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James J Tomasek

TitlePres,Vc for Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentResearch Administration Office
AddressRP865 450
865 Research Parkway
Oklahoma City OK 73104
Phone405/271-1083
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    Collapse Research 
    Collapse research activities and funding
    R01GM060651     (TOMASEK, JAMES J)Feb 1, 2000 - Jul 31, 2019
    NIH
    Fibroblast Differentiation in Wound Healing
    Role: Principal Investigator

    R01AI047314     (TOMASEK, JAMES J)Apr 1, 2000 - Mar 31, 2006
    NIH
    ADHESIVE AND PROTEOLYTIC FUNCTION OF MDC-L
    Role: Principal Investigator

    R03EY014435     (TOMASEK, JAMES J)Jan 16, 2003 - Dec 31, 2006
    NIH
    Gene Therapy for Retinal Detachment
    Role: Principal Investigator

    P40OD010431     (TOMASEK, JAMES J)Jan 1, 2013 - Dec 31, 2017
    NIH
    OUHSC Specific Pathogen Free Baboon Research Resource
    Role: Principal Investigator

    C06OD028362     (TOMASEK, JAMES J)Sep 20, 2019 - Aug 31, 2021
    NIH
    Renovation and Construction for New Translational Research Animal Facility
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang C, Hays FA, Tomasek JJ, Benyajati S, Zhang XA. Tetraspanin CD82 interaction with cholesterol promotes extracellular vesicle-mediated release of ezrin to inhibit tumour cell movement. J Extracell Vesicles. 2020; 9(1):1692417. PMID: 31807237.
      Citations:    
    2. Ge Y, Weygant N, Qu D, May R, Berry WL, Yao J, Chandrakesan P, Zheng W, Zhao L, Zhao KL, Drake M, Vega KJ, Bronze MS, Tomasek JJ, An G, Houchen CW. Alternative splice variants of DCLK1 mark cancer stem cells, promote self-renewal and drug-resistance, and can be targeted to inhibit tumorigenesis in kidney cancer. Int J Cancer. 2018 09 01; 143(5):1162-1175. PMID: 29577277.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    3. Bergmeier V, Etich J, Pitzler L, Frie C, Koch M, Fischer M, Rappl G, Abken H, Tomasek JJ, Brachvogel B. Identification of a myofibroblast-specific expression signature in skin wounds. Matrix Biol. 2018 01; 65:59-74. PMID: 28797711.
      Citations: 12     Fields:    Translation:AnimalsCells
    4. Weygant N, Ge Y, Qu D, Kaddis JS, Berry WL, May R, Chandrakesan P, Bannerman-Menson E, Vega KJ, Tomasek JJ, Bronze MS, An G, Houchen CW. Survival of Patients with Gastrointestinal Cancers Can Be Predicted by a Surrogate microRNA Signature for Cancer Stem-like Cells Marked by DCLK1 Kinase. Cancer Res. 2016 07 15; 76(14):4090-9. PMID: 27287716.
      Citations: 10     Fields:    Translation:HumansCells
    5. Weygant N, Qu D, May R, Tierney RM, Berry WL, Zhao L, Agarwal S, Chandrakesan P, Chinthalapally HR, Murphy NT, Li JD, Sureban SM, Schlosser MJ, Tomasek JJ, Houchen CW. DCLK1 is a broadly dysregulated target against epithelial-mesenchymal transition, focal adhesion, and stemness in clear cell renal carcinoma. Oncotarget. 2015 Feb 10; 6(4):2193-205. PMID: 25605241.
      Citations: 26     Fields:    Translation:HumansCells
    6. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    7. Van De Water L, Varney S, Tomasek JJ. Mechanoregulation of the Myofibroblast in Wound Contraction, Scarring, and Fibrosis: Opportunities for New Therapeutic Intervention. Adv Wound Care (New Rochelle). 2013 May; 2(4):122-141. PMID: 24527336.
