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Ralf Gregor Janknecht

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBRC 1464
975 NE 10th St
Oklahoma City OK 73104
Phone405/271-8001 ext 47420
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    Collapse Research 
    Collapse research activities and funding
    R01CA233613     (JANKNECHT, RALF)Jan 9, 2019 - Nov 30, 2024
    Role of the DNPH1 Enzyme in Breast Cancer
    Role: Principal Investigator

    R03CA223615     (JANKNECHT, RALF)Jul 6, 2018 - Jun 30, 2020
    Regulation of KDM4A by Lysine Methylation
    Role: Principal Investigator

    R01CA154745     (JANKNECHT, RALF)Jul 1, 2011 - Apr 30, 2017
    ETV1 and JMJD2 Demethylases in Prostate Cancer
    Role: Principal Investigator

    R01CA085257     (JANKNECHT, RALF)Feb 1, 2001 - Jan 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim TD, Gu R, Janknecht R. Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors. Int J Biochem Mol Biol. 2023; 14(6):101-115. PMID: 38213775; PMCID: PMC10776875.
    2. Gu R, Kim TD, Jiang H, Shin S, Oh S, Janknecht R. Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis. Front Oncol. 2023; 13:1295613. PMID: 38045004; PMCID: PMC10690936.
    3. Gu R, Kim TD, Song H, Sui Y, Shin S, Oh S, Janknecht R. SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A. JCI Insight. 2023 Oct 23; 8(20). PMID: 37870957; PMCID: PMC10619491.
      Citations:    Fields:    Translation:HumansCells
    4. Mohammed S, Thadathil N, Ohene-Marfo P, Tran AL, Van Der Veldt M, Georgescu C, Oh S, Nicklas EH, Wang D, Haritha NH, Luo W, Janknecht R, Miller BF, Wren JD, Freeman WM, Deepa SS. Absence of either Ripk3 or Mlkl reduces incidence of hepatocellular carcinoma independent of liver fibrosis. Mol Cancer Res. 2023 May 19. PMID: 37204757.
      Citations: 2     Fields:    Translation:Animals
    5. Sui Y, Jiang H, Kellogg CM, Oh S, Janknecht R. Promotion of colorectal cancer by transcription factor BHLHE40 involves upregulation of ADAM19 and KLF7. Front Oncol. 2023; 13:1122238. PMID: 36890812; PMCID: PMC9986587.
      Citations: 5     
    6. Oh S, Shin S, Janknecht R. Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer. Int J Clin Exp Pathol. 2021; 14(7):795-810. PMID: 34367411.
      Citations: 6     Fields:    
    7. Oh S, Song H, Freeman WM, Shin S, Janknecht R. Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer. Int J Oncol. 2020 12; 57(6):1319-1332. PMID: 33174020.
      Citations: 9     Fields:    Translation:HumansCells
    8. Liu H, Ramachandran S, Fong N, Phang T, Lee S, Parsa P, Liu X, Harmacek L, Danhorn T, Song T, Oh S, Zhang Q, Chen Z, Zhang Q, Tu TH, Happoldt C, O'Conner B, Janknecht R, Li CY, Marrack P, Kappler J, Leach S, Zhang G. JMJD5 couples with CDK9 to release the paused RNA polymerase II. Proc Natl Acad Sci U S A. 2020 08 18; 117(33):19888-19895. PMID: 32747552.
      Citations: 6     Fields:    Translation:HumansCells
    9. Sui Y, Gu R, Janknecht R. Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer. Mol Cancer Res. 2021 01; 19(1):3-13. PMID: 32605929.
      Citations: 18     Fields:    Translation:HumansAnimals
    10. Sui Y, Li X, Oh S, Zhang B, Freeman WM, Shin S, Janknecht R. Opposite Roles of the JMJD1A Interaction Partners MDFI and MDFIC in Colorectal Cancer. Sci Rep. 2020 05 26; 10(1):8710. PMID: 32457453.
