"Prothrombin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein that is the inactive precursor of thrombin. It is converted to thrombin by a prothrombin activator complex consisting of factor Xa, factor V, phospholipid, and calcium ions. Deficiency of prothrombin leads to hypoprothrombinemia.
| Descriptor ID |
D011516
|
| MeSH Number(s) |
D08.622.709 D12.776.124.125.800 D23.119.945
|
| Concept/Terms |
Prothrombin- Prothrombin
- Factor II
- Blood Coagulation Factor II
- Differentiation Reversal Factor
- Factor, Differentiation Reversal
- Coagulation Factor II
- Factor II, Coagulation
- II, Coagulation Factor
|
Below are MeSH descriptors whose meaning is more general than "Prothrombin".
Below are MeSH descriptors whose meaning is more specific than "Prothrombin".
This graph shows the total number of publications written about "Prothrombin" by people in this website by year, and whether "Prothrombin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 2 | 3 |
| 2007 | 1 | 1 | 2 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Prothrombin" by people in Profiles.
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Role of Intrinsic Pathway in Coagulation After Use of Activated Prothrombin Complex Concentrate in Neonatal Cardiac Surgery. Anesth Analg. 2023 06 01; 136(6):e39-e40.
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Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation. Liver Transpl. 2015 May; 21(5):599-606.
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In vitro comparative study of hemostatic components in warfarin-treated and fibrinogen-deficient plasma. J Cardiothorac Vasc Anesth. 2010 Jun; 24(3):408-12.
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Antiphospholipid antibodies and the antiphospholipid syndrome: clinical significance and treatment. Semin Thromb Hemost. 2008 Apr; 34(3):256-66.
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Effects of prothrombin complex concentrate and recombinant activated factor VII on vitamin K antagonist induced anticoagulation. Thromb Res. 2008; 122(1):117-23.
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Thrombin generation assay and viscoelastic coagulation monitors demonstrate differences in the mode of thrombin inhibition between unfractionated heparin and bivalirudin. Anesth Analg. 2007 Oct; 105(4):933-9, table of contents.
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Abnormal melt curve profile during prothrombin 20210G --> A analysis due to the 20209C --> T variant. Blood Coagul Fibrinolysis. 2006 Oct; 17(7):599-602.
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Traces of factor VIIa modulate thromboplastin sensitivity to factors V, VII, X, and prothrombin. J Thromb Haemost. 2006 Jul; 4(7):1553-8.
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Should coagulation tests be used to determine which oral contraceptive users have an increased risk of thrombophlebitis? Contraception. 2006 Jan; 73(1):4-5.
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Correlates of thrombin generation in patients with advanced prostate cancer. Thromb Haemost. 2003 Jan; 89(1):185-9.