"Huntington Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
- Huntington Disease
- Huntington Chorea
- Chorea, Huntington
- Huntington's Disease
- Chronic Progressive Hereditary Chorea (Huntington)
- Huntington Chronic Progressive Hereditary Chorea
- Progressive Chorea, Chronic Hereditary (Huntington)
- Progressive Chorea, Hereditary, Chronic (Huntington)
- Huntington's Chorea
- Chorea, Huntington's
- Chorea, Chronic Progressive Hereditary (Huntington)
Juvenile Huntington Disease
- Juvenile Huntington Disease
- Juvenile-Onset Huntington Disease
- Juvenile Onset Huntington Disease
- Huntington Disease, Juvenile-Onset
- Huntington Disease, Juvenile Onset
- Huntington Disease, Juvenile
Below are MeSH descriptors whose meaning is more general than "Huntington Disease".
Below are MeSH descriptors whose meaning is more specific than "Huntington Disease".
This graph shows the total number of publications written about "Huntington Disease" by people in this website by year, and whether "Huntington Disease" was a major or minor topic of these publications.
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Below are the most recent publications written about "Huntington Disease" by people in Profiles.
Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux. Cell Death Dis. 2018 02 08; 9(2):201.
Decreased O-linked GlcNAcylation protects from cytotoxicity mediated by huntingtin exon1 protein fragment. J Biol Chem. 2014 May 09; 289(19):13543-53.
trans-(-)-e-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Biol Chem. 2012 Jul 13; 287(29):24460-72.
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets. Nat Med. 2011 Dec 18; 18(1):153-8.
Probing the metabolic aberrations underlying mutant huntingtin toxicity in yeast and assessing their degree of preservation in humans and mice. J Proteome Res. 2010 Jan; 9(1):404-12.
Presymptomatic diagnosis in Huntington's disease: the Mexican experience. Genet Test Mol Biomarkers. 2009 Dec; 13(6):717-20.
Clinical and genetic characteristics of Mexican Huntington's disease patients. Mov Disord. 2009 Oct 15; 24(13):2012-5.
Huntington's Disease-like 2 (HDL2) in North America and Japan. Ann Neurol. 2004 Nov; 56(5):670-4.
Analyzing the subcortical dementia syndrome of Parkinson's disease using the RBANS. Arch Clin Neuropsychol. 2003 Jul; 18(5):509-20.