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Umesh Deshmukh

TitleAssociate Member
InstitutionOklahoma Medical Research Foundation
DepartmentArthritis and Clinical Immunology
Address825 N.E. 13th Street
Oklahoma City OK 73104
Phone405/271-2463
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    Collapse Research 
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    K01AR051391     (DESHMUKH, UMESH S)Jul 20, 2004 - Mar 31, 2010
    NIH
    Genetics of Autontibody Diversification
    Role: Principal Investigator

    R01AI079621     (FU, SHU MAN)Jul 16, 2009 - Jun 30, 2014
    NIH
    T Cell Epitope Mimicry for Autoimmune Responses in SLE
    Role: Co-Principal Investigator

    R21DE019883     (DESHMUKH, UMESH S)May 1, 2010 - Apr 30, 2013
    NIH
    Innate Immunity Activation In Pathogenesis of Sjogren's Syndrome
    Role: Principal Investigator

    R21DE022977     (DESHMUKH, UMESH S)Jul 10, 2012 - Dec 30, 2014
    NIH
    Adenosine Receptors and Restoration of Salivary Gland in Sjogren's Syndrome
    Role: Principal Investigator

    R01DE025030     (DESHMUKH, UMESH S)Dec 7, 2015 - Nov 30, 2021
    NIH
    Innate immunity and autoantibodies in the pathogenesis of Sjogren's Syndrome
    Role: Principal Investigator

    R21DE029707     (DESHMUKH, UMESH S)Sep 17, 2020 - Aug 31, 2022
    NIH
    Cytosolic DNA sensing pathway in the pathogenesis of Sjogren's Syndrome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Garman L, Pelikan RC, Rasmussen A, Lareau CA, Savoy KA, Deshmukh US, Bagavant H, Levin AM, Daouk S, Drake WP, Montgomery CG. Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis. Front Immunol. 2020; 11:567342. PMID: 33363531.
      Citations: 1     Fields:    Translation:HumansCells
    2. Bagavant H, Deshmukh US. Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol. 2020 12; 131(1):e114. PMID: 33252847.
      Citations:    Fields:    
    3. Bagavant H, Michrowska A, Deshmukh US. The NZB/W F1 mouse model for Sjögren's syndrome: A historical perspective and lessons learned. Autoimmun Rev. 2020 Dec; 19(12):102686. PMID: 33131691.
      Citations:    Fields:    Translation:HumansAnimals
    4. Papinska J, Bagavant H, Gmyrek GB, Deshmukh US. Pulmonary Involvement in a Mouse Model of Sjögren's Syndrome Induced by STING Activation. Int J Mol Sci. 2020 Jun 25; 21(12). PMID: 32630417.
      Citations:    Fields:    Translation:Animals
    5. Allushi B, Bagavant H, Papinska J, Deshmukh US. Hyperglycemia and Salivary Gland Dysfunction in the Non-obese Diabetic Mouse: Caveats for Preclinical Studies in Sjögren's Syndrome. Sci Rep. 2019 11 29; 9(1):17969. PMID: 31784615.
      Citations:    Fields:    Translation:Animals
    6. Trzeciak M, Bagavant H, Papinska J, Deshmukh US. Immune Response Targeting Sjögren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice. Int J Mol Sci. 2018 Sep 27; 19(10). PMID: 30261673.
      Citations: 3     Fields:    Translation:Animals
    7. Bagavant H, Dunkleberger ML, Wolska N, Sroka M, Rasmussen A, Adrianto I, Montgomery C, Sivils K, Guthridge JM, James JA, Merrill JT, Deshmukh US. Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients. Clin Exp Rheumatol. 2019 Jan-Feb; 37(1):106-111. PMID: 29998833.
      Citations: 5     Fields:    Translation:HumansCells
    8. Papinska J, Bagavant H, Gmyrek GB, Sroka M, Tummala S, Fitzgerald KA, Deshmukh US. Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome. J Dent Res. 2018 07; 97(8):893-900. PMID: 29505322.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Sroka M, Bagavant H, Biswas I, Ballard A, Deshmukh US. Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction. Clin Exp Rheumatol. 2018 May-Jun; 36 Suppl 112(3):41-46. PMID: 29465352.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Bagavant H, Trzeciak M, Papinska J, Biswas I, Dunkleberger ML, Sosnowska A, Deshmukh US. A Method for the Measurement of Salivary Gland Function in Mice. J Vis Exp. 2018 01 25; (131). PMID: 29443033.
      Citations: 3     Fields:    Translation:Animals
    11. Danda D, Sharma R, Truong D, Koelsch KA, Kurien BT, Bagavant H, Deshmukh U, Kaufman CE, Lewis DM, Stone DU, Radfar L, Rasmussen A, Sivils KL, Scofield RH. Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? Clin Exp Rheumatol. 2017 May-Jun; 35(3):438-444. PMID: 28229827.
