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Trent E Tipple

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Pediatrics
AddressET 7335
1200 Everett Dr
Oklahoma City OK 73104
Phone405/271-8001 ext 42087
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    Collapse Biography 
    Collapse education and training
    Indiana University School of Medicine, Indianapolis, INMD6/2000
    Nationwide Children's Hospital & The Ohio State University College of Medicine, Columbus, OH6/2003General Pediatrics
    Nationwide Children's Hospital & The Ohio State University College of Medicine, Columbus, OH6/2006Neonatal-Perinatal Medicine

    Collapse Research 
    Collapse research activities and funding
    R01HL119280     (TIPPLE, TRENT)May 1, 2014 - Apr 30, 2020
    NIH
    Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary Dysplasia
    Role: Principal Investigator
    K08HL093365     (TIPPLE, TRENT)Apr 1, 2010 - Mar 31, 2014
    NIH
    Regulation of Lung Growth and Development by Thioredoxin Interacting Protein
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heyob KM, Khuhro Z, Khan AQ, Brown D, Tipple TE, Rogers LK. Effects of DNA methylase inhibitors in a murine model of severe BPD. Respir Physiol Neurobiol. 2023 Apr 07; 313:104060. PMID: 37031925.
      Citations:    Fields:    Translation:Animals
    2. Freeman AE, Willis KA, Qiao L, Abdelgawad AS, Halloran B, Rezonzew G, Nizami Z, Wenger N, Gaggar A, Ambalavanan N, Tipple TE, Lal CV. Microbial-induced Redox Imbalance in the Neonatal Lung Is Ameliorated by Live Biotherapeutics. Am J Respir Cell Mol Biol. 2023 03; 68(3):267-278. PMID: 36287630; PMCID: PMC9989473.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Sherlock LG, McCarthy WC, Grayck MR, Solar M, Hernandez A, Zheng L, Delaney C, Tipple TE, Wright CJ, Nozik ES. Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development. Antioxidants (Basel). 2022 Dec 07; 11(12). PMID: 36552625; PMCID: PMC9774937.
      Citations: 1     
    4. Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12(10). PMID: 36295835; PMCID: PMC9612261.
      Citations:    
    5. Larcade R, DeShea L, Lang GA, Caballero MT, Ferretti A, Beasley WH, Tipple TE, Vain N, Prudent L, Lang ML, Polack FP, Ofman G. Maternal-Fetal Immunologic Response to SARS-CoV-2 Infection in a Symptomatic Vulnerable Population: A Prospective Cohort. J Infect Dis. 2022 03 02; 225(5):800-809. PMID: 34865064.
      Citations: 3     Fields:    Translation:HumansCells
    6. Starr MC, Charlton JR, Guillet R, Reidy K, Tipple TE, Jetton JG, Kent AL, Abitbol CL, Ambalavanan N, Mhanna MJ, Askenazi DJ, Selewski DT, Harer MW. Advances in Neonatal Acute Kidney Injury. Pediatrics. 2021 11; 148(5). PMID: 34599008.
      Citations: 27     Fields:    Translation:Humans
    7. Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10(5). PMID: 33919055.
      Citations: 4     
    8. Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber GS, Gaggar A, Tipple TE, Ambalavanan N, Lal CV. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respir Res. 2021 Feb 17; 22(1):57. PMID: 33596914.
      Citations: 4     Fields:    Translation:HumansAnimals
    9. Sherlock LG, Balasubramaniyan D, Zheng L, Zarate M, Sizemore T, Delaney C, Tipple TE, Wright CJ, Nozik-Grayck E. Neonatal Selenoenzyme Expression Is Variably Susceptible to Duration of Maternal Selenium Deficiency. Antioxidants (Basel). 2021 Feb 14; 10(2). PMID: 33672905.
      Citations: 4     
    10. Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 01; 38:101797. PMID: 33254076.
      Citations: 10     Fields:    Translation:Animals
    11. Sherlock LG, Sjostrom K, Sian L, Delaney C, Tipple TE, Krebs NF, Nozik-Grayck E, Wright CJ. Hepatic-Specific Decrease in the Expression of Selenoenzymes and Factors Essential for Selenium Processing After Endotoxemia. Front Immunol. 2020; 11:595282. PMID: 33224150.
      Citations: 10     Fields:    Translation:AnimalsCells
    12. Staples S, Wall SB, Li R, Tipple TE. Selenium-independent antioxidant and anti-inflammatory effects of thioredoxin reductase inhibition in alveolar macrophages. Life Sci. 2020 Oct 15; 259:118285. PMID: 32798556.
