Gene Knockout Techniques

"Gene Knockout Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Techniques to alter a gene sequence that result in an inactivated gene, or one in which the expression can be inactivated at a chosen time during development to study the loss of function of a gene.

Descriptor ID	D055786
MeSH Number(s)	E05.393.335.750
Concept/Terms	Gene Knockout Techniques Gene Knockout Techniques Gene Knockout Technique Knockout Technique, Gene Knockout Techniques, Gene Technique, Gene Knockout Techniques, Gene Knockout Gene Knockout Gene Knockouts Knockout, Gene Knockouts, Gene Gene Knock-Out Techniques Gene Knock-Out Technique Knock-Out Technique, Gene Knock-Out Techniques, Gene Technique, Gene Knock-Out Techniques, Gene Knock-Out Gene Knock Out Gene Knock Outs Knock Out, Gene Knock Outs, Gene Out, Gene Knock Outs, Gene Knock Gene Knock Out Techniques

Below are MeSH descriptors whose meaning is more general than "Gene Knockout Techniques".

Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
Investigative Techniques [E05]
Genetic Techniques [E05.393]
Gene Targeting [E05.393.335]
Gene Knockout Techniques [E05.393.335.750]

Below are MeSH descriptors whose meaning is related to "Gene Knockout Techniques".

Below are MeSH descriptors whose meaning is more specific than "Gene Knockout Techniques".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Gene Knockout Techniques" by people in this website by year, and whether "Gene Knockout Techniques" was a major or minor topic of these publications.

Bar chart showing 28 publications over 12 distinct years, with a maximum of 4 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	2	2
2010	0	1	1
2011	0	3	3
2012	0	1	1
2014	0	3	3
2015	0	2	2
2016	0	3	3
2017	0	3	3
2018	0	3	3
2019	1	3	4
2020	1	1	2
2021	0	1	1

Below are the most recent publications written about "Gene Knockout Techniques" by people in Profiles.

Lane BM, Chryst-Stangl M, Wu G, Shalaby M, El Desoky S, Middleton CC, Huggins K, Sood A, Ochoa A, Malone AF, Vancini R, Miller SE, Hall G, Kim SY, Howell DN, Kari JA, Gbadegesin R. Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. JCI Insight. 2022 01 25; 7(2).

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Gao S, Menendez M, Kurylowicz K, Griffin CT. Genomic locus proteomic screening identifies the NF-?B signaling pathway components NF?B1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells. PLoS One. 2021; 16(6):e0253519.

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Singh HD, Ma JX, Takahashi Y. Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina. Biochem Biophys Res Commun. 2021 03 19; 545:8-13.

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Chai G, Webb A, Li C, Antaki D, Lee S, Breuss MW, Lang N, Stanley V, Anzenberg P, Yang X, Marshall T, Gaffney P, Wierenga KJ, Chung BH, Tsang MH, Pais LS, Lovgren AK, VanNoy GE, Rehm HL, Mirzaa G, Leon E, Diaz J, Neumann A, Kalverda AP, Manfield IW, Parry DA, Logan CV, Johnson CA, Bonthron DT, Valleley EMA, Issa MY, Abdel-Ghafar SF, Abdel-Hamid MS, Jennings P, Zaki MS, Sheridan E, Gleeson JG. Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly. Neuron. 2021 01 20; 109(2):241-256.e9.

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Grant CV, Cai S, Risinger AL, Liang H, O'Keefe BR, Doench JG, Cichewicz RH, Mooberry SL. CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells. J Nat Prod. 2020 10 23; 83(10):3080-3092.

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Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA. PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21. JCI Insight. 2019 10 17; 4(20).

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Zhang J, Niu H, Zhao ZJ, Fu X, Wang Y, Zhang X, Zhang F, Zeng L. CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNFa/CHX-induced Apoptosis. Biomed Res Int. 2019; 2019:9071297.

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Hannafon BN, Cai A, Calloway CL, Xu YF, Zhang R, Fung KM, Ding WQ. miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study. BMC Cancer. 2019 Jun 28; 19(1):642.

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Chen C, Li J, Matye DJ, Wang Y, Li T. Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice. J Lipid Res. 2019 03; 60(3):539-549.

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Patel MM, Behar AR, Silasi R, Regmi G, Sansam CL, Keshari RS, Lupu F, Lupu C. Role of ADTRP (Androgen-Dependent Tissue Factor Pathway Inhibitor Regulating Protein) in Vascular Development and Function. J Am Heart Assoc. 2018 11 20; 7(22):e010690.

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