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Kenneth Darrell Berlin

TitleProfessor
InstitutionOklahoma State University
DepartmentChemistry
AddressR 422
Physical Science I
Stillwater OK 74078
Phone405/744-5950
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    S07RR007077     (BERLIN, KENNETH DARRELL)Apr 1, 1979 - Sep 29, 1993
    NIH
    BIOMEDICAL RESEARCH SUPPORT
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Muddala NP, White JC, Nammalwar B, Pratt I, Thomas LM, Bunce RA, Berlin KD, Bourne CR. Inhibitor design to target a unique feature in the folate pocket of Staphylococcus aureus dihydrofolate reductase. Eur J Med Chem. 2020 Aug 15; 200:112412. PMID: 32502861.
      Citations:    Fields:    Translation:Cells
    2. Nammalwar B, Bunce RA, Berlin KD, Benbrook DM, Toal C. Synthesis and biological evaluation of SHetA2 (NSC-721689) analogs against the ovarian cancer cell line A2780. Eur J Med Chem. 2019 May 15; 170:16-27. PMID: 30878829.
      Citations: 1     Fields:    Translation:HumansCells
    3. Watts FM, Pouland T, Bunce RA, Berlin KD, Benbrook DM, Mashayekhi M, Bhandari D, Zhou D. Activity of oxygen-versus sulfur-containing analogs of the Flex-Het anticancer agent SHetA2. Eur J Med Chem. 2018 Oct 05; 158:720-732. PMID: 30245396.
      Citations: 1     Fields:    Translation:HumansCells
    4. Muddala NP, Nammalwar B, Selvaraju S, Bourne CR, Henry M, Bunce RA, Berlin KD, Barrow EW, Barrow WW. Evaluation of New Dihydrophthalazine-Appended 2,4-Diaminopyrimidines against Bacillus anthracis: Improved Syntheses Using a New Pincer Complex. Molecules. 2015 Apr 21; 20(4):7222-44. PMID: 25905602.
      Citations: 1     Fields:    Translation:Cells
    5. Gnanasekaran KK, Benbrook DM, Nammalwar B, Thavathiru E, Bunce RA, Berlin KD. Synthesis and evaluation of second generation Flex-Het scaffolds against the human ovarian cancer A2780 cell line. Eur J Med Chem. 2015; 96:209-17. PMID: 25880346.
      Citations: 2     Fields:    Translation:HumansCells
    6. Nammalwar B, Bourne CR, Wakeham N, Bourne PC, Barrow EW, Muddala NP, Bunce RA, Berlin KD, Barrow WW. Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis. Bioorg Med Chem. 2015 Jan 01; 23(1):203-11. PMID: 25435253.
      Citations: 4     Fields:    Translation:Cells
    7. Nammalwar B, Muddala NP, Bourne CR, Henry M, Bourne PC, Bunce RA, Barrow EW, Berlin KD, Barrow WW. Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis. Molecules. 2014 Mar 17; 19(3):3231-46. PMID: 24642909.
      Citations: 2     Fields:    Translation:Cells
    8. Bourne CR, Wakeham N, Webb N, Nammalwar B, Bunce RA, Berlin KD, Barrow WW. The structure and competitive substrate inhibition of dihydrofolate reductase from Enterococcus faecalis reveal restrictions to cofactor docking. Biochemistry. 2014 Feb 25; 53(7):1228-38. PMID: 24495113.
      Citations: 2     Fields:    Translation:Cells
    9. Benbrook DM, Nammalwar B, Long A, Matsumoto H, Singh A, Bunce RA, Berlin KD. SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheres. Invest New Drugs. 2014 Jun; 32(3):412-23. PMID: 24254390.
      Citations: 11     Fields:    Translation:HumansCells
    10. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2013; 45(1):66-71. PMID: 23788820.
      Citations:    
    11. Bourne CR, Wakeham N, Nammalwar B, Tseitin V, Bourne PC, Barrow EW, Mylvaganam S, Ramnarayan K, Bunce RA, Berlin KD, Barrow WW. Structure-activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase. Biochim Biophys Acta. 2013 Jan; 1834(1):46-52. PMID: 22999981.
      Citations: 5     Fields:    Translation:Cells
    12. Nammalwar B, Bourne CR, Bunce RA, Wakeham N, Bourne PC, Ramnarayan K, Mylvaganam S, Berlin KD, Barrow EW, Barrow WW. Inhibition of bacterial dihydrofolate reductase by 6-alkyl-2,4-diaminopyrimidines. ChemMedChem. 2012 Nov; 7(11):1974-82. PMID: 22930550.