      Citations: 15     Fields:    Translation:HumansCells
    11. Andrade D, Mehta M, Griffith J, Oh S, Corbin J, Babu A, De S, Chen A, Zhao YD, Husain S, Roy S, Xu L, Aube J, Janknecht R, Gorospe M, Herman T, Ramesh R, Munshi A. HuR Reduces Radiation-Induced DNA Damage by Enhancing Expression of ARID1A. Cancers (Basel). 2019 Dec 13; 11(12). PMID: 31847141.
      Citations: 17     
    12. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. Correction: JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2019 Aug; 17(8):e3000454. PMID: 31433800.
      Citations:    Fields:    
    13. Matsukura T, Inaba C, Weygant EA, Kitamura D, Janknecht R, Matsumoto H, Hyink DP, Kashiwada S, Obara T. Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model. Physiol Rep. 2019 07; 7(14):e14172. PMID: 31325249.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    14. Oh S, Shin S, Song H, Grande JP, Janknecht R. Relationship between ETS Transcription Factor ETV1 and TGF-ß-regulated SMAD Proteins in Prostate Cancer. Sci Rep. 2019 06 03; 9(1):8186. PMID: 31160676.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    15. Oh S, Shin S, Janknecht R. The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim Biophys Acta Rev Cancer. 2019 04; 1871(2):406-418. PMID: 31034925.
      Citations: 25     Fields:    Translation:HumansAnimals
    16. Neelakantan D, Dogra S, Devapatla B, Jaiprasart P, Mukashyaka MC, Janknecht R, Dwivedi SKD, Bhattacharya R, Husain S, Ding K, Woo S. Multifunctional APJ Pathway Promotes Ovarian Cancer Progression and Metastasis. Mol Cancer Res. 2019 06; 17(6):1378-1390. PMID: 30858172.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    17. Saran AR, Kalinowska D, Oh S, Janknecht R, DiTacchio L. JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 2018 11; 16(11):e2006145. PMID: 30500822.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    18. Li X, Oh S, Song H, Shin S, Zhang B, Freeman WM, Janknecht R. A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett. 2018 Nov; 16(5):6652-6662. PMID: 30405805.
      Citations: 15     
    19. Li X, Moon G, Shin S, Zhang B, Janknecht R. Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases. Mol Med Rep. 2018 04; 17(4):5518-5527. PMID: 29393482.
      Citations: 12     Fields:    Translation:HumansCells
    20. Andrade D, Mehta M, Griffith J, Panneerselvam J, Srivastava A, Kim TD, Janknecht R, Herman T, Ramesh R, Munshi A. YAP1 inhibition radiosensitizes triple negative breast cancer cells by targeting the DNA damage response and cell survival pathways. Oncotarget. 2017 Nov 17; 8(58):98495-98508. PMID: 29228705.
      Citations: 25     Fields:    
    21. Liu H, Wang C, Lee S, Deng Y, Wither M, Oh S, Ning F, Dege C, Zhang Q, Liu X, Johnson AM, Zang J, Chen Z, Janknecht R, Hansen K, Marrack P, Li CY, Kappler JW, Hagman J, Zhang G. Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7717-E7726. PMID: 28847961.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    22. O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM. A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. J Cell Sci. 2017 Oct 15; 130(20):3467-3480. PMID: 28839075.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    23. McBride JD, Liu X, Berry WL, Janknecht R, Cheng R, Zhou K, Badiavas EV, Ma JX. Transgenic expression of a canonical Wnt inhibitor, kallistatin, is associated with decreased circulating CD19+ B lymphocytes in the peripheral blood. Int J Hematol. 2017 Jun; 105(6):748-757. PMID: 28299632.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD, Janknecht R. Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int J Clin Exp Med. 2016; 9(6):10123-10134. PMID: 28883898.
      Citations: 12     
    25. Hysolli E, Tanaka Y, Su J, Kim KY, Zhong T, Janknecht R, Zhou XL, Geng L, Qiu C, Pan X, Jung YW, Cheng J, Lu J, Zhong M, Weissman SM, Park IH. Regulation of the DNA Methylation Landscape in Human Somatic Cell Reprogramming by the miR-29 Family. Stem Cell Reports. 2016 07 12; 7(1):43-54. PMID: 27373925.
