"Alkylating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases.
| Descriptor ID |
D000477
|
| MeSH Number(s) |
D27.505.519.124 D27.888.569.035
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Alkylating Agents".
Below are MeSH descriptors whose meaning is more specific than "Alkylating Agents".
This graph shows the total number of publications written about "Alkylating Agents" by people in this website by year, and whether "Alkylating Agents" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 2 | 2 |
| 2016 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alkylating Agents" by people in Profiles.
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Therapy-related myeloid neoplasms in lymphoma survivors: Reducing risks. Best Pract Res Clin Haematol. 2019 03; 32(1):47-53.
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Outcomes of Bleb Revision With Mitomycin C After Ex-PRESS Shunt Surgery. J Glaucoma. 2016 Apr; 25(4):e318-23.
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Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure. Mutagenesis. 2008 Sep; 23(5):341-6.
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Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. Carcinogenesis. 2007 May; 28(5):1111-6.
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Removal of O6-methylguanine from plant DNA in vivo is accelerated under conditions of clastogenic adaptation. Environ Mol Mutagen. 1997; 29(4):400-5.
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Formation and repair of O6-methylguanine in recombination hot spots of plant chromosomes. Environ Mol Mutagen. 1997; 29(4):394-9.
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N-methyl-N-nitrosourea-induced mutations in human cells. Effects of the transcriptional activity of the target gene. J Mol Biol. 1992 Feb 05; 223(3):587-94.
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Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med. 1987 Nov 19; 317(21):1315-21.
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Quantitation and visualization of alkyl deoxynucleosides in the DNA of mammalian cells by monoclonal antibodies. Environ Health Perspect. 1985 Oct; 62:49-55.
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Highly sensitive sites for guanine-O6 ethylation in rat brain DNA exposed to N-ethyl-N-nitrosourea in vivo. EMBO J. 1984 Feb; 3(2):327-32.