    10. Mohammed S, Thadathil N, Selvarani R, Nicklas EH, Wang D, Miller BF, Richardson A, Deepa SS. Necroptosis contributes to chronic inflammation and fibrosis in aging liver. Aging Cell. 2021 12; 20(12):e13512. PMID: 34761505.
      Citations: 50     Fields:    
    11. Thadathil N, Nicklas EH, Mohammed S, Lewis TL, Richardson A, Deepa SS. Necroptosis increases with age in the brain and contributes to age-related neuroinflammation. Geroscience. 2021 10; 43(5):2345-2361. PMID: 34515928.
      Citations: 23     Fields:    Translation:Animals
    12. Mohammed S, Nicklas EH, Thadathil N, Selvarani R, Royce GH, Kinter M, Richardson A, Deepa SS. Role of necroptosis in chronic hepatic inflammation and fibrosis in a mouse model of increased oxidative stress. Free Radic Biol Med. 2021 02 20; 164:315-328. PMID: 33429022.
      Citations: 40     Fields:    Translation:Animals
    13. Royce GH, Brown-Borg HM, Deepa SS. The potential role of necroptosis in inflammaging and aging. Geroscience. 2019 Dec; 41(6):795-811. PMID: 31721033; PMCID: PMC6925091.
      Citations: 57     Fields:    Translation:Animals
    14. Logan S, Royce GH, Owen D, Farley J, Ranjo-Bishop M, Sonntag WE, Deepa SS. Accelerated decline in cognition in a mouse model of increased oxidative stress. Geroscience. 2019 10; 41(5):591-607. PMID: 31641924.
      Citations: 26     Fields:    Translation:Animals
    15. Deepa SS, Van Remmen H, Brooks SV, Faulkner JA, Larkin L, McArdle A, Jackson MJ, Vasilaki A, Richardson A. Accelerated sarcopenia in Cu/Zn superoxide dismutase knockout mice. Free Radic Biol Med. 2019 02 20; 132:19-23. PMID: 30670156.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    16. Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H. Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice. Aging Cell. 2018 08; 17(4):e12769. PMID: 29696791.
      Citations: 11     Fields:    Translation:AnimalsCells
    17. Deepa SS, Unnikrishnan A, Matyi S, Hadad N, Richardson A. Necroptosis increases with age and is reduced by dietary restriction. Aging Cell. 2018 08; 17(4):e12770. PMID: 29696779.
      Citations: 27     Fields:    Translation:Animals
    18. Snider TA, Richardson A, Stoner JA, Deepa SS. The Geropathology Grading Platform demonstrates that mice null for Cu/Zn-superoxide dismutase show accelerated biological aging. Geroscience. 2018 04; 40(2):97-103. PMID: 29478190.
      Citations: 14     Fields:    Translation:Animals
    19. Matyi S, Jackson J, Garrett K, Deepa SS, Unnikrishnan A. The effect of different levels of dietary restriction on glucose homeostasis and metabolic memory. Geroscience. 2018 04; 40(2):139-149. PMID: 29455275.
      Citations: 19     Fields:    Translation:AnimalsCells
    20. Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep. 2018 03; 19(3). PMID: 29420235; PMCID: PMC5836096.
      Citations: 42     Fields:    Translation:AnimalsCells
    21. Bhaskaran S, Unnikrishnan A, Ranjit R, Qaisar R, Pharaoh G, Matyi S, Kinter M, Deepa SS. A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice. Free Radic Biol Med. 2017 07; 108:704-714. PMID: 28455142.
      Citations: 15     Fields:    Translation:AnimalsCells
    22. Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H. Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Nov 05; 455:103-114. PMID: 28428045; PMCID: PMC5592144.
      Citations: 9     Fields:    Translation:AnimalsCells
    23. Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse. Geroscience. 2017 04; 39(2):187-198. PMID: 28409332.