      Citations: 5     Fields:    Translation:HumansCells
    13. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Eur J Med Chem. 2012 Aug; 54:387-96. PMID: 22703705.
      Citations: 10     Fields:    Translation:Cells
    14. Bourne CR, Wakeham N, Bunce RA, Nammalwar B, Berlin KD, Barrow WW. Classifying compound mechanism of action for linking whole cell phenotypes to molecular targets. J Mol Recognit. 2012 Apr; 25(4):216-23. PMID: 22434711.
      Citations: 3     Fields:    Translation:Cells
    15. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Approaches to Iodinated Derivatives of Vanillin and Isovanillin. Org Prep Proced Int. 2012; 44(2):146-152. PMID: 23805008.
      Citations:    
    16. Nammalwar B, Bunce RA, Berlin KD, Bourne CR, Bourne PC, Barrow EW, Barrow WW. Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics. Org Prep Proced Int. 2012; 44(3):281-287. PMID: 23805009.
      Citations:    
    17. Bourne CR, Barrow EW, Bunce RA, Bourne PC, Berlin KD, Barrow WW. Inhibition of antibiotic-resistant Staphylococcus aureus by the broad-spectrum dihydrofolate reductase inhibitor RAB1. Antimicrob Agents Chemother. 2010 Sep; 54(9):3825-33. PMID: 20606069.
      Citations: 14     Fields:    Translation:Cells
    18. Liu T, Masamha CP, Chengedza S, Berlin KD, Lightfoot S, He F, Benbrook DM. Development of flexible-heteroarotinoids for kidney cancer. . 2009 May; 8(5):1227-38. PMID: 19417155.
      Citations:    
    19. Bourne CR, Bunce RA, Bourne PC, Berlin KD, Barrow EW, Barrow WW. Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity. Antimicrob Agents Chemother. 2009 Jul; 53(7):3065-73. PMID: 19364848.
      Citations: 16     Fields:    Translation:Cells
    20. Le TC, Berlin KD, Benson SD, Eastman MA, Bell-Eunice G, Nelson AC, Benbrook DM. Heteroarotinoids with anti-cancer activity against ovarian cancer cells. Open Med Chem J. 2007 Oct 24; 1:11-23. PMID: 19662136.
      Citations:    
    21. Patterson E, Scherlag BJ, Lazzara R, Garrison GL, Berlin KD. Electrophysiologic actions of d,l-sotalol and GLG-V-13 in ischemically injured canine epicardium. J Cardiovasc Pharmacol. 2007 Sep; 50(3):304-13. PMID: 17878760.
      Citations:    Fields:    Translation:Animals
    22. Benbrook DM, Kamelle SA, Guruswamy SB, Lightfoot SA, Rutledge TL, Gould NS, Hannafon BN, Dunn ST, Berlin KD. Flexible heteroarotinoids (Flex-Hets) exhibit improved therapeutic ratios as anti-cancer agents over retinoic acid receptor agonists. Invest New Drugs. 2005 Oct; 23(5):417-28. PMID: 16133793.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    23. Liu S, Brown CW, Berlin KD, Dhar A, Guruswamy S, Brown D, Gardner GJ, Birrer MJ, Benbrook DM. Synthesis of flexible sulfur-containing heteroarotinoids that induce apoptosis and reactive oxygen species with discrimination between malignant and benign cells. J Med Chem. 2004 Feb 12; 47(4):999-1007. PMID: 14761202.
      Citations: 20     Fields:    Translation:HumansCells
    24. Brown CW, Liu S, Klucik J, Berlin KD, Brennan PJ, Kaur D, Benbrook DM. Novel heteroarotinoids as potential antagonists of Mycobacterium bovis BCG. J Med Chem. 2004 Feb 12; 47(4):1008-17. PMID: 14761203.
      Citations: 2     Fields:    Translation:Cells
    25. Guruswamy S, Lightfoot S, Gold MA, Hassan R, Berlin KD, Ivey RT, Benbrook DM. Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma. J Natl Cancer Inst. 2001 Apr 04; 93(7):516-25. PMID: 11287445.
      Citations: 17     Fields:    Translation:HumansCells
    26. Chen CL, Chandra AM, Kim S, Sangiah S, Chen H, Roder JD, Qualls CW, Garrison GL, Cowell RL, Berlin KD, Scherlag BJ, Lazzara R. The acute and subchronic toxicity of BRB-I-28, a novel class Ib antiarrhythmic agent, in CD-1 mice. Food Chem Toxicol. 2000 Sep; 38(9):817-23. PMID: 10930703.