      Citations: 17     Fields:    Translation:HumansCells
    26. Kim TD, Shin S, Janknecht R. ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol Rep. 2016 Jun; 35(6):3679-88. PMID: 27109047.
      Citations: 22     Fields:    Translation:HumansCells
    27. Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb; 126(2):706-20. PMID: 26731476.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    28. Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015 Jul 16; 14:133. PMID: 26178901.
      Citations: 110     Fields:    Translation:HumansCells
    29. Qi Y, Marlin MC, Liang Z, Berry WL, Janknecht R, Zhou J, Wang Z, Lu G, Li G. Distinct biochemical and functional properties of two Rab5 homologs from the rice blast fungus Magnaporthe oryzae. J Biol Chem. 2014 Oct 10; 289(41):28299-309. PMID: 25164815.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    30. Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 2014; 6(3):236-47. PMID: 24936217.
      Citations: 42     
    31. Weygant N, Qu D, Berry WL, May R, Chandrakesan P, Owen DB, Sureban SM, Ali N, Janknecht R, Houchen CW. Small molecule kinase inhibitor LRRK2-IN-1 demonstrates potent activity against colorectal and pancreatic cancer through inhibition of doublecortin-like kinase 1. Mol Cancer. 2014 May 06; 13:103. PMID: 24885928.
      Citations: 60     Fields:    Translation:HumansCells
    32. Berry WL, Kim TD, Janknecht R. Stimulation of ß-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 2014 Apr; 44(4):1341-8. PMID: 24481461.
      Citations: 31     Fields:    Translation:HumansCells
    33. McBride JD, Jenkins AJ, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin CT, Aston CE, Lyons TJ, Tomasek JJ, Ma JX. Elevated circulation levels of an antiangiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol. 2014 Jun; 134(6):1725-1734. PMID: 24463424.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    34. Fukuyo Y, Nakamura T, Bubenshchikova E, Powell R, Tsuji T, Janknecht R, Obara T. Nephrin and Podocin functions are highly conserved between the zebrafish pronephros and mammalian metanephros. Mol Med Rep. 2014 Feb; 9(2):457-65. PMID: 24337247.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    35. Ali N, Allam H, Bader T, May R, Basalingappa KM, Berry WL, Chandrakesan P, Qu D, Weygant N, Bronze MS, Umar S, Janknecht R, Sureban SM, Huycke M, Houchen CW. Fluvastatin interferes with hepatitis C virus replication via microtubule bundling and a doublecortin-like kinase-mediated mechanism. PLoS One. 2013; 8(11):e80304. PMID: 24260365.
      Citations: 22     Fields:    Translation:HumansCells
    36. Oh S, Shin S, Lightfoot SA, Janknecht R. 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 2013 Aug 15; 73(16):5110-9. PMID: 23774214.
      Citations: 29     Fields:    Translation:HumansCells
    37. Berry WL, Janknecht R. KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res. 2013 May 15; 73(10):2936-42. PMID: 23644528.
      Citations: 220     Fields:    Translation:HumansAnimals
    38. Ichimura K, Fukuyo Y, Nakamura T, Powell R, Sakai T, Janknecht R, Obara T. Developmental localization of nephrin in zebrafish and medaka pronephric glomerulus. J Histochem Cytochem. 2013 Apr; 61(4):313-24. PMID: 23324868.
      Citations: 12     Fields:    Translation:AnimalsCells
    39. Shin S, Oh S, An S, Janknecht R. ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol Rep. 2013 Jan; 29(1):306-14. PMID: 23076342.
      Citations: 30     Fields:    Translation:HumansCells
    40. Berry WL, Shin S, Lightfoot SA, Janknecht R. Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int J Oncol. 2012 Nov; 41(5):1701-6. PMID: 22948256.
