Argininosuccinate Synthase
"Argininosuccinate Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
| Descriptor ID |
D001124
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| MeSH Number(s) |
D08.811.464.259.300
|
| Concept/Terms |
Argininosuccinate Synthase- Argininosuccinate Synthase
- Synthase, Argininosuccinate
- Argininosuccinate Synthetase
- Synthetase, Argininosuccinate
|
Below are MeSH descriptors whose meaning is more general than "Argininosuccinate Synthase".
Below are MeSH descriptors whose meaning is more specific than "Argininosuccinate Synthase".
This graph shows the total number of publications written about "Argininosuccinate Synthase" by people in this website by year, and whether "Argininosuccinate Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Argininosuccinate Synthase" by people in Profiles.
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Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells. FEBS J. 2021 12; 288(23):6683-6699.
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Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase. Alcohol Clin Exp Res. 2014 Mar; 38(3):649-56.
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Argininosuccinate synthase conditions the response to acute and chronic ethanol-induced liver injury in mice. Hepatology. 2012 05; 55(5):1596-1609.
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Partial deletion of argininosuccinate synthase protects from pyrazole plus lipopolysaccharide-induced liver injury by decreasing nitrosative stress. Am J Physiol Gastrointest Liver Physiol. 2012 Feb 01; 302(3):G287-95.