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Marie H Hanigan

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBRC 264
975 NE 10th St
Oklahoma City OK 73104
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    R01CA057530     (HANIGAN, MARIE H)Aug 1, 1992 - Aug 31, 2009
    Significance of GGT Expression in Tumors
    Role: Principal Investigator

    R56CA057530     (HANIGAN, MARIE H)Aug 1, 1992 - Aug 31, 2011
    Significance of GGT Expression in Tumors
    Role: Principal Investigator

    R01GM125952     (HANIGAN, MARIE H)Sep 1, 2018 - Aug 31, 2021
    Mechanistic studies of gamma-glutamyl transpeptidase inhibition: A novel approach to modulating serum levels of cysteine
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Terzyan SS, Nguyen LT, Burgett AWG, Heroux A, Smith CA, You Y, Hanigan MH. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J Biol Chem. 2021 Jan-Jun; 296:100066. PMID: 33187988.
      Citations:    Fields:    Translation:HumansCells
    2. Terzyan SS, Cook PF, Heroux A, Hanigan MH. Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 06; 26(6):1196-1205. PMID: 28378915.
      Citations: 4     Fields:    Translation:HumansCells
      Citations: 14     Fields:    Translation:HumansCells
    4. West MB, Partyka K, Feasley CL, Maupin KA, Goppallawa I, West CM, Haab BB, Hanigan MH. Detection of distinct glycosylation patterns on human ?-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotechnol. 2014 Dec 06; 14:101. PMID: 25479762.
      Citations: 1     Fields:    Translation:HumansCells
    5. Hanigan MH, Gillies EM, Wickham S, Wakeham N, Wirsig-Wiechmann CR. Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol. 2015 May; 143(5):505-15. PMID: 25377544.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    6. Hanigan MH. Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res. 2014; 122:103-41. PMID: 24974180.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    7. West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13. PMID: 24047895.
      Citations: 22     Fields:    Translation:HumansCells
    8. West MB, Wickham S, Parks EE, Sherry DM, Hanigan MH. Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling. Antioxid Redox Signal. 2013 Dec 01; 19(16):1877-88. PMID: 23682772.
      Citations: 7     Fields:    Translation:HumansCells
    9. Wickham S, Regan N, West MB, Thai J, Cook PF, Terzyan SS, Li PK, Hanigan MH. Inhibition of human ?-glutamyl transpeptidase: development of more potent, physiologically relevant, uncompetitive inhibitors. Biochem J. 2013 Mar 15; 450(3):547-57. PMID: 23301618.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    10. Cooper AJ, Hanigan MH. Food and Chemical Toxicology, 2011, 'Possible role of cysteine-S-conjugate ß-lyase in species differences in cisplatin nephrotoxicity', R. Katayama, S. Nagata, H. Iida, N. Yamagishi, T. Yamashita, K. Furuhama. Food Chem Toxicol. 2011 Dec; 49(12):3279-80. PMID: 21925563.
      Citations:    Fields:    Translation:Animals
    11. Wickham S, Regan N, West MB, Kumar VP, Thai J, Li PK, Cook PF, Hanigan MH. Divergent effects of compounds on the hydrolysis and transpeptidation reactions of ?-glutamyl transpeptidase. J Enzyme Inhib Med Chem. 2012 Aug; 27(4):476-89. PMID: 21864033.
      Citations: 6     Fields:    Translation:HumansCells
    12. West MB, Wickham S, Quinalty LM, Pavlovicz RE, Li C, Hanigan MH. Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95. J Biol Chem. 2011 Aug 19; 286(33):28876-28888. PMID: 21712391.
      Citations: 14     Fields:    Translation:HumansCells
    13. Wickham S, West MB, Cook PF, Hanigan MH. Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes. Anal Biochem. 2011 Jul 15; 414(2):208-14. PMID: 21447318.
      Citations: 30     Fields:    Translation:Humans
    14. Hanigan MH, Dela Cruz BL, Shord SS, Medina PJ, Fazili J, Thompson DM. Optimizing chemotherapy: concomitant medication lists. Clin Pharmacol Ther. 2011 Jan; 89(1):114-9. PMID: 21124312.
      Citations: 4     Fields:    Translation:Humans
    15. West MB, Hanigan MH. ?-Glutamyl transpeptidase is a heavily N-glycosylated heterodimer in HepG2 cells. Arch Biochem Biophys. 2010 Dec 15; 504(2):177-81. PMID: 20831856.
      Citations: 4     Fields:    Translation:HumansCells
    16. Zheng J, Lou JR, Zhang XX, Benbrook DM, Hanigan MH, Lind SE, Ding WQ. N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death. Cancer Lett. 2010 Dec 08; 298(2):186-94. PMID: 20667650.
