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Ann H West

TitleProfessor
InstitutionUniversity of Oklahoma, Norman
DepartmentChemistry/Biochemistry
Addressn/a
620 Parrington Oval
Norman OK 73019
Phone405/325-1529
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    Collapse Research 
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    P30GM145423     (WEST, ANN H)Jun 1, 2022 - May 31, 2027
    NIH
    Oklahoma COBRE in Structural Biology
    Role: Principal Investigator
    P20GM103640     (WEST, ANN H)Aug 1, 2012 - May 31, 2022
    NIH
    Oklahoma COBRE in Structural Biology
    Role: Principal Investigator
    R01GM059311     (WEST, ANN H)May 1, 1999 - Apr 30, 2010
    NIH
    Histidine to Aspartate Phosphoryl Transfer in Yeast
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kempher ML, Morris SC, Shadid TM, Menon SK, Ballard JD, West AH. Response Regulator CD1688 Is a Negative Modulator of Sporulation in Clostridioides difficile. J Bacteriol. 2022 08 16; 204(8):e0013022. PMID: 35852332.
      Citations: 5     Fields:    Translation:Cells
    2. Branscum KM, Menon SK, Foster CA, West AH. Insights revealed by the co-crystal structure of the Saccharomyces cerevisiae histidine phosphotransfer protein Ypd1 and the receiver domain of its downstream response regulator Ssk1. Protein Sci. 2019 12; 28(12):2099-2111. PMID: 31642125.
      Citations: 4     Fields:    Translation:Cells
    3. Kennedy EN, Hebdon SD, Menon SK, Foster CA, Copeland DM, Xu Q, Janiak-Spens F, West AH. Role of the highly conserved G68 residue in the yeast phosphorelay protein Ypd1: implications for interactions between histidine phosphotransfer (HPt) and response regulator proteins. BMC Biochem. 2019 01 21; 20(1):1. PMID: 30665347.
      Citations: 2     Fields:    Translation:AnimalsCells
    4. Hebdon SD, Menon SK, Richter-Addo GB, Karr EA, West AH. Regulatory Targets of the Response Regulator RR_1586 from Clostridioides difficile Identified Using a Bacterial One-Hybrid Screen. J Bacteriol. 2018 12 01; 200(23). PMID: 30201779.
      Citations: 4     Fields:    Translation:Cells
    5. Foster CA, West AH. Use of restrained molecular dynamics to predict the conformations of phosphorylated receiver domains in two-component signaling systems. Proteins. 2017 01; 85(1):155-176. PMID: 27802580.
      Citations: 4     Fields:    Translation:AnimalsCells
    6. Isom CE, Menon SK, Thomas LM, West AH, Richter-Addo GB, Karr EA. Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291. BMC Microbiol. 2016 Oct 04; 16(1):231. PMID: 27716049.
      Citations: 7     Fields:    Translation:Cells
    7. Wang B, Powell SM, Hessami N, Najar FZ, Thomas LM, Karr EA, West AH, Richter-Addo GB. Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole. Nitric Oxide. 2016 11 30; 60:32-39. PMID: 27623089.
      Citations: 2     Fields:    Translation:Cells
    8. Kennedy EN, Menon SK, West AH. Extended N-terminal region of the essential phosphorelay signaling protein Ypd1 from Cryptococcus neoformans contributes to structural stability, phosphostability and binding of calcium ions. FEMS Yeast Res. 2016 09; 16(6). PMID: 27549628.
      Citations: 5     Fields:    Translation:AnimalsCells
    9. Vashishtha AK, West AH, Cook PF. Probing the chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae using site-directed mutagenesis. Arch Biochem Biophys. 2015 Oct 15; 584:98-106. PMID: 26342457.
      Citations:    Fields:    Translation:Animals
    10. Hsu C, West AH, Cook PF. Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme. Arch Biochem Biophys. 2015 Oct 15; 584:20-7. PMID: 26325079.
      Citations:    Fields:    Translation:AnimalsCells
    11. Fassler JS, West AH. Histidine phosphotransfer proteins in fungal two-component signal transduction pathways. Eukaryot Cell. 2013 Aug; 12(8):1052-60. PMID: 23771905.
      Citations: 30     Fields:    Translation:AnimalsCells
    12. Popova L, Smith K, West AH, Wilson PC, James JA, Thompson LF, Air GM. Immunodominance of antigenic site B over site A of hemagglutinin of recent H3N2 influenza viruses. PLoS One. 2012; 7(7):e41895. PMID: 22848649.
