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Ralf Gregor Janknecht

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBRC 1464
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-8001 ext 47420
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    Collapse Research 
    Collapse research activities and funding
    R01CA233613     (JANKNECHT, RALF)Jan 9, 2019 - Nov 30, 2023
    Role of the DNPH1 Enzyme in Breast Cancer
    Role: Principal Investigator

    R03CA223615     (JANKNECHT, RALF)Jul 6, 2018 - Jun 30, 2020
    Regulation of KDM4A by Lysine Methylation
    Role: Principal Investigator

    R01CA154745     (JANKNECHT, RALF)Jul 1, 2011 - Apr 30, 2017
    ETV1 and JMJD2 Demethylases in Prostate Cancer
    Role: Principal Investigator

    R01CA085257     (JANKNECHT, RALF)Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mohammed S, Thadathil N, Ohene-Marfo P, Tran AL, Van Der Veldt M, Georgescu C, Oh S, Nicklas EH, Wang D, Haritha NH, Luo W, Janknecht R, Miller BF, Wren JD, Freeman WM, Deepa SS. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis. Mol Cancer Res. 2023 May 19. PMID: 37204757.
      Citations:    Fields:    
    2. Sui Y, Jiang H, Kellogg CM, Oh S, Janknecht R. Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7. Front Oncol. 2023; 13:1122238. PMID: 36890812; PMCID: PMC9986587.
      Citations: 1     
    3. Oh S, Shin S, Janknecht R. Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer. Int J Clin Exp Pathol. 2021; 14(7):795-810. PMID: 34367411.
      Citations: 3     Fields:    
    4. Oh S, Song H, Freeman WM, Shin S, Janknecht R. Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. Int J Oncol. 2020 12; 57(6):1319-1332. PMID: 33174020.
      Citations: 6     Fields:    Translation:HumansCells
    5. Liu H, Ramachandran S, Fong N, Phang T, Lee S, Parsa P, Liu X, Harmacek L, Danhorn T, Song T, Oh S, Zhang Q, Chen Z, Zhang Q, Tu TH, Happoldt C, O'Conner B, Janknecht R, Li CY, Marrack P, Kappler J, Leach S, Zhang G. JMJD5 couples with CDK9 to release the paused RNA polymerase II. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19888-19895. PMID: 32747552.
      Citations: 6     Fields:    Translation:HumansCells
    6. Sui Y, Gu R, Janknecht R. Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer. Mol Cancer Res. 2021 01; 19(1):3-13. PMID: 32605929.
      Citations: 15     Fields:    Translation:HumansAnimals
    7. Sui Y, Li X, Oh S, Zhang B, Freeman WM, Shin S, Janknecht R. Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer. Sci Rep. 2020 05 26; 10(1):8710. PMID: 32457453.
      Citations: 10     Fields:    Translation:HumansCells
    8. Andrade D, Mehta M, Griffith J, Oh S, Corbin J, Babu A, De S, Chen A, Zhao YD, Husain S, Roy S, Xu L, Aube J, Janknecht R, Gorospe M, Herman T, Ramesh R, Munshi A. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A. Cancers (Basel). 2019 Dec 13; 11(12). PMID: 31847141.
      Citations: 14     
    9. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. Correction: JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2019 Aug; 17(8):e3000454. PMID: 31433800.
      Citations:    Fields:    
    10. Matsukura T, Inaba C, Weygant EA, Kitamura D, Janknecht R, Matsumoto H, Hyink DP, Kashiwada S, Obara T. Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model. Physiol Rep. 2019 07; 7(14):e14172. PMID: 31325249.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Oh S, Shin S, Song H, Grande JP, Janknecht R. Relationship between ETS Transcription Factor ETV1 and TGF-ß-regulated SMAD Proteins in Prostate Cancer. Sci Rep. 2019 06 03; 9(1):8186. PMID: 31160676.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Oh S, Shin S, Janknecht R. The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim Biophys Acta Rev Cancer. 2019 04; 1871(2):406-418. PMID: 31034925.
