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Hala Chaaban

TitleProf,Asoc
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentDept of Pediatrics
AddressET 7NP
1200 Everett Dr
Oklahoma City OK 73104
Phone405/271-5215
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    Collapse Research 
    Collapse research activities and funding
    R01HD109784     (CHAABAN, HALA)Apr 1, 2023 - Jan 31, 2028
    NIH
    Prevention of Necrotizing Enterocolitis
    Role: Principal Investigator
    K08GM127308     (CHAABAN, HALA)Sep 1, 2017 - Aug 31, 2021
    NIH
    The Role of Extracellular Histones and Neutrophil Extracellular traps in Necrotizing Enterocolitis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Monzon N, Kasahara EM, Gunasekaran A, Burge KY, Chaaban H. Impact of neonatal nutrition on necrotizing enterocolitis. Semin Pediatr Surg. 2023 Jun; 32(3):151305. PMID: 37257267.
      Citations:    Fields:    Translation:Humans
    2. Liebe H, Lewis S, Loerke C, Golubkova A, Leiva T, Stewart K, Sarwar Z, Gin A, Porter M, Chaaban H, Hunter CJ. A Retrospective Case Control Study Examining Procalcitonin as a Biomarker for Necrotizing Enterocolitis. Surg Infect (Larchmt). 2023 May 03. PMID: 37134209.
      Citations:    Fields:    Translation:Humans
    3. Wilson A, Bogie B, Chaaban H, Burge K. The Nonbacterial Microbiome: Fungal and Viral Contributions to the Preterm Infant Gut in Health and Disease. Microorganisms. 2023 Mar 31; 11(4). PMID: 37110332; PMCID: PMC10144239.
      Citations:    
    4. Leiva T, Lueschow S, Burge K, Devette C, McElroy S, Chaaban H. Biomarkers of necrotizing enterocolitis in the era of machine learning and omics. Semin Perinatol. 2023 02; 47(1):151693. PMID: 36604292; PMCID: PMC9975050.
      Citations:    Fields:    Translation:Humans
    5. Chaaban H, Hunter C. Introduction. Semin Perinatol. 2023 Feb; 47(1):151697. PMID: 36599762.
      Citations:    Fields:    
    6. Wilson A, Burge K, Eckert J, Chaaban H. Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing using Enteroid-derived Monolayers. J Vis Exp. 2022 07 28; (185). PMID: 35943893; PMCID: PMC9680908.
      Citations:    Fields:    Translation:Animals
    7. Mayes RA, Johnson PN, White BP, Neely SB, Chaaban H, Miller JL. Impact of Ceftazidime Use on Susceptibility Patterns in a Neonatal Intensive Care Unit: A 7.5-year Evaluation. J Pediatric Infect Dis Soc. 2022 07 21; 11(7):349-350. PMID: 35390154.
      Citations:    Fields:    Translation:HumansCells
    8. Burge KY, Gunasekaran A, Makoni MM, Mir AM, Burkhart HM, Chaaban H. Clinical Characteristics and Potential Pathogenesis of Cardiac Necrotizing Enterocolitis in Neonates with Congenital Heart Disease: A Narrative Review. J Clin Med. 2022 Jul 09; 11(14). PMID: 35887751.
      Citations: 4     
    9. Burge K, Wilson A, Chaaban H. In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis. J Vis Exp. 2022 06 08; (184). PMID: 35758712.
      Citations: 1     Fields:    Translation:HumansAnimals
    10. Mayes RA, Johnson PN, White BP, Neely SB, Chaaban H, Miller JL. Evaluation of Ceftazidime Use in the Neonatal Intensive Care Unit and Association With Cephalosporin-Resistant Gram-Negative Bacteria. Ann Pharmacother. 2022 Dec; 56(12):1325-1332. PMID: 35484966.
      Citations: 1     Fields:    Translation:HumansCells
    11. Burge K, Eckert J, Wilson A, Trammell M, Lueschow SR, McElroy SJ, Dyer D, Chaaban H. Hyaluronic Acid 35 kDa Protects against a Hyperosmotic, Formula Feeding Model of Necrotizing Enterocolitis. Nutrients. 2022 Apr 24; 14(9). PMID: 35565748.
      Citations: 3     Fields:    Translation:HumansAnimals
    12. Box DM, Makkar A, Yu Z, Chaaban H, Tran HH, Burge KY, Eckert JV. Placental Neutrophil Infiltration Associated with Tobacco Exposure but Not Development of Bronchopulmonary Dysplasia. Children (Basel). 2022 Mar 09; 9(3). PMID: 35327753.
      Citations:    
    13. Chaaban H, Patel MM, Burge K, Eckert JV, Lupu C, Keshari RS, Silasi R, Regmi G, Trammell M, Dyer D, McElroy SJ, Lupu F. Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study. Microorganisms. 2022 Feb 27; 10(3). PMID: 35336095.