      Citations: 63     Fields:    Translation:HumansCellsPHPublic Health
    13. Kumar VP, West AH, Cook PF. Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2012 Jun 01; 522(1):57-61. PMID: 22521736.
      Citations: 3     Fields:    Translation:AnimalsCells
    14. Kumar VP, Thomas LM, Bobyk KD, Andi B, Cook PF, West AH. Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2012 Jan 31; 51(4):857-66. PMID: 22243403.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Bobyk KD, Kim SG, Kumar VP, Kim SK, West AH, Cook PF. The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH. Arch Biochem Biophys. 2011 Sep 15; 513(2):71-80. PMID: 21798231.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Ekanayake DK, West AH, Cook PF. Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction. Arch Biochem Biophys. 2011 Oct; 514(1-2):8-15. PMID: 21819960.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Kumar VP, West AH, Cook PF. Kinetic and chemical mechanisms of homocitrate synthase from Thermus thermophilus. J Biol Chem. 2011 Aug 19; 286(33):29428-29439. PMID: 21733842.
      Citations: 2     Fields:    Translation:Cells
    18. Fassler JS, West AH. Fungal Skn7 stress responses and their relationship to virulence. Eukaryot Cell. 2011 Feb; 10(2):156-67. PMID: 21131436.
      Citations: 32     Fields:    Translation:AnimalsCells
    19. Ekanayake DK, Andi B, Bobyk KD, West AH, Cook PF. Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts. J Biol Chem. 2010 Jul 02; 285(27):20756-68. PMID: 20427272.
      Citations: 4     Fields:    Translation:AnimalsCells
    20. Kaserer AO, Andi B, Cook PF, West AH. Kinetic studies of the yeast His-Asp phosphorelay signaling pathway. Methods Enzymol. 2010; 471:59-75. PMID: 20946842.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Fassler JS, West AH. Genetic and biochemical analysis of the SLN1 pathway in Saccharomyces cerevisiae. Methods Enzymol. 2010; 471:291-317. PMID: 20946854.
      Citations: 11     Fields:    Translation:AnimalsCells
    22. Kaserer AO, Andi B, Cook PF, West AH. Effects of osmolytes on the SLN1-YPD1-SSK1 phosphorelay system from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 25; 48(33):8044-50. PMID: 19618914.
      Citations: 13     Fields:    Translation:AnimalsCells
    23. Lin Y, West AH, Cook PF. Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2009 Aug 04; 48(30):7305-12. PMID: 19530703.
      Citations: 4     Fields:    Translation:AnimalsCells
    24. Vashishtha AK, West AH, Cook PF. Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. Biochemistry. 2009 Jun 30; 48(25):5899-907. PMID: 19449898.
      Citations: 5     Fields:    Translation:Animals
    25. Lin Y, West AH, Cook PF. Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Oct 07; 47(40):10809-15. PMID: 18785753.
      Citations: 10     Fields:    Translation:AnimalsCells
    26. Qian J, Khandogin J, West AH, Cook PF. Evidence for a catalytic dyad in the active site of homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2008 Jul 01; 47(26):6851-8. PMID: 18533686.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. Vashishtha AK, West AH, Cook PF. Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae. Biochemistry. 2008 May 13; 47(19):5417-23. PMID: 18416559.
      Citations: 3     Fields:    Translation:Animals
    28. Lin Y, Volkman J, Nicholas KM, Yamamoto T, Eguchi T, Nimmo SL, West AH, Cook PF. Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2008 Apr 01; 47(13):4169-80. PMID: 18321070.
      Citations: 9     Fields:    Translation:AnimalsCells
    29. Zhao X, Copeland DM, Soares AS, West AH. Crystal structure of a complex between the phosphorelay protein YPD1 and the response regulator domain of SLN1 bound to a phosphoryl analog. J Mol Biol. 2008 Jan 25; 375(4):1141-51. PMID: 18076904.
      Citations: 33     Fields:    Translation:Cells
    30. Andi B, Xu H, Cook PF, West AH. Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Nov 06; 46(44):12512-21. PMID: 17939687.
      Citations: 8     Fields:    Translation:AnimalsCells
    31. Zahran ZN, Chooback L, Copeland DM, West AH, Richter-Addo GB. Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J Inorg Biochem. 2008 Feb; 102(2):216-33. PMID: 17905436.
