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Eric W Howard

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBMSB 553
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-8001 ext 45530
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    R25GM144169     (HOWARD, ERIC W)Mar 17, 2023 - Feb 28, 2028
    Post-Baccalaureate Research and Education Program (PREP) for Oklahoma
    Role: Principal Investigator

    R01GM063638     (HOWARD, ERIC W)Jun 1, 2002 - May 31, 2008
    Regulation of Angiogenesis During Wound Healing
    Role: Principal Investigator

    R01HL062268     (HOWARD, ERIC W)Sep 1, 1999 - Aug 31, 2004
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miller LR, Bickel MA, Tarantini S, Runion ME, Matacchiera Z, Vance ML, Hibbs C, Vaden H, Nagykaldi D, Martin T, Bullen EC, Pinckard J, Kiss T, Howard EW, Yabluchanskiy A, Conley SM. IGF1R deficiency in vascular smooth muscle cells impairs myogenic autoregulation and cognition in mice. Front Aging Neurosci. 2024; 16:1320808. PMID: 38425784; PMCID: PMC10902040.
    2. Bickel MA, Sherry DM, Bullen EC, Vance ML, Jones KL, Howard EW, Conley SM. Microvascular smooth muscle cells exhibit divergent phenotypic switching responses to platelet-derived growth factor and insulin-like growth factor 1. Microvasc Res. 2023 Sep 15; 151:104609. PMID: 37716411.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Doughty ACV, Hoover AR, Layton E, Murray CK, Howard EW, Chen WR. Nanomaterial Applications in Photothermal Therapy for Cancer. Materials (Basel). 2019 Mar 07; 12(5). PMID: 30866416.
      Citations: 102     
    4. Zhou B, Song J, Wang M, Wang X, Wang J, Howard EW, Zhou F, Qu J, Chen WR. BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy. Nanoscale. 2018 Nov 29; 10(46):21640-21647. PMID: 30232481.
      Citations: 36     Fields:    Translation:AnimalsCells
    5. Wiechmann AF, Ceresa BP, Howard EW. Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation. PLoS One. 2014; 9(11):e113810. PMID: 25412440.
      Citations: 7     Fields:    Translation:AnimalsCells
    6. Sherry DM, Parks EE, Bullen EC, Updike DL, Howard EW. A simple method for using silicone elastomer masks for quantitative analysis of cell migration without cellular damage or substrate disruption. Cell Adh Migr. 2013 Nov-Dec; 7(6):469-75. PMID: 24430202.
      Citations: 4     Fields:    Translation:HumansCells
    7. Howard EW, Been LF, Lerner M, Brackett D, Lightfoot S, Bullen EC, Sanghera DK. Carriers of a novel frame-shift insertion in WNT16a possess elevated pancreatic expression of TCF7L2. BMC Genet. 2013 Apr 23; 14:28. PMID: 23617586.
      Citations:    Fields:    Translation:HumansCells
    8. Tomasek JJ, Haaksma CJ, Schwartz RJ, Howard EW. Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen. 2013 Jan-Feb; 21(1):166-76. PMID: 23253249.
      Citations: 19     Fields:    Translation:AnimalsCells
    9. Howard EW, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res. 2012 Aug 01; 318(13):1542-53. PMID: 22449415.
      Citations: 16     Fields:    Translation:AnimalsCells
    10. Crider BJ, Risinger GM, Haaksma CJ, Howard EW, Tomasek JJ. Myocardin-related transcription factors A and B are key regulators of TGF-ß1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol. 2011 Dec; 131(12):2378-85. PMID: 21776010.
      Citations: 69     Fields:    Translation:AnimalsCells
    11. Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem. 2010 Aug 27; 285(35):26852-26860. PMID: 20581113.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    12. Risinger GM, Updike DL, Bullen EC, Tomasek JJ, Howard EW. TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol Cell Physiol. 2010 Jan; 298(1):C191-201. PMID: 19846754.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    13. Vogel JS, Bullen EC, Teygong CL, Howard EW. Identification of the RLBP1 gene promoter. Invest Ophthalmol Vis Sci. 2007 Aug; 48(8):3872-7. PMID: 17652763.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Risinger GM, Hunt TS, Updike DL, Bullen EC, Howard EW. Matrix metalloproteinase-2 expression by vascular smooth muscle cells is mediated by both stimulatory and inhibitory signals in response to growth factors. J Biol Chem. 2006 Sep 08; 281(36):25915-25. PMID: 16854986.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    15. Zang XP, Bullen EC, Manjeshwar S, Jupe ER, Howard EW, Pento JT. Enhanced motility of KGF-transfected breast cancer cells. Anticancer Res. 2006 Mar-Apr; 26(2A):961-6. PMID: 16619493.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Phelps ED, Updike DL, Bullen EC, Grammas P, Howard EW. Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C352-61. PMID: 16176970.
      Citations: 23     Fields:    Translation:AnimalsCells
    17. Moore P, Ridgway TD, Higbee RG, Howard EW, Lucroy MD. Effect of wavelength on low-intensity laser irradiation-stimulated cell proliferation in vitro. Lasers Surg Med. 2005 Jan; 36(1):8-12. PMID: 15662631.
      Citations: 82     Fields:    Translation:AnimalsCells
    18. Chen WR, Jeong SW, Lucroy MD, Wolf RF, Howard EW, Liu H, Nordquist RE. Induced antitumor immunity against DMBA-4 metastatic mammary tumors in rats using laser immunotherapy. Int J Cancer. 2003 Dec 20; 107(6):1053-7. PMID: 14601069.
      Citations: 18     Fields:    Translation:Animals