      Citations: 7     Fields:    Translation:AnimalsCells
    13. Dunigan-Russell K, Silverberg M, Lin VY, Li R, Wall SB, Li Q, Nicola T, Gotham J, Crowe DR, Vitiello PF, Agarwal A, Tipple TE. Club Cell Heme Oxygenase-1 Deletion: Effects in Hyperoxia-Exposed Adult Mice. Oxid Med Cell Longev. 2020; 2020:2908271. PMID: 32587658.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Gotham JP, Li R, Tipple TE, Lancaster JR, Liu T, Li Q. Quantitation of spin probe-detectable oxidants in cells using electron paramagnetic resonance spectroscopy: To probe or to trap? Free Radic Biol Med. 2020 07; 154:84-94. PMID: 32376456.
      Citations: 5     Fields:    
    15. Dunigan-Russell K, Lin V, Silverberg M, Wall SB, Li R, Gotham J, Nicola T, Sridharan A, Snowball J, Delaney C, Li Q, Tipple TE. Aurothioglucose enhances proangiogenic pathway activation in lungs from room air and hyperoxia-exposed newborn mice. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1165-L1171. PMID: 32292070.
      Citations: 3     Fields:    Translation:AnimalsCells
    16. Harer MW, Charlton JR, Tipple TE, Reidy KJ. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes. J Perinatol. 2020 09; 40(9):1286-1295. PMID: 32277164.
      Citations: 12     Fields:    Translation:Humans
    17. Gentle SJ, Tipple TE, Patel R. Neonatal comorbidities and gasotransmitters. Nitric Oxide. 2020 04 01; 97:27-32. PMID: 32014495.
      Citations:    Fields:    Translation:HumansAnimalsCells
    18. Ofman G, Caballero MT, Alvarez Paggi D, Marzec J, Nowogrodzki F, Cho HY, Sorgetti M, Colantonio G, Bianchi A, Prudent LM, Vain N, Mariani G, Digregorio J, Turconi EL, Osio C, Galletti F, Quiros M, Brum A, Lopez Garcia S, Garcia S, Bell D, Jones MH, Tipple TE, Kleeberger SR, Polack FP. The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants. BMC Pediatr. 2019 07 06; 19(1):227. PMID: 31279333.
      Citations: 2     Fields:    Translation:HumansAnimalsPHPublic Health
    19. Tipple TE, Ambalavanan N. Oxygen Toxicity in the Neonate: Thinking Beyond the Balance. Clin Perinatol. 2019 09; 46(3):435-447. PMID: 31345539.
      Citations: 8     Fields:    Translation:Humans
    20. Liu T, Zhang M, Mukosera GT, Borchardt D, Li Q, Tipple TE, Ishtiaq Ahmed AS, Power GG, Blood AB. L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation. Redox Biol. 2019 09; 26:101238. PMID: 31200239.
      Citations: 21     Fields:    Translation:AnimalsCells
    21. Jiang C, Stewart LT, Kuo HC, McGilberry W, Wall SB, Liang B, van Groen T, Bailey SM, Kim YI, Tipple TE, Jones DP, McMahon LL, Liu RM. Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE e3, but not APOE e4, targeted replacement mice. Neurobiol Aging. 2019 09; 81:9-21. PMID: 31207469.
      Citations: 5     Fields:    Translation:AnimalsPHPublic Health
    22. Ofman G, Tipple TE. Thiol-Redox Regulation in Lung Development and Vascular Remodeling. Antioxid Redox Signal. 2019 10 20; 31(12):858-873. PMID: 30648397.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    23. Ofman G, Tipple TE. Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse? Free Radic Biol Med. 2019 10; 142:138-145. PMID: 30769161.
      Citations: 12     Fields:    Translation:Humans
    24. Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019:7945983. PMID: 30805084.
      Citations: 12     Fields:    Translation:AnimalsCells
    25. Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19(1):229. PMID: 30463566.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    26. Tindell R, Wall SB, Li Q, Li R, Dunigan K, Wood R, Tipple TE. Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition. Redox Biol. 2018 10; 19:331-338. PMID: 30212802.
      Citations: 11     Fields:    Translation:AnimalsCells
    27. Mukosera GT, Liu T, Ishtiaq Ahmed AS, Li Q, Sheng MH, Tipple TE, Baylink DJ, Power GG, Blood AB. Detection of dinitrosyl iron complexes by ozone-based chemiluminescence. Nitric Oxide. 2018 09 01; 79:57-67. PMID: 30059767.