      Citations: 63     Fields:    Translation:HumansCells
    41. Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, Nunez S, Janknecht R, Hayashi-Takanaka Y, Wilson MD, Marshall A, Odom DT, Babu MM, Bazett-Jones DP, Tavaré S, Edwards PA, Lowe SW, Kimura H, Gilbert DM, Narita M. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell. 2012 Jul 27; 47(2):203-14. PMID: 22795131.
      Citations: 172     Fields:    Translation:HumansCells
    42. DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P, Janknecht R. Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 2012 Jul 06; 287(28):23657-66. PMID: 22613723.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    43. Kim TD, Oh S, Shin S, Janknecht R. Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One. 2012; 7(4):e34618. PMID: 22514644.
      Citations: 45     Fields:    Translation:HumansCells
    44. Kim TD, Shin S, Berry WL, Oh S, Janknecht R. The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 2012 Apr; 113(4):1368-76. PMID: 22134899.
      Citations: 59     Fields:    Translation:HumansCells
    45. Oh S, Shin S, Janknecht R. ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochim Biophys Acta. 2012 Aug; 1826(1):1-12. PMID: 22425584.
      Citations: 140     Fields:    Translation:HumansCells
    46. Oh S, Janknecht R. Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):61-5. PMID: 22402282.
      Citations: 46     Fields:    Translation:AnimalsCells
    47. Kimura R, Ishikawa C, Rokkaku T, Janknecht R, Mori N. Phosphorylated c-Jun and Fra-1 induce matrix metalloproteinase-1 and thereby regulate invasion activity of 143B osteosarcoma cells. Biochim Biophys Acta. 2011 Aug; 1813(8):1543-53. PMID: 21640141.
      Citations: 29     Fields:    Translation:HumansCells
    48. Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, Hawse JR, Spelsberg TC, Janknecht R. Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun. 2010 Oct 22; 401(3):412-6. PMID: 20863814.
      Citations: 36     Fields:    Translation:HumansCells
    49. Mooney SM, Goel A, D'Assoro AB, Salisbury JL, Janknecht R. Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 2010 Oct 01; 285(40):30443-52. PMID: 20663877.
      Citations: 33     Fields:    Translation:HumansCells
    50. Janknecht R. Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). Am J Transl Res. 2010 May 05; 2(3):223-34. PMID: 20589163.
      Citations: 52     
    51. Mooney SM, Grande JP, Salisbury JL, Janknecht R. Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 2010 Jan 12; 49(1):1-10. PMID: 19995069.
      Citations: 58     Fields:    Translation:HumansCells
    52. Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 2009 Oct 15; 69(20):8102-10. PMID: 19789348.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    53. Hamada S, Kim TD, Suzuki T, Itoh Y, Tsumoto H, Nakagawa H, Janknecht R, Miyata N. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15; 19(10):2852-5. PMID: 19359167.
      Citations: 55     Fields:    Translation:HumansCells
    54. Shin S, Bosc DG, Ingle JN, Spelsberg TC, Janknecht R. Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. J Cell Biochem. 2008 Oct 15; 105(3):866-74. PMID: 18726892.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    55. Lee D, Park C, Lee H, Lugus JJ, Kim SH, Arentson E, Chung YS, Gomez G, Kyba M, Lin S, Janknecht R, Lim DS, Choi K. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008 May 08; 2(5):497-507. PMID: 18462699.
      Citations: 181     Fields:    Translation:AnimalsCells
    56. Kim TD, Shin S, Janknecht R. Repression of Smad3 activity by histone demethylase SMCX/JARID1C. Biochem Biophys Res Commun. 2008 Feb 08; 366(2):563-7. PMID: 18078810.
