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Ralf Gregor Janknecht

TitleProf
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBMSB 553
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-8001
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    Collapse Research 
    Collapse research activities and funding
    R01CA085257     (JANKNECHT, RALF)Feb 1, 2001 - Jan 31, 2006
    NIH
    DYSREGULATION OF THE TRANSCRIPTION FACTOR ER81
    Role: Principal Investigator

    R01CA154745     (JANKNECHT, RALF)Jul 1, 2011 - Apr 30, 2017
    NIH
    ETV1 and JMJD2 Demethylases in Prostate Cancer
    Role: Principal Investigator

    R03CA223615     (JANKNECHT, RALF)Jul 6, 2018 - Jun 30, 2020
    NIH
    Regulation of KDM4A by Lysine Methylation
    Role: Principal Investigator

    R01CA233613     (JANKNECHT, RALF)Jan 9, 2019 - Nov 30, 2023
    NIH
    Role of the DNPH1 Enzyme in Breast Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Oh S, Song H, Freeman WM, Shin S, Janknecht R. Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. Int J Oncol. 2020 Dec; 57(6):1319-1332. PMID: 33174020.
      Citations:    Fields:    
    2. Liu H, Ramachandran S, Fong N, Phang T, Lee S, Parsa P, Liu X, Harmacek L, Danhorn T, Song T, Oh S, Zhang Q, Chen Z, Zhang Q, Tu TH, Happoldt C, O'Conner B, Janknecht R, Li CY, Marrack P, Kappler J, Leach S, Zhang G. JMJD5 couples with CDK9 to release the paused RNA polymerase II. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19888-19895. PMID: 32747552.
      Citations:    Fields:    Translation:HumansCells
    3. Sui Y, Gu R, Janknecht R. Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer. Mol Cancer Res. 2021 01; 19(1):3-13. PMID: 32605929.
      Citations: 2     Fields:    
    4. Sui Y, Li X, Oh S, Zhang B, Freeman WM, Shin S, Janknecht R. Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer. Sci Rep. 2020 05 26; 10(1):8710. PMID: 32457453.
      Citations: 2     Fields:    Translation:HumansCells
    5. Andrade D, Mehta M, Griffith J, Oh S, Corbin J, Babu A, De S, Chen A, Zhao YD, Husain S, Roy S, Xu L, Aube J, Janknecht R, Gorospe M, Herman T, Ramesh R, Munshi A. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A. Cancers (Basel). 2019 Dec 13; 11(12). PMID: 31847141.
      Citations:    
    6. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. Correction: JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2019 Aug; 17(8):e3000454. PMID: 31433800.
      Citations:    Fields:    
    7. Matsukura T, Inaba C, Weygant EA, Kitamura D, Janknecht R, Matsumoto H, Hyink DP, Kashiwada S, Obara T. Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model. Physiol Rep. 2019 07; 7(14):e14172. PMID: 31325249.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Oh S, Shin S, Song H, Grande JP, Janknecht R. Relationship between ETS Transcription Factor ETV1 and TGF-ß-regulated SMAD Proteins in Prostate Cancer. Sci Rep. 2019 06 03; 9(1):8186. PMID: 31160676.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Oh S, Shin S, Janknecht R. The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim Biophys Acta Rev Cancer. 2019 04; 1871(2):406-418. PMID: 31034925.
      Citations: 5     Fields:    Translation:HumansAnimals
    10. Neelakantan D, Dogra S, Devapatla B, Jaiprasart P, Mukashyaka MC, Janknecht R, Dwivedi SKD, Bhattacharya R, Husain S, Ding K, Woo S. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. Mol Cancer Res. 2019 06; 17(6):1378-1390. PMID: 30858172.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2018 11; 16(11):e2006145. PMID: 30500822.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    12. Li X, Oh S, Song H, Shin S, Zhang B, Freeman WM, Janknecht R. A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett. 2018 Nov; 16(5):6652-6662. PMID: 30405805.
      Citations:    
    13. Li X, Moon G, Shin S, Zhang B, Janknecht R. Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases. Mol Med Rep. 2018 Apr; 17(4):5518-5527. PMID: 29393482.