    19. Buller CJ, Zang XP, Howard EW, Pento JT. Measurement of beta-galactosidase tissue levels in a tumor cell xenograft model. Methods Find Exp Clin Pharmacol. 2003 Nov; 25(9):713-6. PMID: 14685298.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Matsumoto RR, Liu Y, Lerner M, Howard EW, Brackett DJ. Sigma receptors: potential medications development target for anti-cocaine agents. Eur J Pharmacol. 2003 May 23; 469(1-3):1-12. PMID: 12782179.
      Citations: 70     Fields:    Translation:HumansAnimals
    21. Chen EI, Li W, Godzik A, Howard EW, Smith JW. A residue in the S2 subsite controls substrate selectivity of matrix metalloproteinase-2 and matrix metalloproteinase-9. J Biol Chem. 2003 May 09; 278(19):17158-63. PMID: 12591933.
      Citations: 17     Fields:    Translation:HumansCells
    22. Wiechmann A, Howard E. Functional analysis of the human recoverin gene promoter. Curr Eye Res. 2003 Jan; 26(1):25-32. PMID: 12789533.
      Citations: 1     Fields:    Translation:HumansCells
    23. Peled ZM, Phelps ED, Updike DL, Chang J, Krummel TM, Howard EW, Longaker MT. Matrix metalloproteinases and the ontogeny of scarless repair: the other side of the wound healing balance. Plast Reconstr Surg. 2002 Sep 01; 110(3):801-11. PMID: 12172142.
      Citations: 12     Fields:    Translation:AnimalsCells
    24. Chen EI, Kridel SJ, Howard EW, Li W, Godzik A, Smith JW. A unique substrate recognition profile for matrix metalloproteinase-2. J Biol Chem. 2002 Feb 08; 277(6):4485-91. PMID: 11694539.
      Citations: 30     Fields:    Translation:HumansCells
    25. Spyres LM, Qa'Dan M, Meader A, Tomasek JJ, Howard EW, Ballard JD. Cytosolic delivery and characterization of the TcdB glucosylating domain by using a heterologous protein fusion. Infect Immun. 2001 Jan; 69(1):599-601. PMID: 11119561.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    26. Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000 May 25; 257(1):180-9. PMID: 10854066.
      Citations: 168     Fields:    Translation:HumansCells
    27. Parizi M, Howard EW, Tomasek JJ. Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. Exp Cell Res. 2000 Feb 01; 254(2):210-20. PMID: 10640419.
      Citations: 59     Fields:    Translation:HumansCells
    28. Soo C, Shaw WW, Zhang X, Longaker MT, Howard EW, Ting K. Differential expression of matrix metalloproteinases and their tissue-derived inhibitors in cutaneous wound repair. Plast Reconstr Surg. 2000 Feb; 105(2):638-47. PMID: 10697171.
      Citations: 46     Fields:    Translation:Animals
    29. Bottles KD, Bullen EC, Updike DL, Vu TK, Phelps E, Grammas P, Howard EW. Gelatinase A expression in endothelial cells is regulated by at least two cis-acting promoter elements. Biochim Biophys Acta. 1999 Aug 05; 1428(2-3):147-60. PMID: 10434032.
      Citations:    Fields:    Translation:AnimalsCells
    30. von Bredow DC, Cress AE, Howard EW, Bowden GT, Nagle RB. Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin. Biochem J. 1998 May 01; 331 ( Pt 3):965-72. PMID: 9560329.
      Citations: 23     Fields:    Translation:HumansCells
    31. Abidi SM, Howard EW, Dmytryk JJ, Pento JT. The influence of antiestrogens on the release of plasminogen activator (uPA) by MDA-MB-231 and MCF-7 breast cancer cells. Clin Exp Metastasis. 1998 Apr; 16(3):235-41. PMID: 9568641.
      Citations:    Fields:    Translation:HumansCells
    32. Vu TK, Liu RW, Haaksma CJ, Tomasek JJ, Howard EW. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem. 1997 Dec 12; 272(50):31315-20. PMID: 9395459.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    33. Abbas Abidi SM, Howard EW, Dmytryk JJ, Pento JT. Differential influence of antiestrogens on the in vitro release of gelatinases (type IV collagenases) by invasive and non-invasive breast cancer cells. Clin Exp Metastasis. 1997 Jul; 15(4):432-9. PMID: 9219732.
      Citations: 7     Fields:    Translation:HumansCells
    34. Tomasek JJ, Halliday NL, Updike DL, Ahern-Moore JS, Vu TK, Liu RW, Howard EW. Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton. J Biol Chem. 1997 Mar 14; 272(11):7482-7. PMID: 9054450.
      Citations: 31     Fields:    Translation:HumansCells
    35. Howard EW, Benton R, Ahern-Moore J, Tomasek JJ. Cellular contraction of collagen lattices is inhibited by nonenzymatic glycation. Exp Cell Res. 1996 Oct 10; 228(1):132-7. PMID: 8892980.
      Citations: 21     Fields:    Translation:HumansCells
    36. Bullen EC, Longaker MT, Updike DL, Benton R, Ladin D, Hou Z, Howard EW. Tissue inhibitor of metalloproteinases-1 is decreased and activated gelatinases are increased in chronic wounds. J Invest Dermatol. 1995 Feb; 104(2):236-40. PMID: 7829879.
      Citations: 52     Fields:    Translation:HumansCells
    37. Howard EW, Bullen EC, Banda MJ. Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2. J Biol Chem. 1991 Jul 15; 266(20):13070-5. PMID: 1649175.
      Citations: 32     Fields:    Translation:HumansCells
    38. Howard EW, Bullen EC, Banda MJ. Regulation of the autoactivation of human 72-kDa progelatinase by tissue inhibitor of metalloproteinases-2. J Biol Chem. 1991 Jul 15; 266(20):13064-9. PMID: 2071592.
      Citations: 38     Fields:    Translation:HumansCells
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