      Citations:    
    8. Tomasek JJ, Haaksma CJ, Schwartz RJ, Howard EW. Whole animal knockout of smooth muscle alpha-actin does not alter excisional wound healing or the fibroblast-to-myofibroblast transition. Wound Repair Regen. 2013 Jan-Feb; 21(1):166-76. PMID: 23253249.
      Citations: 13     Fields:    Translation:AnimalsCells
    9. Howard EW, Crider BJ, Updike DL, Bullen EC, Parks EE, Haaksma CJ, Sherry DM, Tomasek JJ. MMP-2 expression by fibroblasts is suppressed by the myofibroblast phenotype. Exp Cell Res. 2012 Aug 01; 318(13):1542-53. PMID: 22449415.
      Citations: 9     Fields:    Translation:AnimalsCells
    10. Crider BJ, Risinger GM, Haaksma CJ, Howard EW, Tomasek JJ. Myocardin-related transcription factors A and B are key regulators of TGF-ß1-induced fibroblast to myofibroblast differentiation. J Invest Dermatol. 2011 Dec; 131(12):2378-85. PMID: 21776010.
      Citations: 52     Fields:    Translation:AnimalsCells
    11. Haaksma CJ, Schwartz RJ, Tomasek JJ. Myoepithelial cell contraction and milk ejection are impaired in mammary glands of mice lacking smooth muscle alpha-actin. Biol Reprod. 2011 Jul; 85(1):13-21. PMID: 21368298.
      Citations: 29     Fields:    Translation:Animals
    12. Komatsu I, Bond J, Selim A, Tomasek JJ, Levin LS, Levinson H. Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. J Hand Surg Am. 2010 Oct; 35(10):1580-8. PMID: 20888494.
      Citations: 4     Fields:    Translation:HumansCells
    13. Mirastschijski U, Schnabel R, Claes J, Schneider W, Agren MS, Haaksma C, Tomasek JJ. Matrix metalloproteinase inhibition delays wound healing and blocks the latent transforming growth factor-beta1-promoted myofibroblast formation and function. Wound Repair Regen. 2010 Mar-Apr; 18(2):223-34. PMID: 20409148.
      Citations: 22     Fields:    Translation:AnimalsCells
    14. Risinger GM, Updike DL, Bullen EC, Tomasek JJ, Howard EW. TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. . 2010 Jan; 298(1):C191-201. PMID: 19846754.
      Citations:    
    15. Tomasek JJ, Haaksma CJ, Schwartz RJ, Vuong DT, Zhang SX, Ash JD, Ma JX, Al-Ubaidi MR. Deletion of smooth muscle alpha-actin alters blood-retina barrier permeability and retinal function. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2693-700. PMID: 16723488.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Tomasek JJ, Vaughan MB, Kropp BP, Gabbiani G, Martin MD, Haaksma CJ, Hinz B. Contraction of myofibroblasts in granulation tissue is dependent on Rho/Rho kinase/myosin light chain phosphatase activity. Wound Repair Regen. 2006 May-Jun; 14(3):313-20. PMID: 16808810.
      Citations: 33     Fields:    Translation:AnimalsCells
    17. Gallucci RM, Lee EG, Tomasek JJ. IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol. 2006 Mar; 126(3):561-8. PMID: 16397521.
      Citations: 38     Fields:    Translation:AnimalsCells
    18. Tomasek JJ, McRae J, Owens GK, Haaksma CJ. Regulation of alpha-smooth muscle actin expression in granulation tissue myofibroblasts is dependent on the intronic CArG element and the transforming growth factor-beta1 control element. Am J Pathol. 2005 May; 166(5):1343-51. PMID: 15855636.
      Citations: 32     Fields:    Translation:AnimalsCells
    19. Mirastschijski U, Haaksma CJ, Tomasek JJ, Agren MS. Matrix metalloproteinase inhibitor GM 6001 attenuates keratinocyte migration, contraction and myofibroblast formation in skin wounds. Exp Cell Res. 2004 Oct 01; 299(2):465-75. PMID: 15350544.
