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Karen Lynn Abbott

InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentStephenson Cancer Center
AddressBRC 411A
975 NE 10th St
Oklahoma City OK 73104
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    Collapse Research 
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    U01CA168870     (ABBOTT, KAREN L.)Sep 3, 2012 - Jun 30, 2018
    Glycomics Laboratory for the Early Detection of Epithelial Ovarian Cancer
    Role: Principal Investigator

    U01CA226055     (ABBOTT, KAREN L.)Apr 18, 2018 - Mar 31, 2023
    Glycomics Laboratory for the Development of Ovarian Cancer Biomarkers
    Role: Principal Investigator

    R21CA229044     (ABBOTT, KAREN L.)Sep 12, 2018 - Aug 31, 2021
    Novel Platform linking cancer-specific glycosylation with cell signaling outcomes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rikitake M, Matsuda A, Murata D, Dejima K, Nomura KH, Abbott KL, Mitani S, Nomura K. Analysis of GPI-anchored proteins involved in germline stem cell proliferation in the Caenorhabditis elegans germline stem cell niche. J Biochem. 2020 Dec 26; 168(6):589-602. PMID: 32844210.
      Citations:    Fields:    
    2. Murali P, Johnson BP, Lu Z, Climer L, Scott DA, Foulquier F, Oprea-Ilies G, Lupashin V, Drake RR, Abbott KL. Novel role for the Golgi membrane protein TMEM165 in control of migration and invasion for breast carcinoma. Oncotarget. 2020 Jul 14; 11(28):2747-2762. PMID: 32733646.
      Citations:    Fields:    
    3. Lu Z, Kamat K, Johnson BP, Yin CC, Scholler N, Abbott KL. Generation of a Fully Human scFv that binds Tumor-Specific Glycoforms. Sci Rep. 2019 03 25; 9(1):5101. PMID: 30911061.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Allam H, Johnson BP, Zhang M, Lu Z, Cannon MJ, Abbott KL. The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer. J Biol Chem. 2017 09 29; 292(39):16351-16359. PMID: 28842505.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    5. Guo H, Abbott KL. Functional impact of tumor-specific N-linked glycan changes in breast and ovarian cancers. Adv Cancer Res. 2015; 126:281-303. PMID: 25727151.
      Citations: 11     Fields:    Translation:HumansCells
    6. Allam H, Aoki K, Benigno BB, McDonald JF, Mackintosh SG, Tiemeyer M, Abbott KL. Glycomic analysis of membrane glycoproteins with bisecting glycosylation from ovarian cancer tissues reveals novel structures and functions. J Proteome Res. 2015 Jan 02; 14(1):434-46. PMID: 25437919.
      Citations: 19     Fields:    Translation:HumansCells
    7. Dolezal S, Hester S, Kirby PS, Nairn A, Pierce M, Abbott KL. Elevated levels of glycosylphosphatidylinositol (GPI) anchored proteins in plasma from human cancers detected by C. septicum alpha toxin. Cancer Biomark. 2014 Jan 01; 14(1):55-62. PMID: 24643042.
      Citations: 8     Fields:    Translation:HumansCells
    8. Zhao P, Nairn AV, Hester S, Moremen KW, O'Regan RM, Oprea G, Wells L, Pierce M, Abbott KL. Proteomic identification of glycosylphosphatidylinositol anchor-dependent membrane proteins elevated in breast carcinoma. J Biol Chem. 2012 Jul 20; 287(30):25230-40. PMID: 22654114.
      Citations: 20     Fields:    Translation:HumansCells
    9. Dangaj D, Abbott KL, Mookerjee A, Zhao A, Kirby PS, Sandaltzopoulos R, Powell DJ, Lamazière A, Siegel DL, Wolf C, Scholler N. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody. PLoS One. 2011; 6(12):e28386. PMID: 22163010.
      Citations: 8     Fields:    Translation:HumansCells
    10. Abbott KL, Lim JM, Wells L, Benigno BB, McDonald JF, Pierce M. Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis. Proteomics. 2010 Feb; 10(3):470-81. PMID: 19953551.
      Citations: 42     Fields:    Translation:HumansCells
    11. Abbott KL, Pierce JM. Lectin-based glycoproteomic techniques for the enrichment and identification of potential biomarkers. Methods Enzymol. 2010; 480:461-76. PMID: 20816222.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    12. Abbott KL. Glycomic analysis of ovarian cancer: past, present, and future. Cancer Biomark. 2010-2011; 8(4-5):273-80. PMID: 22045358.
      Citations: 3     Fields:    Translation:Humans
    13. Yang A, Abbott KL, Desjardins A, Di Lello P, Omichinski JG, Legault P. NMR structure of a complex formed by the carboxyl-terminal domain of human RAP74 and a phosphorylated peptide from the central domain of the FCP1 phosphatase. Biochemistry. 2009 Mar 10; 48(9):1964-74. PMID: 19215094.
