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Kelly M Standifer

TitleProf & Chair
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentPharmaceutical Sciences
AddressCPB 329
1110 N Stonewall Ave
Oklahoma City OK 73117
Phone405/271-6593 ext 47333
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    R01DA017380     (STANDIFER, KELLY M)Apr 16, 2004 - Sep 30, 2009
    NIH
    Cellular mechanisms of ORL1 regulation and cross talk
    Role: Principal Investigator
    R29DA010738     (STANDIFER, KELLY M)Apr 1, 1996 - Feb 28, 2002
    NIH
    OPIOID RECEPTOR SIGNAL TRANSDUCTION MECHANISMS
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Al Yacoub ON, Zhang Y, Patankar PS, Standifer KM. Traumatic Brain Injury Induces Nociceptin/Orphanin FQ and Nociceptin Opioid Peptide Receptor Expression within 24 Hours. Int J Mol Sci. 2024 Jan 29; 25(3). PMID: 38338936; PMCID: PMC10855772.
      Citations:    Fields:    Translation:Animals
    2. Al Yacoub ON, Tarantini S, Zhang Y, Csiszar A, Standifer KM. The Nociceptin/Orphanin FQ peptide receptor antagonist, SB-612111, improves cerebral blood flow in a rat model of traumatic brain injury. Front Pharmacol. 2023; 14:1272969. PMID: 37920208; PMCID: PMC10618424.
      Citations: 1     
    3. Al Yacoub ON, Awwad HO, Standifer KM. Recovery from traumatic brain injury (TBI) is Nociceptin/Orphanin FQ peptide (NOP) receptor genotype-, sex-, and injury severity-dependent. J Pharmacol Exp Ther. 2023 Jul 13. PMID: 37442620.
      Citations: 2     Fields:    
    4. Al Yacoub ON, Awwad HO, Zhang Y, Standifer KM. Therapeutic potential of nociceptin/orphanin FQ peptide (NOP) receptor modulators for treatment of traumatic brain injury, traumatic stress, and their co-morbidities. Pharmacol Ther. 2022 03; 231:107982. PMID: 34480968.
      Citations: 5     Fields:    Translation:Humans
    5. Dib P, Zhang Y, Ihnat MA, Gallucci RM, Standifer KM. TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain. Front Psychiatry. 2021; 12:721999. PMID: 34512420.
      Citations: 8     
    6. Standifer KM, Inturrisi CE, Foley KM, Pan YX. Understanding Opioid Actions, Pain and Analgesia: A Tribute to Dr. Gavril Pasternak. Cell Mol Neurobiol. 2021 Jul; 41(5):827-834. PMID: 33978862.
      Citations:    Fields:    Translation:Humans
    7. Zhang Y, Standifer KM. Exacerbated Headache-Related Pain in the Single Prolonged Stress Preclinical Model of Post-traumatic Stress Disorder. Cell Mol Neurobiol. 2021 Jul; 41(5):1009-1018. PMID: 32930941.
      Citations: 2     Fields:    Translation:Animals
    8. Toll L, Standifer KM, Massotte D. Editorial: Current Topics in Opioid Research. Front Psychiatry. 2019; 10:586. PMID: 31474891.
      Citations: 1     
    9. Zhang Y, Schalo I, Durand C, Standifer KM. Sex Differences in Nociceptin/Orphanin FQ Peptide Receptor-Mediated Pain and Anxiety Symptoms in a Preclinical Model of Post-traumatic Stress Disorder. Front Psychiatry. 2018; 9:731. PMID: 30670988.
      Citations: 12     
    10. Awwad HO, Durand CD, Gonzalez LP, Tompkins P, Zhang Y, Lerner MR, Brackett DJ, Sherry DM, Awasthi V, Standifer KM. Post-blast treatment with Nociceptin/Orphanin FQ peptide (NOP) receptor antagonist reduces brain injury-induced hypoxia and signaling proteins in vestibulomotor-related brain regions. Behav Brain Res. 2018 03 15; 340:183-194. PMID: 27793733.
