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Douglas A Drevets

TitleProf,Regents
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Infectious Diseases
AddressAAT 7300
800 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-6434
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    Collapse Research 
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    R21AI046651     (DREVETS, DOUGLAS ALLEN)Apr 1, 1999 - Mar 31, 2001
    NIH
    TROJAN HORSE MECHANISM OF ENDOTHELIAL INVASION
    Role: Principal Investigator

    R56AI057796     (DREVETS, DOUGLAS ALLEN)Apr 1, 2005 - Mar 31, 2007
    NIH
    Monocyte Biology and Biodefense
    Role: Principal Investigator

    R21NS082639     (DREVETS, DOUGLAS ALLEN)May 1, 2014 - Apr 30, 2017
    NIH
    Inflammatory mediators and mechanisms during central nervous system infection
    Role: Principal Investigator

    R01NS098891     (DREVETS, DOUGLAS ALLEN)Jul 15, 2016 - May 31, 2021
    NIH
    Using Host Responses to Neurocysticercosis to Develop Novel, Brain-imaging Free Diagnostics: a US-India Partnership
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Csipo T, Cassidy BR, Balasubramanian P, Drevets DA, Ungvari ZI, Yabluchanskiy A. Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis. Front Aging Neurosci. 2021; 13:644733. PMID: 34054502.
      Citations:    
    2. McGrew KM, Garwe T, Jafarzadeh SR, Drevets DA, Zhao YD, Williams MB, Carabin H. Misclassification Error-Adjusted Prevalence of Injection Drug Use Among Infective Endocarditis Hospitalizations in the United States: A Serial Cross-Sectional Analysis of the 2007-2016 National Inpatient Sample. Am J Epidemiol. 2021 04 06; 190(4):588-599. PMID: 32997130.
      Citations:    Fields:    Translation:Humans
    3. Mera J, Williams MB, Essex W, McGrew KM, Boeckman L, Gahn D, Miller A, Durham D, Fox J, David C, Ritter T, Jones S, Bouse S, Galvani A, Ward JW, Drevets DA, Carabin H. Evaluation of the Cherokee Nation Hepatitis C Virus Elimination Program in the First 22 Months of Implementation. JAMA Netw Open. 2020 12 01; 3(12):e2030427. PMID: 33337496.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    4. Kim AY, Davis AS, Moreau A, Drevets DA, Melendez DP. Management of nontuberculous mycobacterial infections of the eye and orbit: A retrospective case series. Am J Ophthalmol Case Rep. 2020 Dec; 20:100971. PMID: 33163690.
      Citations:    
    5. McKernan P, Cassidy B, Woodward A, Battiste J, Drevets D, Harrison R. Anionic phospholipid expression as a molecular target in Listeria monocytogenes and Escherichia coli. Int J Antimicrob Agents. 2020 Dec; 56(6):106183. PMID: 33045345.
      Citations:    Fields:    Translation:HumansCells
    6. Cassidy BR, Zhang M, Sonntag WE, Drevets DA. Neuroinvasive Listeria monocytogenes infection triggers accumulation of brain CD8+ tissue-resident memory T cells in a miR-155-dependent fashion. J Neuroinflammation. 2020 Sep 02; 17(1):259. PMID: 32878636.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Hanas JS, Hocker JRS, Evangeline B, Prabhakaran V, Oommen A, Rajshekhar V, Drevets DA, Carabin H. Distinguishing patients with idiopathic epilepsy from solitary cysticercus granuloma epilepsy and biochemical phenotype assessment using a serum biomolecule profiling platform. PLoS One. 2020; 15(8):e0237064. PMID: 32823271.
      Citations:    Fields:    Translation:HumansAnimals
    8. Hanas JS, Hocker JRS, Vannarath C, Evangeline B, Prabhakaran V, Oommen A, Couch J, Anderson M, Rajshekhar V, Carabin H, Drevets D. Distinguishing and Biochemical Phenotype Analysis of Epilepsy Patients Using a Novel Serum Profiling Platform. Brain Sci. 2020 Jul 31; 10(8). PMID: 32751954.
      Citations:    
    9. McGrew KM, Carabin H, Garwe T, Jafarzadeh SR, Williams MB, Zhao YD, Drevets DA. Validity of ICD-based algorithms to estimate the prevalence of injection drug use among infective endocarditis hospitalizations in the absence of a reference standard. Drug Alcohol Depend. 2020 04 01; 209:107906. PMID: 32145659.