      Citations: 4     Fields:    Translation:HumansCells
    14. Abbott KL, Matthews RT, Pierce M. Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. J Biol Chem. 2008 Nov 28; 283(48):33026-35. PMID: 18838383.
      Citations: 36     Fields:    Translation:HumansCells
    15. Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008 Aug; 8(16):3210-20. PMID: 18690643.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    16. Abbott KL, Aoki K, Lim JM, Porterfield M, Johnson R, O'Regan RM, Wells L, Tiemeyer M, Pierce M. Targeted glycoproteomic identification of biomarkers for human breast carcinoma. J Proteome Res. 2008 Apr; 7(4):1470-80. PMID: 18271524.
      Citations: 37     Fields:    Translation:HumansCells
    17. Abbott KL, Troupe K, Lee I, Pierce M. Integrin-dependent neuroblastoma cell adhesion and migration on laminin is regulated by expression levels of two enzymes in the O-mannosyl-linked glycosylation pathway, PomGnT1 and GnT-Vb. Exp Cell Res. 2006 Sep 10; 312(15):2837-50. PMID: 16857188.
      Citations: 15     Fields:    Translation:HumansCells
    18. Lee I, Guo HB, Kamar M, Abbott K, Troupe K, Lee JK, Alvarez-Manilla G, Pierce M. N-acetylglucosaminyltranferase VB expression enhances beta1 integrin- dependent PC12 neurite outgrowth on laminin and collagen. J Neurochem. 2006 May; 97(4):947-56. PMID: 16606368.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    19. Abbott KL, Renfrow MB, Chalmers MJ, Nguyen BD, Marshall AG, Legault P, Omichinski JG. Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylation. Biochemistry. 2005 Mar 01; 44(8):2732-45. PMID: 15723518.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Abbott KL, Archambault J, Xiao H, Nguyen BD, Roeder RG, Greenblatt J, Omichinski JG, Legault P. Interactions of the HIV-1 Tat and RAP74 proteins with the RNA polymerase II CTD phosphatase FCP1. Biochemistry. 2005 Mar 01; 44(8):2716-31. PMID: 15723517.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Nguyen BD, Abbott KL, Potempa K, Kobor MS, Archambault J, Greenblatt J, Legault P, Omichinski JG. NMR structure of a complex containing the TFIIF subunit RAP74 and the RNA polymerase II carboxyl-terminal domain phosphatase FCP1. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5688-93. PMID: 12732728.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    22. Murphy TJ, Pavlath GK, Wang X, Boss V, Abbott KL, Robida AM, Nichols J, Xu K, Ellington ML, Loss JR. Retroviral vectors applied to gene regulation studies. Methods Enzymol. 2002; 345:539-51. PMID: 11665637.
      Citations: 4     Fields:    Translation:Cells
    23. Abbott KL, Loss JR, Robida AM, Murphy TJ. Evidence that Galpha(q)-coupled receptor-induced interleukin-6 mRNA in vascular smooth muscle cells involves the nuclear factor of activated T cells. Mol Pharmacol. 2000 Nov; 58(5):946-53. PMID: 11040041.
      Citations: 12     Fields:    Translation:AnimalsCells
    24. Minneman KP, Lee D, Zhong H, Berts A, Abbott KL, Murphy TJ. Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes. J Neurochem. 2000 Jun; 74(6):2392-400. PMID: 10820200.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    25. Abbott KL, Robida AM, Davis ME, Pavlath GK, Camden JM, Turner JT, Murphy TJ. Differential regulation of vascular smooth muscle nuclear factor kappa-B by G alpha q-coupled and cytokine receptors. J Mol Cell Cardiol. 2000 Mar; 32(3):391-403. PMID: 10731439.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    26. Abbott KL, Friday BB, Thaloor D, Murphy TJ, Pavlath GK. Activation and cellular localization of the cyclosporine A-sensitive transcription factor NF-AT in skeletal muscle cells. Mol Biol Cell. 1998 Oct; 9(10):2905-16. PMID: 9763451.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    27. Boss V, Abbott KL, Wang XF, Pavlath GK, Murphy TJ. The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells. Differential localization of NFAT isoforms and induction of NFAT-mediated transcription by phospholipase C-coupled cell surface receptors. J Biol Chem. 1998 Jul 31; 273(31):19664-71. PMID: 9677394.
      Citations: 29     Fields:    Translation:AnimalsCells
    28. Sgoutas DS, Abbott KL. Cyclosporine does not interfere in total and high-density lipoprotein cholesterol measurement with use of enzymatic cholesterol assays. Clin Chem. 1989 Nov; 35(11):2251-2. PMID: 2582627.
      Citations:    Fields:    Translation:Humans
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