Epidermal Growth Factor

"Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.

Descriptor ID	D004815
MeSH Number(s)	D06.472.317.350 D12.644.276.382.500 D12.776.467.382.500 D23.529.382.500
Concept/Terms	Epidermal Growth Factor Epidermal Growth Factor Growth Factor, Epidermal Urogastrone Epidermal Growth Factor-Urogastrone Growth Factor-Urogastrone, Epidermal Human Urinary Gastric Inhibitor beta-Urogastrone beta Urogastrone EGF

Below are MeSH descriptors whose meaning is more general than "Epidermal Growth Factor".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Gastrointestinal Hormones [D06.472.317]
Epidermal Growth Factor [D06.472.317.350]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intercellular Signaling Peptides and Proteins [D12.644.276]
EGF Family of Proteins [D12.644.276.382]
Epidermal Growth Factor [D12.644.276.382.500]
Proteins [D12.776]
Intercellular Signaling Peptides and Proteins [D12.776.467]
EGF Family of Proteins [D12.776.467.382]
Epidermal Growth Factor [D12.776.467.382.500]
Biological Factors [D23]
Intercellular Signaling Peptides and Proteins [D23.529]
EGF Family of Proteins [D23.529.382]
Epidermal Growth Factor [D23.529.382.500]

Below are MeSH descriptors whose meaning is related to "Epidermal Growth Factor".

Below are MeSH descriptors whose meaning is more specific than "Epidermal Growth Factor".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Epidermal Growth Factor" by people in this website by year, and whether "Epidermal Growth Factor" was a major or minor topic of these publications.

Bar chart showing 23 publications over 16 distinct years, with a maximum of 3 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1991	1	1	2
1993	2	0	2
1994	0	1	1
1995	1	0	1
1996	0	1	1
2000	0	3	3
2001	1	0	1
2003	1	1	2
2004	0	1	1
2005	1	0	1
2006	1	1	2
2010	1	0	1
2011	0	1	1
2013	0	1	1
2014	1	1	2
2018	1	0	1

Below are the most recent publications written about "Epidermal Growth Factor" by people in Profiles.

Farinas AF, Bamba R, Pollins AC, Cardwell NL, Nanney LB, Thayer WP. Burn wounds in the young versus the aged patient display differential immunological responses. Burns. 2018 09; 44(6):1475-1481.

View in: PubMed
Falcon BL, Swearingen M, Gough WH, Lee L, Foreman R, Uhlik M, Hanson JC, Lee JA, McClure DB, Chintharlapalli S. An in vitro cord formation assay identifies unique vascular phenotypes associated with angiogenic growth factors. PLoS One. 2014; 9(9):e106901.

View in: PubMed
Parks EE, Ceresa BP. Cell surface epidermal growth factor receptors increase Src and c-Cbl activity and receptor ubiquitylation. J Biol Chem. 2014 Sep 12; 289(37):25537-45.

View in: PubMed
Saxena R, Fatima I, Chandra V, Blesson CS, Kharkwal G, Hussain MK, Hajela K, Roy BG, Dwivedi A. Benzopyran derivative CDRI-85/287 induces G2-M arrest in estrogen receptor-positive breast cancer cells via modulation of estrogen receptors a- and ß-mediated signaling, in parallel to EGFR signaling and suppresses the growth of tumor xenograft. Steroids. 2013 Nov; 78(11):1071-86.

View in: PubMed
Rush JS, Quinalty LM, Engelman L, Sherry DM, Ceresa BP. Endosomal accumulation of the activated epidermal growth factor receptor (EGFR) induces apoptosis. J Biol Chem. 2012 Jan 02; 287(1):712-722.

View in: PubMed
Vranic S, Tawfik O, Palazzo J, Bilalovic N, Eyzaguirre E, Lee LM, Adegboyega P, Hagenkord J, Gatalica Z. EGFR and HER-2/neu expression in invasive apocrine carcinoma of the breast. Mod Pathol. 2010 May; 23(5):644-53.

View in: PubMed
Wang N, Li Z, Ding R, Frank GD, Senbonmatsu T, Landon EJ, Inagami T, Zhao ZJ. Antagonism or synergism. Role of tyrosine phosphatases SHP-1 and SHP-2 in growth factor signaling. J Biol Chem. 2006 Aug 04; 281(31):21878-21883.

View in: PubMed
Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res. 2006 Feb 15; 66(4):2116-28.

View in: PubMed
Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol. 2005 Sep; 25(18):8285-98.

View in: PubMed
Zimmerman RA, Dozmorov I, Nunlist EH, Tang Y, Li X, Cowan R, Centola M, Frank MB, Culkin DJ, Lin HK. 5alpha-Androstane-3alpha,17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation. Prostate Cancer Prostatic Dis. 2004; 7(4):364-74.

View in: PubMed

People

Explore

Similar Concepts

Top Journals