      Citations: 37     Fields:    Translation:AnimalsCells
    20. Zimmerman RA, Tomasek JJ, McRae J, Haaksma CJ, Schwartz RJ, Lin HK, Cowan RL, Jones AN, Kropp BP. Decreased expression of smooth muscle alpha-actin results in decreased contractile function of the mouse bladder. J Urol. 2004 Oct; 172(4 Pt 2):1667-72. PMID: 15371786.
      Citations: 7     Fields:    Translation:Animals
    21. Lin HK, Cowan R, Moore P, Zhang Y, Yang Q, Peterson JA, Tomasek JJ, Kropp BP, Cheng E. Characterization of neuropathic bladder smooth muscle cells in culture. J Urol. 2004 Mar; 171(3):1348-52. PMID: 14767346.
      Citations: 19     Fields:    Translation:HumansCells
    22. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol. 2002 May; 3(5):349-63. PMID: 11988769.
      Citations: 1184     Fields:    Translation:HumansAnimalsCells
    23. Hinz B, Celetta G, Tomasek JJ, Gabbiani G, Chaponnier C. Alpha-smooth muscle actin expression upregulates fibroblast contractile activity. Mol Biol Cell. 2001 Sep; 12(9):2730-41. PMID: 11553712.
      Citations: 365     Fields:    Translation:AnimalsCells
    24. Spyres LM, Qa'Dan M, Meader A, Tomasek JJ, Howard EW, Ballard JD. Cytosolic delivery and characterization of the TcdB glucosylating domain by using a heterologous protein fusion. Infect Immun. 2001 Jan; 69(1):599-601. PMID: 11119561.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    25. Vaughan MB, Howard EW, Tomasek JJ. Transforming growth factor-beta1 promotes the morphological and functional differentiation of the myofibroblast. Exp Cell Res. 2000 May 25; 257(1):180-9. PMID: 10854066.
      Citations: 138     Fields:    Translation:HumansCells
    26. Parizi M, Howard EW, Tomasek JJ. Regulation of LPA-promoted myofibroblast contraction: role of Rho, myosin light chain kinase, and myosin light chain phosphatase. Exp Cell Res. 2000 Feb 01; 254(2):210-20. PMID: 10640419.
      Citations: 49     Fields:    Translation:HumansCells
    27. Rayan GM, Haaksma CJ, Tomasek JJ, McCarthy KJ. Basement membrane chondroitin sulfate proteoglycan and vascularization of the developing mammalian limb bud. J Hand Surg Am. 2000 Jan; 25(1):150-8. PMID: 10642486.
      Citations: 1     Fields:    Translation:Animals
    28. Kropp BP, Zhang Y, Tomasek JJ, Cowan R, Furness PD, Vaughan MB, Parizi M, Cheng EY. Characterization of cultured bladder smooth muscle cells: assessment of in vitro contractility. J Urol. 1999 Nov; 162(5):1779-84. PMID: 10524934.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    29. Rayan GM, Abercrombie MP, Linsenmayer TF, Fitch JM, Tomasek JJ. Distribution of type IV collagen during avian limb bud development. J Hand Surg Am. 1999 May; 24(3):619-27. PMID: 10357545.
      Citations:    Fields:    Translation:Animals
    30. Tomasek JJ, Vaughan MB, Haaksma CJ. Cellular structure and biology of Dupuytren's disease. Hand Clin. 1999 Feb; 15(1):21-34. PMID: 10050239.
      Citations: 19     Fields:    Translation:HumansCells
    31. Tavella M, Tomasek J, Mills E, McConathy WJ. Lp(a) and LDL2: differences in fatty acid composition and collagen lattice contraction activity. Acta Physiol Pharmacol Ther Latinoam. 1999; 49(2):93-9. PMID: 10797846.
