"Hyperhomocysteinemia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
| Descriptor ID |
D020138
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| MeSH Number(s) |
C16.320.565.100.480 C18.452.603.378 C18.452.648.100.480 C18.654.521.500.133.699.418
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hyperhomocysteinemia".
Below are MeSH descriptors whose meaning is more specific than "Hyperhomocysteinemia".
This graph shows the total number of publications written about "Hyperhomocysteinemia" by people in this website by year, and whether "Hyperhomocysteinemia" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 2 | 0 | 2 |
| 2003 | 1 | 0 | 1 |
| 2005 | 1 | 0 | 1 |
| 2006 | 4 | 0 | 4 |
| 2007 | 3 | 1 | 4 |
| 2008 | 3 | 0 | 3 |
| 2009 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Hyperhomocysteinemia" by people in Profiles.
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The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment. Nutrients. 2023 Nov 03; 15(21).
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Cumulative incidence of vitamin B12 deficiency in patients with Alzheimer disease. J Neurol Sci. 2009 Sep 15; 284(1-2):144-8.
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Restoration of contractility in hyperhomocysteinemia by cardiac-specific deletion of NMDA-R1. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H887-92.
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Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H890-7.
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Cytochrome P450 (CYP) 2J2 gene transfection attenuates MMP-9 via inhibition of NF-kappabeta in hyperhomocysteinemia. J Cell Physiol. 2008 Jun; 215(3):771-81.
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Mitochondrial MMP activation, dysfunction and arrhythmogenesis in hyperhomocysteinemia. Curr Vasc Pharmacol. 2008 Apr; 6(2):84-92.
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Cardiac dys-synchronization and arrhythmia in hyperhomocysteinemia. Curr Neurovasc Res. 2007 Nov; 4(4):289-94.
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Cystathionine-beta-synthase gene transfer and 3-deazaadenosine ameliorate inflammatory response in endothelial cells. Am J Physiol Cell Physiol. 2007 Dec; 293(6):C1779-87.
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Cardiac synchronous and dys-synchronous remodeling in diabetes mellitus. Antioxid Redox Signal. 2007 Jul; 9(7):971-8.
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Homocysteine-induced biochemical stress predisposes to cytoskeletal remodeling in stretched endothelial cells. Mol Cell Biochem. 2007 Aug; 302(1-2):133-43.