      Citations: 21     Fields:    Translation:HumansAnimals
    13. Neelakantan D, Dogra S, Devapatla B, Jaiprasart P, Mukashyaka MC, Janknecht R, Dwivedi SKD, Bhattacharya R, Husain S, Ding K, Woo S. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. Mol Cancer Res. 2019 06; 17(6):1378-1390. PMID: 30858172.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    14. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2018 11; 16(11):e2006145. PMID: 30500822.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    15. Li X, Oh S, Song H, Shin S, Zhang B, Freeman WM, Janknecht R. A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett. 2018 Nov; 16(5):6652-6662. PMID: 30405805.
      Citations: 9     
    16. Li X, Moon G, Shin S, Zhang B, Janknecht R. Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases. Mol Med Rep. 2018 04; 17(4):5518-5527. PMID: 29393482.
      Citations: 8     Fields:    Translation:HumansCells
    17. Andrade D, Mehta M, Griffith J, Panneerselvam J, Srivastava A, Kim TD, Janknecht R, Herman T, Ramesh R, Munshi A. YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways. Oncotarget. 2017 Nov 17; 8(58):98495-98508. PMID: 29228705.
      Citations: 24     Fields:    
    18. Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    19. O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM. A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. J Cell Sci. 2017 Oct 15; 130(20):3467-3480. PMID: 28839075.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    20. McBride JD, Liu X, Berry WL, Janknecht R, Cheng R, Zhou K, Badiavas EV, Ma JX. Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. Int J Hematol. 2017 Jun; 105(6):748-757. PMID: 28299632.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    21. Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD, Janknecht R. Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int J Clin Exp Med. 2016; 9(6):10123-10134. PMID: 28883898.
      Citations: 9     
    22. Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports. 2016 07 12; 7(1):43-54. PMID: 27373925.
      Citations: 17     Fields:    Translation:HumansCells
    23. Kim TD, Shin S, Janknecht R. ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol Rep. 2016 Jun; 35(6):3679-88. PMID: 27109047.
      Citations: 16     Fields:    Translation:HumansCells
    24. Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb; 126(2):706-20. PMID: 26731476.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    25. Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015 Jul 16; 14:133. PMID: 26178901.
      Citations: 104     Fields:    Translation:HumansCells
    26. Qi Y, Marlin MC, Liang Z, Berry WL, Janknecht R, Zhou J, Wang Z, Lu G, Li G. Distinct biochemical and functional properties of two Rab5 homologs from the rice blast fungus Magnaporthe oryzae. J Biol Chem. 2014 Oct 10; 289(41):28299-309. PMID: 25164815.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    27. Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014; 6(3):236-47. PMID: 24936217.
      Citations: 36     
    28. Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103. PMID: 24885928.
      Citations: 57     Fields:    Translation:HumansCells
    29. Berry WL, Kim TD, Janknecht R. Stimulation of ß-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 2014 Apr; 44(4):1341-8. PMID: 24481461.
      Citations: 28     Fields:    Translation:HumansCells
    30. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    31. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, Janknecht R, Obara T. Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep. 2014 Feb; 9(2):457-65. PMID: 24337247.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    32. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365.
      Citations: 21     Fields:    Translation:HumansCells
    33. Oh S, Shin S, Lightfoot SA, Janknecht R. 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 2013 Aug 15; 73(16):5110-9. PMID: 23774214.
      Citations: 26     Fields:    Translation:HumansCells
    34. Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res. 2013 May 15; 73(10):2936-42. PMID: 23644528.
      Citations: 209     Fields:    Translation:HumansAnimals
    35. Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Janknecht R, Obara T. Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus. J Histochem Cytochem. 2013 Apr; 61(4):313-24. PMID: 23324868.
      Citations: 12     Fields:    Translation:AnimalsCells
    36. Shin S, Oh S, An S, Janknecht R. ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol Rep. 2013 Jan; 29(1):306-14. PMID: 23076342.
      Citations: 28     Fields:    Translation:HumansCells
    37. Berry WL, Shin S, Lightfoot SA, Janknecht R. Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int J Oncol. 2012 Nov; 41(5):1701-6. PMID: 22948256.
      Citations: 57     Fields:    Translation:HumansCells
    38. Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nunez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27; 47(2):203-14. PMID: 22795131.