      Citations: 5     Fields:    Translation:Humans
    12. Wolska N, Rybakowska P, Rasmussen A, Brown M, Montgomery C, Klopocki A, Grundahl K, Scofield RH, Radfar L, Stone DU, Anaya JM, Ice JA, Lessard CJ, Lewis DM, Rhodus NL, Gopalakrishnan R, Huang AJ, Hughes PJ, Rohrer MD, Weisman MH, Venuturupalli S, Guthridge JM, James JA, Sivils KL, Bagavant H, Deshmukh US. Brief Report: Patients With Primary Sjögren's Syndrome Who Are Positive for Autoantibodies to Tripartite Motif-Containing Protein 38 Show Greater Disease Severity. Arthritis Rheumatol. 2016 Mar; 68(3):724-9. PMID: 26636433.
      Citations: 6     Fields:    Translation:Humans
    13. Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US. Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice. Ann Rheum Dis. 2016 Mar; 75(3):617-22. PMID: 25906316.
      Citations: 18     Fields:    Translation:HumansAnimals
    14. Maier-Moore JS, Koelsch KA, Smith K, Lessard CJ, Radfar L, Lewis D, Kurien BT, Wolska N, Deshmukh U, Rasmussen A, Sivils KL, James JA, Farris AD, Scofield RH. Antibody-secreting cell specificity in labial salivary glands reflects the clinical presentation and serology in patients with Sjögren's syndrome. Arthritis Rheumatol. 2014 Dec; 66(12):3445-56. PMID: 25199908.
      Citations: 15     Fields:    Translation:HumansCells
    15. Nackiewicz D, Dey P, Szczerba B, Mohammad S, Kaplan JL, McNamara CA, Deshmukh US, Bagavant H. Inhibitor of differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease. Nephron Exp Nephrol. 2014; 126(3):141-7. PMID: 24854879.
      Citations: 1     Fields:    Translation:AnimalsCells
    16. Bagavant H, Nandula SR, Kaplonek P, Rybakowska PD, Deshmukh US. Alum, an aluminum-based adjuvant, induces Sjögren's syndrome-like disorder in mice. Clin Exp Rheumatol. 2014 Mar-Apr; 32(2):251-5. PMID: 24739520.
      Citations: 9     Fields:    Translation:Animals
    17. Szymula A, Rosenthal J, Szczerba BM, Bagavant H, Fu SM, Deshmukh US. T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria. Clin Immunol. 2014 May-Jun; 152(1-2):1-9. PMID: 24576620.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    18. Deshmukh US, Bagavant H. When killers become helpers. Sci Transl Med. 2013 Jul 24; 5(195):195fs29. PMID: 23884464.
      Citations: 3     Fields:    Translation:Humans
    19. Szczerba BM, Rybakowska PD, Dey P, Payerhin KM, Peck AB, Bagavant H, Deshmukh US. Type I interferon receptor deficiency prevents murine Sjogren's syndrome. J Dent Res. 2013 May; 92(5):444-9. PMID: 23533183.
      Citations: 15     Fields:    Translation:AnimalsCells
    20. Scindia Y, Nackiewicz D, Dey P, Szymula A, Bajwa A, Rosin DL, Bolton WK, Okusa MD, Deshmukh U, Bagavant H. Activated CD4+ T cells target mesangial antigens and initiate glomerulonephritis. Nephron Exp Nephrol. 2012; 121(1-2):e1-9. PMID: 23095207.
      Citations: 4     Fields:    Translation:AnimalsCells
    21. Nandula SR, Dey P, Corbin KL, Nunemaker CS, Bagavant H, Deshmukh US. Salivary gland hypofunction induced by activation of innate immunity is dependent on type I interferon signaling. J Oral Pathol Med. 2013 Jan; 42(1):66-72. PMID: 22672212.
      Citations: 16     Fields:    Translation:AnimalsCells
    22. Lobo PI, Bajwa A, Schlegel KH, Vengal J, Lee SJ, Huang L, Ye H, Deshmukh U, Wang T, Pei H, Okusa MD. Natural IgM anti-leukocyte autoantibodies attenuate excess inflammation mediated by innate and adaptive immune mechanisms involving Th-17. J Immunol. 2012 Feb 15; 188(4):1675-85. PMID: 22262657.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Deshmukh US, Sim DL, Dai C, Kannapell CJ, Gaskin F, Rajagopalan G, David CS, Fu SM. HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD. J Autoimmun. 2011 Nov; 37(3):254-62. PMID: 21868195.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    24. Nandula SR, Scindia YM, Dey P, Bagavant H, Deshmukh US. Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease. Oral Dis. 2011 Nov; 17(8):801-7. PMID: 21815968.