      Citations: 50     Fields:    Translation:Animals
    24. Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A. A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1-/- mice is correlated to increased cellular senescence. Redox Biol. 2017 04; 11:30-37. PMID: 27846439.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    25. Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H. Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation. Free Radic Biol Med. 2016 Feb; 91:281-92. PMID: 26721594; PMCID: PMC5584630.
      Citations: 41     Fields:    Translation:AnimalsCells
    26. Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H. Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses. Biochem J. 2014 Sep 01; 462(2):359-71. PMID: 24911525; PMCID: PMC4145821.
      Citations: 57     Fields:    Translation:AnimalsCells
    27. Lin AL, Pulliam DA, Deepa SS, Halloran JJ, Hussong SA, Burbank RR, Bresnen A, Liu Y, Podlutskaya N, Soundararajan A, Muir E, Duong TQ, Bokov AF, Viscomi C, Zeviani M, Richardson AG, Van Remmen H, Fox PT, Galvan V. Decreased in vitro mitochondrial function is associated with enhanced brain metabolism, blood flow, and memory in Surf1-deficient mice. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1605-11. PMID: 23838831.
      Citations: 21     Fields:    Translation:AnimalsCells
    28. Deepa SS, Walsh ME, Hamilton RT, Pulliam D, Shi Y, Hill S, Li Y, Van Remmen H. Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice. J Biochem Pharmacol Res. 2013 Jun; 1(2):114-123. PMID: 24010023; PMCID: PMC3760510.
      Citations: 23     
    29. Bhaskaran S, Dileep KV, Deepa SS, Sadasivan C, Klausner M, Krishnegowda NK, Tekmal RR, VandeBerg JL, Nair HB. Gossypin as a novel selective dual inhibitor of V-RAF murine sarcoma viral oncogene homolog B1 and cyclin-dependent kinase 4 for melanoma. Mol Cancer Ther. 2013 Apr; 12(4):361-72. PMID: 23543365.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    30. Deepa SS, Pulliam D, Hill S, Shi Y, Walsh ME, Salmon A, Sloane L, Zhang N, Zeviani M, Viscomi C, Musi N, Van Remmen H. Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity. FASEB J. 2013 Apr; 27(4):1371-80. PMID: 23241310.
      Citations: 21     Fields:    Translation:AnimalsCells
    31. Mizumoto S, Murakoshi S, Kalayanamitra K, Deepa SS, Fukui S, Kongtawelert P, Yamada S, Sugahara K. Highly sulfated hexasaccharide sequences isolated from chondroitin sulfate of shark fin cartilage: insights into the sugar sequences with bioactivities. Glycobiology. 2013 Feb; 23(2):155-68. PMID: 23019154.
      Citations: 10     Fields:    Translation:AnimalsCells
    32. Deepa SS, Zhou L, Ryu J, Wang C, Mao X, Li C, Zhang N, Musi N, DeFronzo RA, Liu F, Dong LQ. APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol Endocrinol. 2011 Oct; 25(10):1773-85. PMID: 21835890; PMCID: PMC3182423.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    33. Carulli D, Pizzorusso T, Kwok JC, Putignano E, Poli A, Forostyak S, Andrews MR, Deepa SS, Glant TT, Fawcett JW. Animals lacking link protein have attenuated perineuronal nets and persistent plasticity. Brain. 2010 Aug; 133(Pt 8):2331-47. PMID: 20566484.
      Citations: 230     Fields:    Translation:AnimalsCells
    34. Zhou L, Deepa SS, Etzler JC, Ryu J, Mao X, Fang Q, Liu DD, Torres JM, Jia W, Lechleiter JD, Liu F, Dong LQ. Adiponectin activates AMP-activated protein kinase in muscle cells via APPL1/LKB1-dependent and phospholipase C/Ca2+/Ca2+/calmodulin-dependent protein kinase kinase-dependent pathways. J Biol Chem. 2009 Aug 14; 284(33):22426-22435. PMID: 19520843; PMCID: PMC2755964.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    35. Deepa SS, Dong LQ. APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab. 2009 Jan; 296(1):E22-36. PMID: 18854421; PMCID: PMC2636986.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    36. Pothacharoen P, Kalayanamitra K, Deepa SS, Fukui S, Hattori T, Fukushima N, Hardingham T, Kongtawelert P, Sugahara K. Two related but distinct chondroitin sulfate mimetope octasaccharide sequences recognized by monoclonal antibody WF6. J Biol Chem. 2007 Nov 30; 282(48):35232-46. PMID: 17884822.
