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Lucila Garcia-Contreras

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 323
1110 N Stonewall Ave
Oklahoma City OK 73117
Phone405/271-6593 ext 47205
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bourlon M, Feng Y, Garcia-Contreras L. Designing Aerosol Therapies Based on the Integrated Evaluation of In Vitro, In Vivo, and In Silico Data. Pharmaceutics. 2023 Jun 09; 15(6). PMID: 37376143; PMCID: PMC10305213.
    2. Ren X, Kang C, Garcia-Contreras L, Kim D. Understanding of Ovarian Cancer Cell-Derived Exosome Tropism for Future Therapeutic Applications. Int J Mol Sci. 2023 May 03; 24(9). PMID: 37175872; PMCID: PMC10179437.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Garcia-Contreras L, Sethuraman V, Kazantseva M, Hickey A. Efficacy of Combined Rifampicin Formulations Delivered by the Pulmonary Route to Treat Tuberculosis in the Guinea Pig Model. Pharmaceutics. 2021 Aug 21; 13(8). PMID: 34452270.
    4. Mahjabeen S, Hatipoglu MK, Kosanke SD, Garcia-Contreras D, Benbrook DM, Garcia-Contreras L. Vaginal Suppositories Containing SHetA2 to Treat Cervical Dysplasia: Pharmacokinetics of Daily Doses and Preliminary Safety Profile. J Pharm Sci. 2020 06; 109(6):2000-2008. PMID: 32113976.
      Citations: 2     Fields:    Translation:HumansAnimals
    5. Sharma A, Li M, Thavathiru E, Ibrahim M, Garcia-Contreras L, Benbrook DM, Woo S. Physiologically Based Pharmacokinetic Modeling and Tissue Distribution Characteristics of SHetA2 in Tumor-Bearing Mice. AAPS J. 2020 02 21; 22(2):51. PMID: 32086622.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Kukut Hatipoglu M, Mahjabeen S, Garcia-Contreras L. Development and validation of a reverse phase HPLC method for SHetA2, a novel anti-cancer drug, in mouse biological samples. J Pharm Biomed Anal. 2019 Jun 05; 170:124-131. PMID: 30921646.
      Citations: 2     Fields:    Translation:Animals
    7. Ibrahim M, Hatipoglu MK, Garcia-Contreras L. Cryogenic Fabrication of Dry Powders to Enhance the Solubility of a Promising Anticancer Drug, SHetA2, for Oral Administration. AAPS PharmSciTech. 2019 Jan 02; 20(1):20. PMID: 30604109.
      Citations: 2     Fields:    Translation:HumansCells
    8. Mahjabeen S, Hatipoglu MK, Benbrook DM, Garcia-Contreras L. Pharmacokinetics and Pharmacodynamics of Escalating Doses of SHetA2 After Vaginal Administration to Mice. J Pharm Sci. 2018 12; 107(12):3179-3186. PMID: 30196041.
      Citations: 3     Fields:    Translation:Animals
    9. Kukut Hatipoglu M, Hickey AJ, Garcia-Contreras L. Pharmacokinetics and pharmacodynamics of high doses of inhaled dry powder drugs. Int J Pharm. 2018 Oct 05; 549(1-2):306-316. PMID: 30077761.
      Citations: 7     Fields:    Translation:HumansAnimals
    10. Mahjabeen S, Hatipoglu MK, Benbrook DM, Kosanke SD, Garcia-Contreras D, Garcia-Contreras L. Influence of the estrus cycle of the mouse on the disposition of SHetA2 after vaginal administration. Eur J Pharm Biopharm. 2018 Sep; 130:272-280. PMID: 30064701.
      Citations: 4     Fields:    Translation:Animals
    11. Benbrook DM, Janakiram NB, Chandra V, Pathuri G, Madka V, Stratton NC, Masamha CP, Farnsworth CN, Garcia-Contreras L, Hatipoglu MK, Lighfoot S, Rao CV. Development of a dietary formulation of the SHetA2 chemoprevention drug for mice. Invest New Drugs. 2018 08; 36(4):561-570. PMID: 29273857.
      Citations: 6     Fields:    Translation:Animals
    12. Ibrahim M, Hatipoglu MK, Garcia-Contreras L. SHetA2 Dry Powder Aerosols for Tuberculosis: Formulation, Design, and Optimization Using Quality by Design. Mol Pharm. 2018 01 02; 15(1):300-313. PMID: 29219321.
      Citations: 5     Fields:    Translation:Cells
    13. Mahjabeen S, Hatipoglu MK, Chandra V, Benbrook DM, Garcia-Contreras L. Optimization of a Vaginal Suppository Formulation to Deliver SHetA2 as a Novel Treatment for Cervical Dysplasia. J Pharm Sci. 2018 02; 107(2):638-646. PMID: 28989018.
