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Rheal Towner

TitleProf,Asoc of Research
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPhysiology
AddressBMSB 653
940 Stanton L Young Blvd
Oklahoma City OK 73104
Phone405/271-2226
Fax0
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    Collapse Research 
    Collapse research activities and funding
    R03CA121359     (TOWNER, RHEAL A)Apr 1, 2006 - Mar 31, 2008
    NIH
    Molecular-Specific Detection of Tumors: MRI Investigations
    Role: Principal Investigator

    R03CA133936     (TOWNER, RHEAL A)Jul 1, 2008 - Dec 30, 2010
    NIH
    Chemoprevention of Gliomas using Nitrones with Anti-c-Met Activity
    Role: Principal Investigator

    R21CA136642     (TOWNER, RHEAL A)May 17, 2009 - Jan 30, 2012
    NIH
    Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Role: Principal Investigator

    R01NS092458     (MORTON, KATHRYN ANN)Apr 1, 2015 - Mar 31, 2021
    NIH
    Causes, consequences, imaging and mitigation of sepsis-induced encephalopathy
    Role: Co-Principal Investigator

    S10OD023508     (TOWNER, RHEAL A)Apr 1, 2017 - Mar 31, 2018
    NIH
    Pre-Clinical 7T MRI for Oklahoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Towner RA, Gulej R, Zalles M, Saunders D, Smith N, Lerner M, Morton KA, Richardson A. Rapamycin restores brain vasculature, metabolism, and blood-brain barrier in an inflammaging model. Geroscience. 2021 04; 43(2):563-578. PMID: 33846885.
      Citations:    Fields:    
    2. Towner RA, Greenwood-Van Meerveld B, Mohammadi E, Saunders D, Smith N, Sant GR, Shain HC, Jozefiak TH, Hurst RE. SuperGAG biopolymers for treatment of excessive bladder permeability. Pharmacol Res Perspect. 2021 02; 9(1):e00709. PMID: 33540486.
      Citations:    Fields:    
    3. Towner RA, Smith N, Zalles M, Morris S, Toliver M, Saunders D, Lerner M, Kumar G, Axtell RC. ELTD1 as a biomarker for multiple sclerosis: Pre-clinical molecular-targeted studies in a mouse experimental autoimmune encephalomyelitis model. Mult Scler Relat Disord. 2021 Apr; 49:102786. PMID: 33517175.
      Citations:    Fields:    Translation:Animals
    4. Chelluri LK, Mohanram Y, Jain R, Mallarpu CS, Ponnana M, Kumar D, Krishna Venuganti VV, Kancherla R, Papineni RV, Towner R, Ghosal P. Effect of engineered superparamagnetic iron oxide nanoparticles in targeted cardiac precursor cell delivery by MRI. Biochem Biophys Res Commun. 2021 Feb 19; 541:15-21. PMID: 33461063.
      Citations: 1     Fields:    
    5. Thomas L, Smith N, Saunders D, Zalles M, Gulej R, Lerner M, Fung KM, Carcaboso AM, Towner RA. OKlahoma Nitrone-007: novel treatment for diffuse intrinsic pontine glioma. J Transl Med. 2020 11 10; 18(1):424. PMID: 33168005.
      Citations:    Fields:    Translation:HumansAnimals
    6. Yabluchanskiy A, Nyul-Toth A, Csiszar A, Gulej R, Saunders D, Towner R, Turner M, Zhao Y, Abdelkari D, Rypma B, Tarantini S. Age-related alterations in the cerebrovasculature affect neurovascular coupling and BOLD fMRI responses: Insights from animal models of aging. Psychophysiology. 2020 Nov 03; e13718. PMID: 33141436.
      Citations:    Fields:    
    7. Smith N, Saunders D, Lerner M, Zalles M, Mamedova N, Cheong D, Mohammadi E, Yuan T, Luo Y, Hurst RE, Greenwood-Van Meerveld B, Towner RA. In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis. PLoS One. 2020; 15(10):e0239282. PMID: 33095778.
      Citations: 1     Fields:    Translation:Animals
    8. Wang M, Zhou B, Wang L, Zhou F, Smith N, Saunders D, Towner RA, Song J, Qu J, Chen WR. Biodegradable pH-responsive amorphous calcium carbonate nanoparticles as immunoadjuvants for multimodal imaging and enhanced photoimmunotherapy. J Mater Chem B. 2020 09 23; 8(36):8261-8270. PMID: 32812632.
      Citations:    Fields:    Translation:AnimalsCells
    9. Hudson LT, Jett SV, Kramer KE, Laurence DW, Ross CJ, Towner RA, Baumwart R, Lim KM, Mir A, Burkhart HM, Wu Y, Lee CH. A Pilot Study on Linking Tissue Mechanics with Load-Dependent Collagen Microstructures in Porcine Tricuspid Valve Leaflets. Bioengineering (Basel). 2020 Jun 18; 7(2). PMID: 32570939.
      Citations:    
    10. Zhou B, Wu Q, Wang M, Hoover A, Wang X, Zhou F, Towner RA, Smith N, Saunders D, Song J, Qu J, Chen WR. Immunologically modified MnFe2O4 nanoparticles to synergize photothermal therapy and immunotherapy for cancer treatment. Chem Eng J. 2020 Sep 15; 396. PMID: 32523422.
      Citations:    
    11. Zalles M, Smith N, Saunders D, Saran T, Thomas L, Gulej R, Lerner M, Fung KM, Chung J, Hwang K, Jin J, Battiste J, Towner RA. Assessment of an scFv Antibody Fragment Against ELTD1 in a G55 Glioblastoma Xenograft Model. Transl Oncol. 2020 Mar; 13(3):100737. PMID: 32208341.
      Citations:    
    12. Piekarz KM, Bhaskaran S, Sataranatarajan K, Street K, Premkumar P, Saunders D, Zalles M, Gulej R, Khademi S, Laurin J, Peelor R, Miller BF, Towner R, Van Remmen H. Molecular changes associated with spinal cord aging. Geroscience. 2020 04; 42(2):765-784. PMID: 32144690.
      Citations: 4     Fields:    Translation:AnimalsCells
    13. Towner RA, Smith N, Saunders D, Lerner M, Greenwood-Van Meerveld B, Hurst RE. Assessing bladder hyper-permeability biomarkers in vivo using molecularly-targeted MRI. Am J Nucl Med Mol Imaging. 2020; 10(1):57-65. PMID: 32211219.