      Citations: 168     Fields:    Translation:HumansCells
    39. DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R. Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 2012 Jul 06; 287(28):23657-66. PMID: 22613723.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    40. Kim TD, Oh S, Shin S, Janknecht R. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One. 2012; 7(4):e34618. PMID: 22514644.
      Citations: 40     Fields:    Translation:HumansCells
    41. Kim TD, Shin S, Berry WL, Oh S, Janknecht R. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 2012 Apr; 113(4):1368-76. PMID: 22134899.
      Citations: 54     Fields:    Translation:HumansCells
    42. Oh S, Shin S, Janknecht R. ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochim Biophys Acta. 2012 Aug; 1826(1):1-12. PMID: 22425584.
      Citations: 133     Fields:    Translation:HumansCells
    43. Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):61-5. PMID: 22402282.
      Citations: 38     Fields:    Translation:AnimalsCells
    44. Kimura R, Ishikawa C, Rokkaku T, Janknecht R, Mori N. Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1543-53. PMID: 21640141.
      Citations: 27     Fields:    Translation:HumansCells
    45. Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, Hawse JR, Spelsberg TC, Janknecht R. Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun. 2010 Oct 22; 401(3):412-6. PMID: 20863814.
      Citations: 33     Fields:    Translation:HumansCells
    46. Mooney SM, Goel A, D'Assoro AB, Salisbury JL, Janknecht R. Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 01; 285(40):30443-52. PMID: 20663877.
      Citations: 30     Fields:    Translation:HumansCells
    47. Janknecht R. Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). Am J Transl Res. 2010 May 05; 2(3):223-34. PMID: 20589163.
      Citations: 51     
    48. Mooney SM, Grande JP, Salisbury JL, Janknecht R. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 2010 Jan 12; 49(1):1-10. PMID: 19995069.
      Citations: 55     Fields:    Translation:HumansCells
    49. Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 2009 Oct 15; 69(20):8102-10. PMID: 19789348.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    50. Hamada S, Kim TD, Suzuki T, Itoh Y, Tsumoto H, Nakagawa H, Janknecht R, Miyata N. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15; 19(10):2852-5. PMID: 19359167.
      Citations: 52     Fields:    Translation:HumansCells
    51. Shin S, Bosc DG, Ingle JN, Spelsberg TC, Janknecht R. Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. J Cell Biochem. 2008 Oct 15; 105(3):866-74. PMID: 18726892.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    52. Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 08; 2(5):497-507. PMID: 18462699.
      Citations: 174     Fields:    Translation:AnimalsCells
    53. Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun. 2008 Feb 08; 366(2):563-7. PMID: 18078810.
      Citations: 20     Fields:    Translation:HumansCells
    54. Smith EH, Janknecht R, Maher LJ. Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet. 2007 Dec 15; 16(24):3136-48. PMID: 17884808.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    55. Shin S, Rossow KL, Grande JP, Janknecht R. Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 2007 Aug 15; 67(16):7572-8. PMID: 17699760.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    56. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007 Aug 01; 101(5):1252-65. PMID: 17226766.
      Citations: 20     Fields:    Translation:HumansCells
    57. Shin S, Janknecht R. Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem Biophys Res Commun. 2007 Aug 03; 359(3):742-6. PMID: 17555712.
      Citations: 102     Fields:    Translation:HumansCells
    58. Shin S, Janknecht R. Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun. 2007 Feb 23; 353(4):973-7. PMID: 17207460.
      Citations: 71     Fields:    Translation:HumansCells
    59. Knebel J, De Haro L, Janknecht R. Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. J Cell Biochem. 2006 Sep 01; 99(1):319-29. PMID: 16619273.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    60. Janknecht R. EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene. 2005 Dec 19; 363:1-14. PMID: 16202544.
      Citations: 72     Fields:    Translation:HumansCells
    61. De Haro L, Janknecht R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics. 2005 Apr; 85(4):493-502. PMID: 15780752.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    62. Dowdy SC, Mariani A, Reinholz MM, Keeney GL, Spelsberg TC, Podratz KC, Janknecht R. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol. 2005 Feb; 96(2):368-73. PMID: 15661223.
      Citations: 21     Fields:    Translation:HumansCells
    63. Fuchs B, Inwards C, Scully SP, Janknecht R. hTERT Is highly expressed in Ewing's sarcoma and activated by EWS-ETS oncoproteins. Clin Orthop Relat Res. 2004 Sep; (426):64-8. PMID: 15346053.