      Citations: 7     Fields:    Translation:HumansAnimals
    14. Garcia-Contreras L, Padilla-Carlin DJ, Sung J, VerBerkmoes J, Muttil P, Elbert K, Peloquin C, Edwards D, Hickey A. Pharmacokinetics of Ethionamide Delivered in Spray-Dried Microparticles to the Lungs of Guinea Pigs. J Pharm Sci. 2017 01; 106(1):331-337. PMID: 27842973.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Ibrahim M, Verma R, Garcia-Contreras L. Inhalation drug delivery devices: technology update. Med Devices (Auckl). 2015; 8:131-9. PMID: 25709510.
      Citations: 73     
    16. Garcia-Contreras L, Yadav KS. Inhaled Formulation Design for the Treatment of Lung Infections. Curr Pharm Des. 2015; 21(27):3875-901. PMID: 26290199.
      Citations: 3     Fields:    Translation:Humans
    17. Hanif SN, Hickey AJ, Garcia-Contreras L. Liquid chromatographic determination of CPZEN-45, a novel anti-tubercular drug, in biological samples. J Pharm Biomed Anal. 2014 Jan; 88:370-6. PMID: 24176740.
      Citations: 1     Fields:    Translation:AnimalsCells
    18. Ibrahim M, Garcia-Contreras L. Mechanisms of absorption and elimination of drugs administered by inhalation. Ther Deliv. 2013 Aug; 4(8):1027-45. PMID: 23919477.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    19. Garcia-Contreras L, Ibrahim M. Implications of increased nanoparticle absorption by infant lungs: future prospects. Ther Deliv. 2013 Apr; 4(4):417-20. PMID: 23557280.
      Citations:    Fields:    Translation:HumansCells
    20. Hanif SN, Garcia-Contreras L. Pharmaceutical aerosols for the treatment and prevention of tuberculosis. Front Cell Infect Microbiol. 2012; 2:118. PMID: 22973562.
      Citations: 7     Fields:    Translation:Animals
    21. Garcia-Contreras L, Muttil P, Fallon JK, Kabadi M, Gerety R, Hickey AJ. Pharmacokinetics of sequential doses of capreomycin powder for inhalation in guinea pigs. Antimicrob Agents Chemother. 2012 May; 56(5):2612-8. PMID: 22330920.
      Citations: 10     Fields:    Translation:AnimalsCells
    22. Wang C, Garcia-Contreras L, Muttil P, Hickey AJ. Isoxyl assays in plasma. J Pharm Biomed Anal. 2012 Feb 23; 60:1-6. PMID: 22119164.
      Citations: 2     Fields:    Translation:Animals
    23. Muttil P, Pulliam B, Garcia-Contreras L, Fallon JK, Wang C, Hickey AJ, Edwards DA. Pulmonary immunization of guinea pigs with diphtheria CRM-197 antigen as nanoparticle aggregate dry powders enhance local and systemic immune responses. AAPS J. 2010 Dec; 12(4):699-707. PMID: 20878294.
      Citations: 12     Fields:    Translation:Animals
    24. Lu D, Garcia-Contreras L, Muttil P, Padilla D, Xu D, Liu J, Braunstein M, McMurray DN, Hickey AJ. Pulmonary immunization using antigen 85-B polymeric microparticles to boost tuberculosis immunity. AAPS J. 2010 Sep; 12(3):338-47. PMID: 20422340.
      Citations: 19     Fields:    Translation:AnimalsCells
    25. Muttil P, Prego C, Garcia-Contreras L, Pulliam B, Fallon JK, Wang C, Hickey AJ, Edwards D. Immunization of guinea pigs with novel hepatitis B antigen as nanoparticle aggregate powders administered by the pulmonary route. AAPS J. 2010 Sep; 12(3):330-7. PMID: 20419360.
      Citations: 12     Fields:    Translation:Animals
    26. Garcia-Contreras L, Sung JC, Muttil P, Padilla D, Telko M, Verberkmoes JL, Elbert KJ, Hickey AJ, Edwards DA. Dry powder PA-824 aerosols for treatment of tuberculosis in guinea pigs. Antimicrob Agents Chemother. 2010 Apr; 54(4):1436-42. PMID: 20086154.
      Citations: 22     Fields:    Translation:HumansAnimals
    27. Sung JC, Padilla DJ, Garcia-Contreras L, Verberkmoes JL, Durbin D, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA. Formulation and pharmacokinetics of self-assembled rifampicin nanoparticle systems for pulmonary delivery. Pharm Res. 2009 Aug; 26(8):1847-55. PMID: 19407933.
      Citations: 30     Fields:    Translation:Animals
    28. Wang C, Muttil P, Lu D, Beltran-Torres AA, Garcia-Contreras L, Hickey AJ. Screening for potential adjuvants administered by the pulmonary route for tuberculosis vaccines. AAPS J. 2009 Mar; 11(1):139-47. PMID: 19277872.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    29. Sung JC, Garcia-Contreras L, Verberkmoes JL, Peloquin CA, Elbert KJ, Hickey AJ, Edwards DA. Dry powder nitroimidazopyran antibiotic PA-824 aerosol for inhalation. Antimicrob Agents Chemother. 2009 Apr; 53(4):1338-43. PMID: 19139288.
