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Xichun Yu

TitleProf of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentMedicine Endocrinology
AddressORB 331
1122 NE 13th St
Oklahoma City OK 73117
Phone405/271-5896 ext 47779
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    R01HL128393     (YU, XICHUN)Sep 4, 2015 - Apr 30, 2025
    Autoimmune Basis for Postural Tachycardia Syndrome
    Role: Principal Investigator

    R56HL128393     (YU, XICHUN)Sep 4, 2015 - Dec 31, 2016
    Autoimmune Basis for Postural Tachycardia Syndrome
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chakraborty P, Farhat K, Morris L, Whyte S, Yu X, Stavrakis S. Non-invasive Vagus Nerve Simulation in Postural Orthostatic Tachycardia Syndrome. Arrhythm Electrophysiol Rev. 2023; 12:e31. PMID: 38173801; PMCID: PMC10762669.
    2. Stavrakis S, Chakraborty P, Farhat K, Whyte S, Morris L, Abideen Asad ZU, Karfonta B, Anjum J, Matlock HG, Cai X, Yu X. Noninvasive Vagus Nerve Stimulation in?Postural Tachycardia Syndrome: A Randomized Clinical Trial. JACC Clin Electrophysiol. 2023 Nov 10. PMID: 37999672.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Guo Y, Li H, Deng J, Zhang G, Fischer H, Stavrakis S, Yu X. Low-level tragus stimulation improves autoantibody-induced hyperadrenergic postural tachycardia syndrome in rabbits. Heart Rhythm O2. 2023 Feb; 4(2):127-133. PMID: 36873318; PMCID: PMC9975011.
      Citations: 3     
    4. Deng J, Li H, Guo Y, Zhang G, Fischer H, Stavrakis S, Yu X. Transcutaneous vagus nerve stimulation attenuates autoantibody-mediated cardiovagal dysfunction and inflammation in a rabbit model of postural tachycardia syndrome. J Interv Card Electrophysiol. 2022 Feb 04. PMID: 35118574.
      Citations: 5     Fields:    Translation:Animals
    5. Li H, Guo Y, Deng J, Gali H, Weedin EA, Burks HR, Craig LB, Yu X. GnRH receptor-activating autoantibodies in polycystic ovary syndrome: identification of functional epitopes and development of epitope mimetic inhibitors. Endocrine. 2022 Mar; 75(3):959-963. PMID: 34807394.
      Citations: 1     Fields:    Translation:Humans
    6. Li H, Zhang G, Forsythe E, Okamoto LE, Yu X. Implications of Antimuscarinic Autoantibodies in Postural Tachycardia Syndrome. J Cardiovasc Transl Res. 2022 04; 15(2):438-440. PMID: 34409582.
      Citations: 4     Fields:    Translation:Humans
    7. Li H, Guo Y, Deng J, Fischer H, Weedin EA, Burks HR, Craig LB, Yu X. Increased testosterone and proinflammatory cytokines in patients with polycystic ovary syndrome correlate with elevated GnRH receptor autoantibody activity assessed by a fluorescence resonance energy transfer-based bioassay. Endocrine. 2021 10; 74(1):163-171. PMID: 34013495.
      Citations: 4     Fields:    Translation:HumansCells
    8. Li H, Guo Y, Zhang G, Deng J, Fischer H, Craig LB, Yu X, Kem DC. Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model. Exp Physiol. 2021 04; 106(4):902-912. PMID: 33576068.
      Citations: 2     Fields:    Translation:Animals
    9. Li H, Zhang G, Guo Y, Deng J, Fischer H, Craig LB, Kem DC, Yu X. Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model. Physiol Rep. 2021 01; 8(24):e14672. PMID: 33356018.
      Citations: 3     Fields:    Translation:Animals
    10. Weedin EA, Burks HR, Yu X, Li HL, Aston CE, Kem DC, Craig LB. Elevated activity levels of activating autoantibodies to the GnRH receptor in patients with polycystic ovary syndrome. F S Rep. 2020 Dec; 1(3):299-304. PMID: 34223260.
      Citations: 2     
    11. Kem DC, Li H, Yu X, Weedin E, Reynolds AC, Forsythe E, Beel M, Fischer H, Hines B, Guo Y, Deng J, Liles JT, Nuss Z, Elkosseifi M, Aston CE, Burks HR, Craig LB. The Role of GnRH Receptor Autoantibodies in Polycystic Ovary Syndrome. J Endocr Soc. 2020 Aug 01; 4(8):bvaa078. PMID: 32803090.