      Citations: 4     Fields:    Translation:HumansCells
    64. Janknecht R. On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett. 2004 Apr 23; 564(1-2):9-13. PMID: 15094035.
      Citations: 47     Fields:    Translation:HumansCells
    65. Fuchs B, Inwards CY, Janknecht R. Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma. Clin Cancer Res. 2004 Feb 15; 10(4):1344-53. PMID: 14977835.
      Citations: 43     Fields:    Translation:HumansCells
    66. Goel A, Janknecht R. Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 2004 Apr 09; 279(15):14909-16. PMID: 14747462.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    67. Goueli BS, Janknecht R. Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol. 2004 Jan; 24(1):25-35. PMID: 14673140.
      Citations: 49     Fields:    Translation:HumansCells
    68. Fuchs B, Inwards CY, Janknecht R. Upregulation of the matrix metalloproteinase-1 gene by the Ewing's sarcoma associated EWS-ER81 and EWS-Fli-1 oncoproteins, c-Jun and p300. FEBS Lett. 2003 Oct 09; 553(1-2):104-8. PMID: 14550555.
      Citations: 12     Fields:    Translation:HumansCells
    69. Goueli BS, Janknecht R. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene. 2003 Sep 11; 22(39):8042-7. PMID: 12970752.
      Citations: 52     Fields:    Translation:HumansCells
    70. Goel A, Janknecht R. Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol. 2003 Sep; 23(17):6243-54. PMID: 12917345.
      Citations: 43     Fields:    Translation:HumansCells
    71. Dowdy SC, Mariani A, Janknecht R. HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 2003 Nov 07; 278(45):44377-84. PMID: 12947087.
      Citations: 47     Fields:    Translation:HumansCells
    72. Janknecht R. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 2003 Feb 06; 22(5):746-55. PMID: 12569367.
      Citations: 44     Fields:    Translation:AnimalsCells
    73. Rossow KL, Janknecht R. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene. 2003 Jan 09; 22(1):151-6. PMID: 12527917.
      Citations: 46     Fields:    Translation:HumansCells
    74. Wu J, Janknecht R. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem. 2002 Nov 08; 277(45):42669-79. PMID: 12213813.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    75. Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene. 2002 Aug 22; 21(37):5783-90. PMID: 12173049.
      Citations: 66     Fields:    Translation:HumansCells
    76. De Haro L, Janknecht R. Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. Nucleic Acids Res. 2002 Jul 01; 30(13):2972-9. PMID: 12087183.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    77. Johnsen SA, Subramaniam M, Monroe DG, Janknecht R, Spelsberg TC. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J Biol Chem. 2002 Aug 23; 277(34):30754-9. PMID: 12072443.
      Citations: 30     Fields:    Translation:HumansCells
    78. Janknecht R. The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol. 2002 04; 17(2):657-68. PMID: 11962765.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    79. Bosc DG, Janknecht R. Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. J Cell Biochem. 2002; 86(1):174-83. PMID: 12112028.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    80. Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC. Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem. 2002; 87(2):233-41. PMID: 12244575.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    81. Bosc DG, Goueli BS, Janknecht R. HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene. 2001 Sep 27; 20(43):6215-24. PMID: 11593430.
      Citations: 46     Fields:    Translation:AnimalsCells
    82. Janknecht R. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem. 2001 Nov 09; 276(45):41856-61. PMID: 11551945.
      Citations: 11     Fields:    Translation:Cells
    83. Rossow KL, Janknecht R. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 2001 Mar 15; 61(6):2690-5. PMID: 11289149.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    84. Papoutsopoulou S, Janknecht R. Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Mol Cell Biol. 2000 Oct; 20(19):7300-10. PMID: 10982847.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    85. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1020-5. PMID: 10655477.
      Citations: 67     Fields:    Translation:HumansCells
    86. Pearson KL, Hunter T, Janknecht R. Activation of Smad1-mediated transcription by p300/CBP. Biochim Biophys Acta. 1999 Dec 23; 1489(2-3):354-64. PMID: 10673036.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    87. Arbet-Engels C, Janknecht R, Eckhart W. Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin. FEBS Lett. 1999 Jul 09; 454(3):252-6. PMID: 10431817.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    88. Janknecht R, Hunter T. Nuclear fusion of signaling pathways. Science. 1999 Apr 16; 284(5413):443-4. PMID: 10232991.
