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David V Huhman

TitleLaboratory Research Manager
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCore Facilities
AddressBRC 1103A
975 NE 10th St
Oklahoma City OK 73104
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ray P, Guo Y, Chi MH, Krom N, Boschiero C, Watson B, Huhman D, Zhao P, Singan VR, Lindquist EA, Yan J, Adam C, Craven KD. Serendipita Fungi Modulate the Switchgrass Root Transcriptome to Circumvent Host Defenses and Establish a Symbiotic Relationship. Mol Plant Microbe Interact. 2021 Oct; 34(10):1128-1142. PMID: 34260261.
      Citations:    Fields:    Translation:AnimalsCells
    2. Fonseca JP, Oh S, Boschiero C, Watson B, Huhman D, Mysore KS. The Arabidopsis Iron-Sulfur (Fe-S) Cluster Gene MFDX1 Plays a Role in Host and Nonhost Disease Resistance by Accumulation of Defense-Related Metabolites. Int J Mol Sci. 2021 Jul 01; 22(13). PMID: 34281196.
      Citations:    Fields:    Translation:AnimalsCells
    3. Griffiths M, Roy S, Guo H, Seethepalli A, Huhman D, Ge Y, Sharp RE, Fritschi FB, York LM. A multiple ion-uptake phenotyping platform reveals shared mechanisms affecting nutrient uptake by roots. Plant Physiol. 2021 04 02; 185(3):781-795. PMID: 33793942.
      Citations: 3     Fields:    Translation:Animals
    4. Lei Z, Watson BS, Huhman D, Yang DS, Sumner LW. Large-Scale Profiling of Saponins in Different Ecotypes of Medicago truncatula. Front Plant Sci. 2019; 10:850. PMID: 31333696.
    5. Tzin V, Snyder JH, Yang DS, Huhman DV, Watson BS, Allen SN, Tang Y, Miettinen K, Arendt P, Pollier J, Goossens A, Sumner LW. Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins. Metabolomics. 2019 05 29; 15(6):85. PMID: 31144047.
      Citations: 7     Fields:    Translation:AnimalsCells
    6. Kang Y, Torres-Jerez I, An Z, Greve V, Huhman D, Krom N, Cui Y, Udvardi M. Genome-wide association analysis of salinity responsive traits in Medicago truncatula. Plant Cell Environ. 2019 05; 42(5):1513-1531. PMID: 30593671.
      Citations: 10     Fields:    Translation:Animals
    7. Lei Z, Kranawetter C, Sumner BW, Huhman D, Wherritt DJ, Thomas AL, Rohla C, Sumner LW. Metabolomics of Two Pecan Varieties Provides Insights into Scab Resistance. Metabolites. 2018 Sep 23; 8(4). PMID: 30249055.
    8. Cai F, Watson BS, Meek D, Huhman DV, Wherritt DJ, Ben C, Gentzbittel L, Driscoll BT, Sumner LW, Bede JC. Medicago truncatula Oleanolic-Derived Saponins Are Correlated with Caterpillar Deterrence. J Chem Ecol. 2017 Jul; 43(7):712-724. PMID: 28744732.
      Citations: 1     Fields:    Translation:Animals
    9. Liu S, Fu C, Gou J, Sun L, Huhman D, Zhang Y, Wang ZY. Simultaneous Downregulation of MTHFR and COMT in Switchgrass Affects Plant Performance and Induces Lesion-Mimic Cell Death. Front Plant Sci. 2017; 8:982. PMID: 28676804.
    10. Khan BR, Wherritt DJ, Huhman D, Sumner LW, Chapman KD, Blancaflor EB. Malonylation of Glucosylated N-Lauroylethanolamine: A NEW PATHWAY THAT DETERMINES N-ACYLETHANOLAMINE METABOLIC FATE IN PLANTS. J Biol Chem. 2016 12 30; 291(53):27112-27121. PMID: 27856641.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Geng S, Misra BB, de Armas E, Huhman DV, Alborn HT, Sumner LW, Chen S. Jasmonate-mediated stomatal closure under elevated CO2 revealed by time-resolved metabolomics. Plant J. 2016 12; 88(6):947-962. PMID: 27500669.
      Citations: 23     Fields:    Translation:AnimalsCells
    12. Srivastava AC, Chen F, Ray T, Pattathil S, Peña MJ, Avci U, Li H, Huhman DV, Backe J, Urbanowicz B, Miller JS, Bedair M, Wyman CE, Sumner LW, York WS, Hahn MG, Dixon RA, Blancaflor EB, Tang Y. Loss of function of folylpolyglutamate synthetase 1 reduces lignin content and improves cell wall digestibility in Arabidopsis. Biotechnol Biofuels. 2015; 8:224. PMID: 26697113.