      Citations: 9     Fields:    Translation:Animals
    28. Dunigan K, Li Q, Li R, Locy ML, Wall S, Tipple TE. The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2018 10 01; 315(4):L545-L552. PMID: 30024305.
      Citations: 15     Fields:    Translation:AnimalsCells
    29. Liu T, Zhang M, Terry MH, Schroeder H, Wilson SM, Power GG, Li Q, Tipple TE, Borchardt D, Blood AB. Hemodynamic Effects of Glutathione-Liganded Binuclear Dinitrosyl Iron Complex: Evidence for Nitroxyl Generation and Modulation by Plasma Albumin. Mol Pharmacol. 2018 05; 93(5):427-437. PMID: 29476040.
      Citations: 13     Fields:    Translation:Animals
    30. Liu T, Zhang M, Terry MH, Schroeder H, Wilson SM, Power GG, Li Q, Tipple TE, Borchardt D, Blood AB. Nitrite potentiates the vasodilatory signaling of S-nitrosothiols. Nitric Oxide. 2018 05 01; 75:60-69. PMID: 29428841.
      Citations: 8     Fields:    Translation:AnimalsCells
    31. Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L736-L742. PMID: 29368550.
      Citations: 8     Fields:    Translation:AnimalsCells
    32. Tindell R, Tipple T. Selenium: implications for outcomes in extremely preterm infants. J Perinatol. 2018 03; 38(3):197-202. PMID: 29298985.
      Citations: 21     Fields:    Translation:HumansAnimals
    33. Durrani-Kolarik S, Pool CA, Gray A, Heyob KM, Cismowski MJ, Pryhuber G, Lee LJ, Yang Z, Tipple TE, Rogers LK. miR-29b supplementation decreases expression of matrix proteins and improves alveolarization in mice exposed to maternal inflammation and neonatal hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2017 08 01; 313(2):L339-L349. PMID: 28473324.
      Citations: 28     Fields:    Translation:HumansAnimals
    34. Robbins ME, Dakhlallah D, Marsh CB, Rogers LK, Tipple TE. Of mice and men: correlations between microRNA-17~92 cluster expression and promoter methylation in severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 01; 311(5):L981-L984. PMID: 27694474.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    35. Li Q, Wall SB, Ren C, Velten M, Hill CL, Locy ML, Rogers LK, Tipple TE. Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2-Related Factor 2 Activation. Am J Respir Cell Mol Biol. 2016 09; 55(3):419-28. PMID: 27089175.
      Citations: 26     Fields:    Translation:AnimalsCells
    36. Graf AE, Lallier SW, Waidyaratne G, Thompson MD, Tipple TE, Hester ME, Trask AJ, Rogers LK. Maternal high fat diet exposure is associated with increased hepcidin levels, decreased myelination, and neurobehavioral changes in male offspring. Brain Behav Immun. 2016 Nov; 58:369-378. PMID: 27519153.
      Citations: 43     Fields:    Translation:AnimalsCells
    37. Rogers LK, Robbins M, Dakhlallah D, Yang Z, Lee LJ, Mikhail M, Nuovo G, Pryhuber GS, McGwin G, Marsh CB, Tipple TE. Attenuation of miR-17~92 Cluster in Bronchopulmonary Dysplasia. Ann Am Thorac Soc. 2015 Oct; 12(10):1506-13. PMID: 26291337.
      Citations: 33     Fields:    Translation:HumansCells
    38. Ali M, Heyob KM, Velten M, Tipple TE, Rogers LK. DHA suppresses chronic apoptosis in the lung caused by perinatal inflammation. Am J Physiol Lung Cell Mol Physiol. 2015 Sep 01; 309(5):L441-8. PMID: 26138643.
      Citations: 15     Fields:    Translation:AnimalsCells
    39. Jin Y, Jin Y, Chen B, Tipple TE, Nelin LD. Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L197-204. PMID: 24879052.
      Citations: 11     Fields:    Translation:HumansCells
    40. Tipple TE. The thioredoxin system in neonatal lung disease. Antioxid Redox Signal. 2014 Nov 01; 21(13):1916-25. PMID: 24328910.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    41. Britt RD, Velten M, Locy ML, Rogers LK, Tipple TE. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10; 20(17):2681-91. PMID: 24295151.
      Citations: 25     Fields:    Translation:HumansAnimals
    42. Velten M, Britt RD, Heyob KM, Tipple TE, Rogers LK. Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. J Nutr. 2014 Mar; 144(3):258-66. PMID: 24453131.
