gamma-Glutamyltransferase

"gamma-Glutamyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An enzyme, sometimes called GGT, with a key role in the synthesis and degradation of GLUTATHIONE; (GSH, a tripeptide that protects cells from many toxins). It catalyzes the transfer of the gamma-glutamyl moiety to an acceptor amino acid.

Descriptor ID	D005723
MeSH Number(s)	D08.811.913.050.200.500
Concept/Terms	gamma-Glutamyltransferase gamma-Glutamyltransferase gamma Glutamyltransferase GGTP gammaglutamyltransferase Glutamyl Transpeptidase Transpeptidase, Glutamyl gamma-Glutamyl Transpeptidase Transpeptidase, gamma-Glutamyl gamma Glutamyl Transpeptidase

Below are MeSH descriptors whose meaning is more general than "gamma-Glutamyltransferase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Aminoacyltransferases [D08.811.913.050.200]
gamma-Glutamyltransferase [D08.811.913.050.200.500]

Below are MeSH descriptors whose meaning is related to "gamma-Glutamyltransferase".

Below are MeSH descriptors whose meaning is more specific than "gamma-Glutamyltransferase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "gamma-Glutamyltransferase" by people in this website by year, and whether "gamma-Glutamyltransferase" was a major or minor topic of these publications.

Bar chart showing 45 publications over 22 distinct years, with a maximum of 4 publications in 1993 and 1998

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1992	0	1	1
1993	2	2	4
1994	2	0	2
1995	1	0	1
1996	2	0	2
1997	2	0	2
1998	3	1	4
1999	3	0	3
2001	1	0	1
2002	1	1	2
2003	0	3	3
2006	0	1	1
2008	0	2	2
2009	1	0	1
2010	2	0	2
2011	3	0	3
2013	3	0	3
2014	3	0	3
2015	1	0	1
2017	1	0	1
2019	1	0	1
2020	1	1	2

Below are the most recent publications written about "gamma-Glutamyltransferase" by people in Profiles.

Deneau MR, Mack C, Perito ER, Ricciuto A, Valentino PL, Amin M, Amir AZ, Aumar M, Auth M, Broderick A, DiGuglielmo M, Draijer LG, Tavares Fagundes ED, El-Matary W, Ferrari F, Furuya KN, Gupta N, Hochberg JT, Homan M, Horslen S, Iorio R, Jensen MK, Jonas MM, Kamath BM, Kerkar N, Kim KM, Kolho KL, Koot BGP, Laborda TJ, Lee CK, Loomes KM, Martinez M, Miethke A, Miloh T, Mogul D, Mohammad S, Mohan P, Moroz S, Ovchinsky N, Palle S, Papadopoulou A, Rao G, Rodrigues Ferreira A, Sathya P, Schwarz KB, Shah U, Shteyer E, Singh R, Smolka V, Soufi N, Tanaka A, Varier R, Vitola B, Woynarowski M, Zerofsky M, Zizzo A, Guthery SL. The Sclerosing Cholangitis Outcomes in Pediatrics (SCOPE) Index: A Prognostic Tool for Children. Hepatology. 2021 03; 73(3):1074-1087.

View in: PubMed
Terzyan SS, Nguyen LT, Burgett AWG, Heroux A, Smith CA, You Y, Hanigan MH. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site. J Biol Chem. 2021 Jan-Jun; 296:100066.

View in: PubMed
Deneau M, Perito E, Ricciuto A, Gupta N, Kamath BM, Palle S, Vitola B, Smolka V, Ferrari F, Amir AZ, Miloh T, Papadopoulou A, Mohan P, Mack C, Kolho KL, Iorio R, El-Matary W, Venkat V, Chan A, Saubermann L, Valentino PL, Shah U, Miethke A, Lin H, Jensen MK. Ursodeoxycholic Acid Therapy in Pediatric Primary Sclerosing Cholangitis: Predictors of Gamma Glutamyltransferase Normalization and Favorable Clinical Course. J Pediatr. 2019 06; 209:92-96.e1.

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Terzyan SS, Cook PF, Heroux A, Hanigan MH. Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation. Protein Sci. 2017 06; 26(6):1196-1205.

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Terzyan SS, Burgett AW, Heroux A, Smith CA, Mooers BH, Hanigan MH. Human ?-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS. J Biol Chem. 2015 Jul 10; 290(28):17576-86.

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West MB, Partyka K, Feasley CL, Maupin KA, Goppallawa I, West CM, Haab BB, Hanigan MH. Detection of distinct glycosylation patterns on human ?-glutamyl transpeptidase 1 using antibody-lectin sandwich array (ALSA) technology. BMC Biotechnol. 2014 Dec 06; 14:101.

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Hanigan MH, Gillies EM, Wickham S, Wakeham N, Wirsig-Wiechmann CR. Immunolabeling of gamma-glutamyl transferase 5 in normal human tissues reveals that expression and localization differ from gamma-glutamyl transferase 1. Histochem Cell Biol. 2015 May; 143(5):505-15.

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Hanigan MH. Gamma-glutamyl transpeptidase: redox regulation and drug resistance. Adv Cancer Res. 2014; 122:103-41.

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West MB, Chen Y, Wickham S, Heroux A, Cahill K, Hanigan MH, Mooers BH. Novel insights into eukaryotic ?-glutamyltranspeptidase 1 from the crystal structure of the glutamate-bound human enzyme. J Biol Chem. 2013 Nov 01; 288(44):31902-13.

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West MB, Wickham S, Parks EE, Sherry DM, Hanigan MH. Human GGT2 does not autocleave into a functional enzyme: A cautionary tale for interpretation of microarray data on redox signaling. Antioxid Redox Signal. 2013 Dec 01; 19(16):1877-88.

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