      Citations: 4     Fields:    Translation:HumansCells
    14. Andrade D, Mehta M, Griffith J, Panneerselvam J, Srivastava A, Kim TD, Janknecht R, Herman T, Ramesh R, Munshi A. YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways. Oncotarget. 2017 Nov 17; 8(58):98495-98508. PMID: 29228705.
      Citations: 9     Fields:    
    15. Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    16. O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM. A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. J Cell Sci. 2017 Oct 15; 130(20):3467-3480. PMID: 28839075.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    17. McBride JD, Liu X, Berry WL, Janknecht R, Cheng R, Zhou K, Badiavas EV, Ma JX. Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. Int J Hematol. 2017 Jun; 105(6):748-757. PMID: 28299632.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD, Janknecht R. Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int J Clin Exp Med. 2016; 9(6):10123-10134. PMID: 28883898.
      Citations:    
    19. Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports. 2016 07 12; 7(1):43-54. PMID: 27373925.
      Citations: 12     Fields:    Translation:HumansCells
    20. Kim TD, Shin S, Janknecht R. ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol Rep. 2016 Jun; 35(6):3679-88. PMID: 27109047.
      Citations: 10     Fields:    Translation:HumansCells
    21. Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb; 126(2):706-20. PMID: 26731476.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    22. Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015 Jul 16; 14:133. PMID: 26178901.
      Citations: 65     Fields:    Translation:HumansCells
    23. Qi Y, Marlin MC, Liang Z, Berry WL, Janknecht R, Zhou J, Wang Z, Lu G, Li G. Distinct biochemical and functional properties of two Rab5 homologs from the rice blast fungus Magnaporthe oryzae. J Biol Chem. 2014 Oct 10; 289(41):28299-309. PMID: 25164815.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014; 6(3):236-47. PMID: 24936217.
      Citations:    
    25. Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103. PMID: 24885928.
      Citations: 36     Fields:    Translation:HumansCells
    26. Berry WL, Kim TD, Janknecht R. Stimulation of ß-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 2014 Apr; 44(4):1341-8. PMID: 24481461.
      Citations: 20     Fields:    Translation:HumansCells
    27. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    28. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, Janknecht R, Obara T. Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep. 2014 Feb; 9(2):457-65. PMID: 24337247.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    29. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365.
      Citations: 17     Fields:    Translation:HumansCells
    30. Oh S, Shin S, Lightfoot SA, Janknecht R. 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 2013 Aug 15; 73(16):5110-9. PMID: 23774214.
      Citations: 19     Fields:    Translation:HumansCells
    31. Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res. 2013 May 15; 73(10):2936-42. PMID: 23644528.
      Citations: 141     Fields:    Translation:HumansAnimals
    32. Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Janknecht R, Obara T. Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus. J Histochem Cytochem. 2013 Apr; 61(4):313-24. PMID: 23324868.
      Citations: 10     Fields:    Translation:AnimalsCells
    33. Shin S, Oh S, An S, Janknecht R. ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol Rep. 2013 Jan; 29(1):306-14. PMID: 23076342.
      Citations: 24     Fields:    Translation:HumansCells
    34. Berry WL, Shin S, Lightfoot SA, Janknecht R. Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int J Oncol. 2012 Nov; 41(5):1701-6. PMID: 22948256.
      Citations: 37     Fields:    Translation:HumansCells
    35. Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nunez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27; 47(2):203-14. PMID: 22795131.
      Citations: 132     Fields:    Translation:HumansCells
    36. DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R. Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 2012 Jul 06; 287(28):23657-66. PMID: 22613723.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    37. Kim TD, Oh S, Shin S, Janknecht R. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One. 2012; 7(4):e34618. PMID: 22514644.
      Citations: 32     Fields:    Translation:HumansCells
    38. Kim TD, Shin S, Berry WL, Oh S, Janknecht R. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 2012 Apr; 113(4):1368-76. PMID: 22134899.
      Citations: 45     Fields:    Translation:HumansCells
    39. Oh S, Shin S, Janknecht R. ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochim Biophys Acta. 2012 Aug; 1826(1):1-12. PMID: 22425584.