    13. Zhang W, Lei Z, Huhman D, Sumner LW, Zhao PX. MET-XAlign: a metabolite cross-alignment tool for LC/MS-based comparative metabolomics. Anal Chem. 2015 Sep 15; 87(18):9114-9. PMID: 26247233.
      Citations: 8     Fields:    
    14. Ishiga Y, Uppalapati SR, Gill US, Huhman D, Tang Y, Mysore KS. Transcriptomic and metabolomic analyses identify a role for chlorophyll catabolism and phytoalexin during Medicago nonhost resistance against Asian soybean rust. Sci Rep. 2015 Aug 12; 5:13061. PMID: 26267598.
      Citations: 16     Fields:    Translation:AnimalsCells
    15. Abate-Pella D, Freund DM, Ma Y, Simón-Manso Y, Hollender J, Broeckling CD, Huhman DV, Krokhin OV, Stoll DR, Hegeman AD, Kind T, Fiehn O, Schymanski EL, Prenni JE, Sumner LW, Boswell PG. Retention projection enables accurate calculation of liquid chromatographic retention times across labs and methods. J Chromatogr A. 2015 Sep 18; 1412:43-51. PMID: 26292625.
      Citations: 15     Fields:    
    16. Lei Z, Jing L, Qiu F, Zhang H, Huhman D, Zhou Z, Sumner LW. Construction of an Ultrahigh Pressure Liquid Chromatography-Tandem Mass Spectral Library of Plant Natural Products and Comparative Spectral Analyses. Anal Chem. 2015 Jul 21; 87(14):7373-81. PMID: 26107650.
      Citations: 16     Fields:    Translation:Cells
    17. Watson BS, Bedair MF, Urbanczyk-Wochniak E, Huhman DV, Yang DS, Allen SN, Li W, Tang Y, Sumner LW. Integrated metabolomics and transcriptomics reveal enhanced specialized metabolism in Medicago truncatula root border cells. Plant Physiol. 2015 Apr; 167(4):1699-716. PMID: 25667316.
      Citations: 30     Fields:    Translation:AnimalsCells
    18. Young CA, Charlton ND, Takach JE, Swoboda GA, Trammell MA, Huhman DV, Hopkins AA. Characterization of Epichloë coenophiala within the US: are all tall fescue endophytes created equal? Front Chem. 2014; 2:95. PMID: 25408942.
    19. Pant BD, Pant P, Erban A, Huhman D, Kopka J, Scheible WR. Identification of primary and secondary metabolites with phosphorus status-dependent abundance in Arabidopsis, and of the transcription factor PHR1 as a major regulator of metabolic changes during phosphorus limitation. Plant Cell Environ. 2015 Jan; 38(1):172-87. PMID: 24894834.
      Citations: 52     Fields:    Translation:Animals
    20. Zhang W, Chang J, Lei Z, Huhman D, Sumner LW, Zhao PX. MET-COFEA: a liquid chromatography/mass spectrometry data processing platform for metabolite compound feature extraction and annotation. Anal Chem. 2014 Jul 01; 86(13):6245-53. PMID: 24856452.
      Citations: 15     Fields:    
    21. Zhang JY, Cruz DE Carvalho MH, Torres-Jerez I, Kang Y, Allen SN, Huhman DV, Tang Y, Murray J, Sumner LW, Udvardi MK. Global reprogramming of transcription and metabolism in Medicago truncatula during progressive drought and after rewatering. Plant Cell Environ. 2014 Nov; 37(11):2553-76. PMID: 24661137.
      Citations: 55     Fields:    Translation:AnimalsCells
    22. Pang Y, Cheng X, Huhman DV, Ma J, Peel GJ, Yonekura-Sakakibara K, Saito K, Shen G, Sumner LW, Tang Y, Wen J, Yun J, Dixon RA. Medicago glucosyltransferase UGT72L1: potential roles in proanthocyanidin biosynthesis. Planta. 2013 Jul; 238(1):139-54. PMID: 23592226.
      Citations: 16     Fields:    Translation:AnimalsCells
    23. Xu H, Zhang F, Liu B, Huhman DV, Sumner LW, Dixon RA, Wang G. Characterization of the formation of branched short-chain fatty acid:CoAs for bitter acid biosynthesis in hop glandular trichomes. Mol Plant. 2013 Jul; 6(4):1301-17. PMID: 23300257.