      Citations: 6     Fields:    Translation:Animals
    11. Ibach BW, Miller JL, Woo S, Harrison D, Standifer KM, Hagemann T, Johnson PN. Characterization of Tolerance in Children during Fentanyl Continuous Infusions. J Pediatr Intensive Care. 2017 Jun; 6(2):83-90. PMID: 31073429.
      Citations: 2     
    12. Awwad HO, Gonzalez LP, Tompkins P, Lerner M, Brackett DJ, Awasthi V, Standifer KM. Blast Overpressure Waves Induce Transient Anxiety and Regional Changes in Cerebral Glucose Metabolism and Delayed Hyperarousal in Rats. Front Neurol. 2015; 6:132. PMID: 26136722.
      Citations: 16     
    13. Zhang Y, Simpson-Durand CD, Standifer KM. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder. Br J Pharmacol. 2015 Jan; 172(2):571-82. PMID: 24666365.
      Citations: 27     Fields:    Translation:Animals
    14. Donica CL, Awwad HO, Thakker DR, Standifer KM. Cellular mechanisms of nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor regulation and heterologous regulation by N/OFQ. Mol Pharmacol. 2013 May; 83(5):907-18. PMID: 23395957.
      Citations: 15     Fields:    Translation:HumansAnimals
    15. Zhang Y, Gandhi PR, Standifer KM. Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD. Mol Pain. 2012 Oct 20; 8:76. PMID: 23082795.
      Citations: 28     Fields:    Translation:Animals
    16. Zhang Y, Donica CL, Standifer KM. Sex differences in the Nociceptin/Orphanin FQ system in rat spinal cord following chronic morphine treatment. Neuropharmacology. 2012 Sep; 63(3):427-33. PMID: 22575074.
      Citations: 5     Fields:    Translation:AnimalsCells
    17. Donica CL, Ramirez VI, Awwad HO, Zaveri NT, Toll L, Standifer KM. Orphanin FQ/nociceptin activates nuclear factor kappa B. J Neuroimmune Pharmacol. 2011 Dec; 6(4):617-25. PMID: 21547539.
      Citations: 8     Fields:    Translation:HumansCells
    18. Greenwood-Van Meerveld B, Standifer KM. Methylnaltrexone in the treatment of opioid-induced constipation. Clin Exp Gastroenterol. 2008; 1:49-58. PMID: 21677823.
      Citations: 5     
    19. Bawa-Khalfe T, Altememi GF, Mandyam CD, Schwarz LA, Eikenburg DC, Standifer KM. The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment. BMC Pharmacol. 2007 Dec 20; 7:16. PMID: 18096057.
      Citations: 5     Fields:    Translation:HumansCells
    20. Salim S, Standifer KM, Eikenburg DC. Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells. J Pharmacol Exp Ther. 2007 Apr; 321(1):51-9. PMID: 17255468.
      Citations: 10     Fields:    Translation:HumansCells
    21. Sherry DM, Mitchell R, Standifer KM, du Plessis B. Distribution of plasma membrane-associated syntaxins 1 through 4 indicates distinct trafficking functions in the synaptic layers of the mouse retina. BMC Neurosci. 2006 Jul 13; 7:54. PMID: 16839421.
      Citations: 61     Fields:    Translation:AnimalsCells
    22. Desai AN, Salim S, Standifer KM, Eikenburg DC. Involvement of G protein-coupled receptor kinase (GRK) 3 and GRK2 in down-regulation of the alpha2B-adrenoceptor. J Pharmacol Exp Ther. 2006 Jun; 317(3):1027-35. PMID: 16533872.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    23. Ozsoy HZ, Thakker DR, Standifer KM. Orphanin FQ/nociceptin potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin-Induced mu-opioid receptor phosphorylation. Mol Pharmacol. 2005 Aug; 68(2):447-56. PMID: 15890842.