      Citations:    
    14. Zalles M, Smith N, Ziegler J, Saunders D, Remerowski S, Thomas L, Gulej R, Mamedova N, Lerner M, Fung KM, Chung J, Hwang K, Jin J, Wiley G, Brown C, Battiste J, Wren JD, Towner RA. Optimized monoclonal antibody treatment against ELTD1 for GBM in a G55 xenograft mouse model. J Cell Mol Med. 2020 01; 24(2):1738-1749. PMID: 31863639.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Wang L, Wang M, Zhou B, Zhou F, Murray C, Towner RA, Smith N, Saunders D, Xie G, Chen WR. PEGylated reduced-graphene oxide hybridized with Fe3O4 nanoparticles for cancer photothermal-immunotherapy. J Mater Chem B. 2019 12 14; 7(46):7406-7414. PMID: 31710067.
      Citations: 4     Fields:    Translation:AnimalsCells
    16. Damme NM, Fernandez DP, Wang LM, Wu Q, Kirk RA, Towner RA, McNally JS, Hoffman JM, Morton KA. Analysis of retention of gadolinium by brain, bone, and blood following linear gadolinium-based contrast agent administration in rats with experimental sepsis. Magn Reson Med. 2020 06; 83(6):1930-1939. PMID: 31677194.
      Citations: 2     Fields:    Translation:Animals
    17. Smith N, Saunders D, Jensen RL, Towner RA. Association of decreased levels of lipopolysaccharide-binding protein with OKN-007-induced regression of tumor growth in an F98 rat glioma model. J Neurosurg. 2019 Oct 18; 1-9. PMID: 31628293.
      Citations:    Fields:    
    18. Jog NR, McClain MT, Heinlen LD, Gross T, Towner R, Guthridge JM, Axtell RC, Pardo G, Harley JB, James JA. Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. J Autoimmun. 2020 01; 106:102332. PMID: 31515129.
      Citations: 4     Fields:    
    19. Towner RA, Saunders D, Smith N, Gulej R, McKenzie T, Lawrence B, Morton KA. Anti-inflammatory agent, OKN-007, reverses long-term neuroinflammatory responses in a rat encephalopathy model as assessed by multi-parametric MRI: implications for aging-associated neuroinflammation. Geroscience. 2019 08; 41(4):483-494. PMID: 31478121.
      Citations: 4     Fields:    Translation:Animals
    20. Kirk RA, Kesner RP, Wang LM, Wu Q, Towner RA, Hoffman JM, Morton KA. Lipopolysaccharide exposure in a rat sepsis model results in hippocampal amyloid-ß plaque and phosphorylated tau deposition and corresponding behavioral deficits. Geroscience. 2019 08; 41(4):467-481. PMID: 31473912.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Ahn B, Smith N, Saunders D, Ranjit R, Kneis P, Towner RA, Van Remmen H. Using MRI to measure in vivo free radical production and perfusion dynamics in a mouse model of elevated oxidative stress and neurogenic atrophy. Redox Biol. 2019 09; 26:101308. PMID: 31470261.
      Citations: 1     Fields:    Translation:AnimalsCells
    22. Piao D, Towner RA, Smith N, Chen WR. Erratum: Magneto-thermo-acoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: a theoretical feasibility analysis. Med. Phys. 40(6): p. 063301 (2013). Med Phys. 2019 Oct; 46(10):4710. PMID: 31625629.
      Citations:    Fields:    
    23. Ross CJ, Laurence DW, Richardson J, Babu AR, Evans LE, Beyer EG, Childers RC, Wu Y, Towner RA, Fung KM, Mir A, Burkhart HM, Holzapfel GA, Lee CH. An investigation of the glycosaminoglycan contribution to biaxial mechanical behaviours of porcine atrioventricular heart valve leaflets. J R Soc Interface. 2019 07 26; 16(156):20190069. PMID: 31266416.
      Citations: 4     Fields:    Translation:Animals
    24. Kramer KE, Ross CJ, Laurence DW, Babu AR, Wu Y, Towner RA, Mir A, Burkhart HM, Holzapfel GA, Lee CH. An investigation of layer-specific tissue biomechanics of porcine atrioventricular valve anterior leaflets. Acta Biomater. 2019 09 15; 96:368-384. PMID: 31260822.
      Citations: 6     Fields:    Translation:Animals
    25. Lee CH, Laurence DW, Ross CJ, Kramer KE, Babu AR, Johnson EL, Hsu MC, Aggarwal A, Mir A, Burkhart HM, Towner RA, Baumwart R, Wu Y. Mechanics of the Tricuspid Valve-From Clinical Diagnosis/Treatment, In-Vivo and In-Vitro Investigations, to Patient-Specific Biomechanical Modeling. Bioengineering (Basel). 2019 May 22; 6(2). PMID: 31121881.
      Citations:    
    26. Laurence D, Ross C, Jett S, Johns C, Echols A, Baumwart R, Towner R, Liao J, Bajona P, Wu Y, Lee CH. Regional biaxial mechanical data of the mitral and tricuspid valve anterior leaflets. Data Brief. 2019 Jun; 24:103961. PMID: 31194001.
      Citations:    
    27. Ziegler J, Zalles M, Smith N, Saunders D, Lerner M, Fung KM, Patel M, Wren JD, Lupu F, Battiste J, Towner RA. Targeting ELTD1, an angiogenesis marker for glioblastoma (GBM), also affects VEGFR2: molecular-targeted MRI assessment. Am J Nucl Med Mol Imaging. 2019; 9(1):93-109. PMID: 30911439.
      Citations:    
    28. Xia D, Yang Q, Fung KM, Towner RA, Smith N, Saunders D, Greenwood-Van Meerveld B, Kropp BP, Madihally SV, Lin HK. Immunomodulatory response of layered small intestinal submucosa in a rat bladder regeneration model. . 2019 Aug; 107(6):1960-1969. PMID: 30521124.
      Citations:    
    29. Towner RA, Smith N, Saunders D, Brown CA, Cai X, Ziegler J, Mallory S, Dozmorov MG, Coutinho De Souza P, Wiley G, Kim K, Kang S, Kong DS, Kim YT, Fung KM, Wren JD, Battiste J. OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth. Transl Oncol. 2019 Feb; 12(2):320-335. PMID: 30468988.