      Citations: 22     Fields:    Translation:HumansCells
    57. Smith EH, Janknecht R, Maher LJ. Succinate inhibition of alpha-ketoglutarate-dependent enzymes in a yeast model of paraganglioma. Hum Mol Genet. 2007 Dec 15; 16(24):3136-48. PMID: 17884808.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    58. Shin S, Rossow KL, Grande JP, Janknecht R. Involvement of RNA helicases p68 and p72 in colon cancer. Cancer Res. 2007 Aug 15; 67(16):7572-8. PMID: 17699760.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    59. Shin S, Janknecht R. Concerted activation of the Mdm2 promoter by p72 RNA helicase and the coactivators p300 and P/CAF. J Cell Biochem. 2007 Aug 01; 101(5):1252-65. PMID: 17226766.
      Citations: 20     Fields:    Translation:HumansCells
    60. Shin S, Janknecht R. Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem Biophys Res Commun. 2007 Aug 03; 359(3):742-6. PMID: 17555712.
      Citations: 111     Fields:    Translation:HumansCells
    61. Shin S, Janknecht R. Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun. 2007 Feb 23; 353(4):973-7. PMID: 17207460.
      Citations: 75     Fields:    Translation:HumansCells
    62. Knebel J, De Haro L, Janknecht R. Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. J Cell Biochem. 2006 Sep 01; 99(1):319-29. PMID: 16619273.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    63. Janknecht R. EWS-ETS oncoproteins: the linchpins of Ewing tumors. Gene. 2005 Dec 19; 363:1-14. PMID: 16202544.
      Citations: 75     Fields:    Translation:HumansCells
    64. De Haro L, Janknecht R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics. 2005 Apr; 85(4):493-502. PMID: 15780752.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    65. Dowdy SC, Mariani A, Reinholz MM, Keeney GL, Spelsberg TC, Podratz KC, Janknecht R. Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer. Gynecol Oncol. 2005 Feb; 96(2):368-73. PMID: 15661223.
      Citations: 21     Fields:    Translation:HumansCells
    66. Fuchs B, Inwards C, Scully SP, Janknecht R. hTERT Is highly expressed in Ewing's sarcoma and activated by EWS-ETS oncoproteins. Clin Orthop Relat Res. 2004 Sep; (426):64-8. PMID: 15346053.
      Citations: 4     Fields:    Translation:HumansCells
    67. Janknecht R. On the road to immortality: hTERT upregulation in cancer cells. FEBS Lett. 2004 Apr 23; 564(1-2):9-13. PMID: 15094035.
      Citations: 47     Fields:    Translation:HumansCells
    68. Fuchs B, Inwards CY, Janknecht R. Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma. Clin Cancer Res. 2004 Feb 15; 10(4):1344-53. PMID: 14977835.
      Citations: 43     Fields:    Translation:HumansCells
    69. Goel A, Janknecht R. Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 2004 Apr 09; 279(15):14909-16. PMID: 14747462.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    70. Goueli BS, Janknecht R. Upregulation of the Catalytic Telomerase Subunit by the Transcription Factor ER81 and Oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol. 2004 Jan; 24(1):25-35. PMID: 14673140.
      Citations: 51     Fields:    Translation:HumansCells
    71. Fuchs B, Inwards CY, Janknecht R. Upregulation of the matrix metalloproteinase-1 gene by the Ewing's sarcoma associated EWS-ER81 and EWS-Fli-1 oncoproteins, c-Jun and p300. FEBS Lett. 2003 Oct 09; 553(1-2):104-8. PMID: 14550555.
      Citations: 12     Fields:    Translation:HumansCells
    72. Goueli BS, Janknecht R. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene. 2003 Sep 11; 22(39):8042-7. PMID: 12970752.
      Citations: 54     Fields:    Translation:HumansCells
    73. Goel A, Janknecht R. Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol. 2003 Sep; 23(17):6243-54. PMID: 12917345.
      Citations: 47     Fields:    Translation:HumansCells
    74. Dowdy SC, Mariani A, Janknecht R. HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 2003 Nov 07; 278(45):44377-84. PMID: 12947087.
      Citations: 50     Fields:    Translation:HumansCells
    75. Janknecht R. Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 2003 Feb 06; 22(5):746-55. PMID: 12569367.
      Citations: 46     Fields:    Translation:AnimalsCells
    76. Rossow KL, Janknecht R. Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. Oncogene. 2003 Jan 09; 22(1):151-6. PMID: 12527917.
