cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function.
Xu J, Morris L, Thapa A, Ma H, Michalakis S, Biel M, Baehr W, Peshenko IV, Dizhoor AM, Ding XQ. cGMP accumulation causes photoreceptor degeneration in CNG channel deficiency: evidence of cGMP cytotoxicity independently of enhanced CNG channel function. J Neurosci. 2013 Sep 11; 33(37):14939-48.
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Animals
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Animals
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Animals, Newborn
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Animals, Newborn
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Carrier Proteins
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Carrier Proteins
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Cyclic GMP
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Cyclic GMP
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Cyclic GMP-Dependent Protein Kinases
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Cyclic GMP-Dependent Protein Kinases
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Cyclic Nucleotide-Gated Cation Channels
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Cyclic Nucleotide-Gated Cation Channels
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Enzyme-Linked Immunosorbent Assay
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Enzyme-Linked Immunosorbent Assay
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Eye Proteins
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Eye Proteins
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Guanylate Cyclase
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Guanylate Cyclase
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In Vitro Techniques
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In Vitro Techniques
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Mice
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Mice
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Mice, Inbred C57BL
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Knockout
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Nerve Tissue Proteins
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Nerve Tissue Proteins
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Phosphoric Diester Hydrolases
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Phosphoric Diester Hydrolases
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Photoreceptor Cells
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Photoreceptor Cells
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Receptors, Cell Surface
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Receptors, Cell Surface
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Receptors, N-Methyl-D-Aspartate
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Receptors, N-Methyl-D-Aspartate
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Retina
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Retina
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Retinal Degeneration
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Retinal Degeneration