      Citations:    
    30. Laurence D, Ross C, Jett S, Johns C, Echols A, Baumwart R, Towner R, Liao J, Bajona P, Wu Y, Lee CH. An investigation of regional variations in the biaxial mechanical properties and stress relaxation behaviors of porcine atrioventricular heart valve leaflets. J Biomech. 2019 01 23; 83:16-27. PMID: 30497683.
      Citations: 15     Fields:    Translation:Animals
    31. Jett S, Laurence D, Kunkel R, Babu AR, Kramer K, Baumwart R, Towner R, Wu Y, Lee CH. Biaxial mechanical data of porcine atrioventricular valve leaflets. Data Brief. 2018 Dec; 21:358-363. PMID: 30364794.
      Citations:    
    32. Jett S, Laurence D, Kunkel R, Babu AR, Kramer K, Baumwart R, Towner R, Wu Y, Lee CH. An investigation of the anisotropic mechanical properties and anatomical structure of porcine atrioventricular heart valves. J Mech Behav Biomed Mater. 2018 11; 87:155-171. PMID: 30071486.
      Citations: 19     Fields:    Translation:Animals
    33. Wang LM, Wu Q, Kirk RA, Horn KP, Ebada Salem AH, Hoffman JM, Yap JT, Sonnen JA, Towner RA, Bozza FA, Rodrigues RS, Morton KA. Lipopolysaccharide endotoxemia induces amyloid-ß and p-tau formation in the rat brain. Am J Nucl Med Mol Imaging. 2018; 8(2):86-99. PMID: 29755842.
      Citations:    
    34. Greenwood-Van Meerveld B, Mohammadi E, Latorre R, Truitt ER, Jay GD, Sullivan BD, Schmidt TA, Smith N, Saunders D, Ziegler J, Lerner M, Hurst R, Towner RA. Preclinical Animal Studies of Intravesical Recombinant Human Proteoglycan 4 as a Novel Potential Therapy for Diseases Resulting From Increased Bladder Permeability. Urology. 2018 Jun; 116:230.e1-230.e7. PMID: 29545038.
      Citations: 3     Fields:    Translation:HumansAnimals
    35. Towner RA, Saunders D, Smith N, Towler W, Cruz M, Do S, Maher JE, Whitaker K, Lerner M, Morton KA. Assessing long-term neuroinflammatory responses to encephalopathy using MRI approaches in a rat endotoxemia model. Geroscience. 2018 02; 40(1):49-60. PMID: 29417380.
      Citations: 6     Fields:    Translation:Animals
    36. Dong J, Saunders D, Silasi-Mansat R, Yu L, Zhu H, Lupu F, Towner R, Dong Y, Chen H. Therapeutic efficacy of a synthetic epsin mimetic peptide in glioma tumor model: uncovering multiple mechanisms beyond the VEGF-associated tumor angiogenesis. J Neurooncol. 2018 May; 138(1):17-27. PMID: 29357089.
      Citations: 3     Fields:    Translation:AnimalsCells
    37. Srivastava A, Amreddy N, Razaq M, Towner R, Zhao YD, Ahmed RA, Munshi A, Ramesh R. Exosomes as Theranostics for Lung Cancer. Adv Cancer Res. 2018; 139:1-33. PMID: 29941101.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    38. Towner RA, Smith N. In Vivo and In Situ Detection of Macromolecular Free Radicals Using Immuno-Spin Trapping and Molecular Magnetic Resonance Imaging. Antioxid Redox Signal. 2018 05 20; 28(15):1404-1415. PMID: 29084431.
      Citations: 4     Fields:    Translation:AnimalsCells
    39. Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2018 02; 55(2):1795-1813. PMID: 29168048.
      Citations: 5     Fields:    Translation:AnimalsCells
    40. Vargas VE, Gurung S, Grant B, Hyatt K, Singleton K, Myers SM, Saunders D, Njoku C, Towner R, Myers DA. Gestational hypoxia disrupts the neonatal leptin surge and programs hyperphagia and obesity in male offspring in the Sprague-Dawley rat. PLoS One. 2017; 12(9):e0185272. PMID: 28957383.
      Citations: 4     Fields:    Translation:Animals
    41. Yang Q, Xia D, Towner RA, Smith N, Saunders D, Fung KM, Aston CE, Greenwood-Van Meerveld B, Hurst RE, Madihally SV, Kropp BP, Lin HK. Reduced urothelial regeneration in rat bladders augmented with permeable porcine small intestinal submucosa assessed by magnetic resonance imaging. . 2018 07; 106(5):1778-1787. PMID: 28901710.
      Citations:    
    42. Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. AG488 as a therapy against gliomas. Oncotarget. 2017 Sep 22; 8(42):71833-71844. PMID: 29069750.
      Citations: 2     Fields:    
    43. Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Profibrotic Infrapatellar Fat Pad Remodeling Without M1 Macrophage Polarization Precedes Knee Osteoarthritis in Mice With Diet-Induced Obesity. Arthritis Rheumatol. 2017 06; 69(6):1221-1232. PMID: 28141918.
      Citations: 26     Fields:    Translation:AnimalsCells
    44. Dong Y, Wu H, Dong J, Song K, Rahman HA, Towner R, Chen H. Mimetic peptide of ubiquitin-interacting motif of epsin as a cancer therapeutic-perspective in brain tumor therapy through regulating VEGFR2 signaling. Vessel Plus. 2017; 1:3-11. PMID: 29905336.
      Citations:    
    45. Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 02 01; 19(2):175-185. PMID: 27416955.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    46. Dong Y, Fernandes C, Liu Y, Wu Y, Wu H, Brophy ML, Deng L, Song K, Wen A, Wong S, Yan D, Towner R, Chen H. Role of endoplasmic reticulum stress signalling in diabetic endothelial dysfunction and atherosclerosis. Diab Vasc Dis Res. 2017 01; 14(1):14-23. PMID: 27941052.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    47. Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2016 Apr 01; 126(4):1607. PMID: 26999611.
      Citations: 2     Fields:    
    48. Rajagopalan V, Zhang Y, Ojamaa K, Chen YF, Pingitore A, Pol CJ, Saunders D, Balasubramanian K, Towner RA, Gerdes AM. Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias without Cardiovascular Adverse Effects. PLoS One. 2016; 11(3):e0151413. PMID: 26981865.