      Citations: 13     Fields:    Translation:AnimalsCells
    37. Deepa SS, Yamada S, Fukui S, Sugahara K. Structural determination of novel sulfated octasaccharides isolated from chondroitin sulfate of shark cartilage and their application for characterizing monoclonal antibody epitopes. Glycobiology. 2007 Jun; 17(6):631-45. PMID: 17317718.
      Citations: 24     Fields:    Translation:AnimalsCells
    38. Deepa SS, Kalayanamitra K, Ito Y, Kongtawelert P, Fukui S, Yamada S, Mikami T, Sugahara K. Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate E: sequencing and application for determination of the epitope structure of the monoclonal antibody MO-225. Biochemistry. 2007 Mar 06; 46(9):2453-65. PMID: 17284053.
      Citations: 10     Fields:    Translation:Animals
    39. Deepa SS, Carulli D, Galtrey C, Rhodes K, Fukuda J, Mikami T, Sugahara K, Fawcett JW. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. J Biol Chem. 2006 Jun 30; 281(26):17789-800. PMID: 16644727.
      Citations: 164     Fields:    Translation:AnimalsCells
    40. Deepa SS, Yamada S, Zako M, Goldberger O, Sugahara K. Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor. J Biol Chem. 2004 Sep 03; 279(36):37368-76. PMID: 15226297.
      Citations: 73     Fields:    Translation:AnimalsCells
    41. Deepa SS, Arumughan C. Purification and characterization of soluble peroxidase from oil palm (Elaeis guineensis Jacq) leaf. Phytochemistry. 2002 Nov; 61(5):503-11. PMID: 12409016.
      Citations: 5     Fields:    Translation:Animals
    42. Deepa SS, Umehara Y, Higashiyama S, Itoh N, Sugahara K. Specific molecular interactions of oversulfated chondroitin sulfate E with various heparin-binding growth factors. Implications as a physiological binding partner in the brain and other tissues. J Biol Chem. 2002 Nov 15; 277(46):43707-16. PMID: 12221095.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    43. Yamada S, Okada Y, Ueno M, Iwata S, Deepa SS, Nishimura S, Fujita M, Van Die I, Hirabayashi Y, Sugahara K. Determination of the glycosaminoglycan-protein linkage region oligosaccharide structures of proteoglycans from Drosophila melanogaster and Caenorhabditis elegans. J Biol Chem. 2002 Aug 30; 277(35):31877-86. PMID: 12058048.
      Citations: 19     Fields:    Translation:AnimalsCells
    44. Sivan YS, Alwin Jayakumar Y, Arumughan C, Sundaresan A, Jayalekshmy A, Suja KP, Soban Kumar DR, Deepa SS, Damodaran M, Soman CR, Raman Kutty V, Sankara Sarma P. Impact of vitamin A supplementation through different dosages of red palm oil and retinol palmitate on preschool children. J Trop Pediatr. 2002 Feb; 48(1):24-8. PMID: 11871368.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    45. Sivan YS, Jayakumar YA, Arumughan C, Sundaresan A, Balachandran C, Job J, Deepa SS, Shihina SL, Damodaran M, Soman CR, Raman Kutty V, Sankara Sarma P. Impact of beta-carotene supplementation through red palm. J Trop Pediatr. 2001 Apr; 47(2):67-72. PMID: 11336137.
      Citations: 4     Fields:    Translation:Humans
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