Nitric Oxide

"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.

Descriptor ID	D009569
MeSH Number(s)	D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
Concept/Terms	Nitric Oxide Nitric Oxide Oxide, Nitric Nitrogen Monoxide Monoxide, Nitrogen Nitric Oxide, Endothelium-Derived Endothelium-Derived Nitric Oxide Nitric Oxide, Endothelium Derived Endogenous Nitrate Vasodilator Nitrate Vasodilator, Endogenous Vasodilator, Endogenous Nitrate Mononitrogen Monoxide Monoxide, Mononitrogen

Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".

Chemicals and Drugs [D]
Inorganic Chemicals [D01]
Free Radicals [D01.339]
Nitric Oxide [D01.339.387]
Nitrogen Compounds [D01.625]
Nitrogen Oxides [D01.625.550]
Nitric Oxide [D01.625.550.500]
Reactive Nitrogen Species [D01.625.700]
Nitric Oxide [D01.625.700.500]
Oxygen Compounds [D01.650]
Oxides [D01.650.550]
Nitrogen Oxides [D01.650.550.587]
Nitric Oxide [D01.650.550.587.600]

Below are MeSH descriptors whose meaning is related to "Nitric Oxide".

Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nitric Oxide" by people in this website by year, and whether "Nitric Oxide" was a major or minor topic of these publications.

Bar chart showing 101 publications over 25 distinct years, with a maximum of 9 publications in 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	0	2
1996	3	0	3
1997	1	1	2
1998	2	1	3
1999	3	0	3
2001	4	0	4
2002	6	3	9
2003	3	0	3
2004	3	0	3
2005	1	3	4
2006	5	3	8
2007	1	5	6
2008	4	3	7
2009	2	2	4
2010	5	1	6
2011	2	1	3
2012	1	5	6
2013	1	0	1
2014	3	2	5
2015	0	3	3
2016	1	1	2
2017	1	1	2
2018	3	1	4
2019	2	4	6
2020	1	1	2

Below are the most recent publications written about "Nitric Oxide" by people in Profiles.

Carter KJ, Ward AT, Kellawan JM, Eldridge MW, Al-Subu A, Walker BJ, Lee JW, Wieben O, Schrage WG. Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion. J Physiol. 2021 11; 599(22):4973-4989.

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Berndt N, Bippes CC, Michalk I, Bartsch T, Arndt C, Puentes-Cala E, Soto JA, Loureiro LR, Kegler A, Bachmann D, Gross JK, Gross T, Kurien BT, Scofield RH, Farris AD, James JA, Bergmann R, Schmitz M, Feldmann A, Bachmann MP. And Yet It Moves: Oxidation of the Nuclear Autoantigen La/SS-B Is the Driving Force for Nucleo-Cytoplasmic Shuttling. Int J Mol Sci. 2021 Sep 08; 22(18).

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Ranallo CD, Thurman TL, Holt SJ, Frank-Pearce SG, Anderson MP, Heulitt MJ. Effect of Nitric Oxide Delivery Device on Tidal Volume Accuracy During Mechanical Ventilation at Small Tidal Volumes. Respir Care. 2020 Nov; 65(11):1641-1647.

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Gentle SJ, Tipple TE, Patel R. Neonatal comorbidities and gasotransmitters. Nitric Oxide. 2020 04 01; 97:27-32.

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Tarantini S, Yabluchanskiy A, Csipo T, Fulop G, Kiss T, Balasubramanian P, DelFavero J, Ahire C, Ungvari A, Nyúl-Tóth Á, Farkas E, Benyo Z, Tóth A, Csiszar A, Ungvari Z. Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging. Geroscience. 2019 10; 41(5):533-542.

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Abucayon EG, Khade RL, Powell DR, Zhang Y, Richter-Addo GB. Not Limited to Iron: A Cobalt Heme-NO Model Facilitates N-N Coupling with External NO in the Presence of a Lewis Acid to Generate N2 O. Angew Chem Int Ed Engl. 2019 12 16; 58(51):18598-18603.

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Sekar K, Szyld E, McCoy M, Wlodaver A, Dannaway D, Helmbrecht A, Riley J, Manfredo A, Anderson M, Lakshminrusimha S, Noori S. Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial. Pediatr Res. 2020 02; 87(3):523-528.

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Liu T, Zhang M, Mukosera GT, Borchardt D, Li Q, Tipple TE, Ishtiaq Ahmed AS, Power GG, Blood AB. L-NAME releases nitric oxide and potentiates subsequent nitroglycerin-mediated vasodilation. Redox Biol. 2019 09; 26:101238.

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Tarantini S, Valcarcel-Ares MN, Toth P, Yabluchanskiy A, Tucsek Z, Kiss T, Hertelendy P, Kinter M, Ballabh P, Süle Z, Farkas E, Baur JA, Sinclair DA, Csiszar A, Ungvari Z. Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice. Redox Biol. 2019 06; 24:101192.

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Xu N, Guan Y, Nguyen N, Lingafelt C, Powell DR, Richter-Addo GB. Interactions of acetamide and acrylamide with heme models: Synthesis, infrared spectra, and solid state molecular structures of five- and six-coordinate ferric porphyrin derivatives. J Inorg Biochem. 2019 05; 194:160-169.

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