      Citations: 7     
    12. Deng J, Wang M, Guo Y, Fischer H, Yu X, Kem D, Li H. Activation of a7nAChR via vagus nerve prevents obesity-induced insulin resistance via suppressing endoplasmic reticulum stress-induced inflammation in Kupffer cells. Med Hypotheses. 2020 Mar 14; 140:109671. PMID: 32182560.
      Citations: 3     Fields:    
    13. Li H, Zhang G, Zhou L, Nuss Z, Beel M, Hines B, Murphy T, Liles J, Zhang L, Kem DC, Yu X. Adrenergic Autoantibody-Induced Postural Tachycardia Syndrome in Rabbits. J Am Heart Assoc. 2019 10; 8(19):e013006. PMID: 31547749.
      Citations: 19     Fields:    Translation:AnimalsPHPublic Health
    14. Yu X, Li H, Murphy TA, Nuss Z, Liles J, Liles C, Aston CE, Raj SR, Fedorowski A, Kem DC. Angiotensin II Type 1 Receptor Autoantibodies in Postural Tachycardia Syndrome. J Am Heart Assoc. 2018 04 04; 7(8). PMID: 29618472.
      Citations: 36     Fields:    Translation:Humans
    15. Li H, Murphy T, Zhang L, Huang B, Veitla V, Scherlag BJ, Kem DC, Yu X. ß1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits. Endocrinology. 2016 Jan; 157(1):16-22. PMID: 26517045.
      Citations: 9     Fields:    Translation:AnimalsCells
    16. Li H, Zhang L, Huang B, Veitla V, Scherlag BJ, Cunningham MW, Aston CE, Kem DC, Yu X. A peptidomimetic inhibitor suppresses the inducibility of ß1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J Interv Card Electrophysiol. 2015 Dec; 44(3):205-12. PMID: 26446828.
      Citations: 7     Fields:    Translation:AnimalsCells
    17. Liles C, Li H, Veitla V, Liles JT, Murphy TA, Cunningham MW, Yu X, Kem DC. AT2R autoantibodies block angiotensin II and AT1R autoantibody-induced vasoconstriction. Hypertension. 2015 Oct; 66(4):830-5. PMID: 26259590.
      Citations: 10     Fields:    Translation:HumansAnimals
    18. Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW, Yu X. Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension. 2015 Apr; 65(4):793-9. PMID: 25691619.
      Citations: 19     Fields:    Translation:Animals
    19. Galloway A, Li H, Vanderlinde-Wood M, Khan M, Benbrook A, Liles C, Zillner C, Rao V, Cunningham MW, Yu X, Kem DC. Activating autoantibodies to the ß1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism. Endocrine. 2015 Jun; 49(2):457-63. PMID: 25500789.
      Citations: 11     Fields:    Translation:Humans
    20. Li H, Yu X, Cicala MV, Mantero F, Benbrook A, Veitla V, Cunningham MW, Kem DC. Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in primary aldosteronism. J Am Soc Hypertens. 2015 Jan; 9(1):15-20. PMID: 25537460.
      Citations: 16     Fields:    Translation:Humans
    21. Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R, Yu X. Atrial tachyarrhythmias induced by the combined effects of ß1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J Cardiovasc Transl Res. 2014 Aug; 7(6):581-9. PMID: 24903978.
      Citations: 5     Fields:    Translation:Animals
    22. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The Propensity for Inducing Atrial Fibrillation: A Comparative Study on Old versus Young Rabbits. J Aging Res. 2014; 2014:684918. PMID: 24719763.
      Citations: 4     
    23. Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc. 2014 Feb 26; 3(1):e000755. PMID: 24572257.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    24. Kem DC, Li H, Velarde-Miranda C, Liles C, Vanderlinde-Wood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in 'primary' aldosteronism. J Clin Endocrinol Metab. 2014 May; 99(5):1790-7. PMID: 24552217.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    25. Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced ß1-adrenergic autoantibody expression in the rabbit. Am J Physiol Heart Circ Physiol. 2014 Feb; 306(3):H422-8. PMID: 24271491.