      Citations: 5     Fields:    Translation:HumansCells
    24. Desai AN, Standifer KM, Eikenburg DC. Cellular G protein-coupled receptor kinase levels regulate sensitivity of the {alpha}2b-adrenergic receptor to undergo agonist-induced down-regulation. J Pharmacol Exp Ther. 2005 Feb; 312(2):767-73. PMID: 15456839.
      Citations: 4     Fields:    Translation:HumansCells
    25. Desai AN, Standifer KM, Eikenburg DC. Simultaneous alpha2B- and beta2-adrenoceptor activation sensitizes the alpha2B-adrenoceptor for agonist-induced down-regulation. J Pharmacol Exp Ther. 2004 Nov; 311(2):794-802. PMID: 15192083.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    26. Mandyam CD, Thakker DR, Standifer KM. Mu-opioid-induced desensitization of opioid receptor-like 1 and mu-opioid receptors: differential intracellular signaling determines receptor sensitivity. J Pharmacol Exp Ther. 2003 Sep; 306(3):965-72. PMID: 12750434.
      Citations: 11     Fields:    Translation:HumansCells
    27. Bawa T, Altememi GF, Eikenburg DC, Standifer KM. Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation. Br J Pharmacol. 2003 Mar; 138(5):921-31. PMID: 12642394.
      Citations: 10     Fields:    Translation:HumansCells
    28. Thakker DR, Ozsoy HZ, Standifer KM. Assessing opioid regulation of adenylyl cyclase activity in intact cells. Methods Mol Med. 2003; 84:29-37. PMID: 12703314.
      Citations: 1     Fields:    Translation:HumansCells
    29. Thakker DR, Standifer KM. Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure. Neuropharmacology. 2002 Nov; 43(6):979-90. PMID: 12423667.
      Citations: 14     Fields:    Translation:HumansCells
    30. Thakker DR, Standifer KM. Orphanin FQ/nociceptin blocks chronic morphine-induced tyrosine hydroxylase upregulation. Brain Res Mol Brain Res. 2002 Sep 30; 105(1-2):38-46. PMID: 12399106.
      Citations: 3     Fields:    Translation:HumansCells
    31. Mandyam CD, Thakker DR, Christensen JL, Standifer KM. Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk. J Pharmacol Exp Ther. 2002 Aug; 302(2):502-9. PMID: 12130708.
      Citations: 19     Fields:    Translation:HumansCells
    32. Yang H, Standifer KM, Sherry DM. Synaptic protein expression by regenerating adult photoreceptors. J Comp Neurol. 2002 Feb 11; 443(3):275-88. PMID: 11807837.
      Citations: 8     Fields:    Translation:AnimalsCells
    33. Sherry DM, Yang H, Standifer KM. Vesicle-associated membrane protein isoforms in the tiger salamander retina. J Comp Neurol. 2001 Mar 19; 431(4):424-36. PMID: 11223812.
      Citations: 8     Fields:    Translation:AnimalsCells
    34. Mathis JP, Mandyam CD, Altememi GF, Pasternak GW, Standifer KM. Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells. Neurosci Lett. 2001 Feb 23; 299(3):173-6. PMID: 11165763.
      Citations: 4     Fields:    Translation:HumansCells
    35. Silva RM, Rossi GC, Mathis JP, Standifer KM, Pasternak GW, Bodnar RJ. Morphine and morphine-6beta-glucuronide-induced feeding are differentially reduced by G-protein alpha-subunit antisense probes in rats. Brain Res. 2000 Sep 08; 876(1-2):62-75. PMID: 10973594.
      Citations: 4     Fields:    Translation:Animals
    36. Mandyam CD, Altememi GF, Standifer KM. beta-Funaltrexamine inactivates ORL1 receptors in BE(2)-C human neuroblastoma cells. Eur J Pharmacol. 2000 Aug 18; 402(1-2):R1-37. PMID: 10940375.
      Citations: 5     Fields:    Translation:HumansCells
    37. Standifer KM. Reduction of neurotransmitter receptor and G-protein expression in vivo and in vitro by antisense oligodeoxynucleotide treatment. Methods Enzymol. 2000; 314:90-103. PMID: 10565007.