      Citations: 18     Fields:    Translation:HumansCells
    17. West MB, Segu ZM, Feasley CL, Kang P, Klouckova I, Li C, Novotny MV, West CM, Mechref Y, Hanigan MH. Analysis of site-specific glycosylation of renal and hepatic ?-glutamyl transpeptidase from normal human tissue. J Biol Chem. 2010 Sep 17; 285(38):29511-24. PMID: 20622017.
      Citations: 24     Fields:    Translation:HumansCells
    18. Hanigan MH. Possible role of mammography in increased incidence of breast cancer not considered. Arch Intern Med. 2009 May 25; 169(10):998-9. PMID: 19468098.
      Citations:    Fields:    Translation:Humans
    19. King JB, West MB, Cook PF, Hanigan MH. A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase. J Biol Chem. 2009 Apr 03; 284(14):9059-65. PMID: 19203993.
      Citations: 27     Fields:    Translation:AnimalsCells
    20. Hanigan MH. Over-the-counter medications and cancer patients: growing awareness of drug-drug interactions. Expert Opin Drug Metab Toxicol. 2009 Feb; 5(2):105-7. PMID: 19199376.
      Citations:    Fields:    Translation:HumansAnimals
    21. Hanigan MH, Townsend DM, Cooper AJ. Metabolism of cisplatin to a nephrotoxin. Toxicology. 2009 Mar 29; 257(3):174-5; author reply 176-7. PMID: 19135119.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    22. Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP. Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology. 2009 Feb 05; 384(1):125-34. PMID: 19041112.
      Citations: 22     Fields:    Translation:HumansCells
    23. Townsend DM, Tew KD, He L, King JB, Hanigan MH. Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity. Biomed Pharmacother. 2009 Feb; 63(2):79-85. PMID: 18819770.
      Citations: 33     Fields:    Translation:Animals
    24. Hanigan MH, Dela Cruz BL, Thompson DM, Farmer KC, Medina PJ. Use of prescription and nonprescription medications and supplements by cancer patients during chemotherapy: questionnaire validation. J Oncol Pharm Pract. 2008 Sep; 14(3):123-30. PMID: 18719067.
      Citations: 14     Fields:    Translation:Humans
    25. Ju T, Lanneau GS, Gautam T, Wang Y, Xia B, Stowell SR, Willard MT, Wang W, Xia JY, Zuna RE, Laszik Z, Benbrook DM, Hanigan MH, Cummings RD. Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc. Cancer Res. 2008 Mar 15; 68(6):1636-46. PMID: 18339842.
      Citations: 118     Fields:    Translation:HumansCells
    26. Zhang L, Cooper AJ, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH. Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry. 2006 Jul 25; 45(29):8959-71. PMID: 16846239.
      Citations: 18     Fields:    Translation:AnimalsCells
    27. Shord SS, Thompson DM, Krempl GA, Hanigan MH. Effect of concurrent medications on cisplatin-induced nephrotoxicity in patients with head and neck cancer. Anticancer Drugs. 2006 Feb; 17(2):207-15. PMID: 16428940.
      Citations: 34     Fields:    Translation:Humans
    28. Zaman K, Hanigan MH, Smith A, Vaughan J, Macdonald T, Jones DR, Hunt JF, Gaston B. Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol. 2006 Apr; 34(4):387-93. PMID: 16415251.
      Citations: 13     Fields:    Translation:HumansCells
    29. Min J, Van Veldhoven PP, Zhang L, Hanigan MH, Alexander H, Alexander S. Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner. Mol Cancer Res. 2005 May; 3(5):287-96. PMID: 15886300.
      Citations: 38     Fields:    Translation:HumansCells
    30. Min J, Traynor D, Stegner AL, Zhang L, Hanigan MH, Alexander H, Alexander S. Sphingosine kinase regulates the sensitivity of Dictyostelium discoideum cells to the anticancer drug cisplatin. Eukaryot Cell. 2005 Jan; 4(1):178-89. PMID: 15643073.
      Citations: 14     Fields:    Translation:AnimalsCells
    31. Hanigan MH, Deng M, Zhang L, Taylor PT, Lapus MG. Stress response inhibits the nephrotoxicity of cisplatin. Am J Physiol Renal Physiol. 2005 Jan; 288(1):F125-32. PMID: 15353400.
      Citations: 9     Fields:    Translation:AnimalsCells
    32. Townsend DM, Marto JA, Deng M, Macdonald TJ, Hanigan MH. High pressure liquid chromatography and mass spectrometry characterization of the nephrotoxic biotransformation products of Cisplatin. Drug Metab Dispos. 2003 Jun; 31(6):705-13. PMID: 12756201.
