"Complement C1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.
| Descriptor ID |
D003172
|
| MeSH Number(s) |
D12.776.124.486.274.050
|
| Concept/Terms |
Complement C1- Complement C1
- C1, Complement
- C1 Complement
- Complement, C1
- Complement 1
- Complement Component 1
- Component 1, Complement
|
Below are MeSH descriptors whose meaning is more general than "Complement C1".
Below are MeSH descriptors whose meaning is more specific than "Complement C1".
This graph shows the total number of publications written about "Complement C1" by people in this website by year, and whether "Complement C1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C1" by people in Profiles.
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Extracellular Vesicle-Induced Classical Complement Activation Leads to Retinal Endothelial Cell Damage via MAC Deposition. Int J Mol Sci. 2020 Mar 01; 21(5).
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Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging. J Neuroinflammation. 2017 07 21; 14(1):141.
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Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. J Exp Med. 1987 Nov 01; 166(5):1351-61.