Ribonucleoprotein, U1 Small Nuclear
"Ribonucleoprotein, U1 Small Nuclear" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
| Descriptor ID |
D017412
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| MeSH Number(s) |
D12.776.157.725.500.875.600 D12.776.157.725.829.313 D12.776.664.962.500.875.600 D12.776.664.962.829.313
|
| Concept/Terms |
Ribonucleoprotein, U1 Small Nuclear- Ribonucleoprotein, U1 Small Nuclear
- U1 Small Nuclear Ribonucleoproteins
- Ribonucleoproteins, Small, U1
- Small Nuclear Ribonucleoproteins, U1
- U1 snRNP
|
Below are MeSH descriptors whose meaning is more general than "Ribonucleoprotein, U1 Small Nuclear".
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This graph shows the total number of publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in this website by year, and whether "Ribonucleoprotein, U1 Small Nuclear" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ribonucleoprotein, U1 Small Nuclear" by people in Profiles.
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Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmun. 2008 Dec; 31(4):362-71.
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Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3551-6.
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Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. J Mol Recognit. 2002 May-Jun; 15(3):163-70.