      Citations: 16     Fields:    Translation:AnimalsCells
    33. Zhang L, Hanigan MH. Role of cysteine S-conjugate beta-lyase in the metabolism of cisplatin. J Pharmacol Exp Ther. 2003 Sep; 306(3):988-94. PMID: 12750429.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    34. Townsend DM, Deng M, Zhang L, Lapus MG, Hanigan MH. Metabolism of Cisplatin to a nephrotoxin in proximal tubule cells. J Am Soc Nephrol. 2003 Jan; 14(1):1-10. PMID: 12506132.
      Citations: 88     Fields:    Translation:AnimalsCells
    35. Hanigan MH, Devarajan P. Cisplatin nephrotoxicity: molecular mechanisms. Cancer Ther. 2003; 1:47-61. PMID: 18185852.
    36. Townsend DM, Hanigan MH. Inhibition of gamma-glutamyl transpeptidase or cysteine S-conjugate beta-lyase activity blocks the nephrotoxicity of cisplatin in mice. J Pharmacol Exp Ther. 2002 Jan; 300(1):142-8. PMID: 11752109.
      Citations: 33     Fields:    Translation:Animals
    37. Hanigan MH, Lykissa ED, Townsend DM, Ou CN, Barrios R, Lieberman MW. Gamma-glutamyl transpeptidase-deficient mice are resistant to the nephrotoxic effects of cisplatin. Am J Pathol. 2001 Nov; 159(5):1889-94. PMID: 11696449.
      Citations: 30     Fields:    Translation:Animals
    38. Hanigan MH, Frierson HF, Abeler VM, Kaern J, Taylor PT. Human germ cell tumours: expression of gamma-glutamyl transpeptidase and sensitivity to cisplatin. Br J Cancer. 1999 Sep; 81(1):75-9. PMID: 10487615.
      Citations: 2     Fields:    Translation:Humans
    39. Hanigan MH, Gallagher BC, Townsend DM, Gabarra V. Gamma-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo. Carcinogenesis. 1999 Apr; 20(4):553-9. PMID: 10223181.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    40. Hanigan MH, Frierson HF, Swanson PE, De Young BR. Altered expression of gamma-glutamyl transpeptidase in human tumors. Hum Pathol. 1999 Mar; 30(3):300-5. PMID: 10088549.
      Citations: 35     Fields:    Translation:Humans
    41. Hanigan MH, Frierson HF, Taylor PT. Expression of gamma-glutamyl transpeptidase in stage III and IV ovarian surface epithelial carcinomas does not alter response to primary cisplatin-based chemotherapy. Am J Obstet Gynecol. 1998 Aug; 179(2):363-7. PMID: 9731839.
      Citations: 4     Fields:    Translation:Humans
    42. Gallagher BC, Rudolph DB, Hinton BT, Hanigan MH. Differential induction of gamma-glutamyl transpeptidase in primary cultures of rat and mouse hepatocytes parallels induction during hepatocarcinogenesis. Carcinogenesis. 1998 Jul; 19(7):1251-5. PMID: 9683185.
      Citations: 4     Fields:    Translation:AnimalsCells
    43. Nishimura T, Newkirk K, Sessions RB, Andrews PA, Trock BJ, Rusmussen AA, Montogomery EA, Bischoff EK, Hanigan MH, Cullen KJ. Association between expression of glutathione-associated enzymes and response to platinum-based chemotherapy in head and neck cancer. Chem Biol Interact. 1998 Apr 24; 111-112:187-98. PMID: 9679554.
      Citations: 9     Fields:    Translation:Humans
    44. Hanigan MH. gamma-Glutamyl transpeptidase, a glutathionase: its expression and function in carcinogenesis. Chem Biol Interact. 1998 Apr 24; 111-112:333-42. PMID: 9679564.
      Citations: 32     Fields:    Translation:HumansAnimals
    45. Durham JR, Frierson HF, Hanigan MH. Gamma-glutamyl transpeptidase immunoreactivity in benign and malignant breast tissue. Breast Cancer Res Treat. 1997 Aug; 45(1):55-62. PMID: 9285117.
      Citations: 7     Fields:    Translation:Humans
    46. Frierson HF, Theodorescu D, Mills SE, Hanigan MH. gamma-Glutamyl transpeptidase in normal and neoplastic prostate glands. Mod Pathol. 1997 Jan; 10(1):1-6. PMID: 9021720.