      Citations: 101     Fields:    Translation:HumansCells
    40. Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):61-5. PMID: 22402282.
      Citations: 25     Fields:    Translation:AnimalsCells
    41. Kimura R, Ishikawa C, Rokkaku T, Janknecht R, Mori N. Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1543-53. PMID: 21640141.
      Citations: 23     Fields:    Translation:HumansCells
    42. Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, Hawse JR, Spelsberg TC, Janknecht R. Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun. 2010 Oct 22; 401(3):412-6. PMID: 20863814.
      Citations: 26     Fields:    Translation:HumansCells
    43. Mooney SM, Goel A, D'Assoro AB, Salisbury JL, Janknecht R. Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 01; 285(40):30443-52. PMID: 20663877.
      Citations: 27     Fields:    Translation:HumansCells
    44. Janknecht R. Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). Am J Transl Res. 2010 May 05; 2(3):223-34. PMID: 20589163.
      Citations:    
    45. Mooney SM, Grande JP, Salisbury JL, Janknecht R. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 2010 Jan 12; 49(1):1-10. PMID: 19995069.
      Citations: 48     Fields:    Translation:HumansCells
    46. Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 2009 Oct 15; 69(20):8102-10. PMID: 19789348.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    47. Hamada S, Kim TD, Suzuki T, Itoh Y, Tsumoto H, Nakagawa H, Janknecht R, Miyata N. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15; 19(10):2852-5. PMID: 19359167.
      Citations: 45     Fields:    Translation:HumansCells
    48. Shin S, Bosc DG, Ingle JN, Spelsberg TC, Janknecht R. Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. J Cell Biochem. 2008 Oct 15; 105(3):866-74. PMID: 18726892.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    49. Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 08; 2(5):497-507. PMID: 18462699.
      Citations: 143     Fields:    Translation:AnimalsCells
    50. Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun. 2008 Feb 08; 366(2):563-7. PMID: 18078810.
      Citations: 19     Fields:    Translation:HumansCells
    51. Smith EH, Janknecht R, Maher LJ. Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet. 2007 Dec 15; 16(24):3136-48. PMID: 17884808.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    52. Shin S, Rossow KL, Grande JP, Janknecht R. Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 2007 Aug 15; 67(16):7572-8. PMID: 17699760.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    53. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007 Aug 01; 101(5):1252-65. PMID: 17226766.
      Citations: 15     Fields:    Translation:HumansCells
    54. Shin S, Janknecht R. Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem Biophys Res Commun. 2007 Aug 03; 359(3):742-6. PMID: 17555712.
      Citations: 77     Fields:    Translation:HumansCells
    55. Shin S, Janknecht R. Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun. 2007 Feb 23; 353(4):973-7. PMID: 17207460.
      Citations: 59     Fields:    Translation:HumansCells
    56. Knebel J, De Haro L, Janknecht R. Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. J Cell Biochem. 2006 Sep 01; 99(1):319-29. PMID: 16619273.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    57. Janknecht R. EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene. 2005 Dec 19; 363:1-14. PMID: 16202544.
      Citations: 63     Fields:    Translation:HumansCells
    58. De Haro L, Janknecht R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics. 2005 Apr; 85(4):493-502. PMID: 15780752.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    59. Dowdy SC, Mariani A, Reinholz MM, Keeney GL, Spelsberg TC, Podratz KC, Janknecht R. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol. 2005 Feb; 96(2):368-73. PMID: 15661223.
      Citations: 15     Fields:    Translation:HumansCells
    60. Fuchs B, Inwards C, Scully SP, Janknecht R. hTERT Is highly expressed in Ewing's sarcoma and activated by EWS-ETS oncoproteins. Clin Orthop Relat Res. 2004 Sep; (426):64-8. PMID: 15346053.
      Citations: 4     Fields:    Translation:HumansCells
    61. Janknecht R. On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett. 2004 Apr 23; 564(1-2):9-13. PMID: 15094035.
      Citations: 40     Fields:    Translation:HumansCells
    62. Fuchs B, Inwards CY, Janknecht R. Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma. Clin Cancer Res. 2004 Feb 15; 10(4):1344-53. PMID: 14977835.
