Cystathionine beta-Synthase
"Cystathionine beta-Synthase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A multifunctional pyridoxal phosphate enzyme. In the second stage of cysteine biosynthesis it catalyzes the reaction of homocysteine with serine to form cystathionine with the elimination of water. Deficiency of this enzyme leads to HYPERHOMOCYSTEINEMIA and HOMOCYSTINURIA. EC 4.2.1.22.
| Descriptor ID |
D003541
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| MeSH Number(s) |
D08.811.520.241.300.200
|
| Concept/Terms |
Cystathionine beta-Synthase- Cystathionine beta-Synthase
- Cystathionine beta Synthase
- beta-Synthase, Cystathionine
- Serine Sulfhydrase
- Sulfhydrase, Serine
- Cystathionine Synthetase
- Synthetase, Cystathionine
- beta-Thionase
- beta Thionase
|
Below are MeSH descriptors whose meaning is more general than "Cystathionine beta-Synthase".
Below are MeSH descriptors whose meaning is more specific than "Cystathionine beta-Synthase".
This graph shows the total number of publications written about "Cystathionine beta-Synthase" by people in this website by year, and whether "Cystathionine beta-Synthase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cystathionine beta-Synthase" by people in Profiles.
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A role for the cystathionine-?-synthase /H2S axis in astrocyte dysfunction in the aging brain. Redox Biol. 2023 Dec; 68:102958.
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Cystathione ß-synthase regulates HIF-1a stability through persulfidation of PHD2. Sci Adv. 2020 07; 6(27).
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Cystathionine beta synthase regulates mitochondrial dynamics and function in endothelial cells. FASEB J. 2020 07; 34(7):9372-9392.
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Short tandem repeats and methylation in the promoter region affect expression of cystathionine beta-synthase gene in the laying hen. Gene. 2019 Aug 20; 710:367-374.
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Cystathionine ß-synthase regulates mitochondrial morphogenesis in ovarian cancer. FASEB J. 2018 08; 32(8):4145-4157.
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Role of cystathionine beta synthase in lipid metabolism in ovarian cancer. Oncotarget. 2015 Nov 10; 6(35):37367-84.
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Cystathionine ß-synthase regulates endothelial function via protein S-sulfhydration. FASEB J. 2016 Jan; 30(1):441-56.
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Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One. 2013; 8(11):e79167.