      Citations: 5     Fields:    Translation:Humans
    47. Hanigan MH, Frierson HF. Immunohistochemical detection of gamma-glutamyl transpeptidase in normal human tissue. J Histochem Cytochem. 1996 Oct; 44(10):1101-8. PMID: 8813074.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    48. Nichols GE, Frierson HF, Boyd JC, Hanigan MH. Automated immunohistochemical assay for estrogen receptor status in breast cancer using monoclonal antibody CC4-5 on the Ventana ES. Am J Clin Pathol. 1996 Sep; 106(3):332-8. PMID: 8816590.
      Citations: 5     Fields:    Translation:Humans
    49. Hanigan MH, Gallagher BC, Taylor PT. Cisplatin nephrotoxicity: inhibition of gamma-glutamyl transpeptidase blocks the nephrotoxicity of cisplatin without reducing platinum concentrations in the kidney. Am J Obstet Gynecol. 1996 Aug; 175(2):270-3; discussion 273-4. PMID: 8765241.
      Citations: 9     Fields:    Translation:Animals
    50. Hanigan MH. Expression of gamma-glutamyl transpeptidase provides tumor cells with a selective growth advantage at physiologic concentrations of cyst(e)ine. Carcinogenesis. 1995 Feb; 16(2):181-5. PMID: 7859346.
      Citations: 20     Fields:    Translation:AnimalsCells
    51. Hanigan MH, Gallagher BC, Taylor PT, Large MK. Inhibition of gamma-glutamyl transpeptidase activity by acivicin in vivo protects the kidney from cisplatin-induced toxicity. Cancer Res. 1994 Nov 15; 54(22):5925-9. PMID: 7954424.
      Citations: 27     Fields:    Translation:Animals
    52. Hanigan MH, Frierson HF, Brown JE, Lovell MA, Taylor PT. Human ovarian tumors express gamma-glutamyl transpeptidase. Cancer Res. 1994 Jan 01; 54(1):286-90. PMID: 7903206.
      Citations: 18     Fields:    Translation:Humans
    53. Hanigan MH, Brown JE, Ricketts WA. Gamma-glutamyl transpeptidase, a glutathionase, is present in some cell culture grade bovine sera. In Vitro Cell Dev Biol Anim. 1993 Nov; 29A(11):831-3. PMID: 7909487.
      Citations: 1     Fields:    Translation:Animals
    54. Hanigan MH, Ricketts WA. Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase. Biochemistry. 1993 Jun 22; 32(24):6302-6. PMID: 8099811.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    55. Hanigan MH, Winkler ML, Drinkwater NR. Induction of three histochemically distinct populations of hepatic foci in C57BL/6J mice. Carcinogenesis. 1993 May; 14(5):1035-40. PMID: 8099313.
      Citations: 4     Fields:    Translation:Animals
    56. Hanigan MH, Winkler ML, Drinkwater NR. Partial hepatectomy is a promoter of hepatocarcinogenesis in C57BL/6J male mice but not in C3H/HeJ male mice. Carcinogenesis. 1990 Apr; 11(4):589-94. PMID: 2323000.
      Citations: 11     Fields:    Translation:Animals
    57. Campbell HA, Xu YD, Hanigan MH, Pitot HC. Application of quantitative stereology to the evaluation of phenotypically heterogeneous enzyme-altered foci in the rat liver. J Natl Cancer Inst. 1986 Apr; 76(4):751-67. PMID: 2870209.
      Citations: 16     Fields:    Translation:Animals
    58. Hanigan MH, Pitot HC. Growth of carcinogen-altered rat hepatocytes in the liver of syngeneic recipients promoted with phenobarbital. Cancer Res. 1985 Dec; 45(12 Pt 1):6063-70. PMID: 3904978.
      Citations: 4     Fields:    Translation:Animals
    59. Hanigan MH, Pitot HC. Activities of benzphetamine N-demethylase and aryl hydrocarbon hydroxylase in cells isolated from gamma-glutamyl transpeptidase-positive foci and surrounding liver. J Natl Cancer Inst. 1985 Dec; 75(6):1107-12. PMID: 2866268.
      Citations: 3     Fields:    Translation:Animals
    60. Pitot HC, Glauert HP, Hanigan M. The significance of selected biochemical markers in the characterization of putative initiated cell populations in rodent liver. Cancer Lett. 1985 Oct; 29(1):1-14. PMID: 2866027.
      Citations: 5     Fields:    Translation:Animals
    61. Hanigan MH, Pitot HC. Gamma-glutamyl transpeptidase--its role in hepatocarcinogenesis. Carcinogenesis. 1985 Feb; 6(2):165-72. PMID: 2857599.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
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