The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.
Sasaki J, Ramesh R, Chada S, Gomyo Y, Roth JA, Mukhopadhyay T. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther. 2002 Nov; 1(13):1201-9.
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Administration, Oral
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Administration, Oral
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Animals
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Animals
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Antinematodal Agents
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Antinematodal Agents
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Antineoplastic Agents, Phytogenic
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Antineoplastic Agents, Phytogenic
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Apoptosis
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Apoptosis
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Biomarkers, Tumor
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Biomarkers, Tumor
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Blotting, Western
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Blotting, Western
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Carcinoma, Non-Small-Cell Lung
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Carcinoma, Non-Small-Cell Lung
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Caspases
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Caspases
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Cell Cycle
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Cell Cycle
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Cytochrome c Group
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Cytochrome c Group
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Flow Cytometry
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Flow Cytometry
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Humans
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Humans
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In Situ Nick-End Labeling
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In Situ Nick-End Labeling
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Lung Neoplasms
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Lung Neoplasms
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Mebendazole
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Mebendazole
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Mice
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Mice
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Mice, Nude
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Mice, Nude
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Microscopy, Fluorescence
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Microscopy, Fluorescence
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Mitochondria
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Mitochondria
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Paclitaxel
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Paclitaxel
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Spindle Apparatus
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Spindle Apparatus
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Tubulin
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Tubulin
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Tumor Cells, Cultured
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Tumor Cells, Cultured