Unfolded Protein Response

"Unfolded Protein Response" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

Descriptor ID	D056811
MeSH Number(s)	G02.111.660.871.790.600.962 G02.111.691.600.850 G03.734.871.790.600.850 G05.308.670.600.850
Concept/Terms	Unfolded Protein Response Unfolded Protein Response Protein Response, Unfolded Protein Responses, Unfolded Response, Unfolded Protein Responses, Unfolded Protein Unfolded Protein Responses

Below are MeSH descriptors whose meaning is more general than "Unfolded Protein Response".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Peptide Biosynthesis [G02.111.660]
Protein Biosynthesis [G02.111.660.871]
Protein Modification, Translational [G02.111.660.871.790]
Protein Processing, Post-Translational [G02.111.660.871.790.600]
Unfolded Protein Response [G02.111.660.871.790.600.962]
Protein Modification, Translational [G02.111.691]
Protein Processing, Post-Translational [G02.111.691.600]
Unfolded Protein Response [G02.111.691.600.850]
Metabolism [G03]
Peptide Biosynthesis [G03.734]
Protein Biosynthesis [G03.734.871]
Protein Modification, Translational [G03.734.871.790]
Protein Processing, Post-Translational [G03.734.871.790.600]
Unfolded Protein Response [G03.734.871.790.600.850]
Genetic Phenomena [G05]
Gene Expression Regulation [G05.308]
Protein Modification, Translational [G05.308.670]
Protein Processing, Post-Translational [G05.308.670.600]
Unfolded Protein Response [G05.308.670.600.850]

Below are MeSH descriptors whose meaning is related to "Unfolded Protein Response".

Below are MeSH descriptors whose meaning is more specific than "Unfolded Protein Response".

Unfolded Protein Response
Endoplasmic Reticulum-Associated Degradation

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Unfolded Protein Response" by people in this website by year, and whether "Unfolded Protein Response" was a major or minor topic of these publications.

Bar chart showing 9 publications over 6 distinct years, with a maximum of 2 publications in 2011 and 2016 and 2017

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2011	2	0	2
2012	1	0	1
2014	1	0	1
2016	0	2	2
2017	0	2	2
2020	0	1	1

Below are the most recent publications written about "Unfolded Protein Response" by people in Profiles.

Yang F, Ma H, Butler MR, Ding XQ. Potential contribution of ryanodine receptor 2 upregulation to cGMP/PKG signaling-induced cone degeneration in cyclic nucleotide-gated channel deficiency. FASEB J. 2020 05; 34(5):6335-6350.

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Duan H, Li Y, Arora D, Xu D, Lim HY, Wang W. Discovery of a Benzamide Derivative That Protects Pancreatic ß-Cells against Endoplasmic Reticulum Stress. J Med Chem. 2017 07 27; 60(14):6191-6204.

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Bhaskaran S, Unnikrishnan A, Ranjit R, Qaisar R, Pharaoh G, Matyi S, Kinter M, Deepa SS. A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice. Free Radic Biol Med. 2017 07; 108:704-714.

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Duan H, Lee JW, Moon SW, Arora D, Li Y, Lim HY, Wang W. Discovery, Synthesis, and Evaluation of 2,4-Diaminoquinazolines as a Novel Class of Pancreatic ß-Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress. J Med Chem. 2016 09 08; 59(17):7783-800.

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Rao G, Yadav VR, Awasthi S, Roberts PR, Awasthi V. Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G180-91.

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Tran K, Li Y, Duan H, Arora D, Lim HY, Wang W. Identification of small molecules that protect pancreatic ß cells against endoplasmic reticulum stress-induced cell death. ACS Chem Biol. 2014 Dec 19; 9(12):2796-806.

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Li S, Yang Z, Hu J, Gordon WC, Bazan NG, Haas AL, Bok D, Jin M. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). J Biol Chem. 2013 Apr 19; 288(16):11395-406.

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Benbrook DM, Long A. Integration of autophagy, proteasomal degradation, unfolded protein response and apoptosis. Exp Oncol. 2012 Oct; 34(3):286-97.

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Feng X, Krishnan K, Richie DL, Aimanianda V, Hartl L, Grahl N, Powers-Fletcher MV, Zhang M, Fuller KK, Nierman WC, Lu LJ, Latgé JP, Woollett L, Newman SL, Cramer RA, Rhodes JC, Askew DS. HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. PLoS Pathog. 2011 Oct; 7(10):e1002330.

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Gosline SJ, Nascimento M, McCall LI, Zilberstein D, Thomas DY, Matlashewski G, Hallett M. Intracellular eukaryotic parasites have a distinct unfolded protein response. PLoS One. 2011 Apr 29; 6(4):e19118.

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