      Citations: 5     Fields:    Translation:Cells
    89. Janknecht R, Wells NJ, Hunter T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998 Jul 15; 12(14):2114-9. PMID: 9679056.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    90. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998 Jun 18; 8(13):779-82. PMID: 9651683.
      Citations: 83     Fields:    Translation:HumansCells
    91. Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS. p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997 Aug 01; 272(31):19509-17. PMID: 9235954.
      Citations: 35     Fields:    Translation:HumansCells
    92. Malek NP, Casper J, Looijenga LH, Strohmeyer T, Schmoll HJ, Nordheim A, Janknecht R. Quantification of additional short arms of chromosome 12 in germ cell tumours using the polymerase chain reaction. Eur J Cancer. 1997 Aug; 33(9):1488-94. PMID: 9337694.
      Citations: 5     Fields:    Translation:HumansCells
    93. Bredemeier-Ernst I, Nordheim A, Janknecht R. Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1. FEBS Lett. 1997 May 12; 408(1):47-51. PMID: 9180266.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    94. Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 1997 Apr 01; 16(7):1620-7. PMID: 9130707.
      Citations: 46     Fields:    Translation:HumansCells
    95. Janknecht R, Hunter T. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem. 1997 Feb 14; 272(7):4219-24. PMID: 9020136.
      Citations: 28     Fields:    Translation:AnimalsCells
    96. Janknecht R, Nordheim A. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun. 1996 Nov 21; 228(3):831-7. PMID: 8941362.
      Citations: 56     Fields:    Translation:AnimalsCells
    97. Janknecht R, Monté D, Baert JL, de Launoit Y. The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene. 1996 Oct 17; 13(8):1745-54. PMID: 8895521.
      Citations: 29     Fields:    Translation:AnimalsCells
    98. Janknecht R, Hunter T. Transcription. A growing coactivator network. Nature. 1996 Sep 05; 383(6595):22-3. PMID: 8779707.
      Citations: 95     Fields:    Translation:HumansCells
    99. Nassar N, Horn G, Herrmann C, Block C, Janknecht R, Wittinghofer A. Ras/Rap effector specificity determined by charge reversal. Nat Struct Biol. 1996 Aug; 3(8):723-9. PMID: 8756332.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    100. Janknecht R, Hunter T. Versatile molecular glue. Transcriptional control. Curr Biol. 1996 Aug 01; 6(8):951-4. PMID: 8805328.
      Citations: 60     Fields:    Translation:AnimalsCells
    101. Oelgeschläger M, Janknecht R, Krieg J, Schreek S, Lüscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 1996 Jun 03; 15(11):2771-80. PMID: 8654374.
      Citations: 60     Fields:    Translation:AnimalsCells
    102. Janknecht R, Nordheim A. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene. 1996 May 02; 12(9):1961-9. PMID: 8649857.
      Citations: 33     Fields:    Translation:AnimalsCells
    103. Janknecht R. Analysis of the ERK-stimulated ETS transcription factor ER81. Mol Cell Biol. 1996 Apr; 16(4):1550-6. PMID: 8657129.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    104. Block C, Janknecht R, Herrmann C, Nassar N, Wittinghofer A. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat Struct Biol. 1996 Mar; 3(3):244-51. PMID: 8605626.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    105. Cahill MA, Janknecht R, Nordheim A. Signalling pathways: jack of all cascades. Curr Biol. 1996 Jan 01; 6(1):16-9. PMID: 8805215.
      Citations: 36     Fields:    Translation:AnimalsCells
    106. Janknecht R. Regulation of the c-fos promoter. Immunobiology. 1995 Jul; 193(2-4):137-42. PMID: 8530136.
      Citations: 4     Fields:    Translation:HumansCells
    107. Krieg J, Oelgeschläger M, Janknecht R, Lüscher B. High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains. Oncogene. 1995 Jun 01; 10(11):2221-8. PMID: 7784067.