      Citations: 3     Fields:    Translation:Humans
    10. Wendelboe AM, Miller A, Drevets D, Salinas L, Miller EJ, Jackson D, Chou A, Raines J. Tabletop exercise to prepare institutions of higher education for an outbreak of COVID-19. J Emerg Manag. 2020 Mar/Apr; 18(2):183-184. PMID: 32181873.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    11. Wendelboe AM, Miller A, Drevets D, Salinas L, Miller EJ, Jackson D, Chou A, Raines J. Tabletop exercise to prepare institutions of higher education for an outbreak of COVID-19. J Emerg Manag. 2020 Mar/Apr; 18(2):S1-S20. PMID: 32181874.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    12. McGrew KM, Homco JB, Garwe T, Dao HD, Williams MB, Drevets DA, Jafarzadeh SR, Zhao YD, Carabin H. Validity of International Classification of Diseases codes in identifying illicit drug use target conditions using medical record data as a reference standard: A systematic review. Drug Alcohol Depend. 2020 03 01; 208:107825. PMID: 31982637.
      Citations: 4     Fields:    Translation:Humans
    13. Zhang M, Gillaspy AF, Gipson JR, Cassidy BR, Nave JL, Brewer MF, Stoner JA, Chen J, Drevets DA. Neuroinvasive Listeria monocytogenes Infection Triggers IFN-Activation of Microglia and Upregulates Microglial miR-155. Front Immunol. 2018; 9:2751. PMID: 30538705.
      Citations: 5     Fields:    Translation:AnimalsCells
    14. Fares E, McCloskey CB, Gutierrez A, Princiotta M, Salinas LJ, Drevets DA. Vaccine strain Listeria monocytogenes bacteremia occurring 31 months after immunization. Infection. 2019 Jun; 47(3):489-492. PMID: 30430399.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    15. Hanas JS, Hocker JR, Ramajayam G, Prabhakaran V, Rajshekhar V, Oommen A, Manoj JJ, Anderson MP, Drevets DA, Carabin H. Distinguishing neurocysticercosis epilepsy from epilepsy of unknown etiology using a minimal serum mass profiling platform. Exp Parasitol. 2018 Sep; 192:98-107. PMID: 30096291.
      Citations: 5     Fields:    Translation:HumansAnimals
    16. Savitz JB, Teague TK, Misaki M, Macaluso M, Wurfel BE, Meyer M, Drevets D, Yates W, Gleason O, Drevets WC, Preskorn SH. Treatment of bipolar depression with minocycline and/or aspirin: an adaptive, 2×2 double-blind, randomized, placebo-controlled, phase IIA clinical trial. Transl Psychiatry. 2018 01 24; 8(1):27. PMID: 29362444.
      Citations: 29     Fields:    Translation:HumansCTClinical Trials
    17. Prabhakaran V, Drevets DA, Ramajayam G, Manoj JJ, Anderson MP, Hanas JS, Rajshekhar V, Oommen A, Carabin H. Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, Idiopathic Epilepsy and idiopathic headaches in India. PLoS Negl Trop Dis. 2017 Jun; 11(6):e0005664. PMID: 28622332.
      Citations: 6     Fields:    Translation:HumansCells
    18. Drevets DA. The importance of being in or out. FEMS Microbiol Lett. 2017 05 01; 364(10). PMID: 28379419.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Mera J, Vellozzi C, Hariri S, Carabin H, Drevets DA, Miller A, Reilley B, Essex W, Gahn D, Lyons L, Leston J, Ward JW. Identification and Clinical Management of Persons with Chronic Hepatitis C Virus Infection - Cherokee Nation, 2012-2015. MMWR Morb Mortal Wkly Rep. 2016 May 13; 65(18):461-6. PMID: 27172175.
      Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
    20. Drevets DA, Canono BP, Campbell PA. Measurement of bacterial ingestion and killing by macrophages. Curr Protoc Immunol. 2015 Apr 01; 109:14.6.1-14.6.17. PMID: 25845563.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Riddell J, Kauffman CA, Smith JA, Assi M, Blue S, Buitrago MI, Deresinski S, Wright PW, Drevets DA, Norris SA, Vikram HR, Carson PJ, Vergidis P, Carpenter J, Seidenfeld SM, Wheat LJ. Histoplasma capsulatum endocarditis: multicenter case series with review of current diagnostic techniques and treatment. Medicine (Baltimore). 2014 Jul; 93(5):186-193. PMID: 25181311.