      Citations: 27     Fields:    Translation:AnimalsCells
    43. Raffay TM, Locy ML, Hill CL, Jindal NS, Rogers LK, Welty SE, Tipple TE. Neonatal hyperoxic exposure persistently alters lung secretoglobins and annexin A1. Biomed Res Int. 2013; 2013:408485. PMID: 24187664.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    44. Chen B, Nelin VE, Locy ML, Jin Y, Tipple TE. Thioredoxin-1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2013 Sep; 305(5):L389-95. PMID: 23812635.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    45. Britt RD, Velten M, Tipple TE, Nelin LD, Rogers LK. Cyclooxygenase-2 in newborn hyperoxic lung injury. Free Radic Biol Med. 2013 Aug; 61:502-11. PMID: 23624331.
      Citations: 22     Fields:    Translation:Animals
    46. Locy ML, Rogers LK, Prigge JR, Schmidt EE, Arnér ES, Tipple TE. Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury. Antioxid Redox Signal. 2012 Nov 15; 17(10):1407-16. PMID: 22607006.
      Citations: 32     Fields:    Translation:HumansAnimals
    47. Velten M, Britt RD, Heyob KM, Welty SE, Eiberger B, Tipple TE, Rogers LK. Prenatal inflammation exacerbates hyperoxia-induced functional and structural changes in adult mice. Am J Physiol Regul Integr Comp Physiol. 2012 Aug 01; 303(3):R279-90. PMID: 22718803.
      Citations: 26     Fields:    Translation:Animals
    48. Rogers LK, Young CM, Pennell ML, Tipple TE, Leonhart KL, Welty SE. Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia. Acta Paediatr. 2012 Aug; 101(8):e321-6. PMID: 22497282.
      Citations: 7     Fields:    Translation:Humans
    49. Britt RD, Locy ML, Tipple TE, Nelin LD, Rogers LK. Lipopolysaccharide-induced cyclooxygenase-2 expression in mouse transformed Clara cells. Cell Physiol Biochem. 2012; 29(1-2):213-22. PMID: 22415090.
      Citations: 11     Fields:    Translation:AnimalsCells
    50. Tipple TE, Rogers LK. Methods for the determination of plasma or tissue glutathione levels. Methods Mol Biol. 2012; 889:315-24. PMID: 22669674.
      Citations: 38     Fields:    Translation:AnimalsCells
    51. Rogers LK, Valentine CJ, Pennell M, Velten M, Britt RD, Dingess K, Zhao X, Welty SE, Tipple TE. Maternal docosahexaenoic acid supplementation decreases lung inflammation in hyperoxia-exposed newborn mice. J Nutr. 2011 Feb; 141(2):214-22. PMID: 21178083.
      Citations: 26     Fields:    Translation:AnimalsCells
    52. Heyob KM, Rogers LK, Tipple TE, Welty SE. Riboflavin supplementation does not attenuate hyperoxic lung injury in transgenic (spc-mt)hGR mice. Exp Lung Res. 2011 Apr; 37(3):155-61. PMID: 21128861.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    53. Farrell MR, Rogers LK, Liu Y, Welty SE, Tipple TE. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity. Free Radic Biol Med. 2010 Nov 15; 49(9):1361-7. PMID: 20692333.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    54. Rogers LK, Tipple TE, Britt RD, Welty SE. Hyperoxia exposure alters hepatic eicosanoid metabolism in newborn mice. Pediatr Res. 2010 Feb; 67(2):144-9. PMID: 19809377.
      Citations: 10     Fields:    Translation:Animals
    55. Tipple TE, Welty SE, Nelin LD, Hansen JM, Rogers LK. Alterations of the thioredoxin system by hyperoxia: implications for alveolar development. Am J Respir Cell Mol Biol. 2009 Nov; 41(5):612-9. PMID: 19244202.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    56. Rogers LK, Tipple TE, Nelin LD, Welty SE. Differential responses in the lungs of newborn mouse pups exposed to 85% or >95% oxygen. Pediatr Res. 2009 Jan; 65(1):33-8. PMID: 18703992.
      Citations: 38     Fields:    Translation:AnimalsCells
    57. Tipple TE, Welty SE, Rogers LK, Hansen TN, Choi YE, Kehrer JP, Smith CV. Thioredoxin-related mechanisms in hyperoxic lung injury in mice. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):405-13. PMID: 17575077.
      Citations: 30     Fields:    Translation:Animals
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