      Citations: 37     Fields:    Translation:HumansCells
    63. Goel A, Janknecht R. Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 2004 Apr 09; 279(15):14909-16. PMID: 14747462.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    64. Goueli BS, Janknecht R. Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol. 2004 Jan; 24(1):25-35. PMID: 14673140.
      Citations: 46     Fields:    Translation:HumansCells
    65. Fuchs B, Inwards CY, Janknecht R. Upregulation of the matrix metalloproteinase-1 gene by the Ewing's sarcoma associated EWS-ER81 and EWS-Fli-1 oncoproteins, c-Jun and p300. FEBS Lett. 2003 Oct 09; 553(1-2):104-8. PMID: 14550555.
      Citations: 12     Fields:    Translation:HumansCells
    66. Goueli BS, Janknecht R. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene. 2003 Sep 11; 22(39):8042-7. PMID: 12970752.
      Citations: 46     Fields:    Translation:HumansCells
    67. Goel A, Janknecht R. Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol. 2003 Sep; 23(17):6243-54. PMID: 12917345.
      Citations: 39     Fields:    Translation:HumansCells
    68. Dowdy SC, Mariani A, Janknecht R. HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 2003 Nov 07; 278(45):44377-84. PMID: 12947087.
      Citations: 39     Fields:    Translation:HumansCells
    69. Janknecht R. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 2003 Feb 06; 22(5):746-55. PMID: 12569367.
      Citations: 41     Fields:    Translation:AnimalsCells
    70. Rossow KL, Janknecht R. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene. 2003 Jan 09; 22(1):151-6. PMID: 12527917.
      Citations: 39     Fields:    Translation:HumansCells
    71. Wu J, Janknecht R. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem. 2002 Nov 08; 277(45):42669-79. PMID: 12213813.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    72. Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene. 2002 Aug 22; 21(37):5783-90. PMID: 12173049.
      Citations: 58     Fields:    Translation:HumansCells
    73. De Haro L, Janknecht R. Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. Nucleic Acids Res. 2002 Jul 01; 30(13):2972-9. PMID: 12087183.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    74. Johnsen SA, Subramaniam M, Monroe DG, Janknecht R, Spelsberg TC. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J Biol Chem. 2002 Aug 23; 277(34):30754-9. PMID: 12072443.
      Citations: 28     Fields:    Translation:HumansCells
    75. Janknecht R. The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol. 2002 04; 17(2):657-68. PMID: 11962765.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    76. Bosc DG, Janknecht R. Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. J Cell Biochem. 2002; 86(1):174-83. PMID: 12112028.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    77. Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC. Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem. 2002; 87(2):233-41. PMID: 12244575.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    78. Bosc DG, Goueli BS, Janknecht R. HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene. 2001 Sep 27; 20(43):6215-24. PMID: 11593430.
      Citations: 43     Fields:    Translation:AnimalsCells
    79. Janknecht R. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem. 2001 Nov 09; 276(45):41856-61. PMID: 11551945.
      Citations: 11     Fields:    Translation:Cells
    80. Rossow KL, Janknecht R. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 2001 Mar 15; 61(6):2690-5. PMID: 11289149.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    81. Papoutsopoulou S, Janknecht R. Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Mol Cell Biol. 2000 Oct; 20(19):7300-10. PMID: 10982847.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    82. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1020-5. PMID: 10655477.
      Citations: 56     Fields:    Translation:HumansCells
    83. Pearson KL, Hunter T, Janknecht R. Activation of Smad1-mediated transcription by p300/CBP. Biochim Biophys Acta. 1999 Dec 23; 1489(2-3):354-64. PMID: 10673036.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    84. Arbet-Engels C, Janknecht R, Eckhart W. Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin. FEBS Lett. 1999 Jul 09; 454(3):252-6. PMID: 10431817.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    85. Janknecht R, Hunter T. Nuclear fusion of signaling pathways. Science. 1999 Apr 16; 284(5413):443-4. PMID: 10232991.