      Citations: 9     Fields:    Translation:HumansAnimals
    22. Lockhart SM, Drevets DA. Reversible bone lesions induced by tenofovir disoproxil fumarate. AIDS. 2014 Jan 28; 28(3):450-1. PMID: 24670530.
      Citations: 1     Fields:    Translation:Humans
    23. Conrady CD, Zheng M, van Rooijen N, Drevets DA, Royer D, Alleman A, Carr DJ. Microglia and a functional type I IFN pathway are required to counter HSV-1-driven brain lateral ventricle enlargement and encephalitis. J Immunol. 2013 Mar 15; 190(6):2807-17. PMID: 23382563.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    24. Hocker JR, Drevets DA, Dillon MJ, Hanas JS. Discriminating experimental Listeria monocytogenes infections in mice using serum profiling. Appl Microbiol Biotechnol. 2012 Nov; 96(4):1049-58. PMID: 23053068.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Savitz J, Preskorn S, Teague TK, Drevets D, Yates W, Drevets W. Minocycline and aspirin in the treatment of bipolar depression: a protocol for a proof-of-concept, randomised, double-blind, placebo-controlled, 2x2 clinical trial. BMJ Open. 2012; 2(1):e000643. PMID: 22357572.
      Citations: 22     Fields:    
    26. Benefield RJ, Drevets DA, Huycke MM, Gentry CA. A multicenter evaluation of the safety of drotrecogin alfa (activated) in patients with baseline bleeding precautions. Curr Drug Saf. 2012 Feb; 7(1):3-7. PMID: 22663949.
      Citations: 2     Fields:    Translation:Humans
    27. Rakic-Martinez M, Drevets DA, Dutta V, Katic V, Kathariou S. Listeria monocytogenes strains selected on ciprofloxacin or the disinfectant benzalkonium chloride exhibit reduced susceptibility to ciprofloxacin, gentamicin, benzalkonium chloride, and other toxic compounds. Appl Environ Microbiol. 2011 Dec; 77(24):8714-21. PMID: 22003016.
      Citations: 30     Fields:    Translation:Cells
    28. Fleckenstein JM, Bartels SR, Drevets PD, Bronze MS, Drevets DA. Infectious agents of food- and water-borne illnesses. Am J Med Sci. 2010 Sep; 340(3):238-46. PMID: 20823701.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    29. Drevets DA, Schawang JE, Mandava VK, Dillon MJ, Leenen PJ. Severe Listeria monocytogenes infection induces development of monocytes with distinct phenotypic and functional features. J Immunol. 2010 Aug 15; 185(4):2432-41. PMID: 20631315.
      Citations: 13     Fields:    Translation:AnimalsCells
    30. van der Zee M, Dik WA, Kap YS, Dillon MJ, Benner R, Leenen PJ, Khan NA, Drevets DA. Synthetic human chorionic gonadotropin-related oligopeptides impair early innate immune responses to Listeria monocytogenes in Mice. J Infect Dis. 2010 Apr 01; 201(7):1072-80. PMID: 20170375.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    31. Maeda K, Mehta H, Drevets DA, Coggeshall KM. IL-6 increases B-cell IgG production in a feed-forward proinflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood. 2010 Jun 10; 115(23):4699-706. PMID: 20351305.
      Citations: 34     Fields:    Translation:AnimalsCells
    32. Drevets DA, Dillon MJ, Schawang JE, Stoner JA, Leenen PJ. IFN-gamma triggers CCR2-independent monocyte entry into the brain during systemic infection by virulent Listeria monocytogenes. Brain Behav Immun. 2010 Aug; 24(6):919-29. PMID: 20211719.
      Citations: 11     Fields:    Translation:AnimalsCells
    33. Conrady CD, Drevets DA, Carr DJ. Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing? J Neuroimmunol. 2010 Mar 30; 220(1-2):1-9. PMID: 19819030.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    34. Michel RG, Kinasewitz GT, Drevets DA, Levin JH, Warden DW. Prosthetic valve endocarditis caused by Candida lusitaniae, an uncommon pathogen: a case report. J Med Case Rep. 2009 May 14; 3:7611. PMID: 19830215.
      Citations: 6     Fields:    
    35. Gentry CA, Gross KB, Sud B, Drevets DA. Adverse outcomes associated with the use of drotrecogin alfa (activated) in patients with severe sepsis and baseline bleeding precautions. Crit Care Med. 2009 Jan; 37(1):19-25. PMID: 19050637.