      Citations: 3     Fields:    Translation:HumansCells
    108. Janknecht R, Ernst WH, Nordheim A. SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene. 1995 Mar 16; 10(6):1209-16. PMID: 7700646.
      Citations: 32     Fields:    Translation:HumansCells
    109. Janknecht R, Cahill MA, Nordheim A. Signal integration at the c-fos promoter. Carcinogenesis. 1995 Mar; 16(3):443-50. PMID: 7697796.
      Citations: 24     Fields:    Translation:HumansCells
    110. Ernst WH, Janknecht R, Cahill MA, Nordheim A. Transcriptional repression mediated by the serum response factor. FEBS Lett. 1995 Jan 02; 357(1):45-9. PMID: 8001676.
      Citations: 5     Fields:    Translation:AnimalsCells
    111. Cahill MA, Nordheim A, Janknecht R. Co-occurrence of CArG boxes and TCF sites within viral genomes. Biochem Biophys Res Commun. 1994 Nov 30; 205(1):545-51. PMID: 7999077.
      Citations: 2     Fields:    Translation:AnimalsCells
    112. Pingoud V, Zinck R, Hipskind RA, Janknecht R, Nordheim A. Heterogeneity of ternary complex factors in HeLa cell nuclear extracts. J Biol Chem. 1994 Sep 16; 269(37):23310-7. PMID: 8083237.
      Citations: 8     Fields:    Translation:HumansCells
    113. Cahill MA, Ernst WH, Janknecht R, Nordheim A. Regulatory squelching. FEBS Lett. 1994 May 16; 344(2-3):105-8. PMID: 8187867.
      Citations: 25     Fields:    Translation:AnimalsCells
    114. Janknecht R, Zinck R, Ernst WH, Nordheim A. Functional dissection of the transcription factor Elk-1. Oncogene. 1994 Apr; 9(4):1273-8. PMID: 8134131.
      Citations: 40     Fields:    Translation:HumansCells
    115. Janknecht R, Nordheim A. Gene regulation by Ets proteins. Biochim Biophys Acta. 1993 Dec 23; 1155(3):346-56. PMID: 8268191.
      Citations: 46     Fields:    Translation:HumansCells
    116. Janknecht R, Ernst WH, Pingoud V, Nordheim A. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 1993 Dec 15; 12(13):5097-104. PMID: 8262053.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    117. Janknecht R, Ernst WH, Houthaeve T, Nordheim A. C-terminal phosphorylation of the serum-response factor. Eur J Biochem. 1993 Sep 01; 216(2):469-75. PMID: 8375385.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    118. Janknecht R, Nordheim A. Affinity purification of histidine-tagged proteins transiently produced in HeLa cells. Gene. 1992 Nov 16; 121(2):321-4. PMID: 1446830.
      Citations: 8     Fields:    Translation:HumansCells
    119. Janknecht R, Nordheim A. Elk-1 protein domains required for direct and SRF-assisted DNA-binding. Nucleic Acids Res. 1992 Jul 11; 20(13):3317-24. PMID: 1630903.
      Citations: 51     Fields:    Translation:HumansCells
    120. Janknecht R, Hipskind RA, Houthaeve T, Nordheim A, Stunnenberg HG. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J. 1992 Mar; 11(3):1045-54. PMID: 1547771.
      Citations: 44     Fields:    Translation:HumansCells
    121. Janknecht R, Sander C, Pongs O. (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors? FEBS Lett. 1991 Dec 16; 295(1-3):1-2. PMID: 1765137.
      Citations: 6     Fields:    Translation:AnimalsCells
    122. Janknecht R, de Martynoff G, Lou J, Hipskind RA, Nordheim A, Stunnenberg HG. Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):8972-6. PMID: 1924358.
      Citations: 121     Fields:    Translation:HumansCells
    123. Janknecht R, Taube W, Lüdecke HJ, Pongs O. Characterization of a putative transcription factor gene expressed in the 20-OH-ecdysone inducible puff 74EF in Drosophila melanogaster. Nucleic Acids Res. 1989 Jun 26; 17(12):4455-64. PMID: 2501755.
      Citations: 14     Fields:    Translation:AnimalsCells
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