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Weidong Wang

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
AddressBSEB 316
941 Stanton L Young Blvd
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01DK130174     (WANG, WEIDONG)Jul 15, 2022 - May 31, 2027
    NIH
    Developing proinsulin misfolding inhibitors for beta cell protection and diabetes treatment
    Role: Principal Investigator
    R01DK128848     (WANG, WEIDONG)Jun 15, 2021 - Mar 31, 2026
    NIH
    Preclinical Validation of PPARg Acetylation Inhibitors for Diabetes Prevention and Treatment
    Role: Principal Investigator
    R01DK116017     (WANG, WEIDONG)Aug 1, 2018 - Jul 31, 2022
    NIH
    Cytoprotection and the mechanism of action of a natural product Khellin against ER stress
    Role: Principal Investigator
    R56DK108887     (WANG, WEIDONG)Sep 20, 2016 - Jul 31, 2019
    NIH
    Preclinical Development of Khellin Analogs for Anti-Diabetic Therapy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Natarajan D, Plakkot B, Tiwari K, Ekambaram S, Wang W, Rudolph M, Mohammad MA, Chacko SK, Subramanian M, Tarantini S, Yabluchanskiy A, Ungvari Z, Csiszar A, Balasubramanian P. Chronic ?3-AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice. Aging Cell. 2024 Aug 23; e14321. PMID: 39177077.
      Citations:    Fields:    
    2. Li Y, Wang W, Lim HY. Drosophila transmembrane protein 214 (dTMEM214) regulates midgut glucose uptake and systemic glucose homeostasis. Dev Biol. 2023 03; 495:92-103. PMID: 36657508; PMCID: PMC9905329.
      Citations:    Fields:    Translation:AnimalsCells
    3. Luo W, Kim Y, Jensen ME, Herlea-Pana O, Wang W, Rudolph MC, Friedman JE, Chernausek SD, Jiang S. miR-130b/301b Is a Negative Regulator of Beige Adipogenesis and Energy Metabolism In Vitro and In Vivo. Diabetes. 2022 Nov 01; 71(11):2360-2371. PMID: 36001751; PMCID: PMC9630090.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Eeda V, Rawal KN, Matlock HG, Herlea-Pana O, Lim HY, Wang W. Hydroxybenzamide derivatives protect pancreatic ß cell by suppressing unfolded protein response activation. Chem Biol Drug Des. 2022 08; 100(2):155-168. PMID: 35615997.
      Citations:    Fields:    Translation:HumansCells
    5. Li Y, Wang W, Lim HY. Drosophila Solute Carrier 5A5 Regulates Systemic Glucose Homeostasis by Mediating Glucose Absorption in the Midgut. Int J Mol Sci. 2021 Nov 17; 22(22). PMID: 34830305.
      Citations: 3     Fields:    Translation:AnimalsCells
    6. Herlea-Pana O, Eeda V, Undi RB, Lim HY, Wang W. Pharmacological Inhibition of Inositol-Requiring Enzyme 1a RNase Activity Protects Pancreatic Beta Cell and Improves Diabetic Condition in Insulin Mutation-Induced Diabetes. Front Endocrinol (Lausanne). 2021; 12:749879. PMID: 34675883.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Lim HY, Wang W, Nakagawa Y, Pierzchala-Koziec K. Editorial: The Endocrine Regulation of Systemic Energy Homeostasis Under Physiological and Pathological Conditions. Front Physiol. 2020; 11:602942. PMID: 33192620.
      Citations:    
    8. Eeda V, Herlea-Pana O, Lim HY, Wang W. Discovery of N-(2-(Benzylamino)-2-oxoethyl)benzamide analogs as a novel scaffold of pancreatic ß-cell protective agents against endoplasmic reticulum stress. Chem Biol Drug Des. 2020 03; 95(3):388-393. PMID: 31755655.
      Citations: 1     Fields:    Translation:HumansCells
    9. Liu Y, Bao H, Wang W, Lim HY. Cardiac Snail family of transcription factors directs systemic lipid metabolism in Drosophila. PLoS Genet. 2019 11; 15(11):e1008487. PMID: 31725726.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Eeda V, Wu D, Lim HY, Wang W. Design, synthesis, and evaluation of potent novel peroxisome proliferator-activated receptor ? indole partial agonists. Bioorg Med Chem Lett. 2019 11 15; 29(22):126664. PMID: 31591015.
      Citations: 3     Fields:    Translation:Cells
    11. Lim HY, Bao H, Liu Y, Wang W. Select Septate Junction Proteins Direct ROS-Mediated Paracrine Regulation of Drosophila Cardiac Function. Cell Rep. 2019 08 06; 28(6):1455-1470.e4. PMID: 31390561.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Duan H, Li Y, Arora D, Xu D, Lim HY, Wang W. Discovery of a Benzamide Derivative That Protects Pancreatic ß-Cells against Endoplasmic Reticulum Stress. J Med Chem. 2017 07 27; 60(14):6191-6204. PMID: 28696115.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Lee S, Bao H, Ishikawa Z, Wang W, Lim HY. Cardiomyocyte Regulation of Systemic Lipid Metabolism by the Apolipoprotein B-Containing Lipoproteins in Drosophila. PLoS Genet. 2017 01; 13(1):e1006555. PMID: 28095410.
      Citations: 16     Fields:    Translation:AnimalsCells
    14. Duan H, Lee JW, Moon SW, Arora D, Li Y, Lim HY, Wang W. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic ß-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem. 2016 09 08; 59(17):7783-800. PMID: 27505441.
      Citations: 8     Fields:    Translation:HumansCells
    15. Duan H, Arora D, Li Y, Setiadi H, Xu D, Lim HY, Wang W. Identification of 1,2,3-triazole derivatives that protect pancreatic ß cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression. Bioorg Med Chem. 2016 06 15; 24(12):2621-30. PMID: 27157393.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. Duan H, Li Y, Lim HY, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem. 2015 Aug 01; 23(15):4514-4521. PMID: 26116180.
      Citations: 3     Fields:    Translation:HumansCells
    17. Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic ß cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19; 9(12):2796-806. PMID: 25279668.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    18. Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS regulate cardiac function via a distinct paracrine mechanism. Cell Rep. 2014 Apr 10; 7(1):35-44. PMID: 24656823.
      Citations: 29     Fields:    Translation:AnimalsCells
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