Immunoglobulin Heavy Chains
"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
| Descriptor ID |
D007143
|
| MeSH Number(s) |
D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
|
| Concept/Terms |
Immunoglobulin Heavy Chains- Immunoglobulin Heavy Chains
- Heavy Chains, Immunoglobulin
- Ig Heavy Chains
- Heavy Chains, Ig
- Immunoglobulins, Heavy-Chain
- Immunoglobulins, Heavy Chain
- Heavy-Chain Immunoglobulins
- Heavy Chain Immunoglobulins
- Immunoglobulin Heavy Chain
- Heavy Chain, Immunoglobulin
|
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".
This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 1 | 2 |
| 2012 | 0 | 2 | 2 |
| 2015 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.
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Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry. MAbs. 2019 Nov-Dec; 11(8):1351-1357.
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Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody. Anal Chem. 2018 11 06; 90(21):12527-12535.
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IgH sequences in common variable immune deficiency reveal altered B cell development and selection. Sci Transl Med. 2015 Aug 26; 7(302):302ra135.
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Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. J Exp Med. 2013 Jan 14; 210(1):125-42.
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Irreversible heavy chain transfer to hyaluronan oligosaccharides by tumor necrosis factor-stimulated gene-6. J Biol Chem. 2013 Jan 04; 288(1):205-14.
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Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol. 2006 Jun; 26(12):4758-68.
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H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14.
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Bruton's tyrosine kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol. 2005 Mar; 25(6):2073-84.
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Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire. Blood. 2004 Nov 01; 104(9):2981-7.
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Critical interactions in binding antibody NC41 to influenza N9 neuraminidase: amino acid contacts on the antibody heavy chain. Biochemistry. 1998 Jul 28; 37(30):10660-70.