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Gennadiy Petrovich Moiseyev

TitleProf,Asst of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
AddressBSEB 302C
941 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-8001 ext 48443
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    Collapse Research 
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    R01EY012231     (MA, JIAN-XING)Jul 1, 1998 - Aug 31, 2022
    NIH
    Studies of RPE65
    Role: Co-Principal Investigator
    R43EY016298     (MOISEYEV, GENNADIY)Aug 1, 2005 - Jan 31, 2008
    NIH
    Treatment of Retinal Vascular Leakage Using Angiostatin
    Role: Principal Investigator
    R43EY017229     (MOISEYEV, GENNADIY)May 1, 2006 - Apr 30, 2008
    NIH
    Cocktail of Angiogenic Inhibitors for the Treatment of Diabetic Macular Edema
    Role: Principal Investigator
    R01EY032930     (MA, JIAN-XING)Aug 1, 2021 - Jun 30, 2026
    NIH
    Studies of retinyl ester hydrolase in the visual cycle
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen J, Shao Y, Sasore T, Moiseyev G, Zhou K, Ma X, Du Y, Ma JX. Interphotoreceptor Retinol-Binding Protein Ameliorates Diabetes-Induced Retinal Dysfunction and Neurodegeneration Through Rhodopsin. Diabetes. 2021 03; 70(3):788-799. PMID: 33334874.
      Citations: 1     Fields:    Translation:Animals
    2. Malechka VV, Chen J, Cheng R, Ma JX, Moiseyev G. The Single Administration of a Chromophore Alleviates Neural Defects in Diabetic Retinopathy. Am J Pathol. 2020 07; 190(7):1505-1512. PMID: 32275905.
      Citations: 2     Fields:    Translation:Animals
    3. Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul; 1864(7):2420-2429. PMID: 29684583.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Du M, Phelps E, Balangue MJ, Dockins A, Moiseyev G, Shin Y, Kane S, Otalora L, Ma JX, Farjo R, Farjo KM. Transgenic Mice Over-Expressing RBP4 Have RBP4-Dependent and Light-Independent Retinal Degeneration. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):4375–4383. PMID: 28813718.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    5. Malechka VV, Moiseyev G, Takahashi Y, Shin Y, Ma JX. Impaired Rhodopsin Generation in the Rat Model of Diabetic Retinopathy. Am J Pathol. 2017 Oct; 187(10):2222-2231. PMID: 28734946.
      Citations: 12     Fields:    Translation:AnimalsCells
    6. Shin Y, Moiseyev G, Chakraborty D, Ma JX. A Dominant Mutation in Rpe65, D477G, Delays Dark Adaptation and Disturbs the Visual Cycle in the Mutant Knock-In Mice. Am J Pathol. 2017 Mar; 187(3):517-527. PMID: 28041994.
      Citations: 11     Fields:    Translation:AnimalsCells
    7. He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 03; 91(3):642-657. PMID: 27914705.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    8. Harper AR, Wang X, Moiseyev G, Ma JX, Summers JA. Postnatal Chick Choroids Exhibit Increased Retinaldehyde Dehydrogenase Activity During Recovery From Form Deprivation Induced Myopia. Invest Ophthalmol Vis Sci. 2016 Sep 01; 57(11):4886-4897. PMID: 27654415.
      Citations: 1     Fields:    
    9. Stiles M, Moiseyev GP, Budda ML, Linens A, Brush RS, Qi H, White GL, Wolf RF, Ma JX, Floyd R, Anderson RE, Mandal NA. PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One. 2015; 10(12):e0145305. PMID: 26694648.
      Citations: 2     Fields:    Translation:Animals
    10. Du M, Otalora L, Martin AA, Moiseyev G, Vanlandingham P, Wang Q, Farjo R, Yeganeh A, Quiambao A, Farjo KM. Transgenic Mice Overexpressing Serum Retinol-Binding Protein Develop Progressive Retinal Degeneration through a Retinoid-Independent Mechanism. Mol Cell Biol. 2015 Aug; 35(16):2771-89. PMID: 26055327.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    11. Harper AR, Wiechmann AF, Moiseyev G, Ma JX, Summers JA. Identification of active retinaldehyde dehydrogenase isoforms in the postnatal human eye. PLoS One. 2015; 10(3):e0122008. PMID: 25793304.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    12. Takahashi Y, Moiseyev G, Ma JX. Identification of key residues determining isomerohydrolase activity of human RPE65. J Biol Chem. 2014 Sep 26; 289(39):26743-26751. PMID: 25112876.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    13. Dobri N, Qin Q, Kong J, Yamamoto K, Liu Z, Moiseyev G, Ma JX, Allikmets R, Sparrow JR, Petrukhin K. A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis. Invest Ophthalmol Vis Sci. 2013 Jan 07; 54(1):85-95. PMID: 23211825.