      Citations: 14     Fields:    Translation:AnimalsCells
    32. Tan H, Janiak-Spens F, West AH. Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe. FEMS Yeast Res. 2007 Sep; 7(6):912-21. PMID: 17559414.
      Citations: 5     Fields:    Translation:AnimalsCells
    33. Xu H, West AH, Cook PF. Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jun 26; 46(25):7625-36. PMID: 17542618.
      Citations:    Fields:    Translation:AnimalsCells
    34. Xu H, Alguindigue SS, West AH, Cook PF. A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):871-82. PMID: 17223709.
      Citations: 7     Fields:    Translation:Animals
    35. Lin Y, Alguindigue SS, Volkman J, Nicholas KM, West AH, Cook PF. Complete kinetic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2007 Jan 23; 46(3):890-8. PMID: 17223711.
      Citations: 9     Fields:    Translation:Animals
    36. Menon V, Li D, Chauhan N, Rajnarayanan R, Dubrovska A, West AH, Calderone R. Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants. Mol Microbiol. 2006 Nov; 62(4):997-1013. PMID: 17038117.
      Citations: 19     Fields:    Translation:AnimalsCells
    37. Qian J, West AH, Cook PF. Acid-base chemical mechanism of homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 03; 45(39):12136-43. PMID: 17002313.
      Citations: 5     Fields:    Translation:AnimalsCells
    38. Xu H, West AH, Cook PF. Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 2006 Oct 03; 45(39):12156-66. PMID: 17002315.
      Citations: 8     Fields:    Translation:AnimalsCells
    39. Copeland DM, Soares AS, West AH, Richter-Addo GB. Crystal structures of the nitrite and nitric oxide complexes of horse heart myoglobin. J Inorg Biochem. 2006 Aug; 100(8):1413-25. PMID: 16777231.
      Citations: 27     Fields:    Translation:AnimalsCells
    40. Andi B, Cook PF, West AH. Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-A resolution. Cell Biochem Biophys. 2006; 46(1):17-26. PMID: 16943620.
      Citations: 4     Fields:    Translation:Cells
    41. Xu H, Andi B, Qian J, West AH, Cook PF. The alpha-aminoadipate pathway for lysine biosynthesis in fungi. Cell Biochem Biophys. 2006; 46(1):43-64. PMID: 16943623.
      Citations: 64     Fields:    Translation:AnimalsCells
    42. Andi B, West AH, Cook PF. Regulatory mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. I. Kinetic studies. J Biol Chem. 2005 Sep 09; 280(36):31624-32. PMID: 15897192.
      Citations: 11     Fields:    Translation:AnimalsCells
    43. Janiak-Spens F, Cook PF, West AH. Kinetic analysis of YPD1-dependent phosphotransfer reactions in the yeast osmoregulatory phosphorelay system. Biochemistry. 2005 Jan 11; 44(1):377-86. PMID: 15628880.
      Citations: 34     Fields:    Translation:AnimalsCells
    44. Porter SW, West AH. A common docking site for response regulators on the yeast phosphorelay protein YPD1. Biochim Biophys Acta. 2005 May 15; 1748(2):138-45. PMID: 15769590.
      Citations: 20     Fields:    Translation:AnimalsCells
    45. Andi B, West AH, Cook PF. Kinetic mechanism of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Biochemistry. 2004 Sep 21; 43(37):11790-5. PMID: 15362863.
      Citations: 8     Fields:    Translation:Animals
    46. Perez E, West AH, Stock AM, Djordjevic S. Discrimination between different methylation states of chemotaxis receptor Tar by receptor methyltransferase CheR. Biochemistry. 2004 Feb 03; 43(4):953-61. PMID: 14744139.
      Citations: 14     Fields:    Translation:Cells
    47. Andi B, West AH, Cook PF. Stabilization and characterization of histidine-tagged homocitrate synthase from Saccharomyces cerevisiae. Arch Biochem Biophys. 2004 Jan 15; 421(2):243-54. PMID: 14984204.
      Citations: 10     Fields:    Translation:AnimalsCells
    48. Xu Q, Porter SW, West AH. The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems. Structure. 2003 Dec; 11(12):1569-81. PMID: 14656441.
      Citations: 34     Fields:    Translation:AnimalsCells
    49. Copeland DM, West AH, Richter-Addo GB. Crystal structures of ferrous horse heart myoglobin complexed with nitric oxide and nitrosoethane. Proteins. 2003 Nov 01; 53(2):182-92. PMID: 14517970.