      Citations: 25     Fields:    Translation:AnimalsCells
    24. Pang Y, Abeysinghe IS, He J, He X, Huhman D, Mewan KM, Sumner LW, Yun J, Dixon RA. Functional characterization of proanthocyanidin pathway enzymes from tea and their application for metabolic engineering. Plant Physiol. 2013 Mar; 161(3):1103-16. PMID: 23288883.
      Citations: 46     Fields:    Translation:AnimalsCells
    25. Frydman A, Liberman R, Huhman DV, Carmeli-Weissberg M, Sapir-Mir M, Ophir R, W Sumner L, Eyal Y. The molecular and enzymatic basis of bitter/non-bitter flavor of citrus fruit: evolution of branch-forming rhamnosyltransferases under domestication. Plant J. 2013 Jan; 73(1):166-78. PMID: 22989156.
      Citations: 24     Fields:    Translation:Animals
    26. Shen G, Huhman D, Lei Z, Snyder J, Sumner LW, Dixon RA. Characterization of an isoflavonoid-specific prenyltransferase from Lupinus albus. Plant Physiol. 2012 May; 159(1):70-80. PMID: 22430842.
      Citations: 23     Fields:    Translation:AnimalsCells
    27. Quanbeck SM, Brachova L, Campbell AA, Guan X, Perera A, He K, Rhee SY, Bais P, Dickerson JA, Dixon P, Wohlgemuth G, Fiehn O, Barkan L, Lange I, Lange BM, Lee I, Cortes D, Salazar C, Shuman J, Shulaev V, Huhman DV, Sumner LW, Roth MR, Welti R, Ilarslan H, Wurtele ES, Nikolau BJ. Metabolomics as a Hypothesis-Generating Functional Genomics Tool for the Annotation of Arabidopsis thaliana Genes of "Unknown Function". Front Plant Sci. 2012; 3:15. PMID: 22645570.
    28. Lei Z, Huhman DV, Sumner LW. Mass spectrometry strategies in metabolomics. J Biol Chem. 2011 Jul 22; 286(29):25435-42. PMID: 21632543.
      Citations: 130     Fields:    Translation:HumansAnimals
    29. Zhao J, Huhman D, Shadle G, He XZ, Sumner LW, Tang Y, Dixon RA. MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula. Plant Cell. 2011 Apr; 23(4):1536-55. PMID: 21467581.
      Citations: 87     Fields:    Translation:AnimalsCells
    30. Dobritsa AA, Lei Z, Nishikawa S, Urbanczyk-Wochniak E, Huhman DV, Preuss D, Sumner LW. LAP5 and LAP6 encode anther-specific proteins with similarity to chalcone synthase essential for pollen exine development in Arabidopsis. Plant Physiol. 2010 Jul; 153(3):937-55. PMID: 20442277.
      Citations: 96     Fields:    Translation:AnimalsCells
    31. Naoumkina MA, Modolo LV, Huhman DV, Urbanczyk-Wochniak E, Tang Y, Sumner LW, Dixon RA. Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula. Plant Cell. 2010 Mar; 22(3):850-66. PMID: 20348429.
      Citations: 59     Fields:    Translation:AnimalsCells
    32. Pang Y, Wenger JP, Saathoff K, Peel GJ, Wen J, Huhman D, Allen SN, Tang Y, Cheng X, Tadege M, Ratet P, Mysore KS, Sumner LW, Marks MD, Dixon RA. A WD40 repeat protein from Medicago truncatula is necessary for tissue-specific anthocyanin and proanthocyanidin biosynthesis but not for trichome development. Plant Physiol. 2009 Nov; 151(3):1114-29. PMID: 19710231.
      Citations: 58     Fields:    Translation:AnimalsCells
    33. Farag MA, Huhman DV, Dixon RA, Sumner LW. Metabolomics reveals novel pathways and differential mechanistic and elicitor-specific responses in phenylpropanoid and isoflavonoid biosynthesis in Medicago truncatula cell cultures. Plant Physiol. 2008 Feb; 146(2):387-402. PMID: 18055588.
      Citations: 50     Fields:    Translation:AnimalsCells
    34. Sumner LW, Huhman DV, Urbanczyk-Wochniak E, Lei Z. Methods, applications and concepts of metabolite profiling: secondary metabolism. EXS. 2007; 97:195-212. PMID: 17432269.
