"ADAMTS13 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.
| Descriptor ID |
D000071120
|
| MeSH Number(s) |
D08.811.277.656.675.374.102.500.813 D09.400.430.500.500.813 D12.776.395.033.500.813 D12.776.860.300.085.813
|
| Concept/Terms |
ADAMTS13 Protein- ADAMTS13 Protein
- von Willebrand Factor-Cleaving Protease
- von Willebrand Factor Cleaving Protease
- ADAMTS13 Protease
- vWF-Cleaving Protease
- vWF Cleaving Protease
- ADAMTS-13 Protein
- ADAMTS 13 Protein
- A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
|
Below are MeSH descriptors whose meaning is more general than "ADAMTS13 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAMTS13 Protein".
This graph shows the total number of publications written about "ADAMTS13 Protein" by people in this website by year, and whether "ADAMTS13 Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 5 | 5 |
| 2005 | 0 | 3 | 3 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 3 | 3 |
| 2008 | 0 | 7 | 7 |
| 2009 | 0 | 8 | 8 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 3 | 3 |
| 2012 | 0 | 4 | 4 |
| 2013 | 0 | 3 | 3 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 5 | 5 |
| 2016 | 2 | 1 | 3 |
| 2017 | 1 | 2 | 3 |
| 2018 | 0 | 2 | 2 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 5 | 5 |
| 2021 | 0 | 3 | 3 |
| 2022 | 0 | 3 | 3 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "ADAMTS13 Protein" by people in Profiles.
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Recombinant ADAMTS13: an effective rescue therapy for acute cTTP during pregnancy. Blood Adv. 2024 Jul 23; 8(14):3718-3720.
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Prevalence of neuropsychiatric symptoms and stroke in patients with hereditary thrombotic thrombocytopenic purpura. Blood. 2022 08 18; 140(7):785-789.
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Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease. Proc Natl Acad Sci U S A. 2022 08 23; 119(34):e2207592119.
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Aspirin prophylaxis for hereditary and acquired thrombotic thrombocytopenic purpura? Am J Hematol. 2022 08; 97(8):E304-E306.
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TTP or complement-mediated TMA or both? A rare diagnosis and report of a novel plasminogen gene variant. Ann Hematol. 2022 03; 101(3):725-727.
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Redefining outcomes in immune TTP: an international working group consensus report. Blood. 2021 04 08; 137(14):1855-1861.
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Recognizing and managing hereditary and acquired thrombotic thrombocytopenic purpura in infants and children. Pediatr Blood Cancer. 2021 05; 68(5):e28949.
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ISTH guidelines for treatment of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020 10; 18(10):2496-2502.
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Good practice statements (GPS) for the clinical care of patients with thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020 10; 18(10):2503-2512.
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ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020 10; 18(10):2486-2495.