Cyclin-Dependent Kinase Inhibitor p21
"Cyclin-Dependent Kinase Inhibitor p21" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.
| Descriptor ID |
D050759
|
| MeSH Number(s) |
D12.644.360.225.500 D12.776.157.687.250 D12.776.167.187.500 D12.776.476.225.500 D12.776.624.776.355.500 D12.776.660.720.250
|
| Concept/Terms |
Cyclin-Dependent Kinase Inhibitor p21- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin Dependent Kinase Inhibitor p21
- CDKN1 Protein
- Senescent Cell-Derived Inhibitor Protein 1
- Senescent Cell Derived Inhibitor Protein 1
- Cell Cycle Regulator p21
- Cyclin-Dependent Kinase Inhibitor 1A Protein
- Cyclin Dependent Kinase Inhibitor 1A Protein
- Cyclin Kinase Inhibitor p21
- p21 Cyclin Kinase Inhibitor
- CDKN1A Protein
- Cdk-Interacting Protein 1
- Cdk Interacting Protein 1
- Cdk2 Inhibitor Protein
- CDK2-Associated Protein 20 kDa
- CDK2 Associated Protein 20 kDa
- p21 Cell Cycle Regulator
|
Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p21".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p21".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in this website by year, and whether "Cyclin-Dependent Kinase Inhibitor p21" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 3 | 0 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 3 | 1 | 4 |
| 2009 | 1 | 2 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 0 | 1 | 1 |
| 2014 | 2 | 0 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p21" by people in Profiles.
-
Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Redox Biol. 2018 07; 17:411-422.
-
Correlative Studies Unravelling the Possible Mechanism of Cell Death in Tideglusib-Treated Human Ovarian Teratocarcinoma-Derived PA-1 Cells. J Environ Pathol Toxicol Oncol. 2017; 36(4):321-344.
-
The effect of sulforaphane on the cell cycle, apoptosis and expression of cyclin D1 and p21 in the A549 non-small cell lung cancer cell line. Int J Oncol. 2016 Jun; 48(6):2521-33.
-
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell. 2015 Aug; 14(4):644-58.
-
Fusion of cell-penetrating peptides to thermally responsive biopolymer improves tumor accumulation of p21 peptide in a mouse model of pancreatic cancer. Drug Des Devel Ther. 2014; 8:1649-58.
-
Ah receptor-mediated suppression of liver regeneration through NC-XRE-driven p21Cip1 expression. Mol Pharmacol. 2014 Apr; 85(4):533-41.
-
p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice. Neoplasia. 2013 Aug; 15(8):966-74.
-
Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71.
-
Development of mice without Cip/Kip CDK inhibitors. Biochem Biophys Res Commun. 2012 Oct 19; 427(2):285-92.
-
p57 is required for quiescence and maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2011 Sep 02; 9(3):262-71.