"Platelet Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.
| Descriptor ID |
D010978
|
| MeSH Number(s) |
D12.644.276.374.200.120.900 D12.776.124.125.720 D12.776.467.374.200.120.900 D23.119.940 D23.125.300.120.900 D23.469.200.120.900 D23.529.374.200.120.900
|
| Concept/Terms |
Platelet Factor 4- Platelet Factor 4
- Chemokine CXCL4
- CXCL4, Chemokine
- PF4 (Platelet Factor 4)
- gamma-Thromboglobulin
- gamma Thromboglobulin
- Heparin Neutralizing Protein
- Antiheparin Factor
- CXCL4 Chemokine
- Chemokine, CXCL4
|
Below are MeSH descriptors whose meaning is more general than "Platelet Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Platelet Factor 4".
This graph shows the total number of publications written about "Platelet Factor 4" by people in this website by year, and whether "Platelet Factor 4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2018 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Platelet Factor 4" by people in Profiles.
-
Exogenous CXCL4 infusion inhibits macrophage phagocytosis by limiting CD36 signalling to enhance post-myocardial infarction cardiac dilation and mortality. Cardiovasc Res. 2019 02 01; 115(2):395-408.
-
Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines. Microb Pathog. 2018 Aug; 121:9-21.