      Citations: 48     Fields:    Translation:HumansCells
    77. Wu J, Janknecht R. Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem. 2002 Nov 08; 277(45):42669-79. PMID: 12213813.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    78. Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene. 2002 Aug 22; 21(37):5783-90. PMID: 12173049.
      Citations: 69     Fields:    Translation:HumansCells
    79. De Haro L, Janknecht R. Functional analysis of the transcription factor ER71 and its activation of the matrix metalloproteinase-1 promoter. Nucleic Acids Res. 2002 Jul 01; 30(13):2972-9. PMID: 12087183.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    80. Johnsen SA, Subramaniam M, Monroe DG, Janknecht R, Spelsberg TC. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J Biol Chem. 2002 Aug 23; 277(34):30754-9. PMID: 12072443.
      Citations: 30     Fields:    Translation:HumansCells
    81. Janknecht R. The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease. Histol Histopathol. 2002 04; 17(2):657-68. PMID: 11962765.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    82. Bosc DG, Janknecht R. Regulation of Her2/neu promoter activity by the ETS transcription factor, ER81. J Cell Biochem. 2002; 86(1):174-83. PMID: 12112028.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    83. Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC. Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem. 2002; 87(2):233-41. PMID: 12244575.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    84. Bosc DG, Goueli BS, Janknecht R. HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene. 2001 Sep 27; 20(43):6215-24. PMID: 11593430.
      Citations: 46     Fields:    Translation:AnimalsCells
    85. Janknecht R. Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2. J Biol Chem. 2001 Nov 09; 276(45):41856-61. PMID: 11551945.
      Citations: 11     Fields:    Translation:Cells
    86. Rossow KL, Janknecht R. The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 2001 Mar 15; 61(6):2690-5. PMID: 11289149.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    87. Papoutsopoulou S, Janknecht R. Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Mol Cell Biol. 2000 Oct; 20(19):7300-10. PMID: 10982847.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    88. Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM. CBP/p300 interact with and function as transcriptional coactivators of BRCA1. Proc Natl Acad Sci U S A. 2000 Feb 01; 97(3):1020-5. PMID: 10655477.
      Citations: 68     Fields:    Translation:HumansCells
    89. Pearson KL, Hunter T, Janknecht R. Activation of Smad1-mediated transcription by p300/CBP. Biochim Biophys Acta. 1999 Dec 23; 1489(2-3):354-64. PMID: 10673036.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    90. Arbet-Engels C, Janknecht R, Eckhart W. Role of focal adhesion kinase in MAP kinase activation by insulin-like growth factor-I or insulin. FEBS Lett. 1999 Jul 09; 454(3):252-6. PMID: 10431817.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    91. Janknecht R, Hunter T. Nuclear fusion of signaling pathways. Science. 1999 Apr 16; 284(5413):443-4. PMID: 10232991.
      Citations: 5     Fields:    Translation:Cells
    92. Janknecht R, Wells NJ, Hunter T. TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300. Genes Dev. 1998 Jul 15; 12(14):2114-9. PMID: 9679056.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    93. Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998 Jun 18; 8(13):779-82. PMID: 9651683.
      Citations: 86     Fields:    Translation:HumansCells
    94. Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa MS. p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem. 1997 Aug 01; 272(31):19509-17. PMID: 9235954.
      Citations: 35     Fields:    Translation:HumansCells
    95. Malek NP, Casper J, Looijenga LH, Strohmeyer T, Schmoll HJ, Nordheim A, Janknecht R. Quantification of additional short arms of chromosome 12 in germ cell tumours using the polymerase chain reaction. Eur J Cancer. 1997 Aug; 33(9):1488-94. PMID: 9337694.
      Citations: 5     Fields:    Translation:HumansCells
    96. Bredemeier-Ernst I, Nordheim A, Janknecht R. Transcriptional activity and constitutive nuclear localization of the ETS protein Elf-1. FEBS Lett. 1997 May 12; 408(1):47-51. PMID: 9180266.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    97. Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J. 1997 Apr 01; 16(7):1620-7. PMID: 9130707.