      Citations: 1     Fields:    Translation:Animals
    27. Chen CL, Chandra SA, Kim S, Sangiah S, Chen H, Roder JD, Qualls CW, Garrison GL, Cowell RL, Berlin KD, Scherlag BJ, Lazzara R. Preliminary acute and subchronic toxicity studies of GLG-V-13, a novel class III antiarrhythmic agent, in mice. Arzneimittelforschung. 2000 Jan; 50(1):31-8. PMID: 10683713.
      Citations:    Fields:    Translation:Animals
    28. Zacheis D, Dhar A, Lu S, Madler MM, Klucik J, Brown CW, Liu S, Clement F, Subramanian S, Weerasekare GM, Berlin KD, Gold MA, Houck JR, Fountain KR, Benbrook DM. Heteroarotinoids inhibit head and neck cancer cell lines in vitro and in vivo through both RAR and RXR retinoic acid receptors. J Med Chem. 1999 Oct 21; 42(21):4434-45. PMID: 10543887.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Dhar A, Liu S, Klucik J, Berlin KD, Madler MM, Lu S, Ivey RT, Zacheis D, Brown CW, Nelson EC, Birckbichler PJ, Benbrook DM. Synthesis, structure-activity relationships, and RARgamma-ligand interactions of nitrogen heteroarotinoids. J Med Chem. 1999 Sep 09; 42(18):3602-14. PMID: 10479291.
      Citations: 7     Fields:    Translation:HumansCells
    30. Benbrook DM, Subramanian S, Gale JB, Liu S, Brown CW, Boehm MF, Berlin KD. Synthesis and characterization of heteroarotinoids demonstrate structure specificity relationships. J Med Chem. 1998 Sep 10; 41(19):3753-7. PMID: 9733501.
      Citations: 6     Fields:    Translation:AnimalsCells
    31. Benbrook DM, Madler MM, Spruce LW, Birckbichler PJ, Nelson EC, Subramanian S, Weerasekare GM, Gale JB, Patterson MK, Wang B, Wang W, Lu S, Rowland TC, DiSivestro P, Lindamood C, Hill DL, Berlin KD. Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity. J Med Chem. 1997 Oct 24; 40(22):3567-83. PMID: 9357524.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Patterson E, Scherlag BJ, Sangiah S, Garrison GL, Couch KM, Berlin KD, Lazzara R. Class III electrophysiologic actions of imidazole-substituted diheterabicyclononanes in canine myocardium. J Pharmacol Exp Ther. 1997 Apr; 281(1):155-62. PMID: 9103493.
      Citations:    Fields:    Translation:Animals
    33. Garrison GL, Berlin KD, Scherlag BJ, Lazzara R, Patterson E, Fazekas T, Sangiah S, Chen CL, Schubot FD, van der Helm D. Novel 3,7-diheterabicyclo[3.3.1]nonanes that possess predominant class III antiarrhythmic activity in 1-4 day post infarction dog models: X-ray diffraction analysis of 3-[4-(1H-imidazol-1-yl)benzoyl]-7-isopropyl-3,7-diazabicyclo[3.3.1]nona ne dihydroperchlorate. J Med Chem. 1996 Jun 21; 39(13):2559-70. PMID: 8691454.
      Citations:    Fields:    Translation:AnimalsCells
    34. Hossain MB, van der Helm D, Sangiah S, Berlin KD. 7-Benzyl-3-thia-7-azabicyclo[3.3.1]nonane 3-oxide. Acta Crystallogr C. 1996 Apr 15; 52 ( Pt 4):995-8. PMID: 8624242.
      Citations:    Fields:    Translation:Cells
    35. Kuehn RL, Berlin KD, Hawkins WE, Ostrander GK. Relationships among petroleum refining, water and sediment contamination, and fish health. J Toxicol Environ Health. 1995 Sep; 46(1):101-16. PMID: 7666489.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    36. Ostrander GK, Hawkins WE, Kuehn RL, Jacobs AD, Berlin KD, Pigg J. Pigmented subcutaneous spindle cell tumors in native gizzard shad (Dorosoma cepedianum). Carcinogenesis. 1995 Jul; 16(7):1529-35. PMID: 7542176.
