gamma-Glutamyltransferase
"gamma-Glutamyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.
| Descriptor ID |
D005723
|
| MeSH Number(s) |
D08.811.913.050.200.500
|
| Concept/Terms |
gamma-Glutamyltransferase- gamma-Glutamyltransferase
- gamma Glutamyltransferase
- GGTP
- gammaglutamyltransferase
- Glutamyl Transpeptidase
- Transpeptidase, Glutamyl
- gamma-Glutamyl Transpeptidase
- Transpeptidase, gamma-Glutamyl
- gamma Glutamyl Transpeptidase
|
Below are MeSH descriptors whose meaning is more general than "gamma-Glutamyltransferase".
Below are MeSH descriptors whose meaning is more specific than "gamma-Glutamyltransferase".
This graph shows the total number of publications written about "gamma-Glutamyltransferase" by people in this website by year, and whether "gamma-Glutamyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2013 | 3 | 0 | 3 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "gamma-Glutamyltransferase" by people in Profiles.
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Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. Bioorg Med Chem. 2022 11 01; 73:116986.
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The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children. Hepatology. 2021 03; 73(3):1074-1087.
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Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J Biol Chem. 2021 Jan-Jun; 296:100066.
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Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. J Pediatr. 2019 06; 209:92-96.e1.
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Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 06; 26(6):1196-1205.
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Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86.
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Detection of distinct glycosylation patterns on human ?-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotechnol. 2014 Dec 06; 14:101.
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Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol. 2015 May; 143(5):505-15.
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Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res. 2014; 122:103-41.
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Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13.