      Citations: 47     Fields:    Translation:HumansCells
    98. Janknecht R, Hunter T. Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem. 1997 Feb 14; 272(7):4219-24. PMID: 9020136.
      Citations: 29     Fields:    Translation:AnimalsCells
    99. Janknecht R, Nordheim A. MAP kinase-dependent transcriptional coactivation by Elk-1 and its cofactor CBP. Biochem Biophys Res Commun. 1996 Nov 21; 228(3):831-7. PMID: 8941362.
      Citations: 56     Fields:    Translation:AnimalsCells
    100. Janknecht R, Monté D, Baert JL, de Launoit Y. The ETS-related transcription factor ERM is a nuclear target of signaling cascades involving MAPK and PKA. Oncogene. 1996 Oct 17; 13(8):1745-54. PMID: 8895521.
      Citations: 29     Fields:    Translation:AnimalsCells
    101. Janknecht R, Hunter T. Transcription. A growing coactivator network. Nature. 1996 Sep 05; 383(6595):22-3. PMID: 8779707.
      Citations: 96     Fields:    Translation:HumansCells
    102. Nassar N, Horn G, Herrmann C, Block C, Janknecht R, Wittinghofer A. Ras/Rap effector specificity determined by charge reversal. Nat Struct Biol. 1996 Aug; 3(8):723-9. PMID: 8756332.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    103. Janknecht R, Hunter T. Versatile molecular glue. Transcriptional control. Curr Biol. 1996 Aug 01; 6(8):951-4. PMID: 8805328.
      Citations: 60     Fields:    Translation:AnimalsCells
    104. Oelgeschläger M, Janknecht R, Krieg J, Schreek S, Lüscher B. Interaction of the co-activator CBP with Myb proteins: effects on Myb-specific transactivation and on the cooperativity with NF-M. EMBO J. 1996 Jun 03; 15(11):2771-80. PMID: 8654374.
      Citations: 60     Fields:    Translation:AnimalsCells
    105. Janknecht R, Nordheim A. Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. Oncogene. 1996 May 02; 12(9):1961-9. PMID: 8649857.
      Citations: 33     Fields:    Translation:AnimalsCells
    106. Janknecht R. Analysis of the ERK-stimulated ETS transcription factor ER81. Mol Cell Biol. 1996 Apr; 16(4):1550-6. PMID: 8657129.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    107. Block C, Janknecht R, Herrmann C, Nassar N, Wittinghofer A. Quantitative structure-activity analysis correlating Ras/Raf interaction in vitro to Raf activation in vivo. Nat Struct Biol. 1996 Mar; 3(3):244-51. PMID: 8605626.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    108. Cahill MA, Janknecht R, Nordheim A. Signalling pathways: jack of all cascades. Curr Biol. 1996 Jan 01; 6(1):16-9. PMID: 8805215.
      Citations: 36     Fields:    Translation:AnimalsCells
    109. Janknecht R. Regulation of the c-fos promoter. Immunobiology. 1995 Jul; 193(2-4):137-42. PMID: 8530136.
      Citations: 4     Fields:    Translation:HumansCells
    110. Krieg J, Oelgeschläger M, Janknecht R, Lüscher B. High affinity DNA binding of native full length c-Myb and differential proteolytic sensitivity of its N- and C-terminal domains. Oncogene. 1995 Jun 01; 10(11):2221-8. PMID: 7784067.
      Citations: 3     Fields:    Translation:HumansCells
    111. Janknecht R, Ernst WH, Nordheim A. SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene. 1995 Mar 16; 10(6):1209-16. PMID: 7700646.
      Citations: 32     Fields:    Translation:HumansCells
    112. Janknecht R, Cahill MA, Nordheim A. Signal integration at the c-fos promoter. Carcinogenesis. 1995 Mar; 16(3):443-50. PMID: 7697796.