      Citations:    Fields:    Translation:Animals
    37. Chen CL, Sangiah S, Roder JD, Chen H, Berlin KD, Garrison GL, Scherlag BJ, Lazzara R. Pharmacokinetics and plasma protein binding of the new potent class III antiarrhythmic agent 3-[4-(1H-imidazol-1-yl)benzoyl]-7-isopropyl-3, 7-diazabicyclo[3.3.1]nonane dihydroperchlorate. Arzneimittelforschung. 1995 Jun; 45(6):670-5. PMID: 7646568.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Chen CL, Sangiah S, Bourne DW, Roder JD, Chen H, Alavi FK, Clarke CR, Garrison GL, Berlin KD, Couch KM, et al. Metabolism and metabolite pharmacokinetics of BRB-I-28, a class Ib antiarrhythmic agent. Eur J Drug Metab Pharmacokinet. 1995 Apr-Jun; 20(2):151-61. PMID: 8582441.
      Citations: 2     Fields:    Translation:AnimalsCells
    39. Fazekas T, Scherlag BJ, Carlsson L, Mabo P, Patterson E, Berlin KD, Lazzara R. Electrophysiological characterization of a novel class III antiarrhythmic agent, GLG-V-13 in the mammalian heart. Acta Physiol Hung. 1995; 83(1):13-30. PMID: 7660832.
      Citations:    Fields:    Translation:Animals
    40. Chen CL, Sangiah S, Yu CA, Chen H, Berlin KD, Garrison GL, Scherlag BJ, Lazzara R. Effects of novel antiarrhythmic agents, BRB-I-28 and its derivatives, on the heart mitochondrial respiratory chain and sarcoplasmic reticulum Ca(2+)-ATPase. Res Commun Mol Pathol Pharmacol. 1994 Aug; 85(2):193-208. PMID: 7994564.
      Citations: 1     Fields:    Translation:AnimalsCells
    41. Sunthankar PS, Berlin KD, Nelson EC, Thorne RL, Geno PW, Archer JC, Rolf LL, Bartels KE. Synthesis of potential metabolites of ethyl (E)-4-[2-(3,4-dihydro-4,4-dimethyl-2H-1-benzopyran-6-yl)-1-propenyl] benzoate. J Pharm Sci. 1993 May; 82(5):543-5. PMID: 8360834.
      Citations:    Fields:    Translation:Cells
    42. Patterson E, Scherlag BJ, Berlin KD, Lazzara R. Electrophysiologic actions of BRB-I-28 in ischemically injured canine myocardium. J Cardiovasc Pharmacol. 1993 Apr; 21(4):637-46. PMID: 7681911.
      Citations: 3     Fields:    Translation:Animals
    43. Fazekas T, Scherlag BJ, Mabo P, Berlin KD, Garrison GL, Chen CL, Sangiah S, Patterson E, Lazzara R. The comparative antiarrhythmic and proarrhythmic activity of a 3,7-diheterobicyclo[3.3.1]nonane, BRB-I-28, and lidocaine in the 1-4-day-old infarcted dog heart. Acta Physiol Hung. 1993; 81(3):289-99. PMID: 8197884.
      Citations: 1     Fields:    Translation:Animals
    44. Chen CL, Lesseley BA, Clarke CR, Roder JD, Sangiah S, Berlin KD, Garrison GL, Scherlag BJ, Lazzara R, Patterson E. High-performance liquid chromatographic determination of BRB-I-28, a novel antiarrhythmic agent, in dog plasma and urine. J Chromatogr. 1992 Dec 02; 583(2):274-9. PMID: 1478994.
      Citations: 1     Fields:    Translation:Animals
    45. Chen CL, Sangiah S, Patterson E, Berlin KD, Garrison GL, Dunn W, Nan Y, Scherlag BJ, Lazzara R. Effects of BRB-I-28, a novel antiarrhythmic agent, and its derivatives on cardiac Na+,K(+)-ATPase, Mg(2+)-ATPase activities and contractile force. Res Commun Chem Pathol Pharmacol. 1992 Oct; 78(1):3-16. PMID: 1334277.
      Citations: 3     Fields:    Translation:Animals
    46. Patterson E, Scherlag BJ, Berlin KD, Lazzara R. Electrophysiological actions of BRB-I-28 in canine myocardial tissues. J Pharmacol Exp Ther. 1991 Nov; 259(2):558-65. PMID: 1941607.
      Citations: 1     Fields:    Translation:Animals
    47. Rolf LL, Bartels KE, Nelson EC, Berlin KD. Chronic bile duct cannulation in laboratory rats. Lab Anim Sci. 1991 Oct; 41(5):486-92. PMID: 1666154.
      Citations:    Fields:    Translation:Animals
    48. Spruce LW, Gale JB, Berlin KD, Verma AK, Breitman TR, Ji XH, van der Helm D. Novel heteroarotinoids: synthesis and biological activity. J Med Chem. 1991 Jan; 34(1):430-9. PMID: 1992144.
      Citations: 1     Fields:    Translation:AnimalsCells
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