Granulocyte Colony-Stimulating Factor

"Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.

Descriptor ID	D016179
MeSH Number(s)	D12.644.276.374.410.240.350 D12.776.395.240.200 D12.776.467.374.410.240.350 D23.529.374.410.240.350
Concept/Terms	Granulocyte Colony-Stimulating Factor Granulocyte Colony-Stimulating Factor G-CSF

Below are MeSH descriptors whose meaning is more general than "Granulocyte Colony-Stimulating Factor".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
Cytokines [D12.644.276.374]
Hematopoietic Cell Growth Factors [D12.644.276.374.410]
Colony-Stimulating Factors [D12.644.276.374.410.240]
Granulocyte Colony-Stimulating Factor [D12.644.276.374.410.240.350]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Colony-Stimulating Factors [D12.776.395.240]
Granulocyte Colony-Stimulating Factor [D12.776.395.240.200]
Intercellular Signaling Peptides and Proteins [D12.776.467]
Cytokines [D12.776.467.374]
Hematopoietic Cell Growth Factors [D12.776.467.374.410]
Colony-Stimulating Factors [D12.776.467.374.410.240]
Granulocyte Colony-Stimulating Factor [D12.776.467.374.410.240.350]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
Cytokines [D23.529.374]
Hematopoietic Cell Growth Factors [D23.529.374.410]
Colony-Stimulating Factors [D23.529.374.410.240]
Granulocyte Colony-Stimulating Factor [D23.529.374.410.240.350]

Below are MeSH descriptors whose meaning is related to "Granulocyte Colony-Stimulating Factor".

Below are MeSH descriptors whose meaning is more specific than "Granulocyte Colony-Stimulating Factor".

Granulocyte Colony-Stimulating Factor
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publications

Timeline | Most Recent

This graph shows the total number of publications written about "Granulocyte Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte Colony-Stimulating Factor" was a major or minor topic of these publications.

Bar chart showing 12 publications over 9 distinct years, with a maximum of 2 publications in 2007 and 2011 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	1	1	2
2010	0	1	1
2011	1	1	2
2014	1	0	1
2015	1	1	2
2016	0	1	1
2017	1	0	1
2021	1	0	1

Below are the most recent publications written about "Granulocyte Colony-Stimulating Factor" by people in Profiles.

Saunders AS, Bender DE, Ray AL, Wu X, Morris KT. Colony-stimulating factor 3 signaling in colon and rectal cancers: Immune response and CMS classification in TCGA data. PLoS One. 2021; 16(2):e0247233.

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Jing W, Roberts JW, Green DE, Almond A, DeAngelis PL. Synthesis and characterization of heparosan-granulocyte-colony stimulating factor conjugates: a natural sugar-based drug delivery system to treat neutropenia. Glycobiology. 2017 11 01; 27(11):1052-1061.

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Slight-Webb S, Lu R, Ritterhouse LL, Munroe ME, Maecker HT, Fathman CG, Utz PJ, Merrill JT, Guthridge JM, James JA. Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity. Arthritis Rheumatol. 2016 10; 68(10):2492-502.

View in: PubMed
Morris KT, Castillo EF, Ray AL, Weston LL, Nofchissey RA, Hanson JA, Samedi VG, Pinchuk IV, Hudson LG, Beswick EJ. Anti-G-CSF treatment induces protective tumor immunity in mouse colon cancer by promoting protective NK cell, macrophage and T cell responses. Oncotarget. 2015 Sep 08; 6(26):22338-47.

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Price TH, Boeckh M, Harrison RW, McCullough J, Ness PM, Strauss RG, Nichols WG, Hamza TH, Cushing MM, King KE, Young JA, Williams E, McFarland J, Holter Chakrabarty J, Sloan SR, Friedman D, Parekh S, Sachais BS, Kiss JE, Assmann SF. Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection. Blood. 2015 Oct 29; 126(18):2153-61.

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Morris KT, Khan H, Ahmad A, Weston LL, Nofchissey RA, Pinchuk IV, Beswick EJ. G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration. Br J Cancer. 2014 Mar 04; 110(5):1211-20.

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Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N. Olfactomedin 4 defines a subset of human neutrophils. J Leukoc Biol. 2012 Mar; 91(3):495-500.

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Nguyen L, Reese J, George JN. Drug-induced thrombocytopenia: an updated systematic review, 2010. Drug Saf. 2011 May 01; 34(5):437-8.

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Tiersten AD, Sill MW, Knight D, Muggia F, Garcia AA, Swensen R, Warshal DP, Mannel RS, Fracasso PM. A phase I trial of dose-dense (biweekly) carboplatin combined with paclitaxel and pegfilgrastim: a feasibility study in patients with untreated Stage III and IV ovarian, tubal or primary peritoneal cancer: a Gynecologic Oncology Group study. Gynecol Oncol. 2010 Sep; 118(3):303-7.

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Elliott MB, Welliver RC, Laughlin TS, Pryharski KS, LaPierre NA, Chen T, Souza V, Terio NB, Hancock GE. Matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in the respiratory tracts of human infants following paramyxovirus infection. J Med Virol. 2007 Apr; 79(4):447-56.

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