      Citations: 16     Fields:    Translation:Humans
    36. Drevets DA, Schawang JE, Dillon MJ, Lerner MR, Bronze MS, Brackett DJ. Innate responses to systemic infection by intracellular bacteria trigger recruitment of Ly-6Chigh monocytes to the brain. J Immunol. 2008 Jul 01; 181(1):529-36. PMID: 18566419.
      Citations: 11     Fields:    Translation:AnimalsCells
    37. Drevets DA, Bronze MS. Listeria monocytogenes: epidemiology, human disease, and mechanisms of brain invasion. FEMS Immunol Med Microbiol. 2008 Jul; 53(2):151-65. PMID: 18462388.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    38. Lockhart SM, Rathbun RC, Stephens JR, Baker DL, Drevets DA, Greenfield RA, Salvaggio MR, Vincent S. Cutaneous reactions with tenofovir disoproxil fumarate: a report of nine cases. AIDS. 2007 Jun 19; 21(10):1370-3. PMID: 17545718.
      Citations: 7     Fields:    Translation:Humans
    39. Jackson LA, Drevets DA, Dong ZM, Greenfield RA, Murphy JW. Levels of L-selectin (CD62L) on human leukocytes in disseminated cryptococcosis with and without associated HIV-1 infection. J Infect Dis. 2005 Apr 15; 191(8):1361-7. PMID: 15776384.
      Citations: 4     Fields:    Translation:HumansCells
    40. Sunderkötter C, Nikolic T, Dillon MJ, Van Rooijen N, Stehling M, Drevets DA, Leenen PJ. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J Immunol. 2004 Apr 01; 172(7):4410-7. PMID: 15034056.
      Citations: 438     Fields:    Translation:AnimalsCells
    41. Drevets DA, Dillon MJ, Schawang JS, Van Rooijen N, Ehrchen J, Sunderkötter C, Leenen PJ. The Ly-6Chigh monocyte subpopulation transports Listeria monocytogenes into the brain during systemic infection of mice. J Immunol. 2004 Apr 01; 172(7):4418-24. PMID: 15034057.
      Citations: 64     Fields:    Translation:AnimalsCells
    42. Drevets DA, Leenen PJ, Greenfield RA. Invasion of the central nervous system by intracellular bacteria. Clin Microbiol Rev. 2004 Apr; 17(2):323-47. PMID: 15084504.
      Citations: 61     Fields:    Translation:HumansCells
    43. Drevets DA. Plague. J Okla State Med Assoc. 2002 Dec; 95(12):752-4. PMID: 12596433.
      Citations:    Fields:    Translation:Humans
    44. Greenfield RA, Drevets DA, Gilmore MS. Anthrax. J Okla State Med Assoc. 2002 Sep; 95(9):587-91. PMID: 12362648.
      Citations:    Fields:    Translation:HumansAnimalsCells
    45. Greenfield RA, Drevets DA, Machado LJ, Voskuhl GW, Cornea P, Bronze MS. Bacterial pathogens as biological weapons and agents of bioterrorism. Am J Med Sci. 2002 Jun; 323(6):299-315. PMID: 12074485.
      Citations: 24     Fields:    Translation:Humans
    46. Campbell PA, Canono BP, Drevets DA. Measurement of bacterial ingestion and killing by macrophages. Curr Protoc Immunol. 2001 May; Chapter 14:Unit 14.6. PMID: 18432724.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    47. Drevets DA, Jelinek TA, Freitag NE. Listeria monocytogenes-infected phagocytes can initiate central nervous system infection in mice. Infect Immun. 2001 Mar; 69(3):1344-50. PMID: 11179297.
      Citations: 32     Fields:    Translation:AnimalsCells
    48. Drevets DA, Leenen PJ. Leukocyte-facilitated entry of intracellular pathogens into the central nervous system. Microbes Infect. 2000 Nov; 2(13):1609-18. PMID: 11113380.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    49. Drevets DA. Dissemination of Listeria monocytogenes by infected phagocytes. Infect Immun. 1999 Jul; 67(7):3512-7. PMID: 10377133.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    50. Wilson SL, Drevets DA. Listeria monocytogenes infection and activation of human brain microvascular endothelial cells. J Infect Dis. 1998 Dec; 178(6):1658-66. PMID: 9815218.