      Citations:    Fields:    Translation:AnimalsCells
    38. Wang H, Standifer KM, Sherry DM. GABA(A) receptor binding and localization in the tiger salamander retina. Vis Neurosci. 2000 Jan-Feb; 17(1):11-21. PMID: 10750823.
      Citations: 6     Fields:    Translation:AnimalsCells
    39. Brown GP, Yang K, Ouerfelli O, Standifer KM, Byrd D, Pasternak GW. 3H-morphine-6beta-glucuronide binding in brain membranes and an MOR-1-transfected cell line. J Pharmacol Exp Ther. 1997 Sep; 282(3):1291-7. PMID: 9316837.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Standifer KM, Pasternak GW. G proteins and opioid receptor-mediated signalling. Cell Signal. 1997 May-Jun; 9(3-4):237-48. PMID: 9218123.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    41. Ryan-Moro J, Chien CC, Standifer KM, Pasternak GW. Sigma binding in a human neuroblastoma cell line. Neurochem Res. 1996 Nov; 21(11):1309-14. PMID: 8947921.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    42. Ciszewska GR, Ginos JA, Charton M, Standifer KM, Brooks AI, Brown GP, Ryan-Moro JP, Berzetei-Gurske I, Toll L, Pasternak GW. Synthesis and characterization of substituted benzoylhydrazones of naloxone. Synapse. 1996 Oct; 24(2):193-201. PMID: 8890461.
      Citations: 2     Fields:    Translation:AnimalsCells
    43. Standifer KM, Rossi GC, Pasternak GW. Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits. Mol Pharmacol. 1996 Aug; 50(2):293-8. PMID: 8700136.
      Citations: 23     Fields:    Translation:AnimalsCells
    44. Brooks AI, Standifer KM, Rossi GC, Mathis JP, Pasternak GW. Characterizing kappa3 opioid receptors with a selective monoclonal antibody. Synapse. 1996 Mar; 22(3):247-52. PMID: 9132993.
      Citations: 2     Fields:    Translation:AnimalsCells
    45. Standifer KM, Jenab S, Su W, Chien CC, Pan YX, Inturrisi CE, Pasternak GW. Antisense oligodeoxynucleotides to the cloned delta receptor DOR-1: uptake, stability, and regulation of gene expression. J Neurochem. 1995 Nov; 65(5):1981-7. PMID: 7595481.
      Citations: 1     Fields:    Translation:AnimalsCells
    46. Pasternak GW, Standifer KM. Mapping of opioid receptors using antisense oligodeoxynucleotides: correlating their molecular biology and pharmacology. Trends Pharmacol Sci. 1995 Oct; 16(10):344-50. PMID: 7491712.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    47. Rossi GC, Standifer KM, Pasternak GW. Differential blockade of morphine and morphine-6 beta-glucuronide analgesia by antisense oligodeoxynucleotides directed against MOR-1 and G-protein alpha subunits in rats. Neurosci Lett. 1995 Sep 29; 198(2):99-102. PMID: 8592651.
      Citations: 19     Fields:    Translation:AnimalsCells
    48. Cheng J, Standifer KM, Tublin PR, Su W, Pasternak GW. Demonstration of kappa 3-opioid receptors in the SH-SY5Y human neuroblastoma cell line. J Neurochem. 1995 Jul; 65(1):170-5. PMID: 7790858.
      Citations: 10     Fields:    Translation:HumansCells
    49. Pan YX, Cheng J, Xu J, Rossi G, Jacobson E, Ryan-Moro J, Brooks AI, Dean GE, Standifer KM, Pasternak GW. Cloning and functional characterization through antisense mapping of a kappa 3-related opioid receptor. Mol Pharmacol. 1995 Jun; 47(6):1180-8. PMID: 7603458.
      Citations: 33     Fields:    Translation:AnimalsCells
    50. Visconti LM, Standifer KM, Schiller PW, Pasternak GW. TIPP[psi], a highly selective delta ligand. Neurosci Lett. 1994 Nov 07; 181(1-2):47-9. PMID: 7898768.