      Citations: 12     Fields:    Translation:Animals
    49. Hurst RE, Van Gordon S, Tyler K, Kropp B, Towner R, Lin H, Marentette JO, McHowat J, Mohammedi E, Greenwood-Van Meerveld B. In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats. Am J Physiol Renal Physiol. 2016 05 01; 310(10):F1074-80. PMID: 26911855.
      Citations: 3     Fields:    Translation:AnimalsCells
    50. Mohammadi E, Prusator DK, Healing E, Hurst R, Towner RA, Wisniewski AB, Greenwood-Van Meerveld B. Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood. Biol Sex Differ. 2016; 7:8. PMID: 26823967.
      Citations: 1     Fields:    
    51. Du X, West MB, Cheng W, Ewert DL, Li W, Saunders D, Towner RA, Floyd RA, Kopke RD. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxid Med Cell Longev. 2016; 2016:4159357. PMID: 27034735.
      Citations: 11     Fields:    Translation:Animals
    52. Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla JM, Lightfoot S, Towner RA, Wu XR, Steele VE, Kopelovich L, Rao CV. Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila). 2016 Jan; 9(1):53-62. PMID: 26577454.
      Citations: 8     Fields:    Translation:AnimalsCells
    53. Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D'Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec; 125(12):4349-64. PMID: 26571402.
      Citations: 13     Fields:    Translation:AnimalsCells
    54. Hurst RE, Greenwood-Van Meerveld B, Wisniewski AB, VanGordon S, Lin H, Kropp BP, Towner RA. Increased bladder permeability in interstitial cystitis/painful bladder syndrome. Transl Androl Urol. 2015 10; 4(5):563-571. PMID: 26751576.
      Citations:    
    55. Towner RA, Smith N, Saunders D, Van Gordon SB, Tyler KR, Wisniewski AB, Greenwood-Van Meerveld B, Hurst RE. Assessment of colon and bladder crosstalk in an experimental colitis model using contrast-enhanced magnetic resonance imaging. Neurogastroenterol Motil. 2015 Nov; 27(11):1571-9. PMID: 26303228.
      Citations: 1     Fields:    Translation:Animals
    56. Towner RA, Wisniewski AB, Wu DH, Van Gordon SB, Smith N, North JC, McElhaney R, Aston CE, Shobeiri SA, Kropp BP, Greenwood-Van Meerveld B, Hurst RE. A Feasibility Study to Determine Whether Clinical Contrast Enhanced Magnetic Resonance Imaging can Detect Increased Bladder Permeability in Patients with Interstitial Cystitis. J Urol. 2016 Mar; 195(3):631-8. PMID: 26307161.
      Citations: 9     Fields:    Translation:Humans
    57. Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. PLoS One. 2015; 10(8):e0134276. PMID: 26248280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    58. Towner RA, Ihnat M, Saunders D, Bastian A, Smith N, Pavana RK, Gangjee A. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer. 2015 Jul 17; 15:522. PMID: 26177924.
      Citations: 8     Fields:    Translation:AnimalsCells
    59. Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. J Cereb Blood Flow Metab. 2015 Nov; 35(11):1871-81. PMID: 26174328.
      Citations: 50     Fields:    Translation:Animals
    60. Coutinho de Souza P, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. OKN-007 decreases free radical levels in a preclinical F98 rat glioma model. Free Radic Biol Med. 2015 Oct; 87:157-68. PMID: 26119786.
      Citations: 6     Fields:    Translation:HumansAnimals
    61. de Souza PC, Smith N, Pody R, He T, Njoku C, Silasi-Mansat R, Lupu F, Meek B, Chen H, Dong Y, Saunders D, Orock A, Hodges E, Colijn S, Mamedova N, Towner RA. OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model. Am J Nucl Med Mol Imaging. 2015; 5(4):363-78. PMID: 26269774.
      Citations:    
    62. Towner RA, Smith N, Saunders D, Carrizales J, Lupu F, Silasi-Mansat R, Ehrenshaft M, Mason RP. In vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice. Free Radic Res. 2015; 49(9):1140-6. PMID: 25968951.
      Citations: 6     Fields:    Translation:AnimalsCells
    63. de Souza PC, Ranjan A, Towner RA. Nanoformulations for therapy of pancreatic and liver cancers. Nanomedicine (Lond). 2015 May; 10(9):1515-34. PMID: 25996122.
      Citations: 2     Fields:    Translation:Humans
    64. de Souza PC, Balasubramanian K, Njoku C, Smith N, Gillespie DL, Schwager A, Abdullah O, Ritchey JW, Fung KM, Saunders D, Jensen RL, Towner RA. OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model. J Magn Reson Imaging. 2015 Dec; 42(6):1582-91. PMID: 25920494.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    65. Greenwood-Van Meerveld B, Mohammadi E, Tyler K, Van Gordon S, Parker A, Towner R, Hurst R. Mechanisms of Visceral Organ Crosstalk: Importance of Alterations in Permeability in Rodent Models. J Urol. 2015 Sep; 194(3):804-11. PMID: 25776913.
      Citations: 12     Fields:    Translation:Animals
    66. Seong J, Jeong W, Smith N, Towner RA. Hemodynamic effects of long-term morphological changes in the human carotid sinus. J Biomech. 2015 Apr 13; 48(6):956-62. PMID: 25702250.
      Citations: 1     Fields:    Translation:Humans
    67. Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler KR, Greenwood-Van Meerveld B, Hurst RE. Contrast enhanced magnetic resonance imaging as a diagnostic tool to assess bladder permeability and associated colon cross talk: preclinical studies in a rat model. J Urol. 2015 Apr; 193(4):1394-400. PMID: 25463988.
      Citations: 11     Fields:    Translation:Animals
    68. Zhao Y, Ling F, Griffin TM, He T, Towner R, Ruan H, Sun XH. Up-regulation of the Sirtuin 1 (Sirt1) and peroxisome proliferator-activated receptor ? coactivator-1a (PGC-1a) genes in white adipose tissue of Id1 protein-deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem. 2014 Oct 17; 289(42):29112-22. PMID: 25190816.
      Citations: 8     Fields:    Translation:Animals
    69. Towner RA, Wren JD. Prioritizing uncharacterized genes in the search for glioma biomarkers. CNS Oncol. 2014 Mar; 3(2):93-5. PMID: 25055012.