      Citations: 31     Fields:    Translation:HumansAnimals
    14. Farjo KM, Farjo RA, Halsey S, Moiseyev G, Ma JX. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase- and nuclear factor kappa B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012 Dec; 32(24):5103-15. PMID: 23071093.
      Citations: 55     Fields:    Translation:HumansCells
    15. Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD. Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium. J Biol Chem. 2012 Jul 13; 287(29):24092-102. PMID: 22645143.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    16. Takahashi Y, Moiseyev G, Nikolaeva O, Ma JX. Identification of the key residues determining the product specificity of isomerohydrolase. Biochemistry. 2012 May 22; 51(20):4217-25. PMID: 22512451.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Hu Y, Chen Y, Moiseyev G, Takahashi Y, Mott R, Ma JX. Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice. Invest Ophthalmol Vis Sci. 2011 Jul 25; 52(8):5507-14. PMID: 21551411.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem. 2011 Sep 16; 286(37):32491-501. PMID: 21785167.
      Citations: 35     Fields:    Translation:AnimalsCells
    19. Farjo KM, Moiseyev G, Nikolaeva O, Sandell LL, Trainor PA, Ma JX. RDH10 is the primary enzyme responsible for the first step of embryonic Vitamin A metabolism and retinoic acid synthesis. Dev Biol. 2011 Sep 15; 357(2):347-55. PMID: 21782811.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    20. Takahashi Y, Moiseyev G, Chen Y, Nikolaeva O, Ma JX. An alternative isomerohydrolase in the retinal Müller cells of a cone-dominant species. FEBS J. 2011 Aug; 278(16):2913-26. PMID: 21676174.
      Citations: 13     Fields:    Translation:AnimalsCells
    21. Nikolaeva O, Moiseyev G, Rodgers KK, Ma JX. Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity. Biochem J. 2011 Jun 15; 436(3):591-7. PMID: 21446919.
      Citations: 4     Fields:    Translation:AnimalsCells
    22. Takahashi Y, Moiseyev G, Chen Y, Farjo K, Nikolaeva O, Ma JX. An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain. FEBS J. 2011 Apr; 278(6):973-87. PMID: 21235714.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    23. Moiseyev G, Nikolaeva O, Chen Y, Farjo K, Takahashi Y, Ma JX. Inhibition of the visual cycle by A2E through direct interaction with RPE65 and implications in Stargardt disease. Proc Natl Acad Sci U S A. 2010 Oct 12; 107(41):17551-6. PMID: 20876139.
      Citations: 21     Fields:    Translation:AnimalsCells
    24. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Negative charge of the glutamic acid 417 residue is crucial for isomerohydrolase activity of RPE65. Biochem Biophys Res Commun. 2010 Jan 22; 391(4):1757-61. PMID: 20043869.
      Citations: 9     Fields:    Translation:HumansCells
    25. Farjo KM, Moiseyev G, Takahashi Y, Crouch RK, Ma JX. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5089-97. PMID: 19458327.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    26. Nikolaeva O, Takahashi Y, Moiseyev G, Ma JX. Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane. FEBS J. 2009 Jun; 276(11):3020-30. PMID: 19490105.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    27. Takahashi Y, Moiseyev G, Farjo K, Ma JX. Characterization of key residues and membrane association domains in retinol dehydrogenase 10. Biochem J. 2009 Apr 01; 419(1):113-22, 1 p following 122. PMID: 19102727.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    28. Chen Y, Hu Y, Moiseyev G, Zhou KK, Chen D, Ma JX. Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvasc Res. 2009 Jun; 78(1):119-27. PMID: 19281829.
      Citations: 28     Fields:    Translation:AnimalsCells
    29. Takahashi Y, Moiseyev G, Ablonczy Z, Chen Y, Crouch RK, Ma JX. Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65. J Biol Chem. 2009 Jan 30; 284(5):3211-3218. PMID: 19049981.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    30. Moiseyev G, Takahashi Y, Chen Y, Kim S, Ma JX. RPE65 from cone-dominant chicken is a more efficient isomerohydrolase compared with that from rod-dominant species. J Biol Chem. 2008 Mar 28; 283(13):8110-7. PMID: 18216020.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    31. Kanan Y, Kasus-Jacobi A, Moiseyev G, Sawyer K, Ma JX, Al-Ubaidi MR. Retinoid processing in cone and Müller cell lines. Exp Eye Res. 2008 Feb; 86(2):344-54. PMID: 18163989.
      Citations: 15     Fields:    Translation:AnimalsCells
    32. Sandell LL, Sanderson BW, Moiseyev G, Johnson T, Mushegian A, Young K, Rey JP, Ma JX, Staehling-Hampton K, Trainor PA. RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development. Genes Dev. 2007 May 01; 21(9):1113-24. PMID: 17473173.