      Citations: 20     Fields:    Translation:Animals
    50. Chooback L, West AH. Co-crystallization of the yeast phosphorelay protein YPD1 with the SLN1 response-regulator domain and preliminary X-ray diffraction analysis. Acta Crystallogr D Biol Crystallogr. 2003 May; 59(Pt 5):927-9. PMID: 12777814.
      Citations: 1     Fields:    Translation:AnimalsCells
    51. Porter SW, Xu Q, West AH. Ssk1p response regulator binding surface on histidine-containing phosphotransfer protein Ypd1p. Eukaryot Cell. 2003 Feb; 2(1):27-33. PMID: 12582120.
      Citations: 11     Fields:    Translation:AnimalsCells
    52. Lee J, Chen L, West AH, Richter-Addo GB. Interactions of organic nitroso compounds with metals. Chem Rev. 2002 Apr; 102(4):1019-66. PMID: 11942786.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    53. Bourret RB, Charon NW, Stock AM, West AH. Bright lights, abundant operons--fluorescence and genomic technologies advance studies of bacterial locomotion and signal transduction: review of the BLAST meeting, Cuernavaca, Mexico, 14 to 19 January 2001. J Bacteriol. 2002 Jan; 184(1):1-17. PMID: 11741839.
      Citations: 9     Fields:    Translation:Cells
    54. West AH, Stock AM. Histidine kinases and response regulator proteins in two-component signaling systems. Trends Biochem Sci. 2001 Jun; 26(6):369-76. PMID: 11406410.
      Citations: 367     Fields:    Translation:Cells
    55. Janiak-Spens F, Sparling DP, West AH. Novel role for an HPt domain in stabilizing the phosphorylated state of a response regulator domain. J Bacteriol. 2000 Dec; 182(23):6673-8. PMID: 11073911.
      Citations: 29     Fields:    Translation:AnimalsCells
    56. Janiak-Spens F, West AH. Functional roles of conserved amino acid residues surrounding the phosphorylatable histidine of the yeast phosphorelay protein YPD1. Mol Microbiol. 2000 Jul; 37(1):136-44. PMID: 10931311.
      Citations: 20     Fields:    Translation:AnimalsCells
    57. Xu Q, West AH. Conservation of structure and function among histidine-containing phosphotransfer (HPt) domains as revealed by the crystal structure of YPD1. J Mol Biol. 1999 Oct 08; 292(5):1039-50. PMID: 10512701.
      Citations: 31     Fields:    Translation:AnimalsCells
    58. Janiak-Spens F, Sparling JM, Gurfinkel M, West AH. Differential stabilities of phosphorylated response regulator domains reflect functional roles of the yeast osmoregulatory SLN1 and SSK1 proteins. J Bacteriol. 1999 Jan; 181(2):411-7. PMID: 9882653.
      Citations: 27     Fields:    Translation:AnimalsCells
    59. Xu Q, Nguyen V, West AH. Purification, crystallization and preliminary X-ray diffraction analysis of the yeast phosphorelay protein YPD1. Acta Crystallogr D Biol Crystallogr. 1999 Jan; 55(Pt 1):291-3. PMID: 10089428.
      Citations: 7     Fields:    Translation:AnimalsCells
    60. Djordjevic S, Goudreau PN, Xu Q, Stock AM, West AH. Structural basis for methylesterase CheB regulation by a phosphorylation-activated domain. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1381-6. PMID: 9465023.
      Citations: 61     Fields:    Translation:Cells
    61. West AH, Martinez-Hackert E, Stock AM. Crystal structure of the catalytic domain of the chemotaxis receptor methylesterase, CheB. J Mol Biol. 1995 Jul 07; 250(2):276-90. PMID: 7608974.
      Citations: 20     Fields:    Translation:Cells
    62. West AH, Djordjevic S, Martinez-Hackert E, Stock AM. Purification, crystallization, and preliminary X-ray diffraction analyses of the bacterial chemotaxis receptor modifying enzymes. Proteins. 1995 Apr; 21(4):345-50. PMID: 7567955.
      Citations: 1     Fields:    Translation:Cells
    63. Stock AM, Martinez-Hackert E, Rasmussen BF, West AH, Stock JB, Ringe D, Petsko GA. Structure of the Mg(2+)-bound form of CheY and mechanism of phosphoryl transfer in bacterial chemotaxis. Biochemistry. 1993 Dec 14; 32(49):13375-80. PMID: 8257674.
      Citations: 70     Fields:    Translation:Cells
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