"Perforin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.
| Descriptor ID |
D054353
|
| MeSH Number(s) |
D12.776.543.695.875
|
| Concept/Terms |
Perforin- Perforin
- Lymphocyte Pore-Forming Protein
- Lymphocyte Pore Forming Protein
- Pore-Forming Protein, Lymphocyte
- Perforin 1
- Cytolysin
|
Below are MeSH descriptors whose meaning is more general than "Perforin".
Below are MeSH descriptors whose meaning is more specific than "Perforin".
This graph shows the total number of publications written about "Perforin" by people in this website by year, and whether "Perforin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 0 | 2 |
| 2015 | 2 | 0 | 2 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Perforin" by people in Profiles.
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Risks associated with enterococci as probiotics. Food Res Int. 2020 03; 129:108788.
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Potentiating NK cell activity by combination of Rosuvastatin and Difluoromethylornithine for effective chemopreventive efficacy against Colon Cancer. Sci Rep. 2016 11 14; 6:37046.
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Stonefish toxin defines an ancient branch of the perforin-like superfamily. Proc Natl Acad Sci U S A. 2015 Dec 15; 112(50):15360-5.
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The Apicomplexan CDC/MACPF-like pore-forming proteins. Curr Opin Microbiol. 2015 Aug; 26:48-52.
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Packing a punch: the mechanism of pore formation by cholesterol dependent cytolysins and membrane attack complex/perforin-like proteins. Curr Opin Struct Biol. 2012 Jun; 22(3):342-9.
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Monomer-monomer interactions propagate structural transitions necessary for pore formation by the cholesterol-dependent cytolysins. J Biol Chem. 2012 Jul 13; 287(29):24534-43.
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Membrane assembly of the cholesterol-dependent cytolysin pore complex. Biochim Biophys Acta. 2012 Apr; 1818(4):1028-38.
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Structures of perfringolysin O suggest a pathway for activation of cholesterol-dependent cytolysins. J Mol Biol. 2007 Apr 13; 367(5):1227-36.