      Citations: 30     Fields:    Translation:AnimalsCells
    25. Bagavant H, Scindia Y, Nackiewicz D, Nandula SR, Doran A, Cutchins A, Oldham S, Deshmukh U, McNamara C. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. Am J Pathol. 2011 Aug; 179(2):651-60. PMID: 21801865.
      Citations: 8     Fields:    Translation:Animals
    26. Fu SM, Deshmukh US, Gaskin F. Pathogenesis of systemic lupus erythematosus revisited 2011: end organ resistance to damage, autoantibody initiation and diversification, and HLA-DR. J Autoimmun. 2011 Sep; 37(2):104-12. PMID: 21632208.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    27. Sharma R, Sung SS, Ju CY, Deshmukh US, Fu SM, Ju ST. Regulatory T-Cell (Treg) hybridoma as a novel tool to study Foxp3 regulation and Treg fate. J Autoimmun. 2011 Sep; 37(2):113-21. PMID: 21621978.
      Citations: 1     Fields:    Translation:AnimalsCells
    28. Bagavant H, Kalantarinia K, Scindia Y, Deshmukh U. Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice. Am J Kidney Dis. 2011 Mar; 57(3):498-507. PMID: 21239097.
      Citations: 5     Fields:    Translation:HumansAnimals
    29. Scindia YM, Deshmukh US, Bagavant H. Mesangial pathology in glomerular disease: targets for therapeutic intervention. Adv Drug Deliv Rev. 2010 Nov 30; 62(14):1337-43. PMID: 20828589.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    30. Jiang C, Deshmukh US, Gaskin F, Bagavant H, Hanson J, David CS, Fu SM. Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens. J Immunol. 2010 Jan 15; 184(2):1085-91. PMID: 20007529.
      Citations: 10     Fields:    Translation:Animals
    31. Sim DL, Bagavant H, Scindia YM, Ge Y, Gaskin F, Fu SM, Deshmukh US. Genetic complementation results in augmented autoantibody responses to lupus-associated antigens. J Immunol. 2009 Sep 01; 183(5):3505-11. PMID: 19667095.
      Citations: 2     Fields:    Translation:Animals
    32. Sharma R, Deshmukh US, Zheng L, Fu SM, Ju ST. X-linked Foxp3 (Scurfy) mutation dominantly inhibits submandibular gland development and inflammation respectively through adaptive and innate immune mechanisms. J Immunol. 2009 Sep 01; 183(5):3212-8. PMID: 19648271.
      Citations: 14     Fields:    Translation:AnimalsCells
    33. Deshmukh US, Nandula SR, Thimmalapura PR, Scindia YM, Bagavant H. Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function. J Oral Pathol Med. 2009 Jan; 38(1):42-7. PMID: 19192049.
      Citations: 42     Fields:    Translation:AnimalsCells
    34. Scindia Y, Deshmukh U, Thimmalapura PR, Bagavant H. Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus. Arthritis Rheum. 2008 Dec; 58(12):3884-91. PMID: 19035491.
      Citations: 19     Fields:    Translation:AnimalsCells
    35. Deshmukh US, Ohyama Y, Bagavant H, Guo X, Gaskin F, Fu SM. Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 mice. Arthritis Rheum. 2008 May; 58(5):1318-23. PMID: 18438852.
      Citations: 16     Fields:    Translation:Animals
    36. Zheng L, Sharma R, Kung JT, Deshmukh US, Jarjour WN, Fu SM, Ju ST. Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice. Int Immunol. 2008 Apr; 20(4):517-23. PMID: 18310063.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Ranpura SA, Deshmukh U, Reddi PP. NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription. J Androl. 2008 Mar-Apr; 29(2):186-97. PMID: 17942973.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    38. Deshmukh US, Bagavant H, Sim D, Pidiyar V, Fu SM. A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading. J Immunol. 2007 Feb 15; 178(4):2565-71. PMID: 17277166.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Sharma R, Zheng L, Deshmukh US, Jarjour WN, Sung SS, Fu SM, Ju ST. A regulatory T cell-dependent novel function of CD25 (IL-2Ralpha) controlling memory CD8(+) T cell homeostasis. J Immunol. 2007 Feb 01; 178(3):1251-5. PMID: 17237369.
      Citations: 20     Fields:    Translation:AnimalsCells
    40. Bagavant H, Deshmukh US, Wang H, Ly T, Fu SM. Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes. J Immunol. 2006 Dec 01; 177(11):8258-65. PMID: 17114504.