      Citations: 4     Fields:    Translation:Animals
    35. Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. Plant Cell. 2006 Dec; 18(12):3656-69. PMID: 17172354.
      Citations: 30     Fields:    Translation:AnimalsCells
    36. Zhou L, Hopkins AA, Huhman DV, Sumner LW. Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.). J Agric Food Chem. 2006 Dec 13; 54(25):9287-91. PMID: 17147408.
      Citations: 1     Fields:    Translation:Animals
    37. Farag MA, Huhman DV, Lei Z, Sumner LW. Metabolic profiling and systematic identification of flavonoids and isoflavonoids in roots and cell suspension cultures of Medicago truncatula using HPLC-UV-ESI-MS and GC-MS. Phytochemistry. 2007 Feb; 68(3):342-54. PMID: 17156801.
      Citations: 37     Fields:    
    38. Frydman A, Weisshaus O, Huhman DV, Sumner LW, Bar-Peled M, Lewinsohn E, Fluhr R, Gressel J, Eyal Y. Metabolic engineering of plant cells for biotransformation of hesperedin into neohesperidin, a substrate for production of the low-calorie sweetener and flavor enhancer NHDC. J Agric Food Chem. 2005 Dec 14; 53(25):9708-12. PMID: 16332119.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Huhman DV, Berhow MA, Sumner LW. Quantification of saponins in aerial and subterranean tissues of Medicago truncatula. J Agric Food Chem. 2005 Mar 23; 53(6):1914-20. PMID: 15769113.
      Citations: 21     Fields:    Translation:Animals
    40. Achnine L, Huhman DV, Farag MA, Sumner LW, Blount JW, Dixon RA. Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula. Plant J. 2005 Mar; 41(6):875-87. PMID: 15743451.
      Citations: 88     Fields:    Translation:Animals
    41. Suzuki H, Reddy MS, Naoumkina M, Aziz N, May GD, Huhman DV, Sumner LW, Blount JW, Mendes P, Dixon RA. Methyl jasmonate and yeast elicitor induce differential transcriptional and metabolic re-programming in cell suspension cultures of the model legume Medicago truncatula. Planta. 2005 Mar; 220(5):696-707. PMID: 15605242.
      Citations: 50     Fields:    Translation:AnimalsCells
    42. Broeckling CD, Huhman DV, Farag MA, Smith JT, May GD, Mendes P, Dixon RA, Sumner LW. Metabolic profiling of Medicago truncatula cell cultures reveals the effects of biotic and abiotic elicitors on metabolism. J Exp Bot. 2005 Jan; 56(410):323-36. PMID: 15596476.
      Citations: 93     Fields:    Translation:Animals
    43. Frydman A, Weisshaus O, Bar-Peled M, Huhman DV, Sumner LW, Marin FR, Lewinsohn E, Fluhr R, Gressel J, Eyal Y. Citrus fruit bitter flavors: isolation and functional characterization of the gene Cm1,2RhaT encoding a 1,2 rhamnosyltransferase, a key enzyme in the biosynthesis of the bitter flavonoids of citrus. Plant J. 2004 Oct; 40(1):88-100. PMID: 15361143.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    44. Liu CJ, Huhman D, Sumner LW, Dixon RA. Regiospecific hydroxylation of isoflavones by cytochrome p450 81E enzymes from Medicago truncatula. Plant J. 2003 Nov; 36(4):471-84. PMID: 14617078.
      Citations: 40     Fields:    Translation:AnimalsCells
    45. Huhman DV, Sumner LW. Metabolic profiling of saponins in Medicago sativa and Medicago truncatula using HPLC coupled to an electrospray ion-trap mass spectrometer. Phytochemistry. 2002 Feb; 59(3):347-60. PMID: 11830145.
      Citations: 36     Fields:    Translation:Animals
    46. Blount JW, Masoud S, Sumner LW, Huhman D, Dixon RA. Over-expression of cinnamate 4-hydroxylase leads to increased accumulation of acetosyringone in elicited tobacco cell-suspension cultures. Planta. 2002 Apr; 214(6):902-10. PMID: 11941467.
      Citations: 3     Fields:    Translation:AnimalsCells
    47. Felton GW, Korth KL, Bi JL, Wesley SV, Huhman DV, Mathews MC, Murphy JB, Lamb C, Dixon RA. Inverse relationship between systemic resistance of plants to microorganisms and to insect herbivory. Curr Biol. 1999 Mar 25; 9(6):317-20. PMID: 10209100.
      Citations: 54     Fields:    Translation:AnimalsCells
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