      Citations: 24     Fields:    Translation:HumansCells
    113. Ernst WH, Janknecht R, Cahill MA, Nordheim A. Transcriptional repression mediated by the serum response factor. FEBS Lett. 1995 Jan 02; 357(1):45-9. PMID: 8001676.
      Citations: 6     Fields:    Translation:AnimalsCells
    114. Cahill MA, Nordheim A, Janknecht R. Co-occurrence of CArG boxes and TCF sites within viral genomes. Biochem Biophys Res Commun. 1994 Nov 30; 205(1):545-51. PMID: 7999077.
      Citations: 2     Fields:    Translation:AnimalsCells
    115. Pingoud V, Zinck R, Hipskind RA, Janknecht R, Nordheim A. Heterogeneity of ternary complex factors in HeLa cell nuclear extracts. J Biol Chem. 1994 Sep 16; 269(37):23310-7. PMID: 8083237.
      Citations: 9     Fields:    Translation:HumansCells
    116. Cahill MA, Ernst WH, Janknecht R, Nordheim A. Regulatory squelching. FEBS Lett. 1994 May 16; 344(2-3):105-8. PMID: 8187867.
      Citations: 25     Fields:    Translation:AnimalsCells
    117. Janknecht R, Zinck R, Ernst WH, Nordheim A. Functional dissection of the transcription factor Elk-1. Oncogene. 1994 Apr; 9(4):1273-8. PMID: 8134131.
      Citations: 42     Fields:    Translation:HumansCells
    118. Janknecht R, Nordheim A. Gene regulation by Ets proteins. Biochim Biophys Acta. 1993 Dec 23; 1155(3):346-56. PMID: 8268191.
      Citations: 47     Fields:    Translation:HumansCells
    119. Janknecht R, Ernst WH, Pingoud V, Nordheim A. Activation of ternary complex factor Elk-1 by MAP kinases. EMBO J. 1993 Dec 15; 12(13):5097-104. PMID: 8262053.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    120. Janknecht R, Ernst WH, Houthaeve T, Nordheim A. C-terminal phosphorylation of the serum-response factor. Eur J Biochem. 1993 Sep 01; 216(2):469-75. PMID: 8375385.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    121. Janknecht R, Nordheim A. Affinity purification of histidine-tagged proteins transiently produced in HeLa cells. Gene. 1992 Nov 16; 121(2):321-4. PMID: 1446830.
      Citations: 8     Fields:    Translation:HumansCells
    122. Janknecht R, Nordheim A. Elk-1 protein domains required for direct and SRF-assisted DNA-binding. Nucleic Acids Res. 1992 Jul 11; 20(13):3317-24. PMID: 1630903.
      Citations: 51     Fields:    Translation:HumansCells
    123. Janknecht R, Hipskind RA, Houthaeve T, Nordheim A, Stunnenberg HG. Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties. EMBO J. 1992 Mar; 11(3):1045-54. PMID: 1547771.
      Citations: 44     Fields:    Translation:HumansCells
    124. Janknecht R, Sander C, Pongs O. (HX)n repeats: a pH-controlled protein-protein interaction motif of eukaryotic transcription factors? FEBS Lett. 1991 Dec 16; 295(1-3):1-2. PMID: 1765137.
      Citations: 6     Fields:    Translation:AnimalsCells
    125. Janknecht R, de Martynoff G, Lou J, Hipskind RA, Nordheim A, Stunnenberg HG. Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus. Proc Natl Acad Sci U S A. 1991 Oct 15; 88(20):8972-6. PMID: 1924358.
      Citations: 122     Fields:    Translation:HumansCells
    126. Janknecht R, Taube W, Lüdecke HJ, Pongs O. Characterization of a putative transcription factor gene expressed in the 20-OH-ecdysone inducible puff 74EF in Drosophila melanogaster. Nucleic Acids Res. 1989 Jun 26; 17(12):4455-64. PMID: 2501755.
      Citations: 14     Fields:    Translation:AnimalsCells
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