Complement Membrane Attack Complex
"Complement Membrane Attack Complex" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.
| Descriptor ID |
D015938
|
| MeSH Number(s) |
D12.776.124.486.274.930
|
| Concept/Terms |
Complement Membrane Attack Complex- Complement Membrane Attack Complex
- C5b-8-poly-C9
- C5b 8 poly C9
- Terminal Complement Complex
- Complement Complex, Terminal
- Complex, Terminal Complement
- Complement Complex C5b-9
- Complement Complex C5b 9
- Cytolytic Terminal Complement Complex
- Membrane Attack Complex
- C 5b-9
- C5b-9
|
Below are MeSH descriptors whose meaning is more general than "Complement Membrane Attack Complex".
Below are MeSH descriptors whose meaning is more specific than "Complement Membrane Attack Complex".
This graph shows the total number of publications written about "Complement Membrane Attack Complex" by people in this website by year, and whether "Complement Membrane Attack Complex" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement Membrane Attack Complex" by people in Profiles.
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Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria. Nat Commun. 2024 Jun 12; 15(1):5028.
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C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplant. 2022 09; 57(9):1445-1447.
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Premortem Skin Biopsy Assessing Microthrombi, Interferon Type I Antiviral and Regulatory Proteins, and Complement Deposition Correlates with Coronavirus Disease 2019 Clinical Stage. Am J Pathol. 2022 09; 192(9):1282-1294.
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Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition. Int J Mol Sci. 2020 Mar 01; 21(5).
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Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies. Ann Rheum Dis. 2018 04; 77(4):549-555.
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Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype. Medicine (Baltimore). 2017 Jan; 96(3):e5694.
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Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15360-5.
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Conformational changes during pore formation by the perforin-related protein pleurotolysin. PLoS Biol. 2015 Feb; 13(2):e1002049.
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Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins. Curr Opin Struct Biol. 2012 Jun; 22(3):342-9.
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Membrane assembly of the cholesterol-dependent cytolysin pore complex. Biochim Biophys Acta. 2012 Apr; 1818(4):1028-38.