      Citations: 15     Fields:    Translation:Animals
    30. Garcia-Contreras L, Wong YL, Muttil P, Padilla D, Sadoff J, Derousse J, Germishuizen WA, Goonesekera S, Elbert K, Bloom BR, Miller R, Fourie PB, Hickey A, Edwards D. Immunization by a bacterial aerosol. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4656-60. PMID: 18344320.
      Citations: 49     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Cryan SA, Sivadas N, Garcia-Contreras L. In vivo animal models for drug delivery across the lung mucosal barrier. Adv Drug Deliv Rev. 2007 Sep 30; 59(11):1133-51. PMID: 17900750.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    32. Fiegel J, Garcia-Contreras L, Thomas M, VerBerkmoes J, Elbert K, Hickey A, Edwards D. Preparation and in vivo evaluation of a dry powder for inhalation of capreomycin. Pharm Res. 2008 Apr; 25(4):805-11. PMID: 17657592.
      Citations: 26     Fields:    Translation:Animals
    33. Lu D, Garcia-Contreras L, Xu D, Kurtz SL, Liu J, Braunstein M, McMurray DN, Hickey AJ. Poly (lactide-co-glycolide) microspheres in respirable sizes enhance an in vitro T cell response to recombinant Mycobacterium tuberculosis antigen 85B. Pharm Res. 2007 Oct; 24(10):1834-43. PMID: 17657598.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    34. Garcia-Contreras L, Fiegel J, Telko MJ, Elbert K, Hawi A, Thomas M, VerBerkmoes J, Germishuizen WA, Fourie PB, Hickey AJ, Edwards D. Inhaled large porous particles of capreomycin for treatment of tuberculosis in a guinea pig model. Antimicrob Agents Chemother. 2007 Aug; 51(8):2830-6. PMID: 17517845.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    35. Garcia-Contreras L, Sethuraman V, Kazantseva M, Godfrey V, Hickey AJ. Evaluation of dosing regimen of respirable rifampicin biodegradable microspheres in the treatment of tuberculosis in the guinea pig. J Antimicrob Chemother. 2006 Nov; 58(5):980-6. PMID: 16971416.
      Citations: 12     Fields:    Translation:AnimalsCells
    36. Garcia-Contreras L, Morçöl T, Bell SJ, Hickey AJ. Evaluation of novel particles as pulmonary delivery systems for insulin in rats. AAPS PharmSci. 2003; 5(2):E9. PMID: 12866936.
      Citations: 8     Fields:    Translation:Animals
    37. Garcia-Contreras L, Hickey AJ. Aerosol treatment of cystic fibrosis. Crit Rev Ther Drug Carrier Syst. 2003; 20(5):317-56. PMID: 14959788.
      Citations: 13     Fields:    Translation:HumansCells
    38. Garcia-Contreras L, Hickey AJ. Pharmaceutical and biotechnological aerosols for cystic fibrosis therapy. Adv Drug Deliv Rev. 2002 Dec 05; 54(11):1491-504. PMID: 12458157.
      Citations: 10     Fields:    Translation:Humans
    39. Suarez S, Garcia-Contreras L, Sarubbi D, Flanders E, O'Toole D, Smart J, Hickey AJ. Facilitation of pulmonary insulin absorption by H-MAP: pharmacokinetics and pharmacodynamics in rats. Pharm Res. 2001 Dec; 18(12):1677-84. PMID: 11785686.
      Citations: 6     Fields:    Translation:AnimalsCells
    40. Garcia-Contreras L, Sarubbi D, Flanders E, O'Toole D, Smart J, Newcomer C, Hicke AJ. Immediate and short-term cellular and biochemical responses to pulmonary single-dose studies of insulin and H-MAP. Pharm Res. 2001 Dec; 18(12):1685-93. PMID: 11785687.
      Citations: 4     Fields:    Translation:Animals
    41. Hickey AJ, Garcia-Contreras L. Immunological and toxicological implications of short-term studies in animals of pharmaceutical aerosol delivery to the lungs: relevance to humans. Crit Rev Ther Drug Carrier Syst. 2001; 18(4):387-431. PMID: 11605897.
      Citations: 11     Fields:    Translation:HumansAnimals
    42. Abu-Izza K, Garcia-Contreras L, Lu DR. Preparation and evaluation of zidovudine-loaded sustained-release microspheres. 2. Optimization of multiple response variables. J Pharm Sci. 1996 Jun; 85(6):572-6. PMID: 8773951.
      Citations: 6     Fields:    
    43. Abu-Izza KA, Garcia-Contreras L, Lu DR. Preparation and evaluation of sustained release AZT-loaded microspheres: optimization of the release characteristics using response surface methodology. J Pharm Sci. 1996 Feb; 85(2):144-9. PMID: 8683438.
      Citations: 8     Fields:    
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