Suppressor of Cytokine Signaling 3 Protein
"Suppressor of Cytokine Signaling 3 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.
| Descriptor ID |
D000071223
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| MeSH Number(s) |
D12.644.360.024.374.750 D12.776.157.057.249.750 D12.776.476.024.437.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Suppressor of Cytokine Signaling 3 Protein".
Below are MeSH descriptors whose meaning is more specific than "Suppressor of Cytokine Signaling 3 Protein".
This graph shows the total number of publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in this website by year, and whether "Suppressor of Cytokine Signaling 3 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Suppressor of Cytokine Signaling 3 Protein" by people in Profiles.
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Interleukin 6 Function in the Skin and Isolated Keratinocytes Is Modulated by Hyperglycemia. J Immunol Res. 2019; 2019:5087847.
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SOCS3 modulates interleukin-6R signaling preference in dermal fibroblasts. J Interferon Cytokine Res. 2012 May; 32(5):207-15.
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IL-6 modulates alpha-smooth muscle actin expression in dermal fibroblasts from IL-6-deficient mice. J Invest Dermatol. 2006 Mar; 126(3):561-8.
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Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. J Immunol. 2004 Oct 15; 173(8):5036-45.
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Loss of interferon-induced Stat1 phosphorylation in activated T cells. J Interferon Cytokine Res. 2004 Mar; 24(3):169-78.