      Citations: 12     
    14. Gunasekaran A, Devette C, Levin S, Chaaban H. Biomarkers of Necrotizing Enterocolitis: The Search Continues. Clin Perinatol. 2022 03; 49(1):181-194. PMID: 35210000.
      Citations: 3     Fields:    Translation:Humans
    15. Weller BM, Shaddix BP, Oschman A, Johnson PN, Neely SB, Chaaban H, Williams PK, Miller J. A Pilot Evaluation of the Possible Association of Metronidazole With Neurodevelopmental Outcomes in Premature Neonates. J Pediatr Pharmacol Ther. 2021; 26(5):455-459. PMID: 34239396.
      Citations: 1     
    16. Chaaban H, Burge K, Eckert J, Trammell M, Dyer D, Keshari RS, Silasi R, Regmi G, Lupu C, Good M, McElroy SJ, Lupu F. Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice. Nutrients. 2021 Jun 12; 13(6). PMID: 34204790.
      Citations: 8     Fields:    Translation:AnimalsCells
    17. Drennan SE, Burge KY, Szyld EG, Eckert JV, Mir AM, Gormley AK, Schwartz RM, Daves SM, Thompson JL, Burkhart HM, Chaaban H. Clinical and Laboratory Predictors for the Development of Low Cardiac Output Syndrome in Infants Undergoing Cardiopulmonary Bypass: A Pilot Study. J Clin Med. 2021 Feb 11; 10(4). PMID: 33670210.
      Citations: 6     
    18. Burge K, Vieira F, Eckert J, Chaaban H. Lipid Composition, Digestion, and Absorption Differences among Neonatal Feeding Strategies: Potential Implications for Intestinal Inflammation in Preterm Infants. Nutrients. 2021 Feb 08; 13(2). PMID: 33567518.
      Citations: 3     Fields:    Translation:Humans
    19. Keshari RS, Silasi R, Popescu NI, Regmi G, Chaaban H, Lambris JD, Lupu C, Mollnes TE, Lupu F. CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis. J Thromb Haemost. 2021 02; 19(2):429-443. PMID: 33174372.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Markel TA, Martin CA, Chaaban H, Canvasser J, Tanner H, Denchik H, Good M. New directions in necrotizing enterocolitis with early-stage investigators. Pediatr Res. 2020 08; 88(Suppl 1):35-40. PMID: 32855511.
      Citations: 4     Fields:    Translation:HumansCells
    21. Chaaban H, Burge K, Eckert J, Keshari RS, Silasi R, Lupu C, Warner B, Escobedo M, Caplan M, Lupu F. Neutrophil extracellular trap inhibition increases inflammation, bacteraemia and mortality in murine necrotizing enterocolitis. J Cell Mol Med. 2021 12; 25(23):10814-10824. PMID: 32515131.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Alhamad MMA, Kumar A, Chaaban H, Wickline KM, Ho TTB. Platelets and Immature Neutrophils in Preterm Infants with Feeding Intolerance. Am J Perinatol. 2021 09; 38(11):1150-1157. PMID: 32446253.
      Citations: 2     Fields:    Translation:HumansCells
    23. Burge K, Bergner E, Gunasekaran A, Eckert J, Chaaban H. The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review. Nutrients. 2020 Feb 20; 12(2). PMID: 32093194.
      Citations: 5     Fields:    Translation:Humans
    24. Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H. Insights Image for "Hyaluronan 35?kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis". Pediatr Res. 2020 06; 87(7):1272. PMID: 31968356.
      Citations:    Fields:    Translation:Animals
    25. Keshari RS, Silasi R, Popescu NI, Georgescu C, Chaaban H, Lupu C, McCarty OJT, Esmon CT, Lupu F. Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of Escherichia coli sepsis. J Thromb Haemost. 2020 01; 18(1):180-190. PMID: 31549765.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H. Hyaluronan 35?kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis. Pediatr Res. 2020 06; 87(7):1177-1184. PMID: 31499514.
      Citations: 18     Fields:    Translation:AnimalsCells
    27. Miller JL, Johnson PN, White BP, Neely SB, Chaaban H, Kassa N, Welliver RC. Impact of Ceftazidime Use on Susceptibility Patterns in the Neonatal Intensive Care Unit. Pediatr Infect Dis J. 2019 06; 38(6):605-607. PMID: 30489466.
      Citations:    Fields:    Translation:HumansCells
    28. Chaaban H, Markel TA, Canvasser J, Good M. Biobanking for necrotizing enterocolitis: Needs and standards. J Pediatr Surg. 2020 Jul; 55(7):1276-1279. PMID: 31126684.
