Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats.

Treatment with the cytochrome P450 ?-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats. Br J Pharmacol. 2013 Apr; 168(8):1878-88.

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subject areas

Amidines
Amidines
Animals
Animals
Blood Pressure
Blood Pressure
Cells, Cultured
Cells, Cultured
Cerebrovascular Disorders
Cerebrovascular Disorders
Cytochrome P-450 Enzyme System
Cytochrome P-450 Enzyme System
Cytokines
Cytokines
Hydroxyeicosatetraenoic Acids
Hydroxyeicosatetraenoic Acids
Male
Male
Middle Cerebral Artery
Middle Cerebral Artery
NF-kappa B
NF-kappa B
Oxidative Stress
Oxidative Stress
Rats
Rats
Rats, Inbred SHR
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Inbred WKY
Reactive Oxygen Species
Reactive Oxygen Species
Vasomotor System
Vasomotor System

authors with profiles

Anna Csiszar
Stefano Tarantini
William Edmund Sonntag
Zoltan Ungvari