      Citations:    Fields:    Translation:AnimalsCells
    51. Standifer KM, Cheng J, Brooks AI, Honrado CP, Su W, Visconti LM, Biedler JL, Pasternak GW. Biochemical and pharmacological characterization of mu, delta and kappa 3 opioid receptors expressed in BE(2)-C neuroblastoma cells. J Pharmacol Exp Ther. 1994 Sep; 270(3):1246-55. PMID: 7932177.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    52. Standifer KM, Chien CC, Wahlestedt C, Brown GP, Pasternak GW. Selective loss of delta opioid analgesia and binding by antisense oligodeoxynucleotides to a delta opioid receptor. Neuron. 1994 Apr; 12(4):805-10. PMID: 8161452.
      Citations: 35     Fields:    Translation:AnimalsCells
    53. Brooks AI, Standifer KM, Cheng J, Ciszewska G, Pasternak GW. Opioid binding in giant toad and goldfish brain. Receptor. 1994; 4(1):55-62. PMID: 8038707.
      Citations: 2     Fields:    Translation:Animals
    54. Standifer KM, Clark JA, Pasternak GW. Modulation of Mu1 opioid binding by magnesium: evidence for multiple receptor conformations. J Pharmacol Exp Ther. 1993 Jul; 266(1):106-13. PMID: 8392546.
      Citations: 2     Fields:    Translation:AnimalsCells
    55. Kepler KL, Standifer KM, Paul D, Kest B, Pasternak GW, Bodnar RJ. Gender effects and central opioid analgesia. Pain. 1991 Apr; 45(1):87-94. PMID: 1677751.
      Citations: 34     Fields:    Translation:Animals
    56. Standifer KM, Murthy LR, Kinouchi K, Steele L, Pasternak GW. Affinity labeling of mu and kappa receptors with naloxone benzoylhydrazone. Mol Pharmacol. 1991 Mar; 39(3):290-8. PMID: 1848652.
      Citations: 1     Fields:    Translation:AnimalsCells
    57. Arjune D, Standifer KM, Pasternak GW, Bodnar RJ. Reduction by central beta-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions. Brain Res. 1990 Dec 03; 535(1):101-9. PMID: 1963340.
      Citations: 8     Fields:    Translation:Animals
    58. Kinouchi K, Standifer KM, Pasternak GW. Modulation of mu 1, mu 2, and delta opioid binding by divalent cations. Biochem Pharmacol. 1990 Jul 15; 40(2):382-4. PMID: 2165406.
      Citations: 5     Fields:    Translation:Animals
    59. Paul D, Standifer KM, Inturrisi CE, Pasternak GW. Pharmacological characterization of morphine-6 beta-glucuronide, a very potent morphine metabolite. J Pharmacol Exp Ther. 1989 Nov; 251(2):477-83. PMID: 2810109.
      Citations: 69     Fields:    Translation:Animals
    60. Standifer KM, Pitha J, Baker SP. Carbostyril-based beta-adrenergic agonists: evidence for long lasting or apparent irreversible receptor binding and activation of adenylate cyclase activity in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb; 339(1-2):129-37. PMID: 2566922.
      Citations: 6     Fields:    Translation:AnimalsCells
    61. Baker SP, Standifer KM, Kalberg CJ, Pitha J, Sumners C. Irreversible binding and recovery of the norepinephrine uptake system using an alkylating derivative of norepinephrine. J Neurochem. 1988 Apr; 50(4):1044-52. PMID: 2894406.
      Citations:    Fields:    Translation:AnimalsCells
    62. Milecki J, Baker SP, Standifer KM, Ishizu T, Chida Y, Kusiak JW, Pitha J. Carbostyril derivatives having potent beta-adrenergic agonist properties. J Med Chem. 1987 Sep; 30(9):1563-6. PMID: 2887658.
      Citations: 3     Fields:    Translation:AnimalsCells
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