      Citations: 10     Fields:    Translation:Animals
    26. Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem. 2013 Oct 18; 288(42):30734-30741. PMID: 24043632.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    27. Li H, Yu X. Emerging role of JNK in insulin resistance. Curr Diabetes Rev. 2013 Sep; 9(5):422-8. PMID: 23865415.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    28. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to ß2-adrenergic receptor in the rabbit. Heart Rhythm. 2013 Mar; 10(3):436-41. PMID: 23178688.
      Citations: 12     Fields:    Translation:Animals
    29. Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X. Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension. 2012 Feb; 59(2):402-8. PMID: 22215709.
      Citations: 26     Fields:    Translation:HumansAnimals
    30. Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H, Khan M, Hamlett S, Cunningham MW, Kem DC. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. J Am Soc Hypertens. 2012 Jan-Feb; 6(1):40-7. PMID: 22130180.
      Citations: 23     Fields:    Translation:Humans
    31. Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Lazzara R, Yu X. Opposing cardiac effects of autoantibody activation of ß-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol. 2011 May 05; 148(3):331-6. PMID: 20053466.
      Citations: 18     Fields:    Translation:HumansAnimals
    32. Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, Kem DC. Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves' hyperthyroidism. J Am Coll Cardiol. 2009 Sep 29; 54(14):1309-16. PMID: 19778674.
      Citations: 44     Fields:    Translation:HumansAnimals
    33. Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res. 2010 Jan 15; 85(2):312-20. PMID: 19744947.
      Citations: 35     Fields:    Translation:HumansAnimals
    34. Yu X, Patterson E, Stavrakis S, Huang S, De Aos I, Hamlett S, Cunningham MW, Lazarra R, Kem DC. Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors. J Am Soc Hypertens. 2009 Mar-Apr; 3(2):133-40. PMID: 20409953.
      Citations: 5     Fields:    
    35. Yu X, Patterson E, Kem DC. Targeting proteasomes for cardioprotection. Curr Opin Pharmacol. 2009 Apr; 9(2):167-72. PMID: 19097937.
      Citations: 10     Fields:    Translation:HumansAnimals
    36. Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, Cunningham MW. Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity. 2008 Sep; 41(6):442-53. PMID: 18781470.
      Citations: 35     Fields:    Translation:HumansCells
    37. Huang S, Patterson E, Yu X, Garrett MW, De Aos I, Kem DC. Proteasome inhibition 1 h following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1298-303. PMID: 18192226.
      Citations: 11     Fields:    Translation:Animals
    38. Kem DC, Yu X, Patterson E, Huang S, Stavrakis S, Szabo B, Olansky L, McCauley J, Cunningham MW. Autoimmune hypertensive syndrome. Hypertension. 2007 Nov; 50(5):829-34. PMID: 17923587.
      Citations: 6     Fields:    Translation:HumansAnimals
    39. Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X. Is pseudo-Cushing's syndrome in a critically ill patient "pseudo"? Hypothesis and supportive case report. Endocr Pract. 2007 Mar-Apr; 13(2):153-8. PMID: 17490929.
      Citations: 1     Fields:    Translation:Humans
    40. Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol. 2007 Feb 19; 6:6. PMID: 17309798.
      Citations: 27     Fields:    Translation:AnimalsCells
    41. Patterson E, Yu X, Huang S, Garrett M, Kem DC. Suppression of autonomic-mediated triggered firing in pulmonary vein preparations, 24 hours postcoronary artery ligation in dogs. J Cardiovasc Electrophysiol. 2006 Jul; 17(7):763-70. PMID: 16836675.
      Citations: 5     Fields:    Translation:Animals
    42. Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol. 2005 Nov; 289(5):H1960-7. PMID: 15994860.
      Citations: 10     Fields:    Translation:Animals
    43. Kem DC, Lyons DF, Wenzl J, Halverstadt D, Yu X. Renin-dependent hypertension caused by nonfocal stenotic aberrant renal arteries: proof of a new syndrome. Hypertension. 2005 Aug; 46(2):380-5. PMID: 15967872.
      Citations: 11     Fields:    Translation:Humans
    44. Yu X, Patterson E, Huang S, Garrett MW, Kem DC. Tumor necrosis factor alpha, rapid ventricular tachyarrhythmias, and infarct size in canine models of myocardial infarction. J Cardiovasc Pharmacol. 2005 Feb; 45(2):153-9. PMID: 15654264.
      Citations: 10     Fields:    Translation:Animals
    45. Castro OL, Yu X, Kem DC. Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension. 2002 Apr; 39(4):935-8. PMID: 11967253.
      Citations: 8     Fields:    Translation:Humans
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