      Citations: 23     Fields:    Translation:HumansCells
    51. Shaffer DN, Drevets DA, Farr RW. Listeria monocytogenes rhomboencephalitis with cranial-nerve palsies: a case report. W V Med J. 1998 Mar-Apr; 94(2):80-3. PMID: 9581507.
      Citations: 2     Fields:    Translation:HumansCells
    52. Drevets DA. Listeria monocytogenes virulence factors that stimulate endothelial cells. Infect Immun. 1998 Jan; 66(1):232-8. PMID: 9423863.
      Citations: 12     Fields:    Translation:HumansCells
    53. Drevets DA. Listeria monocytogenes infection of cultured endothelial cells stimulates neutrophil adhesion and adhesion molecule expression. J Immunol. 1997 Jun 01; 158(11):5305-13. PMID: 9164950.
      Citations: 10     Fields:    Translation:HumansCells
    54. Sawyer RT, Drevets DA, Campbell PA, Potter TA. Internalin A can mediate phagocytosis of Listeria monocytogenes by mouse macrophage cell lines. J Leukoc Biol. 1996 Nov; 60(5):603-10. PMID: 8929551.
      Citations: 11     Fields:    Translation:AnimalsCells
    55. Drevets DA, Leenen PJ, Campbell PA. Complement receptor type 3 mediates phagocytosis and killing of Listeria monocytogenes by a TNF-alpha- and IFN-gamma-stimulated macrophage precursor hybrid. Cell Immunol. 1996 Apr 10; 169(1):1-6. PMID: 8612281.
      Citations: 9     Fields:    Translation:AnimalsCells
    56. Drevets DA, Elliott AM. Fluorescence labeling of bacteria for studies of intracellular pathogenesis. J Immunol Methods. 1995 Nov 16; 187(1):69-79. PMID: 7490459.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    57. Drevets DA, Sawyer RT, Potter TA, Campbell PA. Listeria monocytogenes infects human endothelial cells by two distinct mechanisms. Infect Immun. 1995 Nov; 63(11):4268-76. PMID: 7591057.
      Citations: 57     Fields:    Translation:HumansCells
    58. Leenen PJ, Canono BP, Drevets DA, Voerman JS, Campbell PA. TNF-alpha and IFN-gamma stimulate a macrophage precursor cell line to kill Listeria monocytogenes in a nitric oxide-independent manner. J Immunol. 1994 Dec 01; 153(11):5141-7. PMID: 7525724.
      Citations: 23     Fields:    Translation:AnimalsCells
    59. Fu YX, Roark CE, Kelly K, Drevets D, Campbell P, O'Brien R, Born W. Immune protection and control of inflammatory tissue necrosis by gamma delta T cells. J Immunol. 1994 Oct 01; 153(7):3101-15. PMID: 8089489.
      Citations: 67     Fields:    Translation:AnimalsCells
    60. Drevets DA, Canono BP, Leenen PJ, Campbell PA. Gentamicin kills intracellular Listeria monocytogenes. Infect Immun. 1994 Jun; 62(6):2222-8. PMID: 8188344.
      Citations: 60     Fields:    Translation:AnimalsCells
    61. Drevets DA, Leenen PJ, Campbell PA. Complement receptor type 3 (CD11b/CD18) involvement is essential for killing of Listeria monocytogenes by mouse macrophages. J Immunol. 1993 Nov 15; 151(10):5431-9. PMID: 8228236.
      Citations: 22     Fields:    Translation:AnimalsCells
    62. Drevets DA, Canono BP, Campbell PA. Listericidal and nonlistericidal mouse macrophages differ in complement receptor type 3-mediated phagocytosis of L. monocytogenes and in preventing escape of the bacteria into the cytoplasm. J Leukoc Biol. 1992 Jul; 52(1):70-9. PMID: 1640177.
      Citations: 20     Fields:    Translation:AnimalsCells
    63. Drevets DA, Campbell PA. Macrophage phagocytosis: use of fluorescence microscopy to distinguish between extracellular and intracellular bacteria. J Immunol Methods. 1991 Aug 28; 142(1):31-8. PMID: 1919019.
      Citations: 47     Fields:    Translation:AnimalsCells
    64. Drevets DA, Campbell PA. Roles of complement and complement receptor type 3 in phagocytosis of Listeria monocytogenes by inflammatory mouse peritoneal macrophages. Infect Immun. 1991 Aug; 59(8):2645-52. PMID: 1906842.
      Citations: 38     Fields:    Translation:AnimalsCells
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