      Citations: 5     Fields:    Translation:Cells
    86. Janknecht R, Wells NJ, Hunter T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998 Jul 15; 12(14):2114-9. PMID: 9679056.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    87. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998 Jun 18; 8(13):779-82. PMID: 9651683.
      Citations: 76     Fields:    Translation:HumansCells
    88. Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS. p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997 Aug 01; 272(31):19509-17. PMID: 9235954.
      Citations: 31     Fields:    Translation:HumansCells
    89. Malek NP, Casper J, Looijenga LH, Strohmeyer T, Schmoll HJ, Nordheim A, Janknecht R. Quantification of additional short arms of chromosome 12 in germ cell tumours using the polymerase chain reaction. Eur J Cancer. 1997 Aug; 33(9):1488-94. PMID: 9337694.
      Citations: 3     Fields:    Translation:HumansCells
    90. Bredemeier-Ernst I, Nordheim A, Janknecht R. Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1. FEBS Lett. 1997 May 12; 408(1):47-51. PMID: 9180266.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    91. Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 1997 Apr 01; 16(7):1620-7. PMID: 9130707.
      Citations: 43     Fields:    Translation:HumansCells
    92. Janknecht R, Hunter T. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem. 1997 Feb 14; 272(7):4219-24. PMID: 9020136.
      Citations: 24     Fields:    Translation:AnimalsCells
    93. Janknecht R, Nordheim A. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun. 1996 Nov 21; 228(3):831-7. PMID: 8941362.
      Citations: 54     Fields:    Translation:AnimalsCells
    94. Janknecht R, Monté D, Baert JL, de Launoit Y. The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene. 1996 Oct 17; 13(8):1745-54. PMID: 8895521.
      Citations: 27     Fields:    Translation:AnimalsCells
    95. Janknecht R, Hunter T. Transcription. A growing coactivator network. Nature. 1996 Sep 05; 383(6595):22-3. PMID: 8779707.
      Citations: 93     Fields:    Translation:HumansCells
    96. Janknecht R, Hunter T. Versatile molecular glue. Transcriptional control. Curr Biol. 1996 Aug 01; 6(8):951-4. PMID: 8805328.
      Citations: 56     Fields:    Translation:AnimalsCells
    97. Nassar N, Horn G, Herrmann C, Block C, Janknecht R, Wittinghofer A. Ras/Rap effector specificity determined by charge reversal. Nat Struct Biol. 1996 Aug; 3(8):723-9. PMID: 8756332.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    98. Oelgeschläger M, Janknecht R, Krieg J, Schreek S, Lüscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 1996 Jun 03; 15(11):2771-80. PMID: 8654374.
      Citations: 58     Fields:    Translation:AnimalsCells
    99. Janknecht R, Nordheim A. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene. 1996 May 02; 12(9):1961-9. PMID: 8649857.
      Citations: 33     Fields:    Translation:AnimalsCells
    100. Janknecht R. Analysis of the ERK-stimulated ETS transcription factor ER81. Mol Cell Biol. 1996 Apr; 16(4):1550-6. PMID: 8657129.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    101. Block C, Janknecht R, Herrmann C, Nassar N, Wittinghofer A. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat Struct Biol. 1996 Mar; 3(3):244-51. PMID: 8605626.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    102. Cahill MA, Janknecht R, Nordheim A. Signalling pathways: jack of all cascades. Curr Biol. 1996 Jan 01; 6(1):16-9. PMID: 8805215.
      Citations: 36     Fields:    Translation:AnimalsCells
    103. Janknecht R. Regulation of the c-fos promoter. Immunobiology. 1995 Jul; 193(2-4):137-42. PMID: 8530136.
      Citations: 4     Fields:    Translation:HumansCells
    104. Krieg J, Oelgeschläger M, Janknecht R, Lüscher B. High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains. Oncogene. 1995 Jun 01; 10(11):2221-8. PMID: 7784067.