      Citations: 140     Fields:    Translation:AnimalsCells
    33. Kanan Y, Moiseyev G, Agarwal N, Ma JX, Al-Ubaidi MR. Light induces programmed cell death by activating multiple independent proteases in a cone photoreceptor cell line. Invest Ophthalmol Vis Sci. 2007 Jan; 48(1):40-51. PMID: 17197514.
      Citations: 27     Fields:    Translation:AnimalsCells
    34. Takahashi Y, Moiseyev G, Chen Y, Ma JX. The roles of three palmitoylation sites of RPE65 in its membrane association and isomerohydrolase activity. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5191-6. PMID: 17122102.
      Citations: 14     Fields:    Translation:HumansCells
    35. Chen Y, Moiseyev G, Takahashi Y, Ma JX. Impacts of two point mutations of RPE65 from Leber's congenital amaurosis on the stability, subcellular localization and isomerohydrolase activity of RPE65. FEBS Lett. 2006 Jul 24; 580(17):4200-4. PMID: 16828753.
      Citations: 18     Fields:    Translation:HumansCells
    36. Takahashi Y, Chen Y, Moiseyev G, Ma JX. Two point mutations of RPE65 from patients with retinal dystrophies decrease the stability of RPE65 protein and abolish its isomerohydrolase activity. J Biol Chem. 2006 Aug 04; 281(31):21820-21826. PMID: 16754667.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    37. Chen Y, Moiseyev G, Takahashi Y, Ma JX. RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):1177-84. PMID: 16505056.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    38. Moiseyev G, Takahashi Y, Chen Y, Gentleman S, Redmond TM, Crouch RK, Ma JX. RPE65 is an iron(II)-dependent isomerohydrolase in the retinoid visual cycle. J Biol Chem. 2006 Feb 03; 281(5):2835-40. PMID: 16319067.
      Citations: 56     Fields:    Translation:AnimalsCells
    39. Takahashi Y, Moiseyev G, Chen Y, Ma JX. Identification of conserved histidines and glutamic acid as key residues for isomerohydrolase activity of RPE65, an enzyme of the visual cycle in the retinal pigment epithelium. FEBS Lett. 2005 Oct 10; 579(24):5414-8. PMID: 16198348.
      Citations: 29     Fields:    Translation:HumansCells
    40. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12413-8. PMID: 16116091.
      Citations: 241     Fields:    Translation:HumansAnimalsCells
    41. Peshenko IV, Moiseyev GP, Olshevskaya EV, Dizhoor AM. Factors that determine Ca2+ sensitivity of photoreceptor guanylyl cyclase. Kinetic analysis of the interaction between the Ca2+-bound and the Ca2+-free guanylyl cyclase activating proteins (GCAPs) and recombinant photoreceptor guanylyl cyclase 1 (RetGC-1). Biochemistry. 2004 Nov 02; 43(43):13796-804. PMID: 15504042.
      Citations: 31     Fields:    Translation:HumansCells
    42. Wu BX, Moiseyev G, Chen Y, Rohrer B, Crouch RK, Ma JX. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):3857-62. PMID: 15505029.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    43. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99. PMID: 14685281.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    44. Chen Y, Moiseyev G, Wu BX, Ma JX, Crouch RK. Visual cycle retinoid processing proteins are present in HEK293S cells. Vision Res. 2003 Dec; 43(28):3037-44. PMID: 14611939.
      Citations: 8     Fields:    Translation:HumansCells
    45. Fan J, Rohrer B, Moiseyev G, Ma JX, Crouch RK. Isorhodopsin rather than rhodopsin mediates rod function in RPE65 knock-out mice. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13662-7. PMID: 14578454.
      Citations: 68     Fields:    Translation:Animals
    46. Moiseyev G, Crouch RK, Goletz P, Oatis J, Redmond TM, Ma JX. Retinyl esters are the substrate for isomerohydrolase. Biochemistry. 2003 Feb 25; 42(7):2229-38. PMID: 12590612.
      Citations: 55     Fields:    Translation:AnimalsCells
    47. Znoiko SL, Crouch RK, Moiseyev G, Ma JX. Identification of the RPE65 protein in mammalian cone photoreceptors. Invest Ophthalmol Vis Sci. 2002 May; 43(5):1604-9. PMID: 11980880.
      Citations: 37     Fields:    Translation:AnimalsCells
    48. Ma J, Zhang J, Othersen KL, Moiseyev G, Ablonczy Z, Redmond TM, Chen Y, Crouch RK. Expression, purification, and MALDI analysis of RPE65. Invest Ophthalmol Vis Sci. 2001 Jun; 42(7):1429-35. PMID: 11381042.