      Citations:    Fields:    Translation:HumansAnimalsCells
    32. Vu TK, Liu RW, Haaksma CJ, Tomasek JJ, Howard EW. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem. 1997 Dec 12; 272(50):31315-20. PMID: 9395459.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    33. Porpaczy Z, Tomasek JJ, Freeman DA. Internalized plasma membrane cholesterol passes through an endosome compartment that is distinct from the acid vesicle-lysosome compartment. Exp Cell Res. 1997 Aug 01; 234(2):217-24. PMID: 9260888.
      Citations: 4     Fields:    Translation:AnimalsCells
    34. Tomasek JJ, Halliday NL, Updike DL, Ahern-Moore JS, Vu TK, Liu RW, Howard EW. Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeleton. J Biol Chem. 1997 Mar 14; 272(11):7482-7. PMID: 9054450.
      Citations: 32     Fields:    Translation:HumansCells
    35. Rayan GM, Parizi M, Tomasek JJ. Pharmacologic regulation of Dupuytren's fibroblast contraction in vitro. J Hand Surg Am. 1996 Nov; 21(6):1065-70. PMID: 8969433.
      Citations: 13     Fields:    Translation:HumansCells
    36. Howard EW, Benton R, Ahern-Moore J, Tomasek JJ. Cellular contraction of collagen lattices is inhibited by nonenzymatic glycation. Exp Cell Res. 1996 Oct 10; 228(1):132-7. PMID: 8892980.
      Citations: 17     Fields:    Translation:HumansCells
    37. Pilcher BK, Levine NS, Tomasek JJ. Thrombin promotion of isometric contraction in fibroblasts: its extracellular mechanism of action. Plast Reconstr Surg. 1995 Oct; 96(5):1188-95. PMID: 7568497.
      Citations: 1     Fields:    Translation:HumansCells
    38. Tomasek J, Rayan GM. Correlation of alpha-smooth muscle actin expression and contraction in Dupuytren's disease fibroblasts. J Hand Surg Am. 1995 May; 20(3):450-5. PMID: 7642925.
      Citations: 18     Fields:    Translation:HumansCells
    39. Inhofe PD, Grana WA, Egle D, Min KW, Tomasek J. The effects of anabolic steroids on rat tendon. An ultrastructural, biomechanical, and biochemical analysis. Am J Sports Med. 1995 Mar-Apr; 23(2):227-32. PMID: 7778710.
      Citations: 16     Fields:    Translation:AnimalsCells
    40. Halliday NL, Tomasek JJ. Mechanical properties of the extracellular matrix influence fibronectin fibril assembly in vitro. Exp Cell Res. 1995 Mar; 217(1):109-17. PMID: 7867709.
      Citations: 56     Fields:    Translation:HumansCells
    41. Rayan GM, Tomasek JJ. Generation of contractile force by cultured Dupuytren's disease and normal palmar fibroblasts. Tissue Cell. 1994 Oct; 26(5):747-56. PMID: 9437248.
      Citations: 6     Fields:    Translation:HumansCells
    42. Halliday NL, Rayan GM, Zardi L, Tomasek JJ. Distribution of ED-A and ED-B containing fibronectin isoforms in Dupuytren's disease. J Hand Surg Am. 1994 May; 19(3):428-34. PMID: 8056970.
      Citations: 5     Fields:    Translation:Humans
    43. Pilcher BK, Kim DW, Carney DH, Tomasek JJ. Thrombin stimulates fibroblast-mediated collagen lattice contraction by its proteolytically activated receptor. Exp Cell Res. 1994 Apr; 211(2):368-73. PMID: 8143785.
      Citations: 8     Fields:    Translation:HumansCells
    44. Tomasek JJ, Meyers SW, Basinger JB, Green DT, Shew RL. Diabetic and age-related enhancement of collagen-linked fluorescence in cortical bones of rats. Life Sci. 1994; 55(11):855-61. PMID: 8072386.
