Receptors, N-Methyl-D-Aspartate

"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.

Descriptor ID	D016194
MeSH Number(s)	D12.776.157.530.400.400.500.500 D12.776.543.550.450.500.200.500 D12.776.543.585.400.500.200.500 D12.776.543.750.720.200.450.400.500
Concept/Terms	Receptors, N-Methyl-D-Aspartate Receptors, N-Methyl-D-Aspartate Receptors, N Methyl D Aspartate N-Methyl-D-Aspartate Receptors N Methyl D Aspartate Receptors NMDA Receptors Receptors, N-Methylaspartate Receptors, N Methylaspartate Receptors, NMDA NMDA Receptor-Ionophore Complex NMDA Receptor Ionophore Complex N-Methylaspartate Receptors N Methylaspartate Receptors

Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
Receptors, Cell Surface [D12.776.543.750]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Amino Acid [D12.776.543.750.720.200]
Receptors, Glutamate [D12.776.543.750.720.200.450]
Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]

Below are MeSH descriptors whose meaning is related to "Receptors, N-Methyl-D-Aspartate".

Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in this website by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publications.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 2 publications in 2000 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	1	2
2006	2	0	2
2011	0	1	1
2013	0	1	1
2014	0	1	1
2017	0	1	1
2019	0	1	1

Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.

Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V. Psychosis in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Rheumatol. 2019 02; 71(2):281-289.

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Wurfel BE, Drevets WC, Bliss SA, McMillin JR, Suzuki H, Ford BN, Morris HM, Teague TK, Dantzer R, Savitz JB. Serum kynurenic acid is reduced in affective psychosis. Transl Psychiatry. 2017 05 02; 7(5):e1115.

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Ashpole NM, Sanders JE, Hodges EL, Yan H, Sonntag WE. Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol. 2015 Aug; 68:76-81.

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Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ. cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. J Neurosci. 2013 Sep 11; 33(37):14939-48.

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Molina DP, Ariwodola OJ, Linville C, Sonntag WE, Weiner JL, Brunso-Bechtold JK, Adams MM. Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats. Neurobiol Aging. 2012 Sep; 33(9):1938-49.

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Shi L, Adams MM, Long A, Carter CC, Bennett C, Sonntag WE, Nicolle MM, Robbins M, D'Agostino R, Brunso-Bechtold JK. Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus. Radiat Res. 2006 Dec; 166(6):892-9.

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Lapteva L, Nowak M, Yarboro CH, Takada K, Roebuck-Spencer T, Weickert T, Bleiberg J, Rosenstein D, Pao M, Patronas N, Steele S, Manzano M, van der Veen JW, Lipsky PE, Marenco S, Wesley R, Volpe B, Diamond B, Illei GG. Anti-N-methyl-D-aspartate receptor antibodies, cognitive dysfunction, and depression in systemic lupus erythematosus. Arthritis Rheum. 2006 Aug; 54(8):2505-14.

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Sonntag WE, Lynch C, Thornton P, Khan A, Bennett S, Ingram R. The effects of growth hormone and IGF-1 deficiency on cerebrovascular and brain ageing. J Anat. 2000 Nov; 197 Pt 4:575-85.

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Sonntag WE, Bennett SA, Khan AS, Thornton PL, Xu X, Ingram RL, Brunso-Bechtold JK. Age and insulin-like growth factor-1 modulate N-methyl-D-aspartate receptor subtype expression in rats. Brain Res Bull. 2000 Mar 01; 51(4):331-8.

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Leander JD, Rathbun RC, Zimmerman DM. Anticonvulsant effects of phencyclidine-like drugs: relation to N-methyl-D-aspartic acid antagonism. Brain Res. 1988 Jun 28; 454(1-2):368-72.

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