Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells.
Banki E, Sosnowska D, Tucsek Z, Gautam T, Toth P, Tarantini S, Tamas A, Helyes Z, Reglodi D, Sonntag WE, Csiszar A, Ungvari Z. Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. J Gerontol A Biol Sci Med Sci. 2015 Jun; 70(6):665-74.
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Aging
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Aging
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Animals
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Animals
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Apoptosis
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Apoptosis
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Brain
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Brain
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Caspase 3
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Caspase 3
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Cell Adhesion
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Cell Adhesion
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Cell Movement
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Cell Movement
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Cells, Cultured
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Cells, Cultured
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Down-Regulation
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Down-Regulation
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Endothelial Cells
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Endothelial Cells
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Gene Knockdown Techniques
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Gene Knockdown Techniques
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Neovascularization, Physiologic
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Neovascularization, Physiologic
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Pituitary Adenylate Cyclase-Activating Polypeptide
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Pituitary Adenylate Cyclase-Activating Polypeptide
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Rats
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Rats
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Rats, Inbred F344
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Rats, Inbred F344
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Reactive Oxygen Species
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Reactive Oxygen Species
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
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Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide
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Recombinant Proteins
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Recombinant Proteins
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RNA, Messenger
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RNA, Messenger
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Signal Transduction
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Signal Transduction
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factor Receptor-2
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Vascular Endothelial Growth Factor Receptor-2