      Citations: 26     Fields:    Translation:AnimalsCells
    49. Moiseyev GP, Fedoreyeva LI, Zhuravlev YN, Yasnetskaya E, Jekel PA, Beintema JJ. Primary structures of two ribonucleases from ginseng calluses. New members of the PR-10 family of intracellular pathogenesis-related plant proteins. FEBS Lett. 1997 Apr 28; 407(2):207-10. PMID: 9166900.
      Citations: 23     Fields:    Translation:AnimalsCells
    50. Moiseyev GP, Yakovlev GI, Chernyi AA, Polyakov KM, Oivanen M, Lönnberg H, Beigelman LN, Efimtseva EV, Mikhailov SN. Determination of the nucleotide conformation in the productive enzyme-substrate complexes of RNA-depolymerases. FEBS Lett. 1997 Mar 10; 404(2-3):169-72. PMID: 9119057.
      Citations:    Fields:    Translation:AnimalsCells
    51. Yakovlev GI, Moiseyev GP, Protasevich II, Ranjbar B, Bocharov AL, Kirpichnikov MP, Gilli RM, Briand CM, Hartley RW, Makarov AA. Dissociation constants and thermal stability of complexes of Bacillus intermedius RNase and the protein inhibitor of Bacillus amyloliquefaciens RNase. FEBS Lett. 1995 Jun 12; 366(2-3):156-8. PMID: 7789535.
      Citations: 5     Fields:    Translation:Cells
    52. Yakovlev GI, Moiseyev GP, Struminskaya NK, Borzykh OA, Kipenskaya LV, Znamenskaya LV, Leschinskaya IB, Chernokalskaya EB, Hartley RW. Mutational analysis of the active site of RNase of Bacillus intermedius (BINASE). FEBS Lett. 1994 Nov 14; 354(3):305-6. PMID: 7957945.
      Citations: 3     Fields:    Translation:Cells
    53. Moiseyev GP, Beintema JJ, Fedoreyeva LI, Yakovlev GI. High sequence similarity between a ribonuclease from ginseng calluses and fungus-elicited proteins from parsley indicates that intracellular pathogenesis-related proteins are ribonucleases. Planta. 1994; 193(3):470-2. PMID: 7764876.
      Citations: 29     Fields:    Translation:AnimalsCells
    54. Dementiev AA, Moiseyev GP, Shlyapnikov SV. Primary structure and catalytic properties of extracellular ribonuclease of Bacillus circulans. FEBS Lett. 1993 Nov 15; 334(2):247-9. PMID: 8224254.
      Citations: 1     Fields:    Translation:Cells
    55. Yakovlev GI, Moiseyev GP, Struminskaya NK, Romakhina ER, Leshchinskaya IB, Hartley RW. Increase of specificity of RNase from Bacillus amyloliquefaciens (barnase) by substitution of Glu for Ser57 using site-directed mutagenesis. Eur J Biochem. 1993 Jul 01; 215(1):167-70. PMID: 8344276.
      Citations: 1     Fields:    Translation:Cells
    56. Yakovlev GI, Moiseyev GP, Bezborodova SI, Both V, Sevcik J. A comparative study on the catalytic properties of guanyl-specific ribonucleases. Eur J Biochem. 1992 Feb 15; 204(1):187-90. PMID: 1310940.
      Citations: 5     Fields:    Translation:AnimalsCells
    57. Both V, Moiseyev GP, Sevcik J. Specificity of guanylic RNases to polynucleotide substrates. Biochem Biophys Res Commun. 1991 Jun 14; 177(2):630-5. PMID: 1904722.
      Citations:    Fields:    Translation:AnimalsCells
    58. Itkes AV, Kartasheva ON, Mikhailov SN, Moiseyev GP, Pfleiderer W, Charubala R, Yakovlev GI. A route to 2',5'-oligoadenylates with increased stability towards phosphodiesterases. FEBS Lett. 1988 Aug 29; 236(2):325-8. PMID: 2842187.
      Citations: 3     Fields:    Translation:AnimalsCells
    59. Yakovlev GI, Bocharov AL, Moiseyev GP, Mikhaylov SN. Stereoelectronic effects in RNase-catalysed reactions of dinucleoside phosphate cleavage. FEBS Lett. 1985 Jan 07; 179(2):217-20. PMID: 3855400.
      Citations:    Fields:    Translation:AnimalsCells
    60. Yakovlev GI, Bocharov AL, Moiseyev GP. Correlative variations of the free energies for enzyme-substrate complex formation and the transition-state stabilization for RNases. FEBS Lett. 1984 Oct 01; 175(2):356-8. PMID: 6479350.
      Citations:    Fields:    Translation:Cells
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