"Protamines" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
| Descriptor ID |
D011479
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| MeSH Number(s) |
D12.776.660.750 D12.776.664.750
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protamines".
Below are MeSH descriptors whose meaning is more specific than "Protamines".
This graph shows the total number of publications written about "Protamines" by people in this website by year, and whether "Protamines" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protamines" by people in Profiles.
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SuperGAG biopolymers for treatment of excessive bladder permeability. Pharmacol Res Perspect. 2021 02; 9(1):e00709.
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Oral GLP1 Gene Delivery by an Antibody-Guided Nanomaterial to Treat Type 2 Diabetes Mellitus. ACS Appl Mater Interfaces. 2020 Sep 02; 12(35):38925-38935.
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Clinical Impact of Protamine Titration-Based Heparin Neutralization in Patients Undergoing Coronary Bypass Grafting Surgery. J Cardiothorac Vasc Anesth. 2019 Aug; 33(8):2153-2160.
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Perioperative Coagulation Management of a Hemophilia A Patient During Cardiac Surgery. Semin Cardiothorac Vasc Anesth. 2017 Dec; 21(4):312-320.
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Nanoparticle-assisted targeted delivery of eye-specific genes to eyes significantly improves the vision of blind mice in vivo. Nano Lett. 2014 Sep 10; 14(9):5257-63.
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Low-dose protamine to facilitate earlier sheath removal from the femoral artery after peripheral endovascular intervention. J Interv Cardiol. 2011 Jun; 24(3):278-84.
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The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations. Anesth Analg. 2010 Sep; 111(3):601-8.
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Anticoagulation and reversal paradigms: is too much of a good thing bad? Anesth Analg. 2009 Mar; 108(3):692-4.
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Effect of estrogen on triacylglycerol metabolism: inhibtion of post-heparin plasma lipoprotein lipase by phosvitin, an estrogen-induced protein. FEBS Lett. 1976 Aug 01; 67(1):28-31.
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Characterization of a triglyceride hydrolase secreted by canine liver maintained in vitro. Proc Soc Exp Biol Med. 1976 Feb; 151(2):390-4.