      Citations: 1     Fields:    Translation:Humans
    70. Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro Oncol. 2013 Dec; 15(12):1625-34. PMID: 24158112.
      Citations: 17     Fields:    Translation:Humans
    71. Towner RA, Garteiser P, Bozza F, Smith N, Saunders D, d'Avila JCP, Magno F, Oliveira MF, Ehrenshaft M, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Mason RP, Castro Faria-Neto HC. In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping. Free Radic Biol Med. 2013 12; 65:828-837. PMID: 23978375.
      Citations: 10     Fields:    Translation:AnimalsCells
    72. Towner RA, Smith N, Saunders D, De Souza PC, Henry L, Lupu F, Silasi-Mansat R, Ehrenshaft M, Mason RP, Gomez-Mejiba SE, Ramirez DC. Combined molecular MRI and immuno-spin-trapping for in vivo detection of free radicals in orthotopic mouse GL261 gliomas. Biochim Biophys Acta. 2013 Dec; 1832(12):2153-61. PMID: 23959048.
      Citations: 10     Fields:    Translation:AnimalsCells
    73. Garteiser P, Doblas S, Towner RA, Griffin TM. Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism. 2013 Nov; 62(11):1686-95. PMID: 23890668.
      Citations: 7     Fields:    Translation:Animals
    74. He T, Smith N, Saunders D, Pittman BP, Lerner M, Lightfoot S, Silasi-Mansat R, Lupu F, Towner RA. Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. Am J Nucl Med Mol Imaging. 2013; 3(4):300-11. PMID: 23901356.
      Citations:    
    75. Piao D, Towner RA, Smith N, Chen WR. Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: a theoretical feasibility analysis. Med Phys. 2013 Jun; 40(6):063301. PMID: 23718611.
      Citations: 3     Fields:    
    76. Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis. Free Radic Biol Med. 2013 Oct; 63:351-60. PMID: 23722162.
      Citations: 9     Fields:    Translation:HumansAnimals
    77. Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Muñoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta. 2014 Feb; 1840(2):722-9. PMID: 23644035.
      Citations: 13     Fields:    Translation:HumansAnimals
    78. Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med. 2013 Sep; 62:145-156. PMID: 23419732.
      Citations: 14     Fields:    Translation:Humans
    79. Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol. 2013 Mar; 15(3):330-40. PMID: 23328810.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    80. Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, a potential new biomarker for gliomas. Neurosurgery. 2013 Jan; 72(1):77-90; discussion 91. PMID: 23096411.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    81. Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38. PMID: 23187125.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    82. Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immuno-spin trapped radicals with molecular magnetic resonance imaging in a diabetic mouse model. Diabetes. 2012 Oct; 61(10):2405-13. PMID: 22698922.
      Citations: 15     Fields:    Translation:AnimalsCells
    83. Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to disturbance of subretinal microenvironment. J Biol Chem. 2012 May 11; 287(20):16424-34. PMID: 22451674.
      Citations: 21     Fields:    Translation:AnimalsCells
    84. Le K, Li X, Figueroa D, Towner RA, Garteiser P, Saunders D, Smith N, Liu H, Hode T, Nordquist RE, Chen WR. Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method. J Biomed Opt. 2011 Dec; 16(12):128001. PMID: 22191937.
      Citations: 4     Fields:    Translation:AnimalsCells
    85. Niu C, Smith N, Garteiser P, Towner R, Verchot J. Comparative analysis of protein transport in the N. benthamiana vasculature reveals different destinations. Plant Signal Behav. 2011 Nov; 6(11):1793-808. PMID: 22057341.
      Citations: 4     Fields:    Translation:Animals
    86. Doblas S, He T, Saunders D, Hoyle J, Smith N, Pye Q, Lerner M, Jensen RL, Towner RA. In vivo characterization of several rodent glioma models by 1H MRS. NMR Biomed. 2012 Apr; 25(4):685-94. PMID: 21954105.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    87. Floyd RA, Chandru HK, He T, Towner R. Anti-cancer activity of nitrones and observations on mechanism of action. Anticancer Agents Med Chem. 2011 May 01; 11(4):373-9. PMID: 21651461.
      Citations: 22     Fields:    Translation:HumansAnimals
    88. He T, Doblas S, Saunders D, Casteel R, Lerner M, Ritchey JW, Snider T, Floyd RA, Towner RA. Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy. Free Radic Biol Med. 2011 Jul 15; 51(2):490-502. PMID: 21600283.
      Citations: 13     Fields:    Translation:AnimalsCells
    89. Floyd RA, Towner RA, He T, Hensley K, Maples KR. Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med. 2011 Sep 01; 51(5):931-41. PMID: 21549833.
      Citations: 28     Fields:    Translation:HumansAnimals
    90. He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA. Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med. 2011 Apr; 15(4):837-49. PMID: 20497492.
      Citations: 8     Fields:    Translation:AnimalsCells
    91. Qiu P, Jensen C, Charity N, Towner R, Mao C. Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles. J Am Chem Soc. 2010 Dec 22; 132(50):17724-32. PMID: 21117657.
      Citations: 11     Fields:    
    92. Doblas S, Pathuri G, Towner RA, Gali H. Feasibility Evaluation of Detecting Hydroxymethylphosphine Oxide In Vivo by (31)P-MRS. Int J Biomed Sci. 2010 Sep; 6(3):228-32. PMID: 23675197.
      Citations:    
    93. Doblas S, He T, Saunders D, Pearson J, Hoyle J, Smith N, Lerner M, Towner RA. Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography. J Magn Reson Imaging. 2010 Aug; 32(2):267-75. PMID: 20677250.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    94. Griffitts J, Saunders D, Tesiram YA, Reid GE, Salih A, Liu S, Lydic TA, Busik JV, Kang JX, Towner RA. Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model: Omega-3 fatty acids prevent liver neoplasia. Biochim Biophys Acta. 2010 Oct; 1801(10):1133-44. PMID: 20620224.
      Citations: 9     Fields:    Translation:Animals
    95. Awasthi V, Agashe H, Doblas S, Towner R. Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid. Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr; 38(2):69-78. PMID: 20196685.
      Citations: 6     Fields:    Translation:HumansAnimals
    96. Garteiser P, Doblas S, Watanabe Y, Saunders D, Hoyle J, Lerner M, He T, Floyd RA, Towner RA. Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging. 2010 Apr; 31(4):796-806. PMID: 20373422.