      Citations: 21     Fields:    Translation:Animals
    45. Tomasek JJ, Akiyama SK. Fibroblast-mediated collagen gel contraction does not require fibronectin-alpha 5 beta 1 integrin interaction. Anat Rec. 1992 Oct; 234(2):153-60. PMID: 1416102.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    46. Tomasek JJ, Haaksma CJ, Eddy RJ, Vaughan MB. Fibroblast contraction occurs on release of tension in attached collagen lattices: dependency on an organized actin cytoskeleton and serum. Anat Rec. 1992 Mar; 232(3):359-68. PMID: 1543260.
      Citations: 53     Fields:    Translation:HumansCells
    47. Tomasek JJ, Haaksma CJ. Fibronectin filaments and actin microfilaments are organized into a fibronexus in Dupuytren's diseased tissue. Anat Rec. 1991 Jun; 230(2):175-82. PMID: 1867394.
      Citations: 7     Fields:    Translation:HumansCells
    48. Abercrombie MP, Tomasek JJ. Effects of enzyme isolation on the basal lamina of developing avian limb bud epithelia. In Vitro Cell Dev Biol. 1988 Aug; 24(8):803-10. PMID: 3045073.
      Citations:    Fields:    Translation:AnimalsCells
    49. Eddy RJ, Petro JA, Tomasek JJ. Evidence for the nonmuscle nature of the "myofibroblast" of granulation tissue and hypertropic scar. An immunofluorescence study. Am J Pathol. 1988 Feb; 130(2):252-60. PMID: 3277440.
      Citations: 30     Fields:    Translation:HumansCells
    50. Tomasek JJ, Schultz RJ, Haaksma CJ. Extracellular matrix-cytoskeletal connections at the surface of the specialized contractile fibroblast (myofibroblast) in Dupuytren disease. J Bone Joint Surg Am. 1987 Dec; 69(9):1400-7. PMID: 3440798.
      Citations: 10     Fields:    Translation:HumansCells
    51. Tomasek JJ, Schultz RJ, Episalla CW, Newman SA. The cytoskeleton and extracellular matrix of the Dupuytren's disease "myofibroblast": an immunofluorescence study of a nonmuscle cell type. J Hand Surg Am. 1986 May; 11(3):365-71. PMID: 3519746.
      Citations: 11     Fields:    Translation:HumansCells
    52. Newman SA, Frenz DA, Tomasek JJ, Paulsen DF. Matrix-driven translocation: possible role in precartilage mesenchymal condensation. Prog Clin Biol Res. 1986; 217B:199-202. PMID: 2428060.
      Citations: 2     Fields:    Translation:AnimalsCells
    53. Newman SA, Frenz DA, Tomasek JJ, Rabuzzi DD. Matrix-driven translocation of cells and nonliving particles. Science. 1985 May 17; 228(4701):885-9. PMID: 4001925.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    54. Tomasek JJ, Hay ED. Analysis of the role of microfilaments and microtubules in acquisition of bipolarity and elongation of fibroblasts in hydrated collagen gels. J Cell Biol. 1984 Aug; 99(2):536-49. PMID: 6146628.
      Citations: 34     Fields:    Translation:AnimalsCells
    55. Tomasek JJ, Hay ED, Fujiwara K. Collagen modulates cell shape and cytoskeleton of embryonic corneal and fibroma fibroblasts: distribution of actin, alpha-actinin, and myosin. Dev Biol. 1982 Jul; 92(1):107-22. PMID: 7106372.
      Citations: 55     Fields:    Translation:AnimalsCells
    56. Tomasek JJ, Mazurkiewicz JE, Newman SA. Nonuniform distribution of fibronectin during avian limb development. Dev Biol. 1982 Mar; 90(1):118-26. PMID: 7037503.
      Citations: 14     Fields:    Translation:Animals
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