      Citations: 6     Fields:    Translation:Humans
    29. Burge KY, Hannah L, Eckert JV, Gunasekaran A, Chaaban H. The Protective Influence of Chondroitin Sulfate, a Component of Human Milk, on Intestinal Bacterial Invasion and Translocation. J Hum Lact. 2019 Aug; 35(3):538-549. PMID: 31051086.
      Citations: 7     Fields:    Translation:HumansCells
    30. Burge K, Gunasekaran A, Eckert J, Chaaban H. Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection. Int J Mol Sci. 2019 Apr 18; 20(8). PMID: 31003422.
      Citations: 53     Fields:    Translation:Humans
    31. Silasi R, Keshari RS, Lupu C, Van Rensburg WJ, Chaaban H, Regmi G, Shamanaev A, Shatzel JJ, Puy C, Lorentz CU, Tucker EI, Gailani D, Gruber A, McCarty OJT, Lupu F. Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death. Blood Adv. 2019 02 26; 3(4):658-669. PMID: 30808684.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    32. Helmbrecht AR, Marfurt S, Chaaban H. Systematic Review of the Effectiveness of the Neonatal Early-Onset Sepsis Calculator. J Perinat Neonatal Nurs. 2019 Jan/Mar; 33(1):82-88. PMID: 30676467.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    33. Allen HC, Garbe MC, Lees J, Aziz N, Chaaban H, Miller JL, Johnson P, DeLeon S. Off-Label Medication use in Children, More Common than We Think: A Systematic Review of the Literature. J Okla State Med Assoc. 2018 Oct; 111(8):776-783. PMID: 31379392.
      Citations: 35     Fields:    
    34. Bailey V, Szyld E, Cagle K, Kurtz D, Chaaban H, Wu D, Williams P. Modern Neonatal Transport: Sound and Vibration Levels and Their Impact on Physiological Stability. Am J Perinatol. 2019 03; 36(4):352-359. PMID: 30112755.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    35. Miller JL, Lepa TM, Ranallo C, Chaaban H, Skrepnek GH, Johnson PN. Detectable Concentrations of Inhaled Tobramycin in Critically Ill Children Without Cystic Fibrosis: Should Routine Monitoring Be Recommended? Pediatr Crit Care Med. 2017 Dec; 18(12):e615-e620. PMID: 29206744.
      Citations: 2     Fields:    Translation:Humans
    36. Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F. Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis. Proc Natl Acad Sci U S A. 2017 Aug 01; 114(31):E6390-E6399. PMID: 28720697.
      Citations: 52     Fields:    
    37. Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban H. FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis. J Inflamm Res. 2017; 10:75-81. PMID: 28652797.
      Citations: 5     
    38. Dannelley JF, Martin EM, Chaaban H, Miller JL. Review of Metronidazole Dosing in Preterm Neonates. Am J Perinatol. 2017 07; 34(9):833-838. PMID: 28273675.
      Citations: 2     Fields:    Translation:Humans
    39. Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D'Souza P, Lim YP, Lupu F. Inter-a inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury. Blood. 2015 Apr 02; 125(14):2286-96. PMID: 25631771.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    40. Keshari RS, Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Chaaban H, Lambris JD, Polf H, Lupu C, Kinasewitz G, Lupu F. Acute lung injury and fibrosis in a baboon model of Escherichia coli sepsis. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):439-50. PMID: 24066737.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    41. Chaaban H, Stonestreet BS. Intestinal hemodynamics and oxygenation in the perinatal period. Semin Perinatol. 2012 Aug; 36(4):260-8. PMID: 22818546.
      Citations: 8     Fields:    Translation:Humans
    42. Chaaban H, Shin M, Sirya E, Lim YP, Caplan M, Padbury JF. Inter-alpha inhibitor protein level in neonates predicts necrotizing enterocolitis. J Pediatr. 2010 Nov; 157(5):757-61. PMID: 20955849.
      Citations: 34     Fields:    Translation:Humans
    43. Chaaban H, Singh K, Huang J, Siryaporn E, Lim YP, Padbury JF. The role of inter-alpha inhibitor proteins in the diagnosis of neonatal sepsis. J Pediatr. 2009 Apr; 154(4):620-622.e1. PMID: 19324226.
      Citations: 30     Fields:    Translation:Humans
    44. Mikati MA, Chaaban HR, Karam PE, Krishnamoorthy KS. Brain malformation and infantile spasms in a SCAD deficiency patient. Pediatr Neurol. 2007 Jan; 36(1):48-50. PMID: 17162197.
      Citations: 7     Fields:    Translation:Humans
    45. Uthman IW, Chaaban H. The use of sildenafil in pediatric Takayasu arteritis. Clin Rheumatol. 2006 Jul; 25(4):550. PMID: 16220221.
      Citations: 4     Fields:    Translation:Humans
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