      Citations: 22     Fields:    Translation:AnimalsCells
    97. Towner RA, Smith N, Asano Y, He T, Doblas S, Saunders D, Silasi-Mansat R, Lupu F, Seeney CE. Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering. Tissue Eng Part A. 2010 Feb; 16(2):357-64. PMID: 19663584.
      Citations: 7     Fields:    Translation:Animals
    98. Towner RA, Smith N, Asano Y, Doblas S, Saunders D, Silasi-Mansat R, Lupu F. Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering. Tissue Eng Part A. 2010 Feb; 16(2):365-71. PMID: 19905873.
      Citations: 4     Fields:    Translation:Animals
    99. Johnson AC, Myers B, Lazovic J, Towner R, Greenwood-Van Meerveld B. Brain activation in response to visceral stimulation in rats with amygdala implants of corticosterone: an FMRI study. PLoS One. 2010 Jan 05; 5(1):e8573. PMID: 20052291.
      Citations: 17     Fields:    Translation:Animals
    100. Floyd RA, Towner RA, Wu D, Abbott A, Cranford R, Branch D, Guo WX, Foster SB, Jones I, Alam R, Moore D, Allen T, Huycke M. Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. Free Radic Res. 2010 Jan; 44(1):108-17. PMID: 19886748.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    101. Towner RA, Smith N, Doblas S, Garteiser P, Watanabe Y, He T, Saunders D, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of inducible nitric oxide synthase in rodent gliomas. Free Radic Biol Med. 2010 Mar 01; 48(5):691-703. PMID: 20034558.
      Citations: 17     Fields:    Translation:AnimalsCells
    102. Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA, Castro-Faria-Neto HC. Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab. 2010 Feb; 30(2):440-8. PMID: 19844239.
      Citations: 25     Fields:    Translation:Animals
    103. Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE. Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience. 2009 Dec 15; 164(3):918-28. PMID: 19735701.
      Citations: 13     Fields:    Translation:Animals
    104. Condac E, Dale GL, Bender-Neal D, Ferencz B, Towner R, Hinsdale ME. Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum. Glycobiology. 2009 Aug; 19(8):829-33. PMID: 19389916.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    105. Gomez-Mejiba SE, Zhai Z, Akram H, Deterding LJ, Hensley K, Smith N, Towner RA, Tomer KB, Mason RP, Ramirez DC. Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process. Free Radic Biol Med. 2009 Apr 01; 46(7):853-65. PMID: 19159679.
      Citations: 24     Fields:    Translation:AnimalsCells
    106. Griffitts J, Tesiram Y, Reid GE, Saunders D, Floyd RA, Towner RA. In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model. J Lipid Res. 2009 Apr; 50(4):611-22. PMID: 19065002.
      Citations: 11     Fields:    Translation:Animals
    107. Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Yasui H, Inanami O, Smith N, Floyd RA, Kotake Y, Towner RA. Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J Magn Reson Imaging. 2008 Sep; 28(3):574-87. PMID: 18777527.
      Citations: 14     Fields:    Translation:AnimalsCells
    108. Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Pearson J, Abbott A, Smith N, Towner RA. Diffusion tensor imaging and fiber tractography of C6 rat glioma. J Magn Reson Imaging. 2008 Sep; 28(3):566-73. PMID: 18777530.
      Citations: 9     Fields:    Translation:AnimalsCells
    109. Floyd RA, Kopke RD, Choi CH, Foster SB, Doblas S, Towner RA. Nitrones as therapeutics. Free Radic Biol Med. 2008 Nov 15; 45(10):1361-74. PMID: 18793715.
      Citations: 55     Fields:    Translation:HumansAnimals
    110. Chen Y, Gnyawali SC, Wu F, Liu H, Tesiram YA, Abbott A, Towner RA, Chen WR. Magnetic resonance imaging guidance for laser photothermal therapy. J Biomed Opt. 2008 Jul-Aug; 13(4):044033. PMID: 19021360.
      Citations: 5     Fields:    Translation:Animals
    111. Tesiram YA, Saunders D, Towner RA. Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds. NMR Biomed. 2008 May; 21(4):345-56. PMID: 17854108.
      Citations: 1     Fields:    Translation:Animals
    112. Saban MR, Towner R, Smith N, Abbott A, Neeman M, Davis CA, Simpson C, Maier J, Mémet S, Wu XR, Saban R. Lymphatic vessel density and function in experimental bladder cancer. BMC Cancer. 2007 Nov 29; 7:219. PMID: 18047671.
      Citations: 12     Fields:    Translation:Animals
    113. Doblas S, Saunders D, Kshirsagar P, Pye Q, Oblander J, Gordon B, Kosanke S, Floyd RA, Towner RA. Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. Free Radic Biol Med. 2008 Jan 01; 44(1):63-72. PMID: 18045548.
      Citations: 20     Fields:    Translation:AnimalsCells
    114. Inoue Y, Asanuma T, Smith N, Saunders D, Oblander J, Kotake Y, Floyd RA, Towner RA. Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free Radic Res. 2007 Sep; 41(9):972-80. PMID: 17729114.
      Citations: 4     Fields:    Translation:Animals
    115. Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9416-21. PMID: 17517600.
      Citations: 16     Fields:    Translation:Animals
    116. Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol. 2007 Feb 19; 6:6. PMID: 17309798.
      Citations: 24     Fields:    Translation:AnimalsCells
    117. Towner RA, Smith N, Doblas S, Tesiram Y, Garteiser P, Saunders D, Cranford R, Silasi-Mansat R, Herlea O, Ivanciu L, Wu D, Lupu F. In vivo detection of c-Met expression in a rat C6 glioma model. J Cell Mol Med. 2008 Jan-Feb; 12(1):174-86. PMID: 18194445.
      Citations: 22     Fields:    Translation:Animals
    118. Towner RA, Smith N, Tesiram YA, Abbott A, Saunders D, Blindauer R, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging. Mol Imaging. 2007 Jan-Feb; 6(1):18-29. PMID: 17311762.
      Citations: 8     Fields:    Translation:AnimalsCells
    119. Asada K, Kotake Y, Asada R, Saunders D, Broyles RH, Towner RA, Fukui H, Floyd RA. LINE-1 hypomethylation in a choline-deficiency-induced liver cancer in rats: dependence on feeding period. J Biomed Biotechnol. 2006; 2006(1):17142. PMID: 16877811.