      Citations: 3     Fields:    Translation:HumansCells
    105. Janknecht R, Ernst WH, Nordheim A. SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene. 1995 Mar 16; 10(6):1209-16. PMID: 7700646.
      Citations: 32     Fields:    Translation:HumansCells
    106. Janknecht R, Cahill MA, Nordheim A. Signal integration at the c-fos promoter. Carcinogenesis. 1995 Mar; 16(3):443-50. PMID: 7697796.
      Citations: 22     Fields:    Translation:HumansCells
    107. Ernst WH, Janknecht R, Cahill MA, Nordheim A. Transcriptional repression mediated by the serum response factor. FEBS Lett. 1995 Jan 02; 357(1):45-9. PMID: 8001676.
      Citations: 5     Fields:    Translation:AnimalsCells
    108. Cahill MA, Nordheim A, Janknecht R. Co-occurrence of CArG boxes and TCF sites within viral genomes. Biochem Biophys Res Commun. 1994 Nov 30; 205(1):545-51. PMID: 7999077.
      Citations: 3     Fields:    Translation:AnimalsCells
    109. Pingoud V, Zinck R, Hipskind RA, Janknecht R, Nordheim A. Heterogeneity of ternary complex factors in HeLa cell nuclear extracts. J Biol Chem. 1994 Sep 16; 269(37):23310-7. PMID: 8083237.
      Citations: 6     Fields:    Translation:HumansCells
    110. Cahill MA, Ernst WH, Janknecht R, Nordheim A. Regulatory squelching. FEBS Lett. 1994 May 16; 344(2-3):105-8. PMID: 8187867.
      Citations: 24     Fields:    Translation:AnimalsCells
    111. Janknecht R, Zinck R, Ernst WH, Nordheim A. Functional dissection of the transcription factor Elk-1. Oncogene. 1994 Apr; 9(4):1273-8. PMID: 8134131.
      Citations: 32     Fields:    Translation:HumansCells
    112. Janknecht R, Nordheim A. Gene regulation by Ets proteins. Biochim Biophys Acta. 1993 Dec 23; 1155(3):346-56. PMID: 8268191.
      Citations: 46     Fields:    Translation:HumansCells
    113. Janknecht R, Ernst WH, Pingoud V, Nordheim A. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 1993 Dec 15; 12(13):5097-104. PMID: 8262053.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    114. Janknecht R, Ernst WH, Houthaeve T, Nordheim A. C-terminal phosphorylation of the serum-response factor. Eur J Biochem. 1993 Sep 01; 216(2):469-75. PMID: 8375385.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    115. Janknecht R, Nordheim A. Affinity purification of histidine-tagged proteins transiently produced in HeLa cells. Gene. 1992 Nov 16; 121(2):321-4. PMID: 1446830.
      Citations: 8     Fields:    Translation:HumansCells
    116. Janknecht R, Nordheim A. Elk-1 protein domains required for direct and SRF-assisted DNA-binding. Nucleic Acids Res. 1992 Jul 11; 20(13):3317-24. PMID: 1630903.
      Citations: 49     Fields:    Translation:HumansCells
    117. Janknecht R, Hipskind RA, Houthaeve T, Nordheim A, Stunnenberg HG. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J. 1992 Mar; 11(3):1045-54. PMID: 1547771.
      Citations: 40     Fields:    Translation:HumansCells
    118. Janknecht R, Sander C, Pongs O. (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors? FEBS Lett. 1991 Dec 16; 295(1-3):1-2. PMID: 1765137.
      Citations: 6     Fields:    Translation:AnimalsCells
    119. Janknecht R, de Martynoff G, Lou J, Hipskind RA, Nordheim A, Stunnenberg HG. Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):8972-6. PMID: 1924358.
      Citations: 114     Fields:    Translation:HumansCells
    120. Janknecht R, Taube W, Lüdecke HJ, Pongs O. Characterization of a putative transcription factor gene expressed in the 20-OH-ecdysone inducible puff 74EF in Drosophila melanogaster. Nucleic Acids Res. 1989 Jun 26; 17(12):4455-64. PMID: 2501755.
      Citations: 14     Fields:    Translation:AnimalsCells
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