      Citations: 31     Fields:    Translation:AnimalsCells
    41. Ohyama Y, Carroll VA, Deshmukh U, Gaskin F, Brown MG, Fu SM. Severe focal sialadenitis and dacryoadenitis in NZM2328 mice induced by MCMV: a novel model for human Sjögren's syndrome. J Immunol. 2006 Nov 15; 177(10):7391-7. PMID: 17082658.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    42. Deshmukh US, Bagavant H, Fu SM. Role of anti-DNA antibodies in the pathogenesis of lupus nephritis. Autoimmun Rev. 2006 Jul; 5(6):414-8. PMID: 16890896.
      Citations: 22     Fields:    Translation:HumansAnimals
    43. Pal R, Deshmukh US, Ohyama Y, Fang Q, Kannapell CC, Gaskin F, Fu SM. Evidence for multiple shared antigenic determinants within Ro60 and other lupus-related ribonucleoprotein autoantigens in human autoimmune responses. J Immunol. 2005 Dec 01; 175(11):7669-77. PMID: 16301677.
      Citations: 4     Fields:    Translation:HumansCells
    44. Deshmukh US, Bagavant H, Lewis J, Gaskin F, Fu SM. Epitope spreading within lupus-associated ribonucleoprotein antigens. Clin Immunol. 2005 Nov; 117(2):112-20. PMID: 16095971.
      Citations: 16     Fields:    Translation:HumansAnimals
    45. Xiao S, Deshmukh US, Jodo S, Koike T, Sharma R, Furusaki A, Sung SS, Ju ST. Novel negative regulator of expression in Fas ligand (CD178) cytoplasmic tail: evidence for translational regulation and against Fas ligand retention in secretory lysosomes. J Immunol. 2004 Oct 15; 173(8):5095-102. PMID: 15470053.
      Citations: 3     Fields:    Translation:AnimalsCells
    46. Bagavant H, Deshmukh US, Gaskin F, Fu SM. Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage. Scand J Immunol. 2004 Jul-Aug; 60(1-2):52-63. PMID: 15238073.
      Citations: 9     Fields:    Translation:HumansAnimals
    47. Waters ST, McDuffie M, Bagavant H, Deshmukh US, Gaskin F, Jiang C, Tung KS, Fu SM. Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis. J Exp Med. 2004 Jan 19; 199(2):255-64. PMID: 14718514.
      Citations: 51     Fields:    Translation:AnimalsCells
    48. Deshmukh US, Gaskin F, Lewis JE, Kannapell CC, Fu SM. Mechanisms of autoantibody diversification to SLE-related autoantigens. Ann N Y Acad Sci. 2003 Apr; 987:91-8. PMID: 12727627.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    49. Fu SM, Castillo JD, Deshmukh US, Lewis JE, Waters ST, Gaskin F. Autoantibodies and glomerulonephritis in systemic lupus erythematosus. Lupus. 2003; 12(3):175-80. PMID: 12708777.
      Citations: 2     Fields:    Translation:HumansAnimals
    50. Paisansinsup T, Deshmukh US, Chowdhary VR, Luthra HS, Fu SM, David CS. HLA class II influences the immune response and antibody diversification to Ro60/Sjögren's syndrome-A: heightened antibody responses and epitope spreading in mice expressing HLA-DR molecules. J Immunol. 2002 Jun 01; 168(11):5876-84. PMID: 12023392.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    51. Deshmukh US, Kannapell CC, Fu SM. Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins. J Immunol. 2002 May 15; 168(10):5326-32. PMID: 11994491.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    52. Waters ST, Fu SM, Gaskin F, Deshmukh US, Sung SS, Kannapell CC, Tung KS, McEwen SB, McDuffie M. NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci. Clin Immunol. 2001 Sep; 100(3):372-83. PMID: 11513551.
      Citations: 50     Fields:    Translation:Animals
    53. Deshmukh US, Lewis JE, Gaskin F, Dhakephalkar PK, Kannapell CC, Waters ST, Fu SM. Ro60 peptides induce antibodies to similar epitopes shared among lupus-related autoantigens. J Immunol. 2000 Jun 15; 164(12):6655-61. PMID: 10843726.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    54. Deshmukh US, Lewis JE, Gaskin F, Kannapell CC, Waters ST, Lou YH, Tung KS, Fu SM. Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies. J Exp Med. 1999 Feb 01; 189(3):531-40. PMID: 9927515.
      Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    55. Deshmukh US, Talwar GP, Gupta SK. Antibody response against three epitopic domains on human chorionic gonadotropin (hCG) in women and rodents immunized with a beta hCG-based immunocontraceptive vaccine. J Clin Immunol. 1994 May; 14(3):162-8. PMID: 7523433.
      Citations: 1     Fields:    Translation:HumansAnimals
    56. Deshmukh US, Pal R, Talwar GP, Gupta SK. Antibody response against epitopes on hCG mapped by monoclonal antibodies in women immunized with an anti-hCG vaccine and its implications for bioneutralization. J Reprod Immunol. 1993 Nov; 25(2):103-17. PMID: 7513023.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
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