      Citations: 17     Fields:    
    120. Tesiram YA, Saunders D, Towner RA. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim Biophys Acta. 2005 Oct 15; 1737(1):61-8. PMID: 16230047.
      Citations: 5     Fields:    Translation:Animals
    121. Towner RA, Foley LM, Painter DM. Hepatocarcinogenesis tumor grading correlated with in vivo image-guided 1H-NMR spectroscopy in a rat model. Toxicol Appl Pharmacol. 2005 Sep 01; 207(2 Suppl):237-44. PMID: 16023158.
      Citations: 3     Fields:    Translation:Animals
    122. Towner RA, Qian SY, Kadiiska MB, Mason RP. In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic Biol Med. 2003 Nov 15; 35(10):1330-40. PMID: 14607532.
      Citations: 14     Fields:    Translation:Animals
    123. Towner RA, Mason RP, Reinke LA. In vivo detection of aflatoxin-induced lipid free radicals in rat bile. Biochim Biophys Acta. 2002 Oct 10; 1573(1):55-62. PMID: 12383942.
      Citations: 2     Fields:    Translation:Animals
    124. Towner RA, Sturgeon SA, Khan N, Hou H, Swartz HM. In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry). Chem Biol Interact. 2002 Mar 20; 139(3):231-50. PMID: 11879814.
      Citations: 6     Fields:    Translation:Animals
    125. Towner RA, Sturgeon SA, Hore KE. Assessment of in vivo oxidative lipid metabolism following acute microcystin-LR-induced hepatotoxicity in rats. Free Radic Res. 2002 Jan; 36(1):63-71. PMID: 11999704.
      Citations: 2     Fields:    Translation:Animals
    126. Appleby CJ, Towner RA. Magnetic resonance imaging of pulmonary damage in the term and premature rat neonate exposed to hyperoxia. Pediatr Res. 2001 Oct; 50(4):502-7. PMID: 11568294.
      Citations: 2     Fields:    Translation:Animals
    127. Foley LM, Towner RA, Painter DM. In vivo image-guided (1)H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model. Biochim Biophys Acta. 2001 Jun 15; 1526(3):230-6. PMID: 11410331.
      Citations: 7     Fields:    Translation:Animals
    128. Towner RA, Hashimoto H, Summers PM. Non-invasive in vivo magnetic resonance imaging assessment of acute aflatoxin B1 hepatotoxicity in rats. Biochim Biophys Acta. 2000 Jul 26; 1475(3):314-20. PMID: 10913831.
      Citations: 3     Fields:    Translation:Animals
    129. Sturgeon SA, Towner RA. In vivo assessment of microcystin-LR-induced hepatotoxicity in the rat using proton nuclear magnetic resonance (1H-NMR) imaging. Biochim Biophys Acta. 1999 Aug 30; 1454(3):227-35. PMID: 10452957.
      Citations: 2     Fields:    Translation:AnimalsCells
    130. Noseworthy MD, Janzen EG, Towner RA, Yamashiro S. In vivo study of halothane hepatotoxicity in the rat using magnetic resonance imaging and 31P spectroscopy. J Biochem Biophys Methods. 1997 Mar 27; 34(2):107-22. PMID: 9178087.
      Citations:    Fields:    Translation:Animals
    131. Kadkhodaee M, Hanson GR, Towner RA, Endre ZH. Detection of hydroxyl and carbon-centred radicals by EPR spectroscopy after ischaemia and reperfusion of the rat kidney. Free Radic Res. 1996 Jul; 25(1):31-42. PMID: 8814442.
      Citations: 4     Fields:    Translation:AnimalsCells
    132. Kadkhodaee M, Endre ZH, Towner RA, Cross M. Hydroxyl radical generation following ischaemia-reperfusion in cell-free perfused rat kidney. Biochim Biophys Acta. 1995 Feb 23; 1243(2):169-74. PMID: 7873560.
      Citations: 1     Fields:    Translation:Animals
    133. Park A, Towner RA, Langer JC. Diagnosis of persistent intestinal ischemia in the rabbit using proton magnetic resonance imaging. J Invest Surg. 1994 Nov-Dec; 7(6):485-92. PMID: 7893635.
      Citations: 1     Fields:    Translation:Animals
    134. Stalker MJ, Towner RA, Kocal TE, Quinn BA, Cameron RG, Hayes MA. Influences of dietary deoxycholic acid on progression of hepatocellular neoplasms and expression of glutathione S-transferases in rats. Toxicol Pathol. 1994 Nov-Dec; 22(6):579-88. PMID: 7732275.
      Citations:    Fields:    Translation:Animals
    135. Towner RA, Reinke LA, Janzen EG, Yamashiro S. In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl4-induced hepatotoxicity in rats. Can J Physiol Pharmacol. 1994 May; 72(5):441-6. PMID: 7954070.
      Citations:    Fields:    Translation:AnimalsCells
    136. Lirette A, Towner RA, Liu Z, Janzen EG, Chambers JR, Fairfull RW, Milligan LP, Crober DC. In vivo nuclear magnetic resonance spectroscopy of chicken embryos from two broiler strains of varying fat content. Poult Sci. 1993 Aug; 72(8):1411-20. PMID: 8378216.
      Citations:    Fields:    Translation:Animals
    137. Grahn BH, Stewart WA, Towner RA, Noseworthy MD. Magnetic resonance imaging of the canine and feline eye, orbit, and optic nerves and its clinical application. Can Vet J. 1993 Jul; 34(7):418-24. PMID: 17424252.
      Citations:    Fields:    
    138. Towner RA, Janzen EG, Zhang YK, Yamashiro S. MRI study of the inhibitory effect of new spin traps on in vivo CCl4-induced hepatotoxicity in rats. Free Radic Biol Med. 1993 Jun; 14(6):677-81. PMID: 8325539.
      Citations: 1     Fields:    Translation:Animals
    139. Park A, Towner RA, Langer JC. Diagnosis of intestinal ischemia in the rat using magnetic resonance imaging. J Invest Surg. 1993 Mar-Apr; 6(2):177-83. PMID: 8512890.
      Citations:    Fields:    Translation:Animals
    140. Tracz RA, Wyman DR, Little PB, Towner RA, Stewart WA, Schatz SW, Wilson BC, Pennock PW, Janzen EG. Comparison of magnetic resonance images and the histopathological findings of lesions induced by interstitial laser photocoagulation in the brain. Lasers Surg Med. 1993; 13(1):45-54. PMID: 8426527.
      Citations: 6     Fields:    Translation:Animals
    141. Gareau PJ, Janzen EG, Towner RA, Stewart WA. In vivo 31P NMR spectroscopy studies of halothane induced porcine stress syndrome. No effect of C-phenyl N-tert-butyl nitrone (PBN). Free Radic Res Commun. 1993; 19(1):43-50. PMID: 8225033.
      Citations:    Fields:    Translation:Animals
    142. Towner RA, Zhdanov RI, Janzen EG. Use of nitroxides as MRI contrast agents to study in vivo carbon tetrachloride induced hepatotoxicity in rats. Free Radic Res Commun. 1993; 19 Suppl 1:S211-8. PMID: 8282226.
      Citations:    Fields:    Translation:Animals
    143. Hutchison MJ, Lirette A, Etches RJ, Towner RA, Janzen EG. Research note: an assessment of egg yolk structure using magnetic resonance imaging. Poult Sci. 1992 Dec; 71(12):2117-21. PMID: 1470595.
      Citations:    Fields:    Translation:Animals
    144. Stewart WA, Parent JM, Towner RA, Dobson H. The use of magnetic resonance imaging in the diagnosis of neurological disease. Can Vet J. 1992 Sep; 33(9):585-90. PMID: 17424074.
      Citations: 5     Fields:    
    145. Tracz RA, Wyman DR, Little PB, Towner RA, Stewart WA, Schatz SW, Pennock PW, Wilson BC. Magnetic resonance imaging of interstitial laser photocoagulation in brain. Lasers Surg Med. 1992; 12(2):165-73. PMID: 1573967.
      Citations: 3     Fields:    Translation:Animals
    146. Reinke LA, Towner RA, Janzen EG. Spin trapping of free radical metabolites of carbon tetrachloride in vitro and in vivo: effect of acute ethanol administration. Toxicol Appl Pharmacol. 1992 Jan; 112(1):17-23. PMID: 1310168.
      Citations: 2     Fields:    Translation:AnimalsCells
    147. Towner RA, Reinke LA, Janzen EG, Yamashiro S. Enhancement of carbon tetrachloride-induced liver injury by a single dose of ethanol: proton magnetic resonance imaging (MRI) studies in vivo. Biochim Biophys Acta. 1991 Apr 15; 1096(3):222-30. PMID: 2018796.
      Citations: 1     Fields:    Translation:Animals
    148. Towner RA, Yamaguchi T, Philbrick DJ, Holub BJ, Janzen EG, Takahashi H. In vivo proton magnetic resonance imaging and localized spectroscopic analysis of polycystic kidney disease in DBA/2FG-pyc mice. Magn Reson Imaging. 1991; 9(3):429-34. PMID: 1881263.
      Citations: 1     Fields:    Translation:Animals
    149. Janzen EG, Towner RA, Yamashiro S. The effect of phenyl tert-butyl nitrone (PBN) on CCl4-induced rat liver injury detected by proton magnetic resonance imaging (MRI) in vivo and electron microscopy (EM). Free Radic Res Commun. 1990; 9(3-6):325-35. PMID: 2167270.
      Citations: 2     Fields:    Translation:Animals
    150. Janzen EG, Towner RA, Krygsman PH, Haire DL, Poyer JL. Structure identification of free radicals by ESR and GC/MS of PBN spin adducts from the in vitro and in vivo rat liver metabolism of halothane. Free Radic Res Commun. 1990; 9(3-6):343-51. PMID: 2167272.
      Citations: 5     Fields:    Translation:AnimalsCells
    151. Janzen EG, Towner RA, Krygsman PH, Lai EK, Poyer JL, Brueggemann G, McCay PB. Mass spectroscopy and chromatography of the trichloromethyl radical adduct of phenyl tert-butyl nitrone. Free Radic Res Commun. 1990; 9(3-6):353-60. PMID: 2167273.
      Citations: 1     Fields:    Translation:AnimalsCells
    152. Taylor CG, Towner RA, Janzen EG, Bray TM. MRI detection of hyperoxia-induced lung edema in Zn-deficient rats. Free Radic Biol Med. 1990; 9(3):229-33. PMID: 2272531.
      Citations: 4     Fields:    Translation:Animals
    153. Oehler UM, Janzen EG, Betteridge K, Fyfe C, Towner RA, Savage N, Scodras J. Investigations of the horse conceptus via magnetic resonance imaging (MRI) and nitroxide spin labels as contrast agents. Free Radic Res Commun. 1990; 9(3-6):391-7. PMID: 2387501.
      Citations:    Fields:    Translation:Animals
    154. Brauer M, Towner RA, Foxall DL. Sodium-23 and proton nuclear magnetic resonance imaging studies of carbon tetrachloride-induced liver damage in the rat. Magn Reson Imaging. 1990; 8(4):459-65. PMID: 2392034.
      Citations:    Fields:    Translation:Animals
    155. Towner RA, Brauer M, Janzen EG, Ling MF. In vivo and in vitro 31P-NMR spectroscopy of rat liver treated with halocarbons. Biochim Biophys Acta. 1989 Oct 13; 993(1):92-9. PMID: 2804127.
      Citations:    Fields:    Translation:Animals
    156. Brauer M, Towner RA, Renaud I, Janzen EG, Foxall DL. In vivo proton nuclear magnetic resonance imaging and spectroscopy studies of halocarbon-induced liver damage. Magn Reson Med. 1989 Feb; 9(2):229-39. PMID: 2541304.
      Citations:    Fields:    Translation:Animals
    157. Janzen EG, Towner RA, Brauer M. Factors influencing the formation of the carbon dioxide radical anion (.CO2-) spin adduct of PBN in the rat liver metabolism of halocarbons. Free Radic Res Commun. 1988; 4(6):359-69. PMID: 2854105.
      Citations: 3     Fields:    Translation:AnimalsCells
    158. Janzen EG, Towner RA, Haire DL. Detection of free radicals generated from the in vitro metabolism of carbon tetrachloride using improved ESR spin trapping techniques. Free Radic Res Commun. 1987; 3(6):357-64. PMID: 2854531.